TP53 c.523_524delinsTA ;(p.R175Y)

Variant ID: 17-7578406-CG-TA

NM_000546.5(TP53):c.523_524delinsTA;(p.R175Y)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Structural and Drug Targeting Insights on Mutant p53.

Cancers
Gomes, Ana Sara AS; Ramos, Helena H; Inga, Alberto A; Sousa, Emília E; Saraiva, Lucília L
Publication Date: 2021-07-03

Variant appearance in text: p53: R175Y
PubMed Link: 34283062
Variant Present in the following documents:
  • Main text
  • cancers-13-03344.pdf
View BVdb publication page



Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene.

Cell Death And Differentiation
Doffe, Flora F; Carbonnier, Vincent V; Tissier, Manon M; Leroy, Bernard B; Martins, Isabelle I; Mattsson, Johanna S M JSM; Micke, Patrick P; Pavlova, Sarka S; Pospisilova, Sarka S; Smardova, Jana J; Joerger, Andreas C AC; Wiman, Klas G KG; Kroemer, Guido G; Soussi, Thierry T
Publication Date: 2021-05

Variant appearance in text: p53: R175Y
PubMed Link: 33257846
Variant Present in the following documents:
  • 41418_2020_672_MOESM1_ESM.pdf
View BVdb publication page



Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene.

Cell Death And Differentiation
Doffe, Flora F; Carbonnier, Vincent V; Tissier, Manon M; Leroy, Bernard B; Martins, Isabelle I; Mattsson, Johanna S M JSM; Micke, Patrick P; Pavlova, Sarka S; Pospisilova, Sarka S; Smardova, Jana J; Joerger, Andreas C AC; Wiman, Klas G KG; Kroemer, Guido G; Soussi, Thierry T
Publication Date: 2021-05

Variant appearance in text: p53: R175Y
PubMed Link: 33257846
Variant Present in the following documents:
  • 41418_2020_672_MOESM1_ESM.pdf
View BVdb publication page



The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation.

Molecular And Cellular Biology
Zilfou, J T JT; Hoffman, W H WH; Sank, M M; George, D L DL; Murphy, M M
Publication Date: 2001-06

Variant appearance in text: p53: R175Y
PubMed Link: 11359905
Variant Present in the following documents:
  • Main text
View BVdb publication page