Genetic Determinants of Cardiovascular Disease: The Endothelial Nitric Oxide Synthase 3 (eNOS3), Krüppel-Like Factor-14 (KLF-14), Methylenetetrahydrofolate Reductase (MTHFR), MiRNAs27a and Their Association with the Predisposition and Susceptibility to Coronary Artery Disease.
Life (Basel, Switzerland)
Mir, Rashid R; Elfaki, Imadeldin I; Javid, Jamsheed J; Barnawi, Jameel J; Altayar, Malik A MA; Albalawi, Salem Owaid SO; Jalal, Mohammed M MM; Tayeb, Faris J FJ; Yousif, Aadil A; Ullah, Mohammad Fahad MF; AbuDuhier, Faisel M FM
Haplotype of ESR1 and PPARD Genes Is Associated with Higher Anthropometric Changes in Han Chinese Obesity by Adjusting Dietary Factors-An 18-Month Follow-Up.
Next-generation whole exome sequencing to delineate the genetic basis of primary congenital glaucoma.
Scientific Reports
Rauf, Bushra B; Khan, Shahid Y SY; Jiao, Xiaodong X; Irum, Bushra B; Ashfaq, Ramla R; Zehra, Mubashra M; Khan, Asma A AA; Naeem, Muhammad Asif MA; Shahzad, Mohsin M; Riazuddin, Sheikh S; Hejtmancik, J Fielding JF; Riazuddin, S Amer SA
SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults.
Bmc Nutrition
Wang, Yining E YE; Kirschke, Catherine P CP; Woodhouse, Leslie R LR; Bonnel, Ellen L EL; Stephensen, Charles B CB; Bennett, Brian J BJ; Newman, John W JW; Keim, Nancy L NL; Huang, Liping L
Protective lipid-lowering variants in healthy older individuals without coronary heart disease.
Open Heart
Lacaze, Paul P; Riaz, Moeen M; Sebra, Robert R; Hooper, Amanda J AJ; Pang, Jing J; Tiller, Jane J; Polekhina, Galina G; Tonkin, Andrew A; Reid, Chris C; Zoungas, Sophia S; Murray, Anne M AM; Nicholls, Stephen S; Watts, Gerald G; Schadt, Eric E; McNeil, John J JJ
Six years' experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias.
Bmc Medical Genomics
Dron, Jacqueline S JS; Wang, Jian J; McIntyre, Adam D AD; Iacocca, Michael A MA; Robinson, John F JF; Ban, Matthew R MR; Cao, Henian H; Hegele, Robert A RA
Identification of disease-associated loci using machine learning for genotype and network data integration.
Bioinformatics (Oxford, England)
Leal, Luis G LG; David, Alessia A; Jarvelin, Marjo-Riita MR; Sebert, Sylvain S; Männikkö, Minna M; Karhunen, Ville V; Seaby, Eleanor E; Hoggart, Clive C; Sternberg, Michael J E MJE
A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR.
Npj Genomic Medicine
Safarova, Maya S MS; Satterfield, Benjamin A BA; Fan, Xiao X; Austin, Erin E EE; Ye, Zhan Z; Bastarache, Lisa L; Zheng, Neil N; Ritchie, Marylyn D MD; Borthwick, Kenneth M KM; Williams, Marc S MS; Larson, Eric B EB; Scrol, Aaron A; Jarvik, Gail P GP; Crosslin, David R DR; Leppig, Kathleen K; Rasmussen-Torvik, Laura J LJ; Pendergrass, Sarah A SA; Sturm, Amy C AC; Namjou, Bahram B; Shah, Amy Sanghavi AS; Carroll, Robert J RJ; Chung, Wendy K WK; Wei, Wei-Qi WQ; Feng, QiPing Q; Stein, C Michael CM; Roden, Dan M DM; Manolio, Teri A TA; Schaid, Daniel J DJ; Denny, Joshua C JC; Hebbring, Scott J SJ; de Andrade, Mariza M; Kullo, Iftikhar J IJ
Early Subclinical Atherosclerosis in Gestational Diabetes: The Predictive Role of Routine Biomarkers and Nutrigenetic Variants.
Journal Of Diabetes Research
Franzago, Marica M; Fraticelli, Federica F; Di Nicola, Marta M; Bianco, Francesco F; Marchetti, Daniela D; Celentano, Claudio C; Liberati, Marco M; De Caterina, Raffaele R; Stuppia, Liborio L; Vitacolonna, Ester E
Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson's Risk.
Frontiers In Neurology
Zhang, Lijun L; Wang, Xue X; Wang, Ming M; Sterling, Nick W NW; Du, Guangwei G; Lewis, Mechelle M MM; Yao, Tao T; Mailman, Richard B RB; Li, Runze R; Huang, Xuemei X
Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women.
Journal Of Diabetes Research
Franzago, Marica M; Fraticelli, Federica F; Nicolucci, Antonio A; Celentano, Claudio C; Liberati, Marco M; Stuppia, Liborio L; Vitacolonna, Ester E
Coronary Artery Calcification and Rheumatoid Arthritis: Lack of Relationship to Risk Alleles for Coronary Artery Disease in the General Population.
