Rational Computational Approaches in Drug Discovery: Potential Inhibitors for Allosteric Regulation of Mutant Isocitrate Dehydrogenase-1 Enzyme in Cancers.
Molecules (Basel, Switzerland)
Thamim, Masthan M; Agrahari, Ashish Kumar AK; Gupta, Pawan P; Thirumoorthy, Krishnan K
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ferraro, Francesca F; Miller, Christopher A CA; Christensen, Keegan A KA; Helton, Nichole M NM; O'Laughlin, Margaret M; Fronick, Catrina C CC; Fulton, Robert S RS; Kohlschmidt, Jessica J; Eisfeld, Ann-Kathrin AK; Bloomfield, Clara D CD; Ramakrishnan, Sai Mukund SM; Day, Ryan B RB; Wartman, Lukas D LD; Uy, Geoffrey L GL; Welch, John S JS; Christopher, Matthew J MJ; Heath, Sharon E SE; Baty, Jack D JD; Schuelke, Matthew J MJ; Payton, Jacqueline E JE; Spencer, David H DH; Rettig, Michael P MP; Link, Daniel C DC; Walter, Matthew J MJ; Westervelt, Peter P; DiPersio, John F JF; Ley, Timothy J TJ
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ferraro, Francesca F; Miller, Christopher A CA; Christensen, Keegan A KA; Helton, Nichole M NM; O'Laughlin, Margaret M; Fronick, Catrina C CC; Fulton, Robert S RS; Kohlschmidt, Jessica J; Eisfeld, Ann-Kathrin AK; Bloomfield, Clara D CD; Ramakrishnan, Sai Mukund SM; Day, Ryan B RB; Wartman, Lukas D LD; Uy, Geoffrey L GL; Welch, John S JS; Christopher, Matthew J MJ; Heath, Sharon E SE; Baty, Jack D JD; Schuelke, Matthew J MJ; Payton, Jacqueline E JE; Spencer, David H DH; Rettig, Michael P MP; Link, Daniel C DC; Walter, Matthew J MJ; Westervelt, Peter P; DiPersio, John F JF; Ley, Timothy J TJ
Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study.
Blood Advances
Middeke, Jan M JM; Metzeler, Klaus H KH; Röllig, Christoph C; Krämer, Michael M; Eckardt, Jan-Niklas JN; Stasik, Sebastian S; Greif, Philipp A PA; Spiekermann, Karsten K; Rothenberg-Thurley, Maja M; Krug, Utz U; Braess, Jan J; Krämer, Alwin A; Hochhaus, Andreas A; Brümmendorf, Tim H TH; Naumann, Ralph R; Steffen, Björn B; Einsele, Hermann H; Schaich, Markus M; Burchert, Andreas A; Neubauer, Andreas A; Görlich, Dennis D; Sauerland, Cristina C; Schäfer-Eckart, Kerstin K; Schliemann, Christoph C; Krause, Stefan W SW; Hänel, Mathias M; Frickhofen, Norbert N; Noppeney, Richard R; Kaiser, Ulrich U; Kaufmann, Martin M; Kunadt, Desiree D; Wörmann, Bernhard B; Sockel, Katja K; von Bonin, Malte M; Herold, Tobias T; Müller-Tidow, Carsten C; Platzbecker, Uwe U; Berdel, Wolfgang E WE; Serve, Hubert H; Baldus, Claudia D CD; Ehninger, Gerhard G; Schetelig, Johannes J; Hiddemann, Wolfgang W; Bornhäuser, Martin M; Stölzel, Friedrich F; Thiede, Christian C
Final Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial.
Jama Oncology
Zhu, Andrew X AX; Macarulla, Teresa T; Javle, Milind M MM; Kelley, R Kate RK; Lubner, Sam J SJ; Adeva, Jorge J; Cleary, James M JM; Catenacci, Daniel V T DVT; Borad, Mitesh J MJ; Bridgewater, John A JA; Harris, William P WP; Murphy, Adrian G AG; Oh, Do-Youn DY; Whisenant, Jonathan R JR; Lowery, Maeve A MA; Goyal, Lipika L; Shroff, Rachna T RT; El-Khoueiry, Anthony B AB; Chamberlain, Christina X CX; Aguado-Fraile, Elia E; Choe, Sung S; Wu, Bin B; Liu, Hua H; Gliser, Camelia C; Pandya, Shuchi S SS; Valle, Juan W JW; Abou-Alfa, Ghassan K GK
Spatially interacting phosphorylation sites and mutations in cancer.
Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
NGS for (Hemato-) Oncology in Belgium: Evaluation of Laboratory Performance and Feasibility of a National External Quality Assessment Program.
Cancers
Delcourt, Thomas T; Vanneste, Kevin K; Soumali, Mohamed Rida MR; Coucke, Wim W; Ghislain, Vanessa V