Preclinical Head and Neck Squamous Cell Carcinoma Models for Combined Targeted Therapy Approaches.
Cancers
Schoenwaelder, Nina N; Krause, Mareike M; Freitag, Thomas T; Schneider, Björn B; Zonnur, Sarah S; Zimpfer, Annette A; Becker, Anne Sophie AS; Salewski, Inken I; Strüder, Daniel Fabian DF; Lemcke, Heiko H; Grosse-Thie, Christina C; Junghanss, Christian C; Maletzki, Claudia C
Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q.
Ebiomedicine
Adema, Vera V; Palomo, Laura L; Walter, Wencke W; Mallo, Mar M; Hutter, Stephan S; La Framboise, Thomas T; Arenillas, Leonor L; Meggendorfer, Manja M; Radivoyevitch, Tomas T; Xicoy, Blanca B; Pellagatti, Andrea A; Haferlach, Claudia C; Boultwood, Jacqueline J; Kern, Wolfgang W; Visconte, Valeria V; Sekeres, Mikkael M; Barnard, John J; Haferlach, Torsten T; Solé, Francesc F; Maciejewski, Jaroslaw P JP
Publication Date: 2022-05-23
Variant appearance in text: TP53: 524G>A; Arg175His
mRNA Subtype of Cancer-Associated Fibroblasts Significantly Affects Key Characteristics of Head and Neck Cancer Cells.
Cancers
Peltanová, Barbora B; Holcová Polanská, Hana H; Raudenská, Martina M; Balvan, Jan J; Navrátil, Jiří J; Vičar, Tomáš T; Gumulec, Jaromír J; Čechová, Barbora B; Kräter, Martin M; Guck, Jochen J; Kalfeřt, David D; Grega, Marek M; Plzák, Jan J; Betka, Jan J; Masařík, Michal M
Space- and Time-Resolved Metabolomics of a High-Grade Serous Ovarian Cancer Mouse Model.
Cancers
Sah, Samyukta S; Ma, Xin X; Botros, Andro A; Gaul, David A DA; Yun, Sylvia R SR; Park, Eun Young EY; Kim, Olga O; Moore, Samuel G SG; Kim, Jaeyeon J; Fernández, Facundo M FM
Fundamental immune-oncogenicity trade-offs define driver mutation fitness.
Nature
Hoyos, David D; Zappasodi, Roberta R; Schulze, Isabell I; Sethna, Zachary Z; de Andrade, Kelvin César KC; Bajorin, Dean F DF; Bandlamundi, Chaitanya C; Callahan, Margaret K MK; Funt, Samuel A SA; Hadrup, Sine R SR; Holm, Jeppe S JS; Rosenberg, Jonathan E JE; Shah, Sohrab P SP; Vázquez-García, Ignacio I; Weigelt, Britta B; Wu, Michelle M; Zamarin, Dmitriy D; Campitelli, Laura F LF; Osborne, Edward J EJ; Klinger, Mark M; Robins, Harlan S HS; Khincha, Payal P PP; Savage, Sharon A SA; Balachandran, Vinod P VP; Wolchok, Jedd D JD; Hellmann, Matthew D MD; Merghoub, Taha T; Levine, Arnold J AJ; Łuksza, Marta M; Greenbaum, Benjamin D BD
Mutual exclusivity of ESR1 and TP53 mutations in endocrine resistant metastatic breast cancer.
Npj Breast Cancer
Li, Zheqi Z; Spoelstra, Nicole S NS; Sikora, Matthew J MJ; Sams, Sharon B SB; Elias, Anthony A; Richer, Jennifer K JK; Lee, Adrian V AV; Oesterreich, Steffi S
Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers.
Npj Breast Cancer
Liu, Xuan X; Ge, Zhongqi Z; Yang, Fei F; Contreras, Alejandro A; Lee, Sanghoon S; White, Jason B JB; Lu, Yiling Y; Labrie, Marilyne M; Arun, Banu K BK; Moulder, Stacy L SL; Mills, Gordon B GB; Piwnica-Worms, Helen H; Litton, Jennifer K JK; Chang, Jeffrey T JT
Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.
American Journal Of Human Genetics
Palles, Claire C; West, Hannah D HD; Chew, Edward E; Galavotti, Sara S; Flensburg, Christoffer C; Grolleman, Judith E JE; Jansen, Erik A M EAM; Curley, Helen H; Chegwidden, Laura L; Arbe-Barnes, Edward H EH; Lander, Nicola N; Truscott, Rebekah R; Pagan, Judith J; Bajel, Ashish A; Sherwood, Kitty K; Martin, Lynn L; Thomas, Huw H; Georgiou, Demetra D; Fostira, Florentia F; Goldberg, Yael Y; Adams, David J DJ; van der Biezen, Simone A M SAM; Christie, Michael M; Clendenning, Mark M; Thomas, Laura E LE; Deltas, Constantinos C; Dimovski, Aleksandar J AJ; Dymerska, Dagmara D; Lubinski, Jan J; Mahmood, Khalid K; van der Post, Rachel S RS; Sanders, Mathijs M; Weitz, Jürgen J; Taylor, Jenny C JC; Turnbull, Clare C; Vreede, Lilian L; van Wezel, Tom T; Whalley, Celina C; Arnedo-Pac, Claudia C; Caravagna, Giulio G; Cross, William W; Chubb, Daniel D; Frangou, Anna A; Gruber, Andreas J AJ; Kinnersley, Ben B; Noyvert, Boris B; Church, David D; Graham, Trevor T; Houlston, Richard R; Lopez-Bigas, Nuria N; Sottoriva, Andrea A; Wedge, David D; , ; , ; , ; Jenkins, Mark A MA; Kuiper, Roland P RP; Roberts, Andrew W AW; Cheadle, Jeremy P JP; Ligtenberg, Marjolijn J L MJL; Hoogerbrugge, Nicoline N; Koelzer, Viktor H VH; Rivas, Andres Dacal AD; Winship, Ingrid M IM; Ponte, Clara Ruiz CR; Buchanan, Daniel D DD; Power, Derek G DG; Green, Andrew A; Tomlinson, Ian P M IPM; Sampson, Julian R JR; Majewski, Ian J IJ; de Voer, Richarda M RM
Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis.
