Variant ID: 17-7577539-G-A

NM_000546.5(TP53):c.742C>T;(p.R248W)

This variant was identified in 1034 publications

View GRCh38 version.




Publications:


Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor.

Acta Neuropathologica Communications
Arunachalam, Sasi S; Szlachta, Karol K; Brady, Samuel W SW; Ma, Xiaotu X; Ju, Bensheng B; Shaner, Bridget B; Mulder, Heather L HL; Easton, John J; Raphael, Benjamin J BJ; Myers, Matthew M; Tinkle, Christopher C; Allen, Sariah J SJ; Orr, Brent A BA; Wetmore, Cynthia J CJ; Baker, Suzanne J SJ; Zhang, Jinghui J
Publication Date: 2022-05-31

Variant appearance in text: TP53: R248W
PubMed Link: 35642016
Variant Present in the following documents:
  • Main text
  • 40478_2022_Article_1381.pdf
  • 40478_2022_1381_MOESM2_ESM.pdf
View BVdb publication page



Effect of Statins on Lung Cancer Molecular Pathways: A Possible Therapeutic Role.

Pharmaceuticals (Basel, Switzerland)
Marcianò, Gianmarco G; Palleria, Caterina C; Casarella, Alessandro A; Rania, Vincenzo V; Basile, Emanuele E; Catarisano, Luca L; Vocca, Cristina C; Bianco, Luigi L; Pelaia, Corrado C; Cione, Erika E; D'Agostino, Bruno B; Citraro, Rita R; De Sarro, Giovambattista G; Gallelli, Luca L
Publication Date: 2022-05-10

Variant appearance in text: p53: R248W
PubMed Link: 35631415
Variant Present in the following documents:
  • Main text
  • pharmaceuticals-15-00589.pdf
View BVdb publication page



Sequencing of Cutaneous Squamous Cell Carcinoma Primary Tumors and Patient-Matched Metastases Reveals ALK as a Potential Driver in Metastases and Low Mutational Concordance in Immunocompromised Patients.

Jid Innovations : Skin Science From Molecules To Population Health
Lobl, Marissa B MB; Clarey, Dillon D DD; Higgins, Shauna S; Sutton, Adam A; Wysong, Ashley A
Publication Date: 2022-07

Variant appearance in text: TP53: R248W
PubMed Link: 35620707
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q.

Ebiomedicine
Adema, Vera V; Palomo, Laura L; Walter, Wencke W; Mallo, Mar M; Hutter, Stephan S; La Framboise, Thomas T; Arenillas, Leonor L; Meggendorfer, Manja M; Radivoyevitch, Tomas T; Xicoy, Blanca B; Pellagatti, Andrea A; Haferlach, Claudia C; Boultwood, Jacqueline J; Kern, Wolfgang W; Visconte, Valeria V; Sekeres, Mikkael M; Barnard, John J; Haferlach, Torsten T; Solé, Francesc F; Maciejewski, Jaroslaw P JP
Publication Date: 2022-05-23

Variant appearance in text: TP53: 742C>T; Arg248Trp
PubMed Link: 35617825
Variant Present in the following documents:
  • mmc3.xlsx
View BVdb publication page



Synthetic lethality between TP53 and ENDOD1.

Nature Communications
Tang, Zizhi Z; Zeng, Ming M; Wang, Xiaojun X; Guo, Chang C; Yue, Peng P; Zhang, Xiaohu X; Lou, Huiqiang H; Chen, Jun J; Mu, Dezhi D; Kong, Daochun D; Carr, Antony M AM; Liu, Cong C
Publication Date: 2022-05-23

Variant appearance in text: TP53: R248W
PubMed Link: 35606358
Variant Present in the following documents:
  • Main text
  • 41467_2022_30311_MOESM1_ESM.pdf
  • 41467_2022_Article_30311.pdf
View BVdb publication page



Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations.

Life Science Alliance
Qin, Zixin Z; Huang, Teng T; Guo, Maoni M; Wang, San Ming SM
Publication Date: 2022-09

Variant appearance in text: TP53: 742C>T; Arg248Trp; rs121912651
PubMed Link: 35595529
Variant Present in the following documents:
  • LSA-2021-01319_TableS1.xlsx
  • LSA-2021-01319_TableS3.xlsx
View BVdb publication page



Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.

Nature Communications
Hassin, Ori O; Nataraj, Nishanth Belugali NB; Shreberk-Shaked, Michal M; Aylon, Yael Y; Yaeger, Rona R; Fontemaggi, Giulia G; Mukherjee, Saptaparna S; Maddalena, Martino M; Avioz, Adi A; Iancu, Ortal O; Mallel, Giuseppe G; Gershoni, Anat A; Grosheva, Inna I; Feldmesser, Ester E; Ben-Dor, Shifra S; Golani, Ofra O; Hendel, Ayal A; Blandino, Giovanni G; Kelsen, David D; Yarden, Yosef Y; Oren, Moshe M
Publication Date: 2022-05-19

Variant appearance in text: p53: R248W
PubMed Link: 35589715
Variant Present in the following documents:
  • Main text
  • 41467_2022_30481_MOESM2_ESM.pdf
  • 41467_2022_Article_30481.pdf
View BVdb publication page



Characterization of acquired nutlin-3 resistant non-small cell lung cancer cells.

Cancer Drug Resistance (Alhambra, Calif.)
Deben, Christophe C; Boullosa, Laurie Freire LF; Domen, Andreas A; Wouters, An A; Cuypers, Bart B; Laukens, Kris K; Lardon, Filip F; Pauwels, Patrick P
Publication Date: 2021

Variant appearance in text: p53: R248W
PubMed Link: 35582010
Variant Present in the following documents:
  • cdr-4-233.pdf
View BVdb publication page



Homologous recombination deficiency in diverse cancer types and its correlation with platinum chemotherapy efficiency in ovarian cancer.

