Publications:

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CTCF DNA-binding domain undergoes dynamic and selective protein-protein interactions.

Iscience

Zhou, Rong R; Tian, Kai K; Huang, Jie J; Duan, Wenjia W; Fu, Hongye H; Feng, Ying Y; Wang, Hui H; Jiang, Yongpeng Y; Li, Yuanjun Y; Wang, Rui R; Hu, Jiazhi J; Ma, Hanhui H; Qi, Zhi Z; Ji, Xiong X

Publication Date: 2022-09-16

Variant appearance in text: p53: 568C>G

PubMed Link: 36117989

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

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Integrated cohort of esophageal squamous cell cancer reveals genomic features underlying clinical characteristics.

Nature Communications

Li, Minghao M; Zhang, Zicheng Z; Wang, Qianrong Q; Yi, Yan Y; Li, Baosheng B

Publication Date: 2022-09-07

Variant appearance in text: TP53: P190A

PubMed Link: 36071046

Variant Present in the following documents:

• 41467_2022_32962_MOESM15_ESM.xlsx, sheet 22

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Ferroptosis: Opportunities and Challenges in Treating Endometrial Cancer.

Frontiers In Molecular Biosciences

Wu, Jianfa J; Zhang, Li L; Wu, Suqin S; Liu, Zhou Z

Publication Date: 2022

Variant appearance in text: p53: p190A

PubMed Link: 35847989

Variant Present in the following documents:

• Main text
• fmolb-09-929832.pdf

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PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.

Cancer Discovery

Patel, Amish J AJ; Warda, Sarah S; Maag, Jesper L V JLV; Misra, Rohan R; Miranda-Román, Miguel A MA; Pachai, Mohini R MR; Lee, Cindy J CJ; Li, Dan D; Wang, Naitao N; Bayshtok, Gabriella G; Fishinevich, Eve E; Meng, Yinuo Y; Wong, Elissa W P EWP; Yan, Juan J; Giff, Emily E; Pappalardi, Melissa B MB; McCabe, Michael T MT; Fletcher, Jonathan A JA; Rudin, Charles M CM; Chandarlapaty, Sarat S; Scandura, Joseph M JM; Koche, Richard P RP; Glass, Jacob L JL; Antonescu, Cristina R CR; Zheng, Deyou D; Chen, Yu Y; Chi, Ping P

Publication Date: 2022-09-02

Variant appearance in text: TP53: P190A

PubMed Link: 35789380

Variant Present in the following documents:

• cd-21-1671_supp1.pdf

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Cell Death by Entosis: Triggers, Molecular Mechanisms and Clinical Significance.

International Journal Of Molecular Sciences

Kianfar, Mostafa M; Balcerak, Anna A; Chmielarczyk, Mateusz M; Tarnowski, Leszek L; Grzybowska, Ewa A EA

Publication Date: 2022-04-30

Variant appearance in text: p53: p190A

PubMed Link: 35563375

Variant Present in the following documents:

• Main text
• ijms-23-04985.pdf

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A High-Throughput Screening System Based on Fluorescence-Activated Cell Sorting for the Directed Evolution of Chitinase A.

International Journal Of Molecular Sciences

Menghiu, Gheorghita G; Ostafe, Vasile V; Prodanović, Radivoje R; Fischer, Rainer R; Ostafe, Raluca R

Publication Date: 2021-03-16

Variant appearance in text: p53: P190A

PubMed Link: 33809788

Variant Present in the following documents:

• ijms-22-03041.pdf

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: TP53: 568C>G; P190A

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

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Involvement of the Actin Machinery in Programmed Cell Death.

Frontiers In Cell And Developmental Biology

Ren, Weida W; Zhao, Wanyu W; Cao, Lingbo L; Huang, Junqi J

Publication Date: 2020

Variant appearance in text: p53: p190A

PubMed Link: 33634110

Variant Present in the following documents:

• Main text
• fcell-08-634849.pdf

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p53-dependent elimination of aneuploid mitotic offspring by entosis.

Cell Death And Differentiation

Liang, Jianqing J; Niu, Zubiao Z; Zhang, Bo B; Yu, Xiaochen X; Zheng, You Y; Wang, Chenxi C; Ren, He H; Wang, Manna M; Ruan, Banzhan B; Qin, Hongquan H; Zhang, Xin X; Gu, Songzhi S; Sai, Xiaoyong X; Tai, Yanhong Y; Gao, Lihua L; Ma, Li L; Chen, Zhaolie Z; Huang, Hongyan H; Wang, Xiaoning X; Sun, Qiang Q

Publication Date: 2021-02

Variant appearance in text: p53: p190A

PubMed Link: 33110215

Variant Present in the following documents:

• Main text

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Defining relative mutational difficulty to understand cancer formation.

