Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis.
Nature Communications
Chen, Ziheng Z; Ho, I-Lin IL; Soeung, Melinda M; Yen, Er-Yen EY; Liu, Jintan J; Yan, Liang L; Rose, Johnathon L JL; Srinivasan, Sanjana S; Jiang, Shan S; Edward Chang, Q Q; Feng, Ningping N; Gay, Jason P JP; Wang, Qi Q; Wang, Jing J; Lorenzi, Philip L PL; Veillon, Lucas J LJ; Wei, Bo B; Weinstein, John N JN; Deem, Angela K AK; Gao, Sisi S; Genovese, Giannicola G; Viale, Andrea A; Yao, Wantong W; Lyssiotis, Costas A CA; Marszalek, Joseph R JR; Draetta, Giulio F GF; Ying, Haoqiang H
Metastatic colorectal cancer treatment response evaluation by ultra-deep sequencing of cell-free DNA and matched white blood cells.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
van 't Erve, Iris I; Medina, Jamie E JE; Leal, Alessandro A; Papp, Eniko E; Phallen, Jillian J; Adleff, Vilmos V; Chiao, Elaine Jiayuee EJ; Arun, Adith S AS; Bolhuis, Karen K; Simmons, John K JK; Karandikar, Aanavi A; Valkenburg, Kenneth C KC; Sausen, Mark M; Angiuoli, Samuel V SV; Scharpf, Robert B RB; Punt, Cornelis J A CJA; Meijer, Gerrit A GA; Velculescu, Victor E VE; Fijneman, Remond J A RJA
A comparison of DNA sequencing and gene expression profiling to assist tissue of origin diagnosis in cancer of unknown primary.
The Journal Of Pathology
Posner, Atara A; Prall, Owen Wj OW; Sivakumaran, Tharani T; Etemadamoghadam, Dariush D; Thio, Niko N; Pattison, Andrew A; Balachander, Shiva S; Fisher, Krista K; Webb, Samantha S; Wood, Colin C; DeFazio, Anna A; Wilcken, Nicholas N; Gao, Bo B; Karapetis, Christos S CS; Singh, Madhu M; Collins, Ian M IM; Richardson, Gary G; Steer, Christopher C; Warren, Mark M; Karanth, Narayan N; Wright, Gavin G; Williams, Scott S; George, Joshy J; Hicks, Rodney J RJ; Boussioutas, Alex A; Gill, Anthony J AJ; Solomon, Benjamin J BJ; Xu, Huiling H; Fellowes, Andrew A; Fox, Stephen B SB; Schofield, Penelope P; Bowtell, David D; Mileshkin, Linda L; Tothill, Richard W RW
Somatic targeted mutation profiling of colorectal cancer precursor lesions.
Bmc Medical Genomics
Dos Santos, Wellington W; Dos Reis, Mariana Bisarro MB; Porto, Jun J; de Carvalho, Ana Carolina AC; Matsushita, Marcus M; Oliveira, Gabriela G; Syrjänen, Kari K; Reis, Rui Manuel RM; Guimarães, Denise Peixoto DP
Longitudinal monitoring by next-generation sequencing of plasma cell-free DNA in ALK rearranged NSCLC patients treated with ALK tyrosine kinase inhibitors.
Cancer Medicine
Kwon, Minsuk M; Ku, Bo Mi BM; Olsen, Steve S; Park, Sehhoon S; Lefterova, Martina M; Odegaard, Justin J; Jung, Hyun-Ae HA; Sun, Jong-Mu JM; Lee, Se-Hoon SH; Ahn, Jin Seok JS; Park, Keunchil K; Ahn, Myung-Ju MJ
Comparison of acute myeloid leukemia and myelodysplastic syndromes with TP53 aberrations.
Annals Of Hematology
Dutta, Sayantanee S; Moritz, Jennifer J; Pregartner, Gudrun G; Thallinger, Gerhard G GG; Brandstätter, Ilona I; Lind, Karin K; Rezania, Simin S; Lyssy, Freya F; Reinisch, Andreas A; Zebisch, Armin A; Berghold, Andrea A; Wölfler, Albert A; Sill, Heinz H
Multi-omic machine learning predictor of breast cancer therapy response.
