Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.
Cancer Research Communications
White, Jason A JA; Kaninjing, Ernest T ET; Adeniji, Kayode A KA; Jibrin, Paul P; Obafunwa, John O JO; Ogo, Chidiebere N CN; Mohammed, Faruk F; Popoola, Ademola A; Fatiregun, Omolara A OA; Oluwole, Olabode P OP; Karanam, Balasubramanyam B; Elhussin, Isra I; Ambs, Stefan S; Tang, Wei W; Davis, Melissa M; Polak, Paz P; Campbell, Moray J MJ; Brignole, Kathryn R KR; Rotimi, Solomon O SO; Dean-Colomb, Windy W; Odedina, Folake T FT; Martin, Damali N DN; Yates, Clayton C
Publication Date: 2022-09
Variant appearance in text: TP53: 644G>A; Ser215Asn; rs587782177
ESR1 gene amplification and MAP3K mutations are selected during adjuvant endocrine therapies in relapsing Hormone Receptor-positive, HER2-negative breast cancer (HR+ HER2- BC).
Plos Genetics
Ferrando, Lorenzo L; Vingiani, Andrea A; Garuti, Anna A; Vernieri, Claudio C; Belfiore, Antonino A; Agnelli, Luca L; Dagrada, Gianpaolo G; Ivanoiu, Diana D; Bonizzi, Giuseppina G; Munzone, Elisabetta E; Lippolis, Luana L; Dameri, Martina M; Ravera, Francesco F; Colleoni, Marco M; Viale, Giuseppe G; Magnani, Luca L; Ballestrero, Alberto A; Zoppoli, Gabriele G; Pruneri, Giancarlo G
Publication Date: 2023-01-03
Variant appearance in text: TP53: 644G>A; rs587782177
Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma.
British Journal Of Cancer
Murumägi, Astrid A; Ungureanu, Daniela D; Khan, Suleiman S; Arjama, Mariliina M; Välimäki, Katja K; Ianevski, Aleksandr A; Ianevski, Philipp P; Bergström, Rebecka R; Dini, Alice A; Kanerva, Anna A; Koivisto-Korander, Riitta R; Tapper, Johanna J; Lassus, Heini H; Loukovaara, Mikko M; Mägi, Andrus A; Hirasawa, Akira A; Aoki, Daisuke D; Pietiäinen, Vilja V; Pellinen, Teijo T; Bützow, Ralf R; Aittokallio, Tero T; Kallioniemi, Olli O
Prevalence of Molecular Alterations in a Swiss Cohort of 512 Colorectal Carcinoma Patients by Targeted Next-Generation Sequencing Analysis in Routine Diagnostics.
Pathobiology : Journal Of Immunopathology, Molecular And Cellular Biology
Haefliger, Simon S; Marston, Katharina K; Alborelli, Ilaria I; Stauffer, Edouard-Jean EJ; Gugger, Mathias M; Jermann, Philip M PM; Hoeller, Sylvia S; Tornillo, Luigi L; Terracciano, Luigi M LM; Bihl, Michel M; Matter, Matthias S MS
GENETIC SUBGROUPS INFORM ON PATHOBIOLOGY IN ADULT AND PEDIATRIC BURKITT LYMPHOMA.
Blood
Thomas, Nicole N; Dreval, Kostiantyn K; Gerhard, Daniela S DS; Hilton, Laura K LK; Abramson, Jeremy S JS; Barta, Stefan K SK; Bartlett, Nancy L NL; Bethony, Jeffrey J; Bhatia, Kishor K; Bowen, Jay J; Bryan, Anthony C AC; Cesarman, Ethel E; Casper, Corey C; Cruz, Manuela M; Dyer, Maureen M; Farinha, Pedro P; Gastier-Foster, Julie J; Gerrie, Alina S AS; Grande, Bruno B; Greiner, Timothy C TC; Griner, Nicholas N; Gross, Thomas G TG; Harris, Nancy Lee NL; Irvin, John D JD; Jaffe, Elaine S ES; Henry, David D; Huppi, Rebecca Liddell RL; Leal, Fabio E FE; Lee, Michael M; Martin, Jean Paul JP; Martin, Marie-Reine MR; Mbulaiteye, Sam M SM; Mitsuyasu, Ronald R; Morris, Vivian V; Mullighan, Charles G CG; Mungall, Andrew J AJ; Mungall, Karen K; Mutyaba, Innocent I; Nokta, Mostafa M; Namirembe, Constance C; Noy, Ariela A; Ogwang, Martin David MD; Omoding, Abrahams A; Orem, Jackson J; Ott, German G; Petrello, Hilary H; Pittaluga, Stefania S; Phelan, James D JD; Ramos, Juan Carlos JC; Ratner, Lee L; Reynolds, Steven J SJ; Rubinstein, Paul G PG; Sissolak, Gerhard G; Slack, Graham W GW; Soudi, Shaghayegh S; Swerdlow, Steven Howard SH; Traverse-Glehen, Alexandra A; Wilson, Wyndham W; Wong, Jasper Chun Hei JCH; Yarchoan, Robert R; ZenKlusen, Jean C JC; Marra, Marco A MA; Staudt, Louis M LM; Scott, David W DW; Morin, Ryan D RD
Publication Date: 2022-10-06
Variant appearance in text: TP53: 644G>A; Ser215Asn
TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome.
