CYP2B6 c.415A>G ;(p.K139E)

Variant ID: 19-41510282-A-G

NM_000767.4(CYP2B6):c.415A>G;(p.K139E)

This variant was identified in 54 publications

View GRCh38 version.




Publications:


Therapeutic and Toxic Effects of Valproic Acid Metabolites.

Metabolites
Shnayder, Natalia A NA; Grechkina, Violetta V VV; Khasanova, Aiperi K AK; Bochanova, Elena N EN; Dontceva, Evgenia A EA; Petrova, Marina M MM; Asadullin, Azat R AR; Shipulin, German A GA; Altynbekov, Kuanysh S KS; Al-Zamil, Mustafa M; Nasyrova, Regina F RF
Publication Date: 2023-01-16

Variant appearance in text: rs12721655
PubMed Link: 36677060
Variant Present in the following documents:
  • Main text
  • metabolites-13-00134.pdf
View BVdb publication page



Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz.

Genetics Research
Mardi, Parham P; Tavakoli-Far, Bahareh B; Sheibani Nia, Samira S; Jazayeri, Roshanak R; Houshmand, Massoud M
Publication Date: 2022

Variant appearance in text: CYP2B6: K139E
PubMed Link: 36320932
Variant Present in the following documents:
  • GR2022-5754776.pdf
View BVdb publication page



Pharmacogenomics in drug-induced cardiotoxicity: Current status and the future.

Frontiers In Cardiovascular Medicine
Li, Mo-Yun MY; Peng, Li-Ming LM; Chen, Xiao-Ping XP
Publication Date: 2022

Variant appearance in text: CYP2B6: 415A>G
PubMed Link: 36312261
Variant Present in the following documents:
  • Main text
  • fcvm-09-966261.pdf
  • Table_1.pdf
View BVdb publication page



The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.

The Pharmacogenomics Journal
Zhou, Yitian Y; Lauschke, Volker M VM
Publication Date: 2022-12

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 36068297
Variant Present in the following documents:
  • Main text
  • 41397_2022_Article_288.pdf
View BVdb publication page



Drug Repurposing in Cancer Therapy: Influence of Patient's Genetic Background in Breast Cancer Treatment.

International Journal Of Molecular Sciences
Rodrigues, Rafaela R; Duarte, Diana D; Vale, Nuno N
Publication Date: 2022-04-14

Variant appearance in text: rs12721655
PubMed Link: 35457144
Variant Present in the following documents:
  • Main text
  • ijms-23-04280.pdf
View BVdb publication page



Effects of cytochrome P450 2B6 and constitutive androstane receptor genetic variation on Efavirenz plasma concentrations among HIV patients in Kenya.

Plos One
Ngayo, Musa Otieno MO; Oluka, Margaret M; Kwena, Zachari Arochi ZA; Bulimo, Wallace Dimbuson WD; Okalebo, Faith Apolot FA
Publication Date: 2022

Variant appearance in text: CYP2B6: K139E
PubMed Link: 35235559
Variant Present in the following documents:
  • Main text
View BVdb publication page



CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function.

Scientific Reports
Mangó, Katalin K; Kiss, Ádám Ferenc ÁF; Fekete, Ferenc F; Erdős, Réka R; Monostory, Katalin K
Publication Date: 2022-02-22

Variant appearance in text: CYP2B6: K139E
PubMed Link: 35194103
Variant Present in the following documents:
  • 41598_2022_Article_7022.pdf
View BVdb publication page



Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.

Npj Genomic Medicine
Lanillos, Javier J; Carcajona, Marta M; Maietta, Paolo P; Alvarez, Sara S; Rodriguez-Antona, Cristina C
Publication Date: 2022-02-18

Variant appearance in text: CYP2B6: K139E
PubMed Link: 35181665
Variant Present in the following documents:
  • 41525_2022_283_MOESM2_ESM.xlsx, sheet 1
  • 41525_2022_283_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



SMAP is a pipeline for sample matching in proteogenomics.