Nature
Sammut, Stephen-John SJ; Crispin-Ortuzar, Mireia M; Chin, Suet-Feung SF; Provenzano, Elena E; Bardwell, Helen A HA; Ma, Wenxin W; Cope, Wei W; Dariush, Ali A; Dawson, Sarah-Jane SJ; Abraham, Jean E JE; Dunn, Janet J; Hiller, Louise L; Thomas, Jeremy J; Cameron, David A DA; Bartlett, John M S JMS; Hayward, Larry L; Pharoah, Paul D PD; Markowetz, Florian F; Rueda, Oscar M OM; Earl, Helena M HM; Caldas, Carlos C
Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations.
Nature Communications
Brady, Samuel W SW; Liu, Yanling Y; Ma, Xiaotu X; Gout, Alexander M AM; Hagiwara, Kohei K; Zhou, Xin X; Wang, Jian J; Macias, Michael M; Chen, Xiaolong X; Easton, John J; Mulder, Heather L HL; Rusch, Michael M; Wang, Lu L; Nakitandwe, Joy J; Lei, Shaohua S; Davis, Eric M EM; Naranjo, Arlene A; Cheng, Cheng C; Maris, John M JM; Downing, James R JR; Cheung, Nai-Kong V NV; Hogarty, Michael D MD; Dyer, Michael A MA; Zhang, Jinghui J
Phase and context shape the function of composite oncogenic mutations.
Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Genomics of lethal prostate cancer at diagnosis and castration resistance.
The Journal Of Clinical Investigation
Mateo, Joaquin J; Seed, George G; Bertan, Claudia C; Rescigno, Pasquale P; Dolling, David D; Figueiredo, Ines I; Miranda, Susana S; Nava Rodrigues, Daniel D; Gurel, Bora B; Clarke, Matthew M; Atkin, Mark M; Chandler, Rob R; Messina, Carlo C; Sumanasuriya, Semini S; Bianchini, Diletta D; Barrero, Maialen M; Petermolo, Antonella A; Zafeiriou, Zafeiris Z; Fontes, Mariane M; Perez-Lopez, Raquel R; Tunariu, Nina N; Fulton, Ben B; Jones, Robert R; McGovern, Ursula U; Ralph, Christy C; Varughese, Mohini M; Parikh, Omi O; Jain, Suneil S; Elliott, Tony T; Sandhu, Shahneen S; Porta, Nuria N; Hall, Emma E; Yuan, Wei W; Carreira, Suzanne S; de Bono, Johann S JS
Pan-cancer whole-genome analyses of metastatic solid tumours.
Nature
Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E
Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma.
Blood Cancer Journal
Mata, Elena E; Fernández, Sara S; Astudillo, Aurora A; Fernández, Rubén R; García-Cosío, Mónica M; Sánchez-Beato, Margarita M; Provencio, Mariano M; Estévez, Mónica M; Montalbán, Carlos C; Piris, Miguel A MA; García, Juan F JF
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.
Scientific Reports
Collord, Grace G; Tarpey, Patrick P; Kurbatova, Natalja N; Martincorena, Inigo I; Moran, Sebastian S; Castro, Manuel M; Nagy, Tibor T; Bignell, Graham G; Maura, Francesco F; Young, Matthew D MD; Berna, Jorge J; Tubio, Jose M C JMC; McMurran, Chris E CE; Young, Adam M H AMH; Sanders, Mathijs M; Noorani, Imran I; Price, Stephen J SJ; Watts, Colin C; Leipnitz, Elke E; Kirsch, Matthias M; Schackert, Gabriele G; Pearson, Danita D; Devadass, Abel A; Ram, Zvi Z; Collins, V Peter VP; Allinson, Kieren K; Jenkinson, Michael D MD; Zakaria, Rasheed R; Syed, Khaja K; Hanemann, C Oliver CO; Dunn, Jemma J; McDermott, Michael W MW; Kirollos, Ramez W RW; Vassiliou, George S GS; Esteller, Manel M; Behjati, Sam S; Brazma, Alvis A; Santarius, Thomas T; McDermott, Ultan U
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing.
Nature Communications
Nahar, Rahul R; Zhai, Weiwei W; Zhang, Tong T; Takano, Angela A; Khng, Alexis J AJ; Lee, Yin Yeng YY; Liu, Xingliang X; Lim, Chong Hee CH; Koh, Tina P T TPT; Aung, Zaw Win ZW; Lim, Tony Kiat Hon TKH; Veeravalli, Lavanya L; Yuan, Ju J; Teo, Audrey S M ASM; Chan, Cheryl X CX; Poh, Huay Mei HM; Chua, Ivan M L IML; Liew, Audrey Ann AA; Lau, Dawn Ping Xi DPX; Kwang, Xue Lin XL; Toh, Chee Keong CK; Lim, Wan-Teck WT; Lim, Bing B; Tam, Wai Leong WL; Tan, Eng-Huat EH; Hillmer, Axel M AM; Tan, Daniel S W DSW
Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study.