Acta Neuropathologica Communications
Perez-Rivas, Luis Gustavo LG; Simon, Julia J; Albani, Adriana A; Tang, Sicheng S; Roeber, Sigrun S; Assié, Guillaume G; Deutschbein, Timo T; Fassnacht, Martin M; Gadelha, Monica R MR; Hermus, Ad R AR; Stalla, Günter K GK; Tichomirowa, Maria A MA; Rotermund, Roman R; Flitsch, Jörg J; Buchfelder, Michael M; Nasi-Kordhishti, Isabella I; Honegger, Jürgen J; Thorsteinsdottir, Jun J; Saeger, Wolfgang W; Herms, Jochen J; Reincke, Martin M; Theodoropoulou, Marily M
DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination.
Frontiers In Oncology
Merlini, Alessandra A; Centomo, Maria Laura ML; Ferrero, Giulio G; Chiabotto, Giulia G; Miglio, Umberto U; Berrino, Enrico E; Giordano, Giorgia G; Brusco, Silvia S; Pisacane, Alberto A; Maldi, Elena E; Sarotto, Ivana I; Capozzi, Federica F; Lano, Cristina C; Isella, Claudio C; Crisafulli, Giovanni G; Aglietta, Massimo M; Dei Tos, Angelo Paolo AP; Sbaraglia, Marta M; Sangiolo, Dario D; D'Ambrosio, Lorenzo L; Bardelli, Alberto A; Pignochino, Ymera Y; Grignani, Giovanni G
Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.
Frontiers In Oncology
Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J
Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.
ACTH-secreting pituitary carcinoma with TP53, NF1, ATRX and PTEN mutations Case report and review of the literature.
Endocrine
Sumislawski, Piotr P; Rotermund, Roman R; Klose, Silke S; Lautenbach, Anne A; Wefers, Annika K AK; Soltwedel, Celina C; Mohammadi, Behnam B; Jacobsen, Frank F; Mawrin, Christian C; Flitsch, Jörg J; Saeger, Wolfgang W
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nature Biotechnology
Sánchez-Rivera, Francisco J FJ; Diaz, Bianca J BJ; Kastenhuber, Edward R ER; Schmidt, Henri H; Katti, Alyna A; Kennedy, Margaret M; Tem, Vincent V; Ho, Yu-Jui YJ; Leibold, Josef J; Paffenholz, Stella V SV; Barriga, Francisco M FM; Chu, Kevan K; Goswami, Sukanya S; Wuest, Alexandra N AN; Simon, Janelle M JM; Tsanov, Kaloyan M KM; Chakravarty, Debyani D; Zhang, Hongxin H; Leslie, Christina S CS; Lowe, Scott W SW; Dow, Lukas E LE
KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.
Plos One
Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW
KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.
Plos One
Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW
PARP1 Inhibitor and Trabectedin Combination Does Not Increase Tumor Mutational Burden in Advanced Sarcomas-A Preclinical and Translational Study.
Cancers
Pignochino, Ymera Y; Crisafulli, Giovanni G; Giordano, Giorgia G; Merlini, Alessandra A; Berrino, Enrico E; Centomo, Maria Laura ML; Chiabotto, Giulia G; Brusco, Silvia S; Basiricò, Marco M; Maldi, Elena E; Pisacane, Alberto A; Leuci, Valeria V; Sangiolo, Dario D; D'Ambrosio, Lorenzo L; Aglietta, Massimo M; Kasper, Bernd B; Bardelli, Alberto A; Grignani, Giovanni G
PARP1 Inhibitor and Trabectedin Combination Does Not Increase Tumor Mutational Burden in Advanced Sarcomas-A Preclinical and Translational Study.