Nature Communications
Li, Ling L; Niu, Mingming M; Erickson, Alyssa A; Luo, Jie J; Rowbotham, Kincaid K; Guo, Kai K; Huang, He H; Li, Yuxin Y; Jiang, Yi Y; Hur, Junguk J; Liu, Chunyu C; Peng, Junmin J; Wang, Xusheng X
Publication Date: 2022-02-08

Variant appearance in text: CYP2B6: K139E
PubMed Link: 35136070
Variant Present in the following documents:
  • 41467_2022_28411_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



The correlation between the level of 3-hydroxypropyl mercapturic acid, CYP2B6 polymorphisms, and hematuria occurrences after cyclophosphamide administration and its bioanalytical methods: A systematic review.

Heliyon
Harahap, Yahdiana Y; Nurahman, Farhan F; Purwanto, Denni Joko DJ; Yanuar, Arry A
Publication Date: 2021-10

Variant appearance in text: CYP2B6: K139E
PubMed Link: 34746455
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology
Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J
Publication Date: 2021-09

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 34621706
Variant Present in the following documents:
  • Main text
  • tcp-29-135-s001.xls, sheet 1
  • tcp-29-135.pdf
View BVdb publication page



Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data.

Journal Of Personalized Medicine
Neyshaburinezhad, Navid N; Ghasim, Hengameh H; Rouini, Mohammadreza M; Daali, Youssef Y; Ardakani, Yalda H YH
Publication Date: 2021-08-18

Variant appearance in text: CYP2B6: K139E
PubMed Link: 34442448
Variant Present in the following documents:
  • jpm-11-00804.pdf
View BVdb publication page



HIV-1 and human genetic variation.

Nature Reviews. Genetics
McLaren, Paul J PJ; Fellay, Jacques J
Publication Date: 2021-10

Variant appearance in text: rs12721655
PubMed Link: 34168330
Variant Present in the following documents:
  • Main text
View BVdb publication page



Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network.

Pharmaceutics
Marok, Fatima Zahra FZ; Fuhr, Laura Maria LM; Hanke, Nina N; Selzer, Dominik D; Lehr, Thorsten T
Publication Date: 2021-03-04

Variant appearance in text: CYP2B6: K139E
PubMed Link: 33806634
Variant Present in the following documents:
  • pharmaceutics-13-00331-s001.pdf
View BVdb publication page



Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon.

Pharmacogenomics And Personalized Medicine
Fernandes, Marianne Rodrigues MR; Rodrigues, Juliana Carla Gomes JCG; Maroñas, Olalla O; Latorre-Pellicer, Ana A; Cruz, Raquel R; Guerreiro, João Farias JF; Burbano, Rommel Mario Rodriguez RMR; de Assumpção, Paulo Pimentel PP; Ribeiro-Dos-Santos, Andrea A; Dos Santos, Sidney Emanuel Batista SEB; Carracedo, Angel A; Dos Santos, Ney Pereira Carneiro NPC
Publication Date: 2021

Variant appearance in text: rs12721655
PubMed Link: 33519226
Variant Present in the following documents:
  • Main text
  • pgpm-14-117.pdf
View BVdb publication page



Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450.

Journal Of Personalized Medicine
Hlaváč, Viktor V; Holý, Petr P; Souček, Pavel P
Publication Date: 2020-08-28

Variant appearance in text: rs12721655
PubMed Link: 32872162
Variant Present in the following documents:
  • Main text
  • jpm-10-00108.pdf
View BVdb publication page



Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Publication Date: 2021-01

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 32607875
Variant Present in the following documents:
  • 40262_2020_913_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



MTHFR and VDR Polymorphisms Improve the Prognostic Value of MYCN Status on Overall Survival in Neuroblastoma Patients.

