DOT1L c.844_845delinsGA ;(p.R282E)

Variant ID: 19-2206784-AG-GA

NM_032482.2(DOT1L):c.844_845delinsGA;(p.R282E)

This variant was identified in 2 publications

View GRCh38 version.




Publications:


Development of multifunctional synthetic nucleosomes to interrogate chromatin-mediated protein interactions.

Science Advances
Liu, Zheng Z; Wu, Yiping Y; Mao, Xin X; Kwan, Ka Chun Jonathan KCJ; Cheng, Xinxin X; Li, Xin X; Jing, Yihang Y; Li, Xiang David XD
Publication Date: 2023-05-03

Variant appearance in text: DOT1L: R282E
PubMed Link: 37134166
Variant Present in the following documents:
  • Main text
  • sciadv.ade5186.pdf
View BVdb publication page



DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding.

Cell Reports
Spangler, Cathy J CJ; Yadav, Satya P SP; Li, Dongxu D; Geil, Carinne N CN; Smith, Charlotte B CB; Wang, Gang Greg GG; Lee, Tae-Hee TH; McGinty, Robert K RK
Publication Date: 2022-02-15

Variant appearance in text: DOT1L: R282E
PubMed Link: 35172132
Variant Present in the following documents:
  • Main text
  • NIHMS1781192-supplement-1.pdf
  • nihms-1781192.pdf
View BVdb publication page