Plos Medicine
Parkinson, Christine A CA; Gale, Davina D; Piskorz, Anna M AM; Biggs, Heather H; Hodgkin, Charlotte C; Addley, Helen H; Freeman, Sue S; Moyle, Penelope P; Sala, Evis E; Sayal, Karen K; Hosking, Karen K; Gounaris, Ioannis I; Jimenez-Linan, Mercedes M; Earl, Helena M HM; Qian, Wendi W; Rosenfeld, Nitzan N; Brenton, James D JD
Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors.
Oncoscience
Wheler, Jennifer J JJ; Atkins, Johnique T JT; Janku, Filip F; Moulder, Stacy L SL; Stephens, Philip J PJ; Yelensky, Roman R; Valero, Vicente V; Miller, Vincent V; Kurzrock, Razelle R; Meric-Bernstam, Funda F
Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors.
Plos One
Froyen, Guy G; Broekmans, An A; Hillen, Femke F; Pat, Karin K; Achten, Ruth R; Mebis, Jeroen J; Rummens, Jean-Luc JL; Willemse, Johan J; Maes, Brigitte B
Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression.
Bmc Cancer
Mota, Alba A; Triviño, Juan Carlos JC; Rojo-Sebastian, Alejandro A; Martínez-Ramírez, Ángel Á; Chiva, Luis L; González-Martín, Antonio A; Garcia, Juan F JF; Garcia-Sanz, Pablo P; Moreno-Bueno, Gema G
Publication Date: 2015-11-30
Variant appearance in text: TP53: 702C>G; Tyr234Ter
Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.
Plos Medicine
Schwarz, Roland F RF; Ng, Charlotte K Y CK; Cooke, Susanna L SL; Newman, Scott S; Temple, Jillian J; Piskorz, Anna M AM; Gale, Davina D; Sayal, Karen K; Murtaza, Muhammed M; Baldwin, Peter J PJ; Rosenfeld, Nitzan N; Earl, Helena M HM; Sala, Evis E; Jimenez-Linan, Mercedes M; Parkinson, Christine A CA; Markowetz, Florian F; Brenton, James D JD
Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Nature Medicine
Xie, Mingchao M; Lu, Charles C; Wang, Jiayin J; McLellan, Michael D MD; Johnson, Kimberly J KJ; Wendl, Michael C MC; McMichael, Joshua F JF; Schmidt, Heather K HK; Yellapantula, Venkata V; Miller, Christopher A CA; Ozenberger, Bradley A BA; Welch, John S JS; Link, Daniel C DC; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Chen, Feng F; Wilson, Richard K RK; Ley, Timothy J TJ; Ding, Li L
Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss.
Nature Genetics
Gross, Andrew M AM; Orosco, Ryan K RK; Shen, John P JP; Egloff, Ann Marie AM; Carter, Hannah H; Hofree, Matan M; Choueiri, Michel M; Coffey, Charles S CS; Lippman, Scott M SM; Hayes, D Neil DN; Cohen, Ezra E EE; Grandis, Jennifer R JR; Nguyen, Quyen T QT; Ideker, Trey T
Integrated analysis of germline and somatic variants in ovarian cancer.
Nature Communications
Kanchi, Krishna L KL; Johnson, Kimberly J KJ; Lu, Charles C; McLellan, Michael D MD; Leiserson, Mark D M MD; Wendl, Michael C MC; Zhang, Qunyuan Q; Koboldt, Daniel C DC; Xie, Mingchao M; Kandoth, Cyriac C; McMichael, Joshua F JF; Wyczalkowski, Matthew A MA; Larson, David E DE; Schmidt, Heather K HK; Miller, Christopher A CA; Fulton, Robert S RS; Spellman, Paul T PT; Mardis, Elaine R ER; Druley, Todd E TE; Graubert, Timothy A TA; Goodfellow, Paul J PJ; Raphael, Benjamin J BJ; Wilson, Richard K RK; Ding, Li L
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.
Plos One
Zanaruddin, Sharifah Nurain Syed SN; Yee, Pei San PS; Hor, Seen Yii SY; Kong, Yink Heay YH; Ghani, Wan Maria Nabillah Wan Abd WM; Mustafa, Wan Mahadzir Wan WM; Zain, Rosnah Binti RB; Prime, Stephen S SS; Rahman, Zainal Ariff Abd ZA; Cheong, Sok-Ching SC