TP53 c.525C>T ;(p.R175=)

Variant ID: 17-7578405-G-A

NM_000546.5(TP53):c.525C>T;(p.R175=)

This variant was identified in 13 publications

View GRCh38 version.




Publications:


ESR1 gene amplification and MAP3K mutations are selected during adjuvant endocrine therapies in relapsing Hormone Receptor-positive, HER2-negative breast cancer (HR+ HER2- BC).

Plos Genetics
Ferrando, Lorenzo L; Vingiani, Andrea A; Garuti, Anna A; Vernieri, Claudio C; Belfiore, Antonino A; Agnelli, Luca L; Dagrada, Gianpaolo G; Ivanoiu, Diana D; Bonizzi, Giuseppina G; Munzone, Elisabetta E; Lippolis, Luana L; Dameri, Martina M; Ravera, Francesco F; Colleoni, Marco M; Viale, Giuseppe G; Magnani, Luca L; Ballestrero, Alberto A; Zoppoli, Gabriele G; Pruneri, Giancarlo G
Publication Date: 2023-01-03

Variant appearance in text: rs976002907
PubMed Link: 36595552
Variant Present in the following documents:
  • pgen.1010563.s004.xlsx, sheet 1
View BVdb publication page



Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition.

Frontiers In Molecular Biosciences
Semenov, Oleg O; Daks, Alexandra A; Fedorova, Olga O; Shuvalov, Oleg O; Barlev, Nickolai A NA
Publication Date: 2022

Variant appearance in text: p53: R175R
PubMed Link: 35813818
Variant Present in the following documents:
  • Main text
  • fmolb-09-928399.pdf
View BVdb publication page



Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer.

Bmc Cancer
Watanabe, Sadanori S; Yogo, Akitada A; Otsubo, Tsuguteru T; Umehara, Hiroki H; Oishi, Jun J; Kodo, Toru T; Masui, Toshihiko T; Takaishi, Shigeo S; Seno, Hiroshi H; Uemoto, Shinji S; Hatano, Etsuro E
Publication Date: 2022-05-03

Variant appearance in text: rs976002907
PubMed Link: 35505283
Variant Present in the following documents:
  • 12885_2022_9619_MOESM1_ESM.xlsx, sheet 9
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: TP53: 525C>T; R175R
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer.

Nature Communications
Leal, Alessandro A; van Grieken, Nicole C T NCT; Palsgrove, Doreen N DN; Phallen, Jillian J; Medina, Jamie E JE; Hruban, Carolyn C; Broeckaert, Mark A M MAM; Anagnostou, Valsamo V; Adleff, Vilmos V; Bruhm, Daniel C DC; Canzoniero, Jenna V JV; Fiksel, Jacob J; Nordsmark, Marianne M; Warmerdam, Fabienne A R M FARM; Verheul, Henk M W HMW; van Spronsen, Dick Johan DJ; Beerepoot, Laurens V LV; Geenen, Maud M MM; Portielje, Johanneke E A JEA; Jansen, Edwin P M EPM; van Sandick, Johanna J; Meershoek-Klein Kranenbarg, Elma E; van Laarhoven, Hanneke W M HWM; van der Peet, Donald L DL; van de Velde, Cornelis J H CJH; Verheij, Marcel M; Fijneman, Remond R; Scharpf, Robert B RB; Meijer, Gerrit A GA; Cats, Annemieke A; Velculescu, Victor E VE
Publication Date: 2020-01-27

Variant appearance in text: TP53: R175R
PubMed Link: 31988276
Variant Present in the following documents:
  • 41467_2020_14310_MOESM8_ESM.xlsx, sheet 1
  • 41467_2020_14310_MOESM6_ESM.xlsx, sheet 8
  • 41467_2020_14310_MOESM11_ESM.xlsx, sheet 1
  • 41467_2020_14310_MOESM6_ESM.xlsx, sheet 9
  • 41467_2020_14310_MOESM10_ESM.xlsx, sheet 1
  • 41467_2020_14310_MOESM6_ESM.xlsx, sheet 6
View BVdb publication page



The Discordance of Gene Mutations between Circulating Tumor Cells and Primary/Metastatic Tumor.