Bmc Cancer
Wen, Hao H; Feng, Zheng Z; Ma, Yutong Y; Liu, Rui R; Ou, Qiuxiang Q; Guo, Qinhao Q; Shen, Yi Y; Wu, Xue X; Shao, Yang Y; Bao, Hua H; Wu, Xiaohua X
Publication Date: 2022-05-16

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35578198
Variant Present in the following documents:
  • 12885_2022_9602_MOESM9_ESM.xlsx
View BVdb publication page



Liquid Biopsy in Squamous Cell Carcinoma of the Esophagus and of the Head and Neck.

Frontiers In Medicine
Iacob, Razvan R; Mandea, Matei M; Iacob, Speranta S; Pietrosanu, Catalina C; Paul, Doru D; Hainarosie, Razvan R; Gheorghe, Cristian C
Publication Date: 2022

Variant appearance in text: TP53: R248W
PubMed Link: 35572996
Variant Present in the following documents:
  • fmed-09-827297.pdf
View BVdb publication page



The Role of E3 Ligase Pirh2 in Disease.

Cells
Daks, Alexandra A; Fedorova, Olga O; Parfenyev, Sergey S; Nevzorov, Ivan I; Shuvalov, Oleg O; Barlev, Nickolai A NA
Publication Date: 2022-04-30

Variant appearance in text: p53: R248W
PubMed Link: 35563824
Variant Present in the following documents:
  • cells-11-01515.pdf
View BVdb publication page



Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.

Nature Communications
Zhang, Yiqun Y; Chen, Fengju F; Chandrashekar, Darshan S DS; Varambally, Sooryanarayana S; Creighton, Chad J CJ
Publication Date: 2022-05-13

Variant appearance in text: p53: R248W
PubMed Link: 35562349
Variant Present in the following documents:
  • 41467_2022_30342_MOESM4_ESM.xlsx
View BVdb publication page



Fundamental immune-oncogenicity trade-offs define driver mutation fitness.

Nature
Hoyos, David D; Zappasodi, Roberta R; Schulze, Isabell I; Sethna, Zachary Z; de Andrade, Kelvin César KC; Bajorin, Dean F DF; Bandlamundi, Chaitanya C; Callahan, Margaret K MK; Funt, Samuel A SA; Hadrup, Sine R SR; Holm, Jeppe S JS; Rosenberg, Jonathan E JE; Shah, Sohrab P SP; Vázquez-García, Ignacio I; Weigelt, Britta B; Wu, Michelle M; Zamarin, Dmitriy D; Campitelli, Laura F LF; Osborne, Edward J EJ; Klinger, Mark M; Robins, Harlan S HS; Khincha, Payal P PP; Savage, Sharon A SA; Balachandran, Vinod P VP; Wolchok, Jedd D JD; Hellmann, Matthew D MD; Merghoub, Taha T; Levine, Arnold J AJ; Łuksza, Marta M; Greenbaum, Benjamin D BD
Publication Date: 2022-05-11

Variant appearance in text: TP53: R248W
PubMed Link: 35545680
Variant Present in the following documents:
  • Main text
  • 41586_2022_Article_4696.pdf
  • 41586_2022_4696_MOESM1_ESM.pdf
View BVdb publication page



Mutual exclusivity of ESR1 and TP53 mutations in endocrine resistant metastatic breast cancer.

Npj Breast Cancer
Li, Zheqi Z; Spoelstra, Nicole S NS; Sikora, Matthew J MJ; Sams, Sharon B SB; Elias, Anthony A; Richer, Jennifer K JK; Lee, Adrian V AV; Oesterreich, Steffi S
Publication Date: 2022-05-10

Variant appearance in text: TP53: R248W
PubMed Link: 35538119
Variant Present in the following documents:
  • 41523_2022_426_MOESM1_ESM.pdf
View BVdb publication page



The dual role of autophagy in acute myeloid leukemia.

Journal Of Hematology & Oncology
Seo, Wonhyoung W; Silwal, Prashanta P; Song, Ik-Chan IC; Jo, Eun-Kyeong EK
Publication Date: 2022-05-07

Variant appearance in text: p53: R248W
PubMed Link: 35526025
Variant Present in the following documents:
  • 13045_2022_Article_1262.pdf
View BVdb publication page



Paclitaxel and cisplatin with or without cetuximab in metastatic esophageal squamous cell carcinoma: a randomized, multicenter phase II trial.

Innovation (Cambridge (Mass.))
Lu, Zhihao Z; Zhang, Yanqiao Y; Fan, Qingxia Q; Pan, Yueyin Y; Jiang, Da D; Lu, Ping P; Zhang, Jingdong J; Yuan, Xianglin X; Feng, Jifeng J; Yang, Shujun S; Yue, Wenbin W; Zhao, Lin L; Xu, Yunhua Y; Luo, Jinhua J; Shen, Lin L
Publication Date: 2022-05-10

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35509869
Variant Present in the following documents:
  • mmc2.xlsx
View BVdb publication page



Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways.

Cold Spring Harbor Molecular Case Studies
Lavoie, Jean-Michel JM; Csizmok, Veronika V; Williamson, Laura M LM; Culibrk, Luka L; Wang, Gang G; Marra, Marco A MA; Laskin, Janessa J; Jones, Steven J M SJM; Renouf, Daniel J DJ; Kollmannsberger, Christian K CK
Publication Date: 2022-04

Variant appearance in text: TP53: 742C>T; Arg248Trp; rs121912651
PubMed Link: 35483882
Variant Present in the following documents:
  • MCS006148Lav.pdf
View BVdb publication page



Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties.

Aging
McCubrey, James A JA; Meher, Akshaya K AK; Akula, Shaw M SM; Abrams, Stephen L SL; Steelman, Linda S LS; LaHair, Michelle M MM; Franklin, Richard A RA; Martelli, Alberto M AM; Ratti, Stefano S; Cocco, Lucio L; Barbaro, Fulvio F; Duda, Przemysław P; Gizak, Agnieszka A
Publication Date: 2022-04-27

Variant appearance in text: TP53: R248W
PubMed Link: 35477123
Variant Present in the following documents:
  • aging-14-204038.pdf
View BVdb publication page



Synergistic blocking of RAS downstream signaling and epigenetic pathway in KRAS mutant pancreatic cancer.