Arthritis & Rheumatology (Hoboken, N.J.)
Ferraz-Amaro, Iván I; Winchester, Robert R; Gregersen, Peter K PK; Reynolds, Richard J RJ; Wasko, Mary Chester MC; Oeser, Anette A; Chung, Cecilia P CP; Stein, C Michael CM; Giles, Jon T JT; Bathon, Joan M JM
The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3.
Molecular Genetics And Metabolism
Hanson, Robert L RL; Leti, Fatjon F; Tsinajinnie, Darwin D; Kobes, Sayuko S; Puppala, Sobha S; Curran, Joanne E JE; Almasy, Laura L; Lehman, Donna M DM; Blangero, John J; Duggirala, Ravindranath R; DiStefano, Johanna K JK
Medical implications of technical accuracy in genome sequencing.
Genome Medicine
Goldfeder, Rachel L RL; Priest, James R JR; Zook, Justin M JM; Grove, Megan E ME; Waggott, Daryl D; Wheeler, Matthew T MT; Salit, Marc M; Ashley, Euan A EA
Whole-genome sequencing of the world's oldest people.
Plos One
Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK
Identification of genes contributing to cardiovascular disease in overweight and obese individuals from West Virginia.
The West Virginia Medical Journal
Dementieva, Yulia Y; Green, Todd L TL; Primerano, Donald A DA; Wei, Liping L; Denvir, James J; Wehner, Paulette P; Dodson, Sarah S; Flood, Mark R MR; Pollock, Bonnie A BA; Huff, Melinda M; Hill, Contessa C; Kreisberg, Robert R; Francis, Amanda A; Morrison, Katie K; Blackwood, Holly H; Davis, Mary M; Lee, Huey Miin HM; Warren, Stafford S; ,
Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme.
Age (Dordrecht, Netherlands)
Alfred, Tamuno T; Ben-Shlomo, Yoav Y; Cooper, Rachel R; Hardy, Rebecca R; Cooper, Cyrus C; Deary, Ian J IJ; Elliott, Jane J; Gunnell, David D; Harris, Sarah E SE; Kivimaki, Mika M; Kumari, Meena M; Martin, Richard M RM; Power, Chris C; Sayer, Avan Aihie AA; Starr, John M JM; Kuh, Diana D; Day, Ian N M IN; ,
Heritability and genomics of gene expression in peripheral blood.
Nature Genetics
Wright, Fred A FA; Sullivan, Patrick F PF; Brooks, Andrew I AI; Zou, Fei F; Sun, Wei W; Xia, Kai K; Madar, Vered V; Jansen, Rick R; Chung, Wonil W; Zhou, Yi-Hui YH; Abdellaoui, Abdel A; Batista, Sandra S; Butler, Casey C; Chen, Guanhua G; Chen, Ting-Huei TH; D'Ambrosio, David D; Gallins, Paul P; Ha, Min Jin MJ; Hottenga, Jouke Jan JJ; Huang, Shunping S; Kattenberg, Mathijs M; Kochar, Jaspreet J; Middeldorp, Christel M CM; Qu, Ani A; Shabalin, Andrey A; Tischfield, Jay J; Todd, Laura L; Tzeng, Jung-Ying JY; van Grootheest, Gerard G; Vink, Jacqueline M JM; Wang, Qi Q; Wang, Wei W; Wang, Weibo W; Willemsen, Gonneke G; Smit, Johannes H JH; de Geus, Eco J EJ; Yin, Zhaoyu Z; Penninx, Brenda W J H BW; Boomsma, Dorret I DI
Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal.
Diabetology & Metabolic Syndrome
Gaio, Vânia V; Nunes, Baltazar B; Fernandes, Aida A; Mendonça, Francisco F; Horta Correia, Filomena F; Beleza, Alvaro A; Gil, Ana Paula AP; Bourbon, Mafalda M; Vicente, Astrid A; Dias, Carlos Matias CM; Barreto da Silva, Marta M
Meta-analysis of gene-level tests for rare variant association.
Nature Genetics
Liu, Dajiang J DJ; Peloso, Gina M GM; Zhan, Xiaowei X; Holmen, Oddgeir L OL; Zawistowski, Matthew M; Feng, Shuang S; Nikpay, Majid M; Auer, Paul L PL; Goel, Anuj A; Zhang, He H; Peters, Ulrike U; Farrall, Martin M; Orho-Melander, Marju M; Kooperberg, Charles C; McPherson, Ruth R; Watkins, Hugh H; Willer, Cristen J CJ; Hveem, Kristian K; Melander, Olle O; Kathiresan, Sekar S; Abecasis, Gonçalo R GR
Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.
Atherosclerosis
Shirts, Brian H BH; Howard, Michael T MT; Hasstedt, Sandra J SJ; Nanjee, M Nazeem MN; Knight, Stacey S; Carlquist, John F JF; Anderson, Jeffrey L JL; Hopkins, Paul N PN; Hunt, Steven C SC
Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis.