International Journal Of Molecular Sciences
Olivera, Gladys G GG; Yáñez, Yania Y; Gargallo, Pablo P; Sendra, Luis L; Aliño, Salvador F SF; Segura, Vanessa V; Sanz, Miguel Ángel MÁ; Cañete, Adela A; Castel, Victoria V; Font De Mora, Jaime J; Hervás, David D; Berlanga, Pablo P; Herrero, María José MJ
Publication Date: 2020-04-14

Variant appearance in text: rs12721655
PubMed Link: 32295184
Variant Present in the following documents:
  • Main text
  • ijms-21-02714.pdf
View BVdb publication page



The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.

British Journal Of Clinical Pharmacology
Helsby, N A NA; Yong, M M; van Kan, M M; de Zoysa, J R JR; Burns, K E KE
Publication Date: 2019-09

Variant appearance in text: rs12721655
PubMed Link: 31218720
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes.

Pharmacology Research & Perspectives
Bloom, Adam Joseph AJ; Wang, Pan-Fen PF; Kharasch, Evan D ED
Publication Date: 2019-04

Variant appearance in text: CYP2B6: K139E
PubMed Link: 30906561
Variant Present in the following documents:
  • PRP2-7-e00468.pdf
View BVdb publication page



The Prevalence of CYP2B6 Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia.

Osong Public Health And Research Perspectives
Hananta, Linawati L; Astuti, Indwiani I; Sadewa, Ahmad Hamim AH; Alice, Josephine J; Hutagalung, Jontari J; Mustofa,
Publication Date: 2018-08

Variant appearance in text: CYP2B6: K139E
PubMed Link: 30159225
Variant Present in the following documents:
  • ophrp-09-0192.pdf
View BVdb publication page



Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.

American Journal Of Medical Genetics. Part A
Padula, Amy M AM; Yang, Wei W; Schultz, Kathleen K; Lurmann, Fred F; Hammond, S Katharine SK; Shaw, Gary M GM
Publication Date: 2018-05

Variant appearance in text: rs12721655
PubMed Link: 29681089
Variant Present in the following documents:
  • Main text
View BVdb publication page



Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.

Nature Communications
Schrader, A A; Crispatzu, G G; Oberbeck, S S; Mayer, P P; Pützer, S S; von Jan, J J; Vasyutina, E E; Warner, K K; Weit, N N; Pflug, N N; Braun, T T; Andersson, E I EI; Yadav, B B; Riabinska, A A; Maurer, B B; Ventura Ferreira, M S MS; Beier, F F; Altmüller, J J; Lanasa, M M; Herling, C D CD; Haferlach, T T; Stilgenbauer, S S; Hopfinger, G G; Peifer, M M; Brümmendorf, T H TH; Nürnberg, P P; Elenitoba-Johnson, K S J KSJ; Zha, S S; Hallek, M M; Moriggl, R R; Reinhardt, H C HC; Stern, M-H MH; Mustjoki, S S; Newrzela, S S; Frommolt, P P; Herling, M M
Publication Date: 2018-02-15

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 29449575
Variant Present in the following documents:
  • 41467_2017_2688_MOESM14_ESM.xls, sheet 3
View BVdb publication page



Genetic variation in human drug-related genes.

Genome Medicine
Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS
Publication Date: 2017-12-22

Variant appearance in text: rs12721655
PubMed Link: 29273096
Variant Present in the following documents:
  • 13073_2017_502_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia.

Acta Neuropathologica
Olney, Nicholas T NT; Alquezar, Carolina C; Ramos, Eliana Marisa EM; Nana, Alissa L AL; Fong, Jamie C JC; Karydas, Anna M AM; Taylor, Joanne B JB; Stephens, Melanie L ML; Argouarch, Andrea R AR; Van Berlo, Victoria A VA; Dokuru, Deepika R DR; Sherr, Elliott H EH; Jicha, Gregory A GA; Dillon, William P WP; Desikan, Rahul S RS; De May, Mary M; Seeley, William W WW; Coppola, Giovanni G; Miller, Bruce L BL; Kao, Aimee W AW
Publication Date: 2017-11

Variant appearance in text: CYP2B6: K139E
PubMed Link: 28828560
Variant Present in the following documents:
  • 401_2017_1764_MOESM1_ESM.pdf
View BVdb publication page



Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

Clinical Pharmacology And Therapeutics
Zhou, Y Y; Ingelman-Sundberg, M M; Lauschke, V M VM
Publication Date: 2017-10

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 28378927
Variant Present in the following documents:
  • Main text
  • CPT-102-688.pdf
View BVdb publication page



Tell-Tale SNPs: The Role of CYP2B6 in Methadone Fatalities.