Aging
Zhang, Xiaofei X; Mao, Tiebo T; Xu, Haiyan H; Li, Shumin S; Yue, Ming M; Ma, Jingyu J; Yao, Jiayu J; Wang, Yongchao Y; Zhang, Xiao X; Ge, Weiyu W; Wang, Yanling Y; Shentu, Daiyuan D; Wang, Liwei L
Publication Date: 2022-04-25

Variant appearance in text: TP53: R248W
PubMed Link: 35468095
Variant Present in the following documents:
  • aging-14-204031.pdf
View BVdb publication page



Models of Renal Cell Carcinoma Used to Investigate Molecular Mechanisms and Develop New Therapeutics.

Frontiers In Oncology
Shapiro, Daniel D DD; Virumbrales-Muñoz, Maria M; Beebe, David J DJ; Abel, E Jason EJ
Publication Date: 2022

Variant appearance in text: TP53: R248W
PubMed Link: 35463327
Variant Present in the following documents:
  • fonc-12-871252.pdf
View BVdb publication page



Enhanced Cytotoxic Effects in Human Oral Squamous Cell Carcinoma Cells Treated with Combined Methyltransferase Inhibitors and Histone Deacetylase Inhibitors.

Biomedicines
Ushio, Ryosuke R; Hiroi, Miki M; Matsumoto, Ari A; Mori, Kazumasa K; Yamamoto, Nobuharu N; Ohmori, Yoshihiro Y
Publication Date: 2022-03-24

Variant appearance in text: p53: R248W
PubMed Link: 35453513
Variant Present in the following documents:
  • biomedicines-10-00763.pdf
View BVdb publication page



Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity.

Nature Communications
Shi, Xiaohan X; Li, Yunguang Y; Yuan, Qiuyue Q; Tang, Shijie S; Guo, Shiwei S; Zhang, Yehan Y; He, Juan J; Zhang, Xiaoyu X; Han, Ming M; Liu, Zhuang Z; Zhu, Yiqin Y; Gao, Suizhi S; Wang, Huan H; Xu, Xiongfei X; Zheng, Kailian K; Jing, Wei W; Chen, Luonan L; Wang, Yong Y; Jin, Gang G; Gao, Dong D
Publication Date: 2022-04-21

Variant appearance in text: TP53: R248W
PubMed Link: 35449156
Variant Present in the following documents:
  • 41467_2022_29857_MOESM5_ESM.xlsx
View BVdb publication page



Integrated DNA and RNA sequencing reveals early drivers involved in metastasis of gastric cancer.

Cell Death & Disease
Zhang, Jieyun J; Liu, Fatao F; Yang, Yanan Y; Yu, Nuoya N; Weng, Xiaoling X; Yang, Yue Y; Gong, Zhe Z; Huang, Shenglin S; Gan, Lu L; Sun, Sijie S; Zhang, Xiaowei X; Gong, Yiwei Y; Liu, Yun Y; Guo, Weijian W
Publication Date: 2022-04-21

Variant appearance in text: TP53: R248W
PubMed Link: 35449126
Variant Present in the following documents:
  • 41419_2022_Article_4838.pdf
View BVdb publication page



Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer.

Nanoscale
Popov, Andrea Bistrović AB; Melle, Francesca F; Linnane, Emily E; González-López, Cristina C; Ahmed, Ishtiaq I; Parshad, Badri B; Franck, Christoph O CO; Rahmoune, Hassan H; Richards, Frances M FM; Muñoz-Espín, Daniel D; Jodrell, Duncan I DI; Fairen-Jimenez, David D; Fruk, Ljiljana L
Publication Date: 2022-04-19

Variant appearance in text: TP53: R248W
PubMed Link: 35438701
Variant Present in the following documents:
  • Main text
View BVdb publication page



PIM1 genetic alterations associated with distinct molecular profiles, phenotypes and drug responses in diffuse large B-cell lymphoma.

Clinical And Translational Medicine
Zhang, Huilai H; Lu, Yaxiao Y; Zhang, Tingting T; Guan, Qingpei Q; Wang, Xiaoxuan X; Guo, Yixian Y; Li, Lanfang L; Qiu, Lihua L; Qian, Zhengzi Z; Zhou, Shiyong S; Gong, Wenchen W; Meng, Bin B; Ren, Xiubao X; Wang, Xianhuo X
Publication Date: 2022-04

Variant appearance in text: TP53: R248W
PubMed Link: 35415904
Variant Present in the following documents:
  • CTM2-12-e808-s003.xlsx
View BVdb publication page



Genomic clonal evolution correlated with phenotype and prognosis in gastric cancer.

Clinical And Translational Medicine
Ge, Jie J; Li, Xuan X; Deng, Zhenghao Z; Gao, Xuan X; Liu, Yaoyao Y; Xiong, Xingui X; Zhao, Xianhui X; Peng, Huan H; Yi, Xin X; Xia, Xuefeng X; Chen, Zihua Z; Li, Lifeng L; Zhou, Haiyan H; Liu, Heli H
Publication Date: 2022-04

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35384329
Variant Present in the following documents:
  • CTM2-12-e799-s006.xlsx
View BVdb publication page



Mutant p53: it's not all one and the same.

Cell Death And Differentiation
Kennedy, Margaret C MC; Lowe, Scott W SW
Publication Date: 2022-03-31

Variant appearance in text: p53: R248W
PubMed Link: 35361963
Variant Present in the following documents:
  • 41418_2022_Article_989.pdf
View BVdb publication page



Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study.