Cell Discovery

Shan, Lin L; Yu, Jiao J; He, Zhengjin Z; Chen, Shishuang S; Liu, Mingxian M; Ding, Hongyu H; Xu, Liang L; Zhao, Jie J; Yang, Ailing A; Jiang, Hai H

Publication Date: 2020

Variant appearance in text: p53: P190A

PubMed Link: 32704382

Variant Present in the following documents:

• 41421_2020_177_MOESM5_ESM.xlsx, sheet 1
• 41421_2020_177_MOESM6_ESM.xlsx, sheet 1

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Phase and context shape the function of composite oncogenic mutations.

Nature

Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS

Publication Date: 2020-06

Variant appearance in text: TP53: P190A

PubMed Link: 32461694

Variant Present in the following documents:

• NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2

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p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer.

Signal Transduction And Targeted Therapy

Wen, Xiaoli X; Wan, Jing J; He, Qizhi Q; Wang, Mengfei M; Li, Shuangdi S; Jiang, Mei M; Qian, Zhen Z; Liu, Binya B; Lu, Wen W; Wang, Kai K; Gao, Kun K; Wan, Xiaoping X

Publication Date: 2020-05-27

Variant appearance in text: p53: p190A

PubMed Link: 32457342

Variant Present in the following documents:

• 41392_2020_170_MOESM2_ESM.xlsx, sheet 2

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: TP53: P190A

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease.

Cells

Héraud, Capucine C; Pinault, Mathilde M; Lagrée, Valérie V; Moreau, Violaine V

Publication Date: 2019-04-12

Variant appearance in text: TP53: P190A

PubMed Link: 31013840

Variant Present in the following documents:

• Main text
• cells-08-00351.pdf

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Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions.

Cancers

Mousson, Antoine A; Sick, Emilie E; Carl, Philippe P; Dujardin, Denis D; De Mey, Jan J; Rondé, Philippe P

Publication Date: 2018-08-21

Variant appearance in text: p53: p190A

PubMed Link: 30134553

Variant Present in the following documents:

• Main text
• cancers-10-00278.pdf

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The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine.

Genes & Development

Chatterji, Priya P; Hamilton, Kathryn E KE; Liang, Shun S; Andres, Sarah F SF; Wijeratne, H R Sagara HRS; Mizuno, Rei R; Simon, Lauren A LA; Hicks, Philip D PD; Foley, Shawn W SW; Pitarresi, Jason R JR; Klein-Szanto, Andres J AJ; Mah, Amanda T AT; Van Landeghem, Laurianne L; Gregory, Brian D BD; Lengner, Christopher J CJ; Madison, Blair B BB; Shah, Premal P; Rustgi, Anil K AK

Publication Date: 2018-08-01

Variant appearance in text: p53: p190A

PubMed Link: 30068703

Variant Present in the following documents:

• supp_32.15-16.1020_Supplemental_Table_S10.xls, sheet 1

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appreci8: a pipeline for precise variant calling integrating 8 tools.

Bioinformatics (Oxford, England)

Sandmann, Sarah S; Karimi, Mohsen M; de Graaf, Aniek O AO; Rohde, Christian C; Göllner, Stefanie S; Varghese, Julian J; Ernsting, Jan J; Walldin, Gunilla G; van der Reijden, Bert A BA; Müller-Tidow, Carsten C; Malcovati, Luca L; Hellström-Lindberg, Eva E; Jansen, Joop H JH; Dugas, Martin M

Publication Date: 2018-12-15

Variant appearance in text: TP53: 568C>G; Pro190Ala

PubMed Link: 29945233

Variant Present in the following documents:

• bty518_supplementary_data_s10.xlsx, sheet 8

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Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA.

The Journal Of Molecular Diagnostics : Jmd

Clark, Travis A TA; Chung, Jon H JH; Kennedy, Mark M; Hughes, Jason D JD; Chennagiri, Niru N; Lieber, Daniel S DS; Fendler, Bernard B; Young, Lauren L; Zhao, Mandy M; Coyne, Michael M; Breese, Virginia V; Young, Geneva G; Donahue, Amy A; Pavlick, Dean D; Tsiros, Alyssa A; Brennan, Timothy T; Zhong, Shan S; Mughal, Tariq T; Bailey, Mark M; He, Jie J; Roels, Steven S; Frampton, Garrett M GM; Spoerke, Jill M JM; Gendreau, Steven S; Lackner, Mark M; Schleifman, Erica E; Peters, Eric E; Ross, Jeffrey S JS; Ali, Siraj M SM; Miller, Vincent A VA; Gregg, Jeffrey P JP; Stephens, Philip J PJ; Welsh, Allison A; Otto, Geoff A GA; Lipson, Doron D

Publication Date: 2018-09

Variant appearance in text: TP53: P190A

PubMed Link: 29936259

Variant Present in the following documents:

• mmc12.xlsx, sheet 1

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Shared mechanisms regulate spatiotemporal RhoA-dependent actomyosin contractility during adhesion and cell division.

