TP53 c.643_644delinsGC ;(p.S215A)

Variant ID: 17-7578205-CT-GC

NM_000546.5(TP53):c.643_644delinsGC;(p.S215A)

This variant was identified in 8 publications

View GRCh38 version.




Publications:


Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80.

Plos Genetics
Chen, Xiangyu X; Gaglione, Robert R; Leong, Trevor T; Bednor, Lauren L; de Los Santos, Teresa T; Luk, Ed E; Airola, Michael M; Hollingsworth, Nancy M NM
Publication Date: 2018-11

Variant appearance in text: p53: S215A
PubMed Link: 30496175
Variant Present in the following documents:
  • Main text
  • pgen.1007832.pdf
View BVdb publication page



Akt signaling dynamics in individual cells.

Journal Of Cell Science
Gross, Sean M SM; Rotwein, Peter P
Publication Date: 2015-07-15

Variant appearance in text: p53: S215A
PubMed Link: 26040286
Variant Present in the following documents:
  • Main text
View BVdb publication page



EBNA3C regulates p53 through induction of Aurora kinase B.

Oncotarget
Jha, Hem C HC; Yang, Karren K; El-Naccache, Darine W DW; Sun, Zhiguo Z; Robertson, Erle S ES
Publication Date: 2015-03-20

Variant appearance in text: p53: S215A
PubMed Link: 25691063
Variant Present in the following documents:
  • Main text
  • oncotarget-06-5788.pdf
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Mutant TP53 posttranslational modifications: challenges and opportunities.

Human Mutation
Nguyen, Thuy-Ai TA; Menendez, Daniel D; Resnick, Michael A MA; Anderson, Carl W CW
Publication Date: 2014-06

Variant appearance in text: TP53: Ser215Ala
PubMed Link: 24395704
Variant Present in the following documents:
  • Main text
View BVdb publication page



Aurora B kinase phosphorylates and instigates degradation of p53.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Gully, Chris P CP; Velazquez-Torres, Guermarie G; Shin, Ji-Hyun JH; Fuentes-Mattei, Enrique E; Wang, Edward E; Carlock, Colin C; Chen, Jian J; Rothenberg, Daniel D; Adams, Henry P HP; Choi, Hyun Ho HH; Guma, Sergei S; Phan, Liem L; Chou, Ping-Chieh PC; Su, Chun-Hui CH; Zhang, Fanmao F; Chen, Jiun-Sheng JS; Yang, Tsung-Ying TY; Yeung, Sai-Ching J SC; Lee, Mong-Hong MH
Publication Date: 2012-06-12

Variant appearance in text: p53: S215A
PubMed Link: 22611192
Variant Present in the following documents:
  • Main text
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Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation.

Plos Pathogens
Cai, Qiliang Q; Xiao, Bingyi B; Si, Huaxin H; Cervini, Amanda A; Gao, Jianming J; Lu, Jie J; Upadhyay, Santosh K SK; Verma, Suhbash C SC; Robertson, Erle S ES
Publication Date: 2012

Variant appearance in text: p53: S215A
PubMed Link: 22396649
Variant Present in the following documents:
  • Main text
  • ppat.1002566.pdf
View BVdb publication page



Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53.

Cancer Biology & Therapy
Warnock, Lorna Jane LJ; Raines, Sally Anne SA; Milner, Jo J
Publication Date: 2011-12-15

Variant appearance in text: p53: S215A
PubMed Link: 22157150
Variant Present in the following documents:
  • Main text
View BVdb publication page



A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53.

The Journal Of Biological Chemistry
Fraser, Jennifer A JA; Madhumalar, Arumugam A; Blackburn, Elizabeth E; Bramham, Janice J; Walkinshaw, Malcolm D MD; Verma, Chandra C; Hupp, Ted R TR
Publication Date: 2010-11-26

Variant appearance in text: p53: S215A
PubMed Link: 20847049
Variant Present in the following documents:
  • Main text
View BVdb publication page