Plos One
Aoyagi, Yasuko Y; Kano, Yoshihito Y; Tohyama, Kohki K; Matsudera, Shotaro S; Kumaki, Yuichi Y; Takahashi, Kenta K; Mitsumura, Takahiro T; Harada, Yohei Y; Sato, Akemi A; Nakamura, Hideaki H; Sueoka, Eisaburo E; Aragane, Naoko N; Kimura, Koichiro K; Onishi, Iichiro I; Takemoto, Akira A; Akahoshi, Keiichi K; Ono, Hiroaki H; Ishikawa, Toshiaki T; Tokunaga, Masanori M; Nakagawa, Tsuyoshi T; Oshima, Noriko N; Nakamura, Reiko R; Takagi, Masatoshi M; Asakage, Takahiro T; Uetake, Hiroyuki H; Tanabe, Minoru M; Miyake, Satoshi S; Kinugasa, Yusuke Y; Ikeda, Sadakatsu S
Publication Date: 2022

Variant appearance in text: TP53: R248W
PubMed Link: 35358259
Variant Present in the following documents:
  • pone.0266112.s001.xlsx
View BVdb publication page



Ultrasensitive profiling of UV mutations identifies thousands of subclinical facial tumors in tuberous sclerosis complex.

The Journal Of Clinical Investigation
Klonowska, Katarzyna K; Grevelink, Joannes M JM; Giannikou, Krinio K; Ogorek, Barbara A BA; Herbert, Zachary T ZT; Thorner, Aaron R AR; Darling, Thomas N TN; Moss, Joel J; Kwiatkowski, David J DJ
Publication Date: 2022-03-31

Variant appearance in text: TP53: R248W
PubMed Link: 35358092
Variant Present in the following documents:
  • jci-132-155858-s182.pdf
View BVdb publication page



Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Stransky, Laura A LA; Vigeant, Sean M SM; Huang, Bofu B; West, Destiny D; Denize, Thomas T; Walton, Emily E; Signoretti, Sabina S; Kaelin, William G WG
Publication Date: 2022-04-05

Variant appearance in text: p53: R248W
PubMed Link: 35357972
Variant Present in the following documents:
  • pnas.2120403119.sapp.pdf
View BVdb publication page



Mechanical stress shapes the cancer cell response to neddylation inhibition.

Journal Of Experimental & Clinical Cancer Research : Cr
Mittler, Frédérique F; Obeïd, Patricia P; Haguet, Vincent V; Allier, Cédric C; Gerbaud, Sophie S; Rulina, Anastasia V AV; Gidrol, Xavier X; Balakirev, Maxim Y MY
Publication Date: 2022-03-30

Variant appearance in text: p53: R248W
PubMed Link: 35354476
Variant Present in the following documents:
  • 13046_2022_2328_MOESM1_ESM.pdf
View BVdb publication page



Next-Generation Sequencing in Lung Cancer Patients: A Comparative Approach in NSCLC and SCLC Mutational Landscapes.

Journal Of Personalized Medicine
Pop-Bica, Cecilia C; Ciocan, Cristina Alexandra CA; Braicu, Cornelia C; Haranguș, Antonia A; Simon, Marioara M; Nutu, Andreea A; Pop, Laura Ancuta LA; Slaby, Ondrej O; Atanasov, Atanas G AG; Pirlog, Radu R; Al Hajjar, Nadim N; Berindan-Neagoe, Ioana I
Publication Date: 2022-03-13

Variant appearance in text: TP53: 742C>T
PubMed Link: 35330454
Variant Present in the following documents:
  • jpm-12-00453.pdf
View BVdb publication page



Response prediction and risk stratification of patients with rectal cancer after neoadjuvant therapy through an analysis of circulating tumour DNA.

Ebiomedicine
Liu, Wenyang W; Li, Yifei Y; Tang, Yuan Y; Song, Qianqian Q; Wang, Jingjing J; Li, Ning N; Chen, Silin S; Shi, Jinming J; Wang, Shulian S; Li, Yexiong Y; Jiao, Yuchen Y; Zeng, Yixin Y; Jin, Jing J
Publication Date: 2022-03-17

Variant appearance in text: TP53: 742C>T
PubMed Link: 35306340
Variant Present in the following documents:
  • mmc3.xlsx
View BVdb publication page



Clonal hematopoiesis in primary immune thrombocytopenia.

Blood Cancer Journal
Wang, Yanming Y; Yu, Tianshu T; Dong, Qiaofeng Q; Liu, Shuang S; Yu, Yafei Y; Zhao, Hong Yu HY; Ma, Ji J; Dong, Lin L; Wang, Liang L; Ma, Daoxin D; Zhao, Yajing Y; Hou, Yu Y; Liu, Xinguang X; Peng, Jun J; Hou, Ming M
Publication Date: 2022-03-15

Variant appearance in text: TP53: R248W
PubMed Link: 35293382
Variant Present in the following documents:
  • 41408_2022_641_MOESM1_ESM.pdf
View BVdb publication page



The Landscape of Actionable Genomic Alterations by Next-Generation Sequencing in Tumor Tissue Versus Circulating Tumor DNA in Chinese Patients With Non-Small Cell Lung Cancer.

Frontiers In Oncology
Cai, Jun J; Jiang, Huihui H; Li, Shuqing S; Yan, Xiaoxia X; Wang, Meng M; Li, Na N; Zhu, Cuimin C; Dong, Hui H; Wang, Dongjuan D; Xu, Yue Y; Xie, Hui H; Wu, Shouxin S; Lou, Jingwei J; Zhao, Jiangman J; Li, Qingshan Q
Publication Date: 2021

Variant appearance in text: TP53: R248W
PubMed Link: 35273907
Variant Present in the following documents:
  • Table_8.xlsx
View BVdb publication page



Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications
Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L
Publication Date: 2022-03-10

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35273153
Variant Present in the following documents:
  • 41467_2022_28840_MOESM7_ESM.xlsx
View BVdb publication page



Identification of Neoantigens in Cancer Cells as Targets for Immunotherapy.

International Journal Of Molecular Sciences
Okada, Masahiro M; Shimizu, Kanako K; Fujii, Shin-Ichiro SI
Publication Date: 2022-02-26

Variant appearance in text: TP53: R248W
PubMed Link: 35269735
Variant Present in the following documents:
  • ijms-23-02594.pdf
View BVdb publication page



Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53.