Small Gtpases

Derksen, Patrick W B PWB; van de Ven, Robert A H RAH

Publication Date: 2020-03

Variant appearance in text: p53: p190A

PubMed Link: 29291271

Variant Present in the following documents:

• Main text

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Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.

Genes & Development

Yue, Xuetian X; Zhang, Cen C; Zhao, Yuhan Y; Liu, Juan J; Lin, Alan W AW; Tan, Victor M VM; Drake, Justin M JM; Liu, Lianxin L; Boateng, Michael N MN; Li, Jun J; Feng, Zhaohui Z; Hu, Wenwei W

Publication Date: 2017-08-15

Variant appearance in text: p53: p190A

PubMed Link: 28947497

Variant Present in the following documents:

• supp_31.16.1641_Supplemental_Data.pdf

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iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports

Wang, Meng M; Wei, Liping L

Publication Date: 2016-08-16

Variant appearance in text: TP53: P190A

PubMed Link: 27527004

Variant Present in the following documents:

• srep31321-s5.xls, sheet 1

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Cellular Stress and p53-Associated Apoptosis by Juniperus communis L. Berry Extract Treatment in the Human SH-SY5Y Neuroblastoma Cells.

International Journal Of Molecular Sciences

Lantto, Tiina A TA; Laakso, Into I; Dorman, H J Damien HJ; Mauriala, Timo T; Hiltunen, Raimo R; Kõks, Sulev S; Raasmaja, Atso A

Publication Date: 2016-07-13

Variant appearance in text: p53: p190A

PubMed Link: 27420050

Variant Present in the following documents:

• Main text
• ijms-17-01113.pdf

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Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.

Journal Of The National Cancer Institute

Herraiz, Cecilia C; Calvo, Fernando F; Pandya, Pahini P; Cantelli, Gaia G; Rodriguez-Hernandez, Irene I; Orgaz, Jose L JL; Kang, NaRa N; Chu, Tinghine T; Sahai, Erik E; Sanz-Moreno, Victoria V

Publication Date: 2016-01

Variant appearance in text: p53: P190A

PubMed Link: 26464464

Variant Present in the following documents:

• Main text
• djv289.pdf
• supp_djv289_Supplementary_Materials.pdf

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: TP53: P190A

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: TP53: P190A

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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The emerging role of class-3 semaphorins and their neuropilin receptors in oncology.

Oncotargets And Therapy

Nasarre, Patrick P; Gemmill, Robert M RM; Drabkin, Harry A HA

Publication Date: 2014

Variant appearance in text: p53: p190a

PubMed Link: 25285016

Variant Present in the following documents:

• Main text

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Opposing signaling of ROCK1 and ROCK2 determines the switching of substrate specificity and the mode of migration of glioblastoma cells.

Molecular Neurobiology

Mertsch, Sonja S; Thanos, Solon S

Publication Date: 2014-04

Variant appearance in text: p53: p190A

PubMed Link: 24170433

Variant Present in the following documents:

• 12035_2013_Article_8568.pdf

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Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer.

Cancer Research

Qian, Xiaolan X; Durkin, Marian E ME; Wang, Dunrui D; Tripathi, Brajendra K BK; Olson, Lyra L; Yang, Xu-Yu XY; Vass, William C WC; Popescu, Nicholas C NC; Lowy, Douglas R DR

Publication Date: 2012-11-15

Variant appearance in text: p53: p190A

PubMed Link: 23010077

Variant Present in the following documents:

• Main text

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: TP53: P190A

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?

Current Drug Targets

McHenry, P R PR; Vargo-Gogola, T T

Publication Date: 2010-09

Variant appearance in text: p53: p190A

PubMed Link: 20545614

Variant Present in the following documents:

• Main text

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Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

The Journal Of Biological Chemistry

Lim, Ssang-Taek ST; Chen, Xiao Lei XL; Tomar, Alok A; Miller, Nichol L G NL; Yoo, Jiyeon J; Schlaepfer, David D DD

Publication Date: 2010-07-09

Variant appearance in text: p53: p190A

PubMed Link: 20442405

Variant Present in the following documents:

• Main text

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Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling.

Plos One

Qureshi, Amir H AH; Chaoji, Vineet V; Maiguel, Dony D; Faridi, Mohd Hafeez MH; Barth, Constantinos J CJ; Salem, Saeed M SM; Singhal, Mudita M; Stoub, Darren D; Krastins, Bryan B; Ogihara, Mitsunori M; Zaki, Mohammed J MJ; Gupta, Vineet V

Publication Date: 2009-10-27

Variant appearance in text: p53: p190A

PubMed Link: 19859549

Variant Present in the following documents:

• pone.0007627.s012.pdf

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Signal-induced functions of the transcription factor TFII-I.

Biochimica Et Biophysica Acta

Roy, Ananda L AL

Publication Date: 2007

Variant appearance in text: p53: p190A

PubMed Link: 17976384

Variant Present in the following documents:

• Main text

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