Cancers
Pignochino, Ymera Y; Crisafulli, Giovanni G; Giordano, Giorgia G; Merlini, Alessandra A; Berrino, Enrico E; Centomo, Maria Laura ML; Chiabotto, Giulia G; Brusco, Silvia S; Basiricò, Marco M; Maldi, Elena E; Pisacane, Alberto A; Leuci, Valeria V; Sangiolo, Dario D; D'Ambrosio, Lorenzo L; Aglietta, Massimo M; Kasper, Bernd B; Bardelli, Alberto A; Grignani, Giovanni G
Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.
Nature Cancer
Westcott, Peter M K PMK; Sacks, Nathan J NJ; Schenkel, Jason M JM; Ely, Zackery A ZA; Smith, Olivia O; Hauck, Haley H; Jaeger, Alex M AM; Zhang, Daniel D; Backlund, Coralie M CM; Beytagh, Mary C MC; Patten, J J JJ; Elbashir, Ryan R; Eng, George G; Irvine, Darrell J DJ; Yilmaz, Omer H OH; Jacks, Tyler T
Publication Date: 2021-10
Variant appearance in text: TP53: 644G>A; Ser215Asn
DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition.
Cancer Discovery
Izquierdo, Elisa E; Carvalho, Diana M DM; Mackay, Alan A; Temelso, Sara S; Boult, Jessica K R JKR; Pericoli, Giulia G; Fernandez, Elisabet E; Das, Molina M; Molinari, Valeria V; Grabovska, Yura Y; Rogers, Rebecca F RF; Ajmone-Cat, Maria Antonietta MA; Proszek, Paula Z PZ; Stubbs, Mark M; Depani, Sarita S; O'Hare, Patricia P; Yu, Lu L; Roumelioti, Georgia G; Choudhary, Jyoti S JS; Clarke, Matthew M; Fairchild, Amy R AR; Jacques, Thomas S TS; Grundy, Richard G RG; Howell, Lisa L; Picton, Susan S; Adamski, Jenny J; Wilson, Shaun S; Gray, Juliet C JC; Zebian, Bassel B; Marshall, Lynley V LV; Carceller, Fernando F; Grill, Jacques J; Vinci, Maria M; Robinson, Simon P SP; Hubank, Michael M; Hargrave, Darren D; Jones, Chris C
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Spatially interacting phosphorylation sites and mutations in cancer.
Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
Thomson, Jason J; Bewicke-Copley, Findlay F; Anene, Chinedu Anthony CA; Gulati, Abha A; Nagano, Ai A; Purdie, Karin K; Inman, Gareth J GJ; Proby, Charlotte M CM; Leigh, Irene M IM; Harwood, Catherine A CA; Wang, Jun J
Publication Date: 2021-07
Variant appearance in text: TP53: 644G>A; S215N; rs587782177
Integrated molecular drivers coordinate biological and clinical states in melanoma.
Nature Genetics
Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM
Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations.
The Journal Of Clinical Endocrinology And Metabolism
Casar-Borota, Olivera O; Boldt, Henning Bünsow HB; Engström, Britt Edén BE; Andersen, Marianne Skovsager MS; Baussart, Bertrand B; Bengtsson, Daniel D; Berinder, Katarina K; Ekman, Bertil B; Feldt-Rasmussen, Ulla U; Höybye, Charlotte C; Jørgensen, Jens Otto L JOL; Kolnes, Anders Jensen AJ; Korbonits, Márta M; Rasmussen, Åse Krogh ÅK; Lindsay, John R JR; Loughrey, Paul Benjamin PB; Maiter, Dominique D; Manojlovic-Gacic, Emilija E; Pahnke, Jens J; Poliani, Pietro Luigi PL; Popovic, Vera V; Ragnarsson, Oskar O; Schalin-Jäntti, Camilla C; Scheie, David D; Tóth, Miklós M; Villa, Chiara C; Wirenfeldt, Martin M; Kunicki, Jacek J; Burman, Pia P
Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.
Gastroenterology
Dreyer, Stephan B SB; Upstill-Goddard, Rosie R; Paulus-Hock, Viola V; Paris, Clara C; Lampraki, Eirini-Maria EM; Dray, Eloise E; Serrels, Bryan B; Caligiuri, Giuseppina G; Rebus, Selma S; Plenker, Dennis D; Galluzzo, Zachary Z; Brunton, Holly H; Cunningham, Richard R; Tesson, Mathias M; Nourse, Craig C; Bailey, Ulla-Maja UM; Jones, Marc M; Moran-Jones, Kim K; Wright, Derek W DW; Duthie, Fraser F; Oien, Karin K; Evers, Lisa L; McKay, Colin J CJ; McGregor, Grant A GA; Gulati, Aditi A; Brough, Rachel R; Bajrami, Ilirjana I; Pettitt, Stephan S; Dziubinski, Michele L ML; Candido, Juliana J; Balkwill, Frances F; Barry, Simon T ST; Grützmann, Robert R; Rahib, Lola L; , ; , ; Johns, Amber A; Pajic, Marina M; Froeling, Fieke E M FEM; Beer, Phillip P; Musgrove, Elizabeth A EA; Petersen, Gloria M GM; Ashworth, Alan A; Frame, Margaret C MC; Crawford, Howard C HC; Simeone, Diane M DM; Lord, Chris C; Mukhopadhyay, Debabrata D; Pilarsky, Christian C; Tuveson, David A DA; Cooke, Susanna L SL; Jamieson, Nigel B NB; Morton, Jennifer P JP; Sansom, Owen J OJ; Bailey, Peter J PJ; Biankin, Andrew V AV; Chang, David K DK
Mutational Signature and Transcriptomic Classification Analyses as the Decisive Diagnostic Tools for a Cancer of Unknown Primary.