Cells
Abrams, Stephen L SL; Duda, Przemysław P; Akula, Shaw M SM; Steelman, Linda S LS; Follo, Matilde L ML; Cocco, Lucio L; Ratti, Stefano S; Martelli, Alberto M AM; Montalto, Giuseppe G; Emma, Maria Rita MR; Cervello, Melchiorre M; Rakus, Dariusz D; Gizak, Agnieszka A; McCubrey, James A JA
Publication Date: 2022-02-24

Variant appearance in text: p53: R248W
PubMed Link: 35269416
Variant Present in the following documents:
  • cells-11-00794.pdf
View BVdb publication page



Cranberry Polyphenols in Esophageal Cancer Inhibition: New Insights.

Nutrients
Weh, Katherine M KM; Zhang, Yun Y; Howard, Connor L CL; Howell, Amy B AB; Clarke, Jennifer L JL; Kresty, Laura A LA
Publication Date: 2022-02-24

Variant appearance in text: TP53: 742C>T
PubMed Link: 35267943
Variant Present in the following documents:
  • nutrients-14-00969.pdf
View BVdb publication page



Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer.

Cancers
Rack, Samuel S; Feeney, Laura L; Hapuarachi, Brindley B; Adderley, Helen H; Woodhouse, Laura L; Betts, Guy G; Burghel, George J GJ; Harrington, Kevin J KJ; Metcalf, Robert R
Publication Date: 2022-02-23

Variant appearance in text: TP53: 742C>T; Arg248Trp
PubMed Link: 35267442
Variant Present in the following documents:
  • cancers-14-01133.pdf
View BVdb publication page



Successful response to first-line treatment with osimertinib for choroidal metastasis from EGFR-mutated non-small-cell lung cancer.

American Journal Of Ophthalmology Case Reports
Field, Matthew G MG; Boldt, H Culver HC; Abu Hejleh, Taher T; Binkley, Elaine M EM
Publication Date: 2022-06

Variant appearance in text: TP53: R248W
PubMed Link: 35265776
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Detection of germline variants in Brazilian breast cancer patients using multigene panel testing.

Scientific Reports
Guindalini, Rodrigo Santa Cruz RSC; Viana, Danilo Vilela DV; Kitajima, João Paulo Fumio Whitaker JPFW; Rocha, Vinícius Marques VM; López, Rossana Verónica Mendoza RVM; Zheng, Yonglan Y; Freitas, Érika É; Monteiro, Fabiola Paoli Mendes FPM; Valim, André A; Schlesinger, David D; Kok, Fernando F; Olopade, Olufunmilayo I OI; Folgueira, Maria Aparecida Azevedo Koike MAAK
Publication Date: 2022-03-09

Variant appearance in text: TP53: 742C>T; Arg248Trp
PubMed Link: 35264596
Variant Present in the following documents:
  • 41598_2022_Article_7383.pdf
  • 41598_2022_7383_MOESM2_ESM.xlsx
View BVdb publication page



Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm-blast phase.

Jci Insight
Wang, Xiaoli X; Rampal, Raajit K RK; Hu, Cing Siang CS; Tripodi, Joseph J; Farnoud, Noushin N; Petersen, Bruce B; Rossi, Michael R MR; Patel, Minal M; McGovern, Erin E; Najfeld, Vesna V; Iancu-Rubin, Camelia C; Lu, Min M; Davis, Andrew A; Kremyanskaya, Marina M; Weinberg, Rona Singer RS; Mascarenhas, John J; Hoffman, Ronald R
Publication Date: 2022-03-08

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35259128
Variant Present in the following documents:
  • jciinsight-7-156534-s066.pdf
  • jciinsight-7-156534-s067.xlsx
View BVdb publication page



Li-Fraumeni syndrome in Tunisian carriers with different and rare tumor phenotype: genotype-phenotype correlation.

Bmc Medical Genomics
Sassi, Hela H; Meddeb, Rym R; Cherif, Mohamed Aziz MA; Nasr, Chiraz C; Riahi, Aouatef A; Hannachi, Samia S; Belguith, Neila N; M'rad, Ridha R
Publication Date: 2022-03-04

Variant appearance in text: TP53: 742C>T
PubMed Link: 35246108
Variant Present in the following documents:
  • 12920_2022_Article_1189.pdf
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: TP53: Arg248Trp
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx
View BVdb publication page



DrABC: deep learning accurately predicts germline pathogenic mutation status in breast cancer patients based on phenotype data.

Genome Medicine
Liu, Jiaqi J; Zhao, Hengqiang H; Zheng, Yu Y; Dong, Lin L; Zhao, Sen S; Huang, Yukuan Y; Huang, Shengkai S; Qian, Tianyi T; Zou, Jiali J; Liu, Shu S; Li, Jun J; Yan, Zihui Z; Li, Yalun Y; Zhang, Shuo S; Huang, Xin X; Wang, Wenyan W; Li, Yiqun Y; Wang, Jie J; Ming, Yue Y; Li, Xiaoxin X; Xing, Zeyu Z; Qin, Ling L; Zhao, Zhengye Z; Jia, Ziqi Z; Li, Jiaxin J; Liu, Gang G; Zhang, Menglu M; Feng, Kexin K; Wu, Jiang J; Zhang, Jianguo J; Yang, Yongxin Y; Wu, Zhihong Z; Liu, Zhihua Z; Ying, Jianming J; Wang, Xin X; Su, Jianzhong J; Wang, Xiang X; Wu, Nan N
Publication Date: 2022-02-25

Variant appearance in text: TP53: 742C>T
PubMed Link: 35209950
Variant Present in the following documents:
  • 13073_2022_1027_MOESM22_ESM.xls
View BVdb publication page



p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance.

Membranes
Souza, Leonel Cardozo de Menezes E LCME; Faletti, Anderson A; Veríssimo, Carla Pires CP; Stelling, Mariana Paranhos MP; Borges, Helena Lobo HL
Publication Date: 2022-02-09

Variant appearance in text: p53: R248W
PubMed Link: 35207121
Variant Present in the following documents:
  • membranes-12-00202.pdf
View BVdb publication page



Use of RNA-Seq and a Transgenic Mouse Model to Identify Genes Which May Contribute to Mutant p53-Driven Prostate Cancer Initiation.

