TP53 c.520_521delinsGC ;(p.R174A)

Variant ID: 17-7578409-CT-GC

NM_000546.5(TP53):c.520_521delinsGC;(p.R174A)

This variant was identified in 4 publications

View GRCh38 version.




Publications:


A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer.

Science Advances
Li, Hong-Mei HM; Bi, Yan-Ran YR; Li, Yang Y; Fu, Rong R; Lv, Wen-Cong WC; Jiang, Nan N; Xu, Ying Y; Ren, Bo-Xue BX; Chen, Ya-Dong YD; Xie, Hui H; Wang, Shui S; Lu, Tao T; Wu, Zhao-Qiu ZQ
Publication Date: 2020-04

Variant appearance in text: p53: R174A
PubMed Link: 32494626
Variant Present in the following documents:
  • Main text
  • aaw8500_SM.pdf
  • aaw8500.pdf
View BVdb publication page



Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy.

Nucleic Acids Research
Krüger, Annika A; Stier, Anna A; Fischbach, Arthur A; Bürkle, Alexander A; Hauser, Karin K; Mangerich, Aswin A
Publication Date: 2019-05-21

Variant appearance in text: p53: R174A
PubMed Link: 30892621
Variant Present in the following documents:
  • Main text
  • gkz175.pdf
View BVdb publication page



Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.

Nucleic Acids Research
Pradhan, Mohan R MR; Siau, Jia Wei JW; Kannan, Srinivasaraghavan S; Nguyen, Minh N MN; Ouaray, Zohra Z; Kwoh, Chee Keong CK; Lane, David P DP; Ghadessy, Farid F; Verma, Chandra S CS
Publication Date: 2019-02-28

Variant appearance in text: p53: R174A
PubMed Link: 30649466
Variant Present in the following documents:
  • Main text
  • gky1314.pdf
View BVdb publication page



Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Ma, Buyong B; Pan, Yongping Y; Gunasekaran, K K; Venkataraghavan, R Babu RB; Levine, Arnold J AJ; Nussinov, Ruth R
Publication Date: 2005-03-15

Variant appearance in text: p53: Arg174Ala
PubMed Link: 15738397
Variant Present in the following documents:
  • Main text
View BVdb publication page