Journal Of Analytical Toxicology
Ahmad, Taha T; Sabet, Samie S; Primerano, Donald A DA; Richards-Waugh, Lauren L LL; Rankin, Gary O GO
Publication Date: 2017-05-01

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 28184434
Variant Present in the following documents:
  • Main text
View BVdb publication page



Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics
Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR
Publication Date: 2017-03

Variant appearance in text: rs12721655
PubMed Link: 27984508
Variant Present in the following documents:
  • fpc-27-089-s005.xlsx, sheet 2
  • fpc-27-089-s004.xlsx, sheet 2
View BVdb publication page



Insights into CYP2B6-mediated drug-drug interactions.

Acta Pharmaceutica Sinica. B
Hedrich, William D WD; Hassan, Hazem E HE; Wang, Hongbing H
Publication Date: 2016-09

Variant appearance in text: CYP2B6: K139E
PubMed Link: 27709010
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Caudle, Kelly E KE; Dunnenberger, Henry M HM; Freimuth, Robert R RR; Peterson, Josh F JF; Burlison, Jonathan D JD; Whirl-Carrillo, Michelle M; Scott, Stuart A SA; Rehm, Heidi L HL; Williams, Marc S MS; Klein, Teri E TE; Relling, Mary V MV; Hoffman, James M JM
Publication Date: 2017-02

Variant appearance in text: CYP2B6: K139E
PubMed Link: 27441996
Variant Present in the following documents:
View BVdb publication page



Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.

Drug Metabolism And Pharmacokinetics
Cho, Doo-Yeoun DY; Shen, Joan H Q JH; Lemler, Suzanne M SM; Skaar, Todd C TC; Li, Lang L; Blievernicht, Julia J; Zanger, Ulrich M UM; Kim, Kwon-Bok KB; Shin, Jae-Gook JG; Flockhart, David A DA; Desta, Zeruesenay Z
Publication Date: 2016-04

Variant appearance in text: CYP2B6: K139E
PubMed Link: 27053325
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling.

Frontiers In Pharmacology
Chua, Eng Wee EW; Cree, Simone L SL; Ton, Kim N T KN; Lehnert, Klaus K; Shepherd, Phillip P; Helsby, Nuala N; Kennedy, Martin A MA
Publication Date: 2016

Variant appearance in text: rs12721655
PubMed Link: 26858644
Variant Present in the following documents:
  • Main text
View BVdb publication page



Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan.

Bmc Genetics
Iskakova, Aisha N AN; Romanova, Aliya A AA; Aitkulova, Akbota M AM; Sikhayeva, Nurgul S NS; Zholdybayeva, Elena V EV; Ramanculov, Erlan M EM
Publication Date: 2016-01-19

Variant appearance in text: rs12721655
PubMed Link: 26785747
Variant Present in the following documents:
  • Main text
View BVdb publication page



Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One
Holehouse, Alex S AS; Naegle, Kristen M KM
Publication Date: 2015

Variant appearance in text: rs12721655
PubMed Link: 26659599
Variant Present in the following documents:
  • pone.0144692.s002.xlsx, sheet 1
View BVdb publication page



Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation.

Plos One
El-Serafi, Ibrahim I; Afsharian, Parvaneh P; Moshfegh, Ali A; Hassan, Moustapha M; Terelius, Ylva Y
Publication Date: 2015

Variant appearance in text: CYP2B6: K139E
PubMed Link: 26544874
Variant Present in the following documents:
  • pone.0141979.pdf
View BVdb publication page



Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine.