Biology
Vinall, Ruth R; Chen, Qian Q; Talbott, George G; Ramsamooj, Rajendra R; Dang, An A; Tepper, Clifford G CG; Borowsky, Alexander A
Publication Date: 2022-01-29

Variant appearance in text: p53: R248W
PubMed Link: 35205085
Variant Present in the following documents:
  • biology-11-00218.pdf
View BVdb publication page



Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes.

Biomolecules
Zavileyskiy, Lev L; Bunik, Victoria V
Publication Date: 2022-02-18

Variant appearance in text: p53: R248W
PubMed Link: 35204825
Variant Present in the following documents:
  • biomolecules-12-00327.pdf
View BVdb publication page



APR-246-The Mutant TP53 Reactivator-Increases the Effectiveness of Berberine and Modified Berberines to Inhibit the Proliferation of Pancreatic Cancer Cells.

Biomolecules
McCubrey, James Andrew JA; Abrams, Stephen L SL; Steelman, Linda S LS; Cocco, Lucio L; Ratti, Stefano S; Martelli, Alberto M AM; Lombardi, Paolo P; Gizak, Agnieszka A; Duda, Przemysław P
Publication Date: 2022-02-08

Variant appearance in text: p53: R248W
PubMed Link: 35204775
Variant Present in the following documents:
  • biomolecules-12-00276.pdf
View BVdb publication page



Molecular and cytogenetic characterization of myelodysplastic syndromes in cell-free DNA.

Blood Advances
Garcia-Gisbert, Nieves N; Garcia-Avila, Sara S; Merchan, Brayan B; Salido, Marta M; Fernández-Rodríguez, Concepción C; Gibert, Joan J; Camacho, Laura L; Fernández-Ibarrondo, Lierni L; Lafuente, Marta M; Longarón, Raquel R; Espinet, Blanca B; Velez, Patricia P; Pujol, Ramon M RM; Andrade-Campos, Marcio M; Arenillas, Leonor L; Salar, Antonio A; Calvo, Xavier X; Besses, Carles C; Bellosillo, Beatriz B
Publication Date: 2022-02-22

Variant appearance in text: TP53: Arg248Trp
PubMed Link: 35192693
Variant Present in the following documents:
  • advancesADV2021006565.pdf
View BVdb publication page



Genome-wide aneuploidy detected by mFast-SeqS in circulating cell-free DNA is associated with poor response to pembrolizumab in patients with advanced urothelial cancer.

Molecular Oncology
Mendelaar, Pauline A J PAJ; Robbrecht, Debbie D; Rijnders, Maud M; de Wit, Ronald R; de Weerd, Vanja V; Deger, Teoman T; Westgeest, Hans M HM; Aarts, Maureen J B MJB; Voortman, Jens J; Martens, John W M JWM; van der Veldt, Astrid A M AAM; Nakauma-González, J Alberto JA; Wilting, Saskia M SM; Lolkema, Martijn M
Publication Date: 2022-02-18

Variant appearance in text: TP53: 742C>T
PubMed Link: 35181986
Variant Present in the following documents:
  • MOL2-16-2086.pdf
View BVdb publication page



Disease characterization in liquid biopsy from HER2-mutated, non-amplified metastatic breast cancer patients treated with neratinib.

Npj Breast Cancer
Shishido, Stephanie N SN; Masson, Rahul R; Xu, Liya L; Welter, Lisa L; Prabakar, Rishvanth Kaliappan RK; D' Souza, Anishka A; Spicer, Darcy D; Kang, Irene I; Jayachandran, Priya P; Hicks, James J; Lu, Janice J; Kuhn, Peter P
Publication Date: 2022-02-18

Variant appearance in text: TP53: R248W
PubMed Link: 35181666
Variant Present in the following documents:
  • 41523_2022_390_MOESM1_ESM.pdf
View BVdb publication page



The genetic landscape of pancreatic head ductal adenocarcinoma in China and prognosis stratification.

Bmc Cancer
Yang, Yefan Y; Ding, Ying Y; Gong, Yuxi Y; Zhao, Sha S; Li, Mingna M; Li, Xiao X; Song, Guoxin G; Zhai, Boya B; Liu, Jin J; Shao, Yang Y; Zhu, Liuqing L; Pang, Jiaohui J; Ma, Yutong Y; Ou, Qiuxiang Q; Wu, Xue X; Zhang, Zhihong Z
Publication Date: 2022-02-18

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35180847
Variant Present in the following documents:
  • 12885_2022_9279_MOESM3_ESM.xlsx
View BVdb publication page



Colonic Adenocarcinoma with Plasmacytoid Feature: Histopathology and Molecular Characteristics of a Rare Neoplasm with an Unusual Presentation.

Case Reports In Pathology
Marji, Noor N; Dhillon, Jasrerman J; Lauwers, Gregory Y GY; Feuerlein, Sebastian S; Nikfar, Reza R; Chatwal, Monica M; Vosoughi, Aram A
Publication Date: 2022

Variant appearance in text: p53: R248W
PubMed Link: 35178262
Variant Present in the following documents:
  • Main text
  • CRIPA2022-2640456.pdf
View BVdb publication page



Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation.

Cell Stem Cell
Merkle, Florian T FT; Ghosh, Sulagna S; Genovese, Giulio G; Handsaker, Robert E RE; Kashin, Seva S; Meyer, Daniel D; Karczewski, Konrad J KJ; O'Dushlaine, Colm C; Pato, Carlos C; Pato, Michele M; MacArthur, Daniel G DG; McCarroll, Steven A SA; Eggan, Kevin K
Publication Date: 2022-02-15

Variant appearance in text: TP53: 742C>T; R248W; rs121912651
PubMed Link: 35176222
Variant Present in the following documents:
  • mmc5.xlsx
View BVdb publication page



Association between TP53 mutation and high 21-gene recurrence score in estrogen receptor-positive/HER2-negative breast cancer.

Npj Breast Cancer
Ji, Jung Hwan JH; Bae, Soong June SJ; Kim, Kyungsoo K; Chu, Chihhao C; Lee, Kyung-A KA; Kim, Yoonjung Y; Kim, Jee Hung JH; Jeong, Joon J; Ahn, Sung Gwe SG
Publication Date: 2022-02-16

Variant appearance in text: TP53: 742C>T; Arg248Trp
PubMed Link: 35173185
Variant Present in the following documents:
  • 41523_2022_384_MOESM1_ESM.pdf
View BVdb publication page



Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma.