Frontiers In Oncology
Kyrochristos, Ioannis D ID; Glantzounis, Georgios K GK; Goussia, Anna A; Eliades, Alexia A; Achilleos, Achilleas A; Tsangaras, Kyriakos K; Hadjidemetriou, Irene I; Elpidorou, Marilena M; Ioannides, Marios M; Koumbaris, George G; Mitsis, Michail M; Patsalis, Philippos C PC; Roukos, Dimitrios D
Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer.
Npj Breast Cancer
Telli, Melinda L ML; Tolaney, Sara M SM; Shapiro, Geoffrey I GI; Middleton, Mark M; Lord, Simon R SR; Arkenau, Hendrik Tobias HT; Tutt, Andrew A; Abramson, Vandana V; Dean, Emma E; Haddad, Tufia C TC; Wesolowski, Robert R; Ferrer-Playan, Jordi J; Goddemeier, Thomas T; Grombacher, Thomas T; Dong, Jennifer J; Fleuranceau-Morel, Patricia P; Diaz-Padilla, Ivan I; Plummer, Ruth R
p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases.
Nature Communications
Ni, Jing J; Kabraji, Sheheryar S; Xie, Shaozhen S; Wang, Yanzhi Y; Pan, Peichen P; He, Xiaofang X; Liu, Zongming Z; Leone, Jose Palbo JP; Long, Henry W HW; Brown, Myles A MA; Winer, Eric P EP; Dillon, Deborah A R DAR; Lin, Nancy U NU; Zhao, Jean J JJ
A general calculus of fitness landscapes finds genes under selection in cancers.
Genome Research
Hsu, Teng-Kuei TK; Asmussen, Jennifer Kay JK; Koire, Amanda Michele AM; Choi, Byung-Kwon BK; Gadhikar, Mayur Arvind MA; Huh, Eunna E; Lin, Chih-Hsu CH; Konecki, Daniel Manuka DM; Kim, Young Won YW; Pickering, Curtis C; Kimmel, Marek M; Donehower, Lawrence Allen LA; Frederick, Mitchell Jay MJ; Myers, Jeffrey N JN; Katsonis, Panagiotis P; Lichtarge, Olivier O
The Landscape of Actionable Genomic Alterations by Next-Generation Sequencing in Tumor Tissue Versus Circulating Tumor DNA in Chinese Patients With Non-Small Cell Lung Cancer.
Estrogen Receptor-Beta2 (ERβ2)-Mutant p53-FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC).
Cancers
Oturkar, Chetan C CC; Gandhi, Nishant N; Rao, Pramod P; Eng, Kevin H KH; Miller, Austin A; Singh, Prashant K PK; Zsiros, Emese E; Odunsi, Kunle O KO; Das, Gokul M GM
Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm-blast phase.
Jci Insight
Wang, Xiaoli X; Rampal, Raajit K RK; Hu, Cing Siang CS; Tripodi, Joseph J; Farnoud, Noushin N; Petersen, Bruce B; Rossi, Michael R MR; Patel, Minal M; McGovern, Erin E; Najfeld, Vesna V; Iancu-Rubin, Camelia C; Lu, Min M; Davis, Andrew A; Kremyanskaya, Marina M; Weinberg, Rona Singer RS; Mascarenhas, John J; Hoffman, Ronald R
Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.
Cell Death & Disease
Zhang, Qiang Q; Balourdas, Dimitrios-Ilias DI; Baron, Bruno B; Senitzki, Alon A; Haran, Tali E TE; Wiman, Klas G KG; Soussi, Thierry T; Joerger, Andreas C AC
Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wang, Yu-Hsiu YH; Ho, Teresa L F TLF; Hariharan, Anushya A; Goh, Hui Chin HC; Wong, Yao Liang YL; Verkaik, Nicole S NS; Lee, May Yin MY; Tam, Wai Leong WL; van Gent, Dik C DC; Venkitaraman, Ashok R AR; Sheetz, Michael P MP; Lane, David P DP
Partial p53 reactivation is sufficient to induce cancer regression.
Journal Of Experimental & Clinical Cancer Research : Cr
Klimovich, Boris B; Meyer, Laura L; Merle, Nastasja N; Neumann, Michelle M; König, Alexander M AM; Ananikidis, Nikolaos N; Keber, Corinna U CU; Elmshäuser, Sabrina S; Timofeev, Oleg O; Stiewe, Thorsten T
Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies.
Nature Communications
Cordo', Valentina V; Meijer, Mariska T MT; Hagelaar, Rico R; de Goeij-de Haas, Richard R RR; Poort, Vera M VM; Henneman, Alex A AA; Piersma, Sander R SR; Pham, Thang V TV; Oshima, Koichi K; Ferrando, Adolfo A AA; Zaman, Guido J R GJR; Jimenez, Connie R CR; Meijerink, Jules P P JPP
The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma.
Investigational New Drugs
Kang, Chang-Won CW; Hannan, Katherine M KM; Blackburn, Anneke C AC; Loh, Amos H P AHP; Hong, Kuick Chik KC; Yuan, Goh Jian GJ; Hein, Nadine N; Drygin, Denis D; Hannan, Ross D RD; Coupland, Lucy A LA