International Journal Of Molecular Sciences
Simeon, Vittorio V; Todoerti, Katia K; La Rocca, Francesco F; Caivano, Antonella A; Trino, Stefania S; Lionetti, Marta M; Agnelli, Luca L; De Luca, Luciana L; Laurenzana, Ilaria I; Neri, Antonino A; Musto, Pellegrino P
Publication Date: 2015-07-30

Variant appearance in text: CYP2B6: Lys139Glu; rs12721655
PubMed Link: 26263974
Variant Present in the following documents:
  • ijms-16-17514-s001.pdf
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: CYP2B6: K139E
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 4
View BVdb publication page



The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers
Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N
Publication Date: 2015

Variant appearance in text: rs12721655
PubMed Link: 25802476
Variant Present in the following documents:
  • 542543.f1.xlsx, sheet 1
View BVdb publication page



Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS.

Scientific Reports
Steinberg, Karyn Meltz KM; Yu, Bing B; Koboldt, Daniel C DC; Mardis, Elaine R ER; Pamphlett, Roger R
Publication Date: 2015-03-16

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 25773295
Variant Present in the following documents:
  • srep09124-s3.xls, sheet 1
View BVdb publication page



CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects.

British Journal Of Clinical Pharmacology
Li, Yibai Y; Jackson, Kate A KA; Slon, Barry B; Hardy, Janet R JR; Franco, Michael M; William, Leeroy L; Poon, Peter P; Coller, Janet K JK; Hutchinson, Mark R MR; Currow, David C DC; Somogyi, Andrew A AA
Publication Date: 2015-08

Variant appearance in text: CYP2B6: 415A>G; rs12721655
PubMed Link: 25702819
Variant Present in the following documents:
  • Main text
View BVdb publication page



Whole-genome sequencing of the world's oldest people.

Plos One
Gierman, Hinco J HJ; Fortney, Kristen K; Roach, Jared C JC; Coles, Natalie S NS; Li, Hong H; Glusman, Gustavo G; Markov, Glenn J GJ; Smith, Justin D JD; Hood, Leroy L; Coles, L Stephen LS; Kim, Stuart K SK
Publication Date: 2014

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 25390934
Variant Present in the following documents:
  • pone.0112430.s004.xlsx, sheet 1
View BVdb publication page



The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports
Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK
Publication Date: 2014

Variant appearance in text: rs12721655
PubMed Link: 25126521
Variant Present in the following documents:
  • mmc1.xls, sheet 1
View BVdb publication page



Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis.

Arthritis & Rheumatology (Hoboken, N.J.)
Kaufman, Kenneth M KM; Linghu, Bolan B; Szustakowski, Joseph D JD; Husami, Ammar A; Yang, Fan F; Zhang, Kejian K; Filipovich, Alexandra H AH; Fall, Ndate N; Harley, John B JB; Nirmala, N R NR; Grom, Alexei A AA
Publication Date: 2014-12

Variant appearance in text: CYP2B6: Lys139Glu
PubMed Link: 25047945
Variant Present in the following documents:
  • Main text
View BVdb publication page



Screening for 392 polymorphisms in 141 pharmacogenes.

Biomedical Reports
Kim, Jason Yongha JY; Cheong, Hyun Sub HS; Park, Tae-Joon TJ; Shin, Hee Jung HJ; Seo, Doo Won DW; Na, Han Sung HS; Chung, Myeon Woo MW; Shin, Hyoung Doo HD
Publication Date: 2014-07

Variant appearance in text: rs12721655
PubMed Link: 24944790
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine.

Colombia Medica (Cali, Colombia)
Isaza, Carlos C; Henao, Julieta J; Beltrán, Leonardo L; Porras, Liliana L; Gonzalez, Martha M; Cruz, Raquel R; Carracedo, Angel A
Publication Date: 2013-01

Variant appearance in text: rs12721655
PubMed Link: 24892317
Variant Present in the following documents:
  • Main text
View BVdb publication page



Evaluation of influence of single nucleotide polymorphisms in cytochrome P450 2B6 on substrate recognition using computational docking and molecular dynamics simulation.