Cancers
Raymond, Jérémy H JH; Aktary, Zackie Z; Larue, Lionel L; Delmas, Véronique V
Publication Date: 2022-01-29

Variant appearance in text: p53: R248W
PubMed Link: 35158973
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets.

Cancers
Karagiannakos, Alexandros A; Adamaki, Maria M; Tsintarakis, Antonis A; Vojtesek, Borek B; Fåhraeus, Robin R; Zoumpourlis, Vassilis V; Karakostis, Konstantinos K
Publication Date: 2022-01-28

Variant appearance in text: p53: R248W
PubMed Link: 35158934
Variant Present in the following documents:
  • cancers-14-00664.pdf
View BVdb publication page



A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome.

Blood Advances
Guney, Ekin E; Lucas, Calixto-Hope G CG; Qi, Zhongxia Z; Yu, Jingwei J; Zhang, Ruth R; Ohgami, Robert S RS; Rubenstein, James L JL; Boué, Daniel R DR; Schafernak, Kristian T KT; Wertheim, Gerald B GB; Dahiya, Sonika S; Giulino-Roth, Lisa L; Attarbaschi, Andishe A; Barth, Matthew J MJ; Kothari, Shalin S; Abla, Oussama O; Cohen, Adam L AL; Mendez, Joe S JS; Bollen, Andrew Wesley AW; Perry, Arie A; Tihan, Tarik T; Pekmezci, Melike M; Solomon, David A DA; Wen, Kwun Wah KW
Publication Date: 2022-02-14

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35157770
Variant Present in the following documents:
  • advancesADV2021006018-suppl1.pdf
View BVdb publication page



LncRNAs, the Molecules Involved in Communications With Colorectal Cancer Stem Cells.

Frontiers In Oncology
Fan, Boyang B; Zhang, Qian Q; Wang, Ning N; Wang, Guiyu G
Publication Date: 2022

Variant appearance in text: p53: R248W
PubMed Link: 35155247
Variant Present in the following documents:
  • Main text
  • fonc-12-811374.pdf
View BVdb publication page



Acquired somatic variants in inherited myeloid malignancies.

Leukemia
Armes, Hannah H; Rio-Machin, Ana A; Krizsán, Szilvia S; Bödör, Csaba C; Kaya, Fadimana F; Bewicke-Copley, Findlay F; Alnajar, Jenna J; Walne, Amanda A; Péterffy, Borbála B; Tummala, Hemanth H; Rouault-Pierre, Kevin K; Dokal, Inderjeet I; Vulliamy, Tom T; Fitzgibbon, Jude J
Publication Date: 2022-02-09

Variant appearance in text: TP53: R248W
PubMed Link: 35140362
Variant Present in the following documents:
  • 41375_2022_1515_MOESM4_ESM.xlsx
View BVdb publication page



The Mutational Landscape of Early-Onset Breast Cancer: A Next-Generation Sequencing Analysis.

Frontiers In Oncology
Andrikopoulou, Angeliki A; Chatzinikolaou, Spyridoula S; Kyriopoulos, Ilias I; Bletsa, Garyfalia G; Kaparelou, Maria M; Liontos, Michalis M; Dimopoulos, Meletios-Athanasios MA; Zagouri, Flora F
Publication Date: 2021

Variant appearance in text: TP53: 742C>T; Arg248Trp
PubMed Link: 35127508
Variant Present in the following documents:
  • Main text
  • fonc-11-797505.pdf
View BVdb publication page



ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation.

Nature Communications
Esposito, Davide D; Pant, Ila I; Shen, Yao Y; Qiao, Rui F RF; Yang, Xiaobao X; Bai, Yiyang Y; Jin, Jian J; Poulikakos, Poulikos I PI; Aaronson, Stuart A SA
Publication Date: 2022-02-04

Variant appearance in text: p53: R248W
PubMed Link: 35121738
Variant Present in the following documents:
  • Main text
  • 41467_2022_Article_28319.pdf
View BVdb publication page



Somatic Mutation Profiles Revealed by Next Generation Sequencing (NGS) in 39 Chinese Hepatocellular Carcinoma Patients.

Frontiers In Molecular Biosciences
Ke, Lixin L; Shen, Jianming J; Feng, Jikun J; Chen, Jialin J; Shen, Shunli S; Li, Shaoqiang S; Kuang, Ming M; Liang, Lijian L; Lu, Cuncun C; Li, Dongming D; He, Qiang Q; Peng, Baogang B; Hua, Yunpeng Y
Publication Date: 2021

Variant appearance in text: rs121912651
PubMed Link: 35118119
Variant Present in the following documents:
  • Table6.xlsx
View BVdb publication page



Application of next-generation sequencing in resistance genes of neoadjuvant chemotherapy for esophageal cancer.

Translational Cancer Research
Liu, Jizhao J; Xing, Wenqun W; Tian, Qingnan Q; Li, Yin Y; Liu, Xianben X; Sun, Haibo H; Gao, Kun K; Chen, Xiankai X; Zheng, Yan Y
Publication Date: 2020-08

Variant appearance in text: TP53: 742C>T; Arg248Trp
PubMed Link: 35117847
Variant Present in the following documents:
  • Main text
  • tcr-09-08-4847.pdf
View BVdb publication page



Suppression of NSCLC A549 tumor growth by a mtDNA mutation-targeting pyrrole-imidazole polyamide-TPP and a senolytic drug.

Cancer Science
Tsuji, Kohei K; Kida, Yuki Y; Koshikawa, Nobuko N; Yamamoto, Seigi S; Shinozaki, Yoshinao Y; Watanabe, Takayoshi T; Lin, Jason J; Nagase, Hiroki H; Takenaga, Keizo K
Publication Date: 2022-02-02

Variant appearance in text: p53: 742C>T
PubMed Link: 35112436
Variant Present in the following documents:
  • CAS-113-1321.pdf
View BVdb publication page



Investigation of PALB2 Mutation and Correlation With Immunotherapy Biomarker in Chinese Non-Small Cell Lung Cancer Patients.