Jco Precision Oncology
Bagge, Roger Olofsson RO; Demir, Akif A; Karlsson, Joakim J; Alaei-Mahabadi, Babak B; Einarsdottir, Berglind O BO; Jespersen, Henrik H; Lindberg, Mattias F MF; Muth, Andreas A; Nilsson, Lisa M LM; Persson, Marta M; Svensson, Johanna B JB; Söderberg, Elin M V EMV; de Krijger, Ronald R RR; Nilsson, Ola O; Larsson, Erik E; Stenman, Göran G; Nilsson, Jonas A JA
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Phase and context shape the function of composite oncogenic mutations.
Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer.
Cell Reports
Brunton, Holly H; Caligiuri, Giuseppina G; Cunningham, Richard R; Upstill-Goddard, Rosie R; Bailey, Ulla-Maja UM; Garner, Ian M IM; Nourse, Craig C; Dreyer, Stephan S; Jones, Marc M; Moran-Jones, Kim K; Wright, Derek W DW; Paulus-Hock, Viola V; Nixon, Colin C; Thomson, Gemma G; Jamieson, Nigel B NB; McGregor, Grant A GA; Evers, Lisa L; McKay, Colin J CJ; Gulati, Aditi A; Brough, Rachel R; Bajrami, Ilirjana I; Pettitt, Stephen J SJ; Dziubinski, Michele L ML; Barry, Simon T ST; Grützmann, Robert R; Brown, Robert R; Curry, Edward E; , ; , ; Pajic, Marina M; Musgrove, Elizabeth A EA; Petersen, Gloria M GM; Shanks, Emma E; Ashworth, Alan A; Crawford, Howard C HC; Simeone, Diane M DM; Froeling, Fieke E M FEM; Lord, Christopher J CJ; Mukhopadhyay, Debabrata D; Pilarsky, Christian C; Grimmond, Sean E SE; Morton, Jennifer P JP; Sansom, Owen J OJ; Chang, David K DK; Bailey, Peter J PJ; Biankin, Andrew V AV
Clinical and genomic insights into circulating tumor DNA-based alterations across the spectrum of metastatic hormone-sensitive and castrate-resistant prostate cancer.
Ebiomedicine
Kohli, Manish M; Tan, Winston W; Zheng, Tiantian T; Wang, Amy A; Montesinos, Carlos C; Wong, Calven C; Du, Pan P; Jia, Shidong S; Yadav, Siddhartha S; Horvath, Lisa G LG; Mahon, Kate L KL; Kwan, Edmond M EM; Fettke, Heidi H; Yu, Jianjun J; Azad, Arun A AA
Publication Date: 2020-04
Variant appearance in text: TP53: Ser215Asn; rs587782177
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Phase I studies of vorinostat with ixazomib or pazopanib imply a role of antiangiogenesis-based therapy for TP53 mutant malignancies.
Scientific Reports
Wang, Yudong Y; Janku, Filip F; Piha-Paul, Sarina S; Hess, Kenneth K; Broaddus, Russell R; Liu, Lidong L; Shi, Naiyi N; Overman, Michael M; Kopetz, Scott S; Subbiah, Vivek V; Naing, Aung A; Hong, David D; Tsimberidou, Apostolia M AM; Karp, Daniel D; Yao, James J; Fu, Siqing S
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.
Nature Communications
Esfahani, Mohammad S MS; Lee, Luke J LJ; Jeon, Young-Jun YJ; Flynn, Ryan A RA; Stehr, Henning H; Hui, Angela B AB; Ishisoko, Noriko N; Kildebeck, Eric E; Newman, Aaron M AM; Bratman, Scott V SV; Porteus, Matthew H MH; Chang, Howard Y HY; Alizadeh, Ash A AA; Diehn, Maximilian M