TP53 c.685_686delinsGC ;(p.C229A)

Variant ID: 17-7577595-CA-GC

NM_000546.5(TP53):c.685_686delinsGC;(p.C229A)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Characterization of neoantigen-specific T cells in cancer resistant to immune checkpoint therapies.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Li, Shamin S; Simoni, Yannick Y; Zhuang, Summer S; Gabel, Austin A; Ma, Shaokang S; Chee, Jonathan J; Islas, Laura L; Cessna, Anthony A; Creaney, Jenette J; Bradley, Robert K RK; Redwood, Alec A; Robinson, Bruce W BW; Newell, Evan W EW
Publication Date: 2021-07-27

Variant appearance in text: p53: C229A
PubMed Link: 34285073
Variant Present in the following documents:
  • pnas.2025570118.sd01.xlsx, sheet 1
View BVdb publication page



APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.

Cell Death & Disease
Zhang, Qiang Q; Bykov, Vladimir J N VJN; Wiman, Klas G KG; Zawacka-Pankau, Joanna J
Publication Date: 2018-05-01

Variant appearance in text: p53: C229A
PubMed Link: 29670092
Variant Present in the following documents:
  • Main text
  • 41419_2018_Article_463.pdf
View BVdb publication page



TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Killela, Patrick J PJ; Reitman, Zachary J ZJ; Jiao, Yuchen Y; Bettegowda, Chetan C; Agrawal, Nishant N; Diaz, Luis A LA; Friedman, Allan H AH; Friedman, Henry H; Gallia, Gary L GL; Giovanella, Beppino C BC; Grollman, Arthur P AP; He, Tong-Chuan TC; He, Yiping Y; Hruban, Ralph H RH; Jallo, George I GI; Mandahl, Nils N; Meeker, Alan K AK; Mertens, Fredrik F; Netto, George J GJ; Rasheed, B Ahmed BA; Riggins, Gregory J GJ; Rosenquist, Thomas A TA; Schiffman, Mark M; Shih, Ie-Ming IeM; Theodorescu, Dan D; Torbenson, Michael S MS; Velculescu, Victor E VE; Wang, Tian-Li TL; Wentzensen, Nicolas N; Wood, Laura D LD; Zhang, Ming M; McLendon, Roger E RE; Bigner, Darell D DD; Kinzler, Kenneth W KW; Vogelstein, Bert B; Papadopoulos, Nickolas N; Yan, Hai H
Publication Date: 2013-04-09

Variant appearance in text: TP53: C229A
PubMed Link: 23530248
Variant Present in the following documents:
  • Main text
View BVdb publication page