Molecular Therapy Oncolytics
Wang, Qi Q; Zhao, Lanbo L; Han, Lu L; Tuo, Xiaoqian X; Ma, Sijia S; Wang, Yiran Y; Feng, Xue X; Liang, Dongxin D; Sun, Chao C; Wang, Qing Q; Song, Qing Q; Li, Qiling Q
Publication Date: 2019-12-20

Variant appearance in text: TP53: R175R
PubMed Link: 31650022
Variant Present in the following documents:
  • mmc3.xls, sheet 1
View BVdb publication page



USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.

Nature Communications
Padmanabhan, Achuth A; Candelaria, Nicholes N; Wong, Kwong-Kwok KK; Nikolai, Bryan C BC; Lonard, David M DM; O'Malley, Bert W BW; Richards, JoAnne S JS
Publication Date: 2018-03-28

Variant appearance in text: p53: R175R
PubMed Link: 29593334
Variant Present in the following documents:
  • 41467_2018_3599_MOESM2_ESM.pdf
View BVdb publication page



Germ-line and somatic EPHA2 coding variants in lens aging and cataract.

Plos One
Bennett, Thomas M TM; M'Hamdi, Oussama O; Hejtmancik, J Fielding JF; Shiels, Alan A
Publication Date: 2017

Variant appearance in text: TP53: R175R
PubMed Link: 29267365
Variant Present in the following documents:
  • pone.0189881.s008.xlsx, sheet 3
  • pone.0189881.s008.xlsx, sheet 1
  • pone.0189881.s008.xlsx, sheet 4
  • pone.0189881.s008.xlsx, sheet 2
View BVdb publication page



Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas.

Acta Neuropathologica Communications
Salloum, Ralph R; McConechy, Melissa K MK; Mikael, Leonie G LG; Fuller, Christine C; Drissi, Rachid R; DeWire, Mariko M; Nikbakht, Hamid H; De Jay, Nicolas N; Yang, Xiaodan X; Boue, Daniel D; Chow, Lionel M L LML; Finlay, Jonathan L JL; Gayden, Tenzin T; Karamchandani, Jason J; Hummel, Trent R TR; Olshefski, Randal R; Osorio, Diana S DS; Stevenson, Charles C; Kleinman, Claudia L CL; Majewski, Jacek J; Fouladi, Maryam M; Jabado, Nada N
Publication Date: 2017-10-30

Variant appearance in text: p53: R175R
PubMed Link: 29084603
Variant Present in the following documents:
  • 40478_2017_479_MOESM2_ESM.xlsx, sheet 10
View BVdb publication page



Mutational analysis of single circulating tumor cells by next generation sequencing in metastatic breast cancer.

Oncotarget
De Luca, Francesca F; Rotunno, Giada G; Salvianti, Francesca F; Galardi, Francesca F; Pestrin, Marta M; Gabellini, Stefano S; Simi, Lisa L; Mancini, Irene I; Vannucchi, Alessandro Maria AM; Pazzagli, Mario M; Di Leo, Angelo A; Pinzani, Pamela P
Publication Date: 2016-05-03

Variant appearance in text: TP53: R175R
PubMed Link: 27034166
Variant Present in the following documents:
  • Main text
View BVdb publication page



In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.

Nature Genetics
Janiszewska, Michalina M; Liu, Lin L; Almendro, Vanessa V; Kuang, Yanan Y; Paweletz, Cloud C; Sakr, Rita A RA; Weigelt, Britta B; Hanker, Ariella B AB; Chandarlapaty, Sarat S; King, Tari A TA; Reis-Filho, Jorge S JS; Arteaga, Carlos L CL; Park, So Yeon SY; Michor, Franziska F; Polyak, Kornelia K
Publication Date: 2015-10

Variant appearance in text: TP53: R175R
PubMed Link: 26301495
Variant Present in the following documents:
  • Main text
  • nihms-712806.pdf
View BVdb publication page



Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.

Plos One
Chen, Zhenbin Z; Feng, Jinong J; Buzin, Carolyn H CH; Sommer, Steve S SS
Publication Date: 2008

Variant appearance in text: TP53: R175R
PubMed Link: 19005564
Variant Present in the following documents:
  • pone.0003714.s005.xls, sheet 1
View BVdb publication page



A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.

Molecular And Cellular Biology
Gaiddon, C C; Lokshin, M M; Ahn, J J; Zhang, T T; Prives, C C
Publication Date: 2001-03

Variant appearance in text: p53: R175R
PubMed Link: 11238924
Variant Present in the following documents:
  • Main text
View BVdb publication page