Publications:

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BAG2 drives chemoresistance of breast cancer by exacerbating mutant p53 aggregate.

Theranostics

Huang, Xinjian X; Shi, Dongni D; Zou, Xuxiazi X; Wu, Xuxia X; Huang, Shumei S; Kong, Lingzhi L; Yang, Muwen M; Xiao, Yunyun Y; Chen, Boyu B; Chen, Xiangfu X; Ouyang, Ying Y; Song, Libing L; Jian, Yunting Y; Lin, Chuyong C

Publication Date: 2023

Variant appearance in text: p53: I254R

PubMed Link: 36593950

Variant Present in the following documents:

• thnov13p0339.pdf

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p53 amyloid aggregation in cancer: function, mechanism, and therapy.

Experimental Hematology & Oncology

Li, Jingzhi J; Guo, Ming M; Chen, Lin L; Chen, Zhuchu Z; Fu, Ying Y; Chen, Yongheng Y

Publication Date: 2022-09-28

Variant appearance in text: p53: I254R

PubMed Link: 36171607

Variant Present in the following documents:

• Main text
• 40164_2022_Article_317.pdf

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Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function.

Nature Communications

Palanikumar, L L; Karpauskaite, Laura L; Al-Sayegh, Mohamed M; Chehade, Ibrahim I; Alam, Maheen M; Hassan, Sarah S; Maity, Debabrata D; Ali, Liaqat L; Kalmouni, Mona M; Hunashal, Yamanappa Y; Ahmed, Jemil J; Houhou, Tatiana T; Karapetyan, Shake S; Falls, Zackary Z; Samudrala, Ram R; Pasricha, Renu R; Esposito, Gennaro G; Afzal, Ahmed J AJ; Hamilton, Andrew D AD; Kumar, Sunil S; Magzoub, Mazin M

Publication Date: 2021-06-25

Variant appearance in text: p53: I254R

PubMed Link: 34172723

Variant Present in the following documents:

• Main text
• 41467_2021_Article_23985.pdf

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Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis.

International Journal Of Molecular Sciences

Stein, Yan Y; Rotter, Varda V; Aloni-Grinstein, Ronit R

Publication Date: 2019-12-08

Variant appearance in text: p53: I254R

PubMed Link: 31817996

Variant Present in the following documents:

• ijms-20-06197.pdf

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Multisite aggregation of p53 and implications for drug rescue.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Wang, GuoZhen G; Fersht, Alan R AR

Publication Date: 2017-03-28

Variant appearance in text: p53: I254R

PubMed Link: 28292898

Variant Present in the following documents:

• Main text

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Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds.

Scientific Reports

Cino, Elio A EA; Soares, Iaci N IN; Pedrote, Murilo M MM; de Oliveira, Guilherme A P GA; Silva, Jerson L JL

Publication Date: 2016-09-07

Variant appearance in text: p53: I254R

PubMed Link: 27600721

Variant Present in the following documents:

• Main text
• srep32535.pdf

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Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?

Cold Spring Harbor Perspectives In Biology

Costa, Danielly C F DC; de Oliveira, Guilherme A P GA; Cino, Elio A EA; Soares, Iaci N IN; Rangel, Luciana P LP; Silva, Jerson L JL

Publication Date: 2016-10-03

Variant appearance in text: p53: I254R

PubMed Link: 27549118

Variant Present in the following documents:

• Main text

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Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family.

Cell Death And Differentiation

Kehrloesser, Sebastian S; Osterburg, Christian C; Tuppi, Marcel M; Schäfer, Birgit B; Vousden, Karen Heather KH; Dötsch, Volker V

Publication Date: 2016-12

Variant appearance in text: p53: I254R

PubMed Link: 27447112

Variant Present in the following documents:

• Main text

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Self-aggregation and coaggregation of the p53 core fragment with its aggregation gatekeeper variant.

Physical Chemistry Chemical Physics : Pccp

Lei, Jiangtao J; Qi, Ruxi R; Wei, Guanghong G; Nussinov, Ruth R; Ma, Buyong B

Publication Date: 2016-03-21

Variant appearance in text: p53: I254R

PubMed Link: 26923710

Variant Present in the following documents:

• Main text

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A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.

Cancer Cell

Soragni, Alice A; Janzen, Deanna M DM; Johnson, Lisa M LM; Lindgren, Anne G AG; Thai-Quynh Nguyen, Anh A; Tiourin, Ekaterina E; Soriaga, Angela B AB; Lu, Jing J; Jiang, Lin L; Faull, Kym F KF; Pellegrini, Matteo M; Memarzadeh, Sanaz S; Eisenberg, David S DS

Publication Date: 2016-01-11

Variant appearance in text: p53: I254R

PubMed Link: 26748848

Variant Present in the following documents:

• Main text

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Functional interplay between MDM2, p63/p73 and mutant p53.

Oncogene

Stindt, M H MH; Muller, P A J PA; Ludwig, R L RL; Kehrloesser, S S; Dötsch, V V; Vousden, K H KH

Publication Date: 2015-08-13

Variant appearance in text: p53: I254R

PubMed Link: 25417702

Variant Present in the following documents:

• Main text
• onc2014359a.pdf

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