Frontiers In Oncology
Zhang, Jiexia J; Tang, Shuangfeng S; Zhang, Chunning C; Li, Mingyao M; Zheng, Yating Y; Hu, Xue X; Huang, Mengli M; Cheng, Xiangyang X
Publication Date: 2021

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35087742
Variant Present in the following documents:
  • Table_2.xlsx
View BVdb publication page



Comparison of acute myeloid leukemia and myelodysplastic syndromes with TP53 aberrations.

Annals Of Hematology
Dutta, Sayantanee S; Moritz, Jennifer J; Pregartner, Gudrun G; Thallinger, Gerhard G GG; Brandstätter, Ilona I; Lind, Karin K; Rezania, Simin S; Lyssy, Freya F; Reinisch, Andreas A; Zebisch, Armin A; Berghold, Andrea A; Wölfler, Albert A; Sill, Heinz H
Publication Date: 2022-01-26

Variant appearance in text: TP53: R248W
PubMed Link: 35083527
Variant Present in the following documents:
  • 277_2022_4766_MOESM1_ESM.pdf
View BVdb publication page



Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity.

Nature Communications
Fu, Rongjie R; He, Wei W; Dou, Jinzhuang J; Villarreal, Oscar D OD; Bedford, Ella E; Wang, Helen H; Hou, Connie C; Zhang, Liang L; Wang, Yalong Y; Ma, Dacheng D; Chen, Yiwen Y; Gao, Xue X; Depken, Martin M; Xu, Han H
Publication Date: 2022-01-25

Variant appearance in text: TP53: 742C>T; R248W
PubMed Link: 35078987
Variant Present in the following documents:
  • Main text
View BVdb publication page



Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal Carcinoma.

Frontiers In Cell And Developmental Biology
Gao, Xiaolei X; Zheng, Xuan X; Zhang, Yixin Y; Dong, Liying L; Sun, Liangjie L; Zhao, Na N; Ding, Chong C; Ma, Zeyun Z; Wang, Yixiang Y
Publication Date: 2021

Variant appearance in text: p53: R248W
PubMed Link: 35071232
Variant Present in the following documents:
  • Main text
  • fcell-09-788331.pdf
View BVdb publication page



Sensitive Quantification of Cell-Free Tumor DNA for Early Detection of Recurrence in Colorectal Cancer.

Frontiers In Genetics
Stasik, Sebastian S; Mende, Marika M; Schuster, Caroline C; Mahler, Sandra S; Aust, Daniela D; Tannapfel, Andrea A; Reinacher-Schick, Anke A; Baretton, Gustavo G; Krippendorf, Claudia C; Bornhäuser, Martin M; Ehninger, Gerhard G; Folprecht, Gunnar G; Thiede, Christian C
Publication Date: 2021

Variant appearance in text: TP53: 742C>T; Arg248Trp
PubMed Link: 35069704
Variant Present in the following documents:
  • Main text
  • fgene-12-811291.pdf
View BVdb publication page



Targeting Stress-Response Pathways and Therapeutic Resistance in Head and Neck Cancer.

Frontiers In Oral Health
Bos, Tasia T; Ratti, J Alex JA; Harada, Hisashi H
Publication Date: 2021

Variant appearance in text: TP53: R248W
PubMed Link: 35048023
Variant Present in the following documents:
  • Main text
  • froh-02-676643.pdf
View BVdb publication page



The dominant TP53 hotspot mutation in -mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications.

Neuro-Oncology Advances
Marker, Daniel F DF; Agnihotri, Sameer S; Amankulor, Nduka N; Murdoch, Geoffrey H GH; Pearce, Thomas M TM
Publication Date: 2022

Variant appearance in text: TP53: R248W
PubMed Link: 35047821
Variant Present in the following documents:
  • vdab182.pdf
View BVdb publication page



TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.

Briefings In Bioinformatics
Ben-Cohen, Gil G; Doffe, Flora F; Devir, Michal M; Leroy, Bernard B; Soussi, Thierry T; Rosenberg, Shai S
Publication Date: 2022-01-18

Variant appearance in text: p53: R248W
PubMed Link: 35043155
Variant Present in the following documents:
  • supplementary_information_bbab524.pdf
View BVdb publication page



Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma.

Bmc Genomics
Chen, Sixian S; Fu, Aizhen A; Lu, Yuan Y; Lu, Wei W; Chen, Yongfeng Y; Hong, Shuiqiang S; Zhou, Suli S; Xiang, Tianmin T; Zhang, Zhenzhen Z; Cai, Yongguang Y
Publication Date: 2022-01-15

Variant appearance in text: TP53: 742C>T; Arg248Trp
PubMed Link: 35031014
Variant Present in the following documents:
  • 12864_2021_8289_MOESM1_ESM.xlsx
View BVdb publication page



Single-cell analysis reveals selection of TP53-mutated clones after MDM2 inhibition.

Blood Advances
Maslah, Nabih N; Verger, Emmanuelle E; Giraudier, Stéphane S; Chea, Mathias M; Hoffman, Ronald R; Mascarenhas, John J; Cassinat, Bruno B; Kiladjian, Jean-Jacques JJ
Publication Date: 2022-01-14

Variant appearance in text: TP53: R248W
PubMed Link: 35030630
Variant Present in the following documents:
  • advancesADV2021005867-suppl1.pdf
  • advancesADV2021005867.pdf
View BVdb publication page



Targeting Post-Translational Regulation of p53 in Colorectal Cancer by Exploiting Vulnerabilities in the p53-MDM2 Axis.

Cancers
Lai, Chunwei W CW; Xie, Cindy C; Raufman, Jean-Pierre JP; Xie, Guofeng G
Publication Date: 2022-01-03

Variant appearance in text: p53: R248W
PubMed Link: 35008383
Variant Present in the following documents:
  • Main text
  • cancers-14-00219.pdf
View BVdb publication page