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TP53 c.520_521delinsGC ;(p.R174A)
Variant ID: 17-7578409-CT-GC
NM_000546.5(
TP53
):c.520_521delinsGC;(p.R174A)
This variant was identified in 4 publications
View GRCh38 version.
Variant-Specific Resource Links:
gnomAD v2.1.1
Mutalizer Name Checker
Google
UCSC Genome Browser
ClinVar
dbSNP
Publications:
A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer.
Science Advances
Li, Hong-Mei HM; Bi, Yan-Ran YR; Li, Yang Y; Fu, Rong R; Lv, Wen-Cong WC; Jiang, Nan N; Xu, Ying Y; Ren, Bo-Xue BX; Chen, Ya-Dong YD; Xie, Hui H; Wang, Shui S; Lu, Tao T; Wu, Zhao-Qiu ZQ
Publication Date: 2020-04
Variant appearance in text: p53: R174A
PubMed Link:
32494626
Variant Present in the following documents:
Main text
aaw8500_SM.pdf
aaw8500.pdf
View BVdb publication page
Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy.
Nucleic Acids Research
Krüger, Annika A; Stier, Anna A; Fischbach, Arthur A; Bürkle, Alexander A; Hauser, Karin K; Mangerich, Aswin A
Publication Date: 2019-05-21
Variant appearance in text: p53: R174A
PubMed Link:
30892621
Variant Present in the following documents:
Main text
gkz175.pdf
View BVdb publication page
Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.
Nucleic Acids Research
Pradhan, Mohan R MR; Siau, Jia Wei JW; Kannan, Srinivasaraghavan S; Nguyen, Minh N MN; Ouaray, Zohra Z; Kwoh, Chee Keong CK; Lane, David P DP; Ghadessy, Farid F; Verma, Chandra S CS
Publication Date: 2019-02-28
Variant appearance in text: p53: R174A
PubMed Link:
30649466
Variant Present in the following documents:
Main text
gky1314.pdf
View BVdb publication page
Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ma, Buyong B; Pan, Yongping Y; Gunasekaran, K K; Venkataraghavan, R Babu RB; Levine, Arnold J AJ; Nussinov, Ruth R
Publication Date: 2005-03-15
Variant appearance in text: p53: Arg174Ala
PubMed Link:
15738397
Variant Present in the following documents:
Main text
View BVdb publication page