Nature Genetics
Feenstra, Bjarke B; Geller, Frank F; Krogh, Camilla C; Hollegaard, Mads V MV; Gørtz, Sanne S; Boyd, Heather A HA; Murray, Jeffrey C JC; Hougaard, David M DM; Melbye, Mads M
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
European Heart Journal
Grallert, Harald H; Dupuis, Josée J; Bis, Joshua C JC; Dehghan, Abbas A; Barbalic, Maja M; Baumert, Jens J; Lu, Chen C; Smith, Nicholas L NL; Uitterlinden, André G AG; Roberts, Robert R; Khuseyinova, Natalie N; Schnabel, Renate B RB; Rice, Kenneth M KM; Rivadeneira, Fernando F; Hoogeveen, Ron C RC; Fontes, João Daniel JD; Meisinger, Christa C; Keaney, John F JF; Lemaitre, Rozenn R; Aulchenko, Yurii S YS; Vasan, Ramachandran S RS; Ellis, Stephen S; Hazen, Stanley L SL; van Duijn, Cornelia M CM; Nelson, Jeanenne J JJ; März, Winfried W; Schunkert, Heribert H; McPherson, Ruth M RM; Stirnadel-Farrant, Heide A HA; Psaty, Bruce M BM; Gieger, Christian C; Siscovick, David D; Hofman, Albert A; Illig, Thomas T; Cushman, Mary M; Yamamoto, Jennifer F JF; Rotter, Jerome I JI; Larson, Martin G MG; Stewart, Alexandre F R AF; Boerwinkle, Eric E; Witteman, Jacqueline C M JC; Tracy, Russell P RP; Koenig, Wolfgang W; Benjamin, Emelia J EJ; Ballantyne, Christie M CM
Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk.
Molecular Neurodegeneration
Simmons, Christopher R CR; Zou, Fanggeng F; Younkin, Steven G SG; Estus, Steven S
Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.
Journal Of Lipid Research
Calandra, Sebastiano S; Tarugi, Patrizia P; Speedy, Helen E HE; Dean, Andrew F AF; Bertolini, Stefano S; Shoulders, Carol C CC
Publication Date: 2011-11
Variant appearance in text: LDLR: 81C>T; C27C; rs2228671
Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.
Bmc Medical Genetics
Antoni, Guillemette G; Oudot-Mellakh, Tiphaine T; Dimitromanolakis, Apostolos A; Germain, Marine M; Cohen, William W; Wells, Philip P; Lathrop, Mark M; Gagnon, France F; Morange, Pierre-Emmanuel PE; Tregouet, David-Alexandre DA
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.
Plos Genetics
Dumitrescu, Logan L; Carty, Cara L CL; Taylor, Kira K; Schumacher, Fredrick R FR; Hindorff, Lucia A LA; Ambite, José L JL; Anderson, Garnet G; Best, Lyle G LG; Brown-Gentry, Kristin K; Bůžková, Petra P; Carlson, Christopher S CS; Cochran, Barbara B; Cole, Shelley A SA; Devereux, Richard B RB; Duggan, Dave D; Eaton, Charles B CB; Fornage, Myriam M; Franceschini, Nora N; Haessler, Jeff J; Howard, Barbara V BV; Johnson, Karen C KC; Laston, Sandra S; Kolonel, Laurence N LN; Lee, Elisa T ET; MacCluer, Jean W JW; Manolio, Teri A TA; Pendergrass, Sarah A SA; Quibrera, Miguel M; Shohet, Ralph V RV; Wilkens, Lynne R LR; Haiman, Christopher A CA; Le Marchand, Loïc L; Buyske, Steven S; Kooperberg, Charles C; North, Kari E KE; Crawford, Dana C DC
Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
Haematologica
Wade, Rachel R; Di Bernardo, Maria Chiara MC; Richards, Sue S; Rossi, Davide D; Crowther-Swanepoel, Dalemari D; Gaidano, Gianluca G; Oscier, David G DG; Catovsky, Daniel D; Houlston, Richard S RS
Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent.
Atherosclerosis
Shirts, Brian H BH; Hasstedt, Sandra J SJ; Hopkins, Paul N PN; Hunt, Steven C SC
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
Plos One
Zeller, Tanja T; Wild, Philipp P; Szymczak, Silke S; Rotival, Maxime M; Schillert, Arne A; Castagne, Raphaele R; Maouche, Seraya S; Germain, Marine M; Lackner, Karl K; Rossmann, Heidi H; Eleftheriadis, Medea M; Sinning, Christoph R CR; Schnabel, Renate B RB; Lubos, Edith E; Mennerich, Detlev D; Rust, Werner W; Perret, Claire C; Proust, Carole C; Nicaud, Viviane V; Loscalzo, Joseph J; Hübner, Norbert N; Tregouet, David D; Münzel, Thomas T; Ziegler, Andreas A; Tiret, Laurence L; Blankenberg, Stefan S; Cambien, François F
Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
Lipids In Health And Disease
Ronald, James J; Rajagopalan, Ramakrishnan R; Ranchalis, Jane E JE; Marshall, Julieann K JK; Hatsukami, Thomas S TS; Heagerty, Patrick J PJ; Jarvik, Gail P GP