Plos One
Kobayashi, Kana K; Takahashi, Ohgi O; Hiratsuka, Masahiro M; Yamaotsu, Noriyuki N; Hirono, Shuichi S; Watanabe, Yurie Y; Oda, Akifumi A
Publication Date: 2014

Variant appearance in text: CYP2B6: Lys139Glu
PubMed Link: 24796891
Variant Present in the following documents:
  • Main text
  • pone.0096789.pdf
View BVdb publication page



CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes.

Plos One
Bloom, A Joseph AJ; Martinez, Maribel M; Chen, Li-Shiun LS; Bierut, Laura J LJ; Murphy, Sharon E SE; Goate, Alison A
Publication Date: 2013

Variant appearance in text: CYP2B6: K139E; rs12721655
PubMed Link: 24260284
Variant Present in the following documents:
  • Main text
  • pone.0079700.pdf
View BVdb publication page



Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance.

Frontiers In Genetics
Zanger, Ulrich M UM; Klein, Kathrin K
Publication Date: 2013

Variant appearance in text: CYP2B6: K139E
PubMed Link: 23467454
Variant Present in the following documents:
  • fgene-04-00024.pdf
View BVdb publication page



Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.

Pharmacogenetics And Genomics
Holzinger, Emily R ER; Grady, Benjamin B; Ritchie, Marylyn D MD; Ribaudo, Heather J HJ; Acosta, Edward P EP; Morse, Gene D GD; Gulick, Roy M RM; Robbins, Gregory K GK; Clifford, David B DB; Daar, Eric S ES; McLaren, Paul P; Haas, David W DW
Publication Date: 2012-12

Variant appearance in text: CYP2B6: K139E
PubMed Link: 23080225
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influence of various polymorphic variants of cytochrome P450 oxidoreductase (POR) on drug metabolic activity of CYP3A4 and CYP2B6.

Plos One
Chen, Xuan X; Pan, Li Qiang LQ; Naranmandura, Hua H; Zeng, Su S; Chen, Shu Qing SQ
Publication Date: 2012

Variant appearance in text: CYP2B6: K139E
PubMed Link: 22719896
Variant Present in the following documents:
  • pone.0038495.pdf
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Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex.

The Journal Of Pharmacology And Experimental Therapeutics
Zhang, Haoming H; Sridar, Chitra C; Kenaan, Cesar C; Amunugama, Hemali H; Ballou, David P DP; Hollenberg, Paul F PF
Publication Date: 2011-09

Variant appearance in text: CYP2B6: K139E
PubMed Link: 21659470
Variant Present in the following documents:
  • Main text
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Genotyping of DNA samples isolated from formalin-fixed paraffin-embedded tissues using preamplification.

The Journal Of Molecular Diagnostics : Jmd
Baak-Pablo, Renee R; Dezentje, Vincent V; Guchelaar, Henk-Jan HJ; van der Straaten, Tahar T
Publication Date: 2010-11

Variant appearance in text: rs12721655
PubMed Link: 20847277
Variant Present in the following documents:
  • Main text
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Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.

British Journal Of Cancer
Bray, J J; Sludden, J J; Griffin, M J MJ; Cole, M M; Verrill, M M; Jamieson, D D; Boddy, A V AV
Publication Date: 2010-03-16

Variant appearance in text: CYP2B6: Lys139Glu
PubMed Link: 20179710
Variant Present in the following documents:
  • Main text
  • 6605587a.pdf
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Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs.

Drug Metabolism And Disposition: The Biological Fate Of Chemicals
Talakad, Jyothi C JC; Kumar, Santosh S; Halpert, James R JR
Publication Date: 2009-03

Variant appearance in text: CYP2B6: K139E
PubMed Link: 19074527
Variant Present in the following documents:
  • Main text
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