Publications:

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding.

Cell Reports

Spangler, Cathy J CJ; Yadav, Satya P SP; Li, Dongxu D; Geil, Carinne N CN; Smith, Charlotte B CB; Wang, Gang Greg GG; Lee, Tae-Hee TH; McGinty, Robert K RK

Publication Date: 2022-02-15

Variant appearance in text: DOT1L: G163R

PubMed Link: 35172132

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• nihms-1781192.pdf

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AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation.

Epigenetics & Chromatin

Uğurlu-Çimen, Deniz D; Odluyurt, Deniz D; Sevinç, Kenan K; Özkan-Küçük, Nazlı Ezgi NE; Özçimen, Burcu B; Demirtaş, Deniz D; Enüstün, Eray E; Aztekin, Can C; Philpott, Martin M; Oppermann, Udo U; Özlü, Nurhan N; Önder, Tamer T TT

Publication Date: 2021-07-02

Variant appearance in text: DOT1L: G163R

PubMed Link: 34215314

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• Main text
• 13072_2021_Article_406.pdf

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AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation.

Epigenetics & Chromatin

Uğurlu-Çimen, Deniz D; Odluyurt, Deniz D; Sevinç, Kenan K; Özkan-Küçük, Nazlı Ezgi NE; Özçimen, Burcu B; Demirtaş, Deniz D; Enüstün, Eray E; Aztekin, Can C; Philpott, Martin M; Oppermann, Udo U; Özlü, Nurhan N; Önder, Tamer T TT

Publication Date: 2021-07-02

Variant appearance in text: DOT1L: G163R

PubMed Link: 34215314

Variant Present in the following documents:

• Main text
• 13072_2021_Article_406.pdf

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Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins.

The Journal Of Biological Chemistry

Shen, Chenxi C; Jo, Stephanie Y SY; Liao, Chenzhong C; Hess, Jay L JL; Nikolovska-Coleska, Zaneta Z

Publication Date: 2013-10-18

Variant appearance in text: DOT1L: G163R

PubMed Link: 23996074

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Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation.

The Journal Of Biological Chemistry

Kim, Wootae W; Kim, Ranah R; Park, Geunyeong G; Park, Jong-Wan JW; Kim, Ja-Eun JE

Publication Date: 2012-02-17

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PubMed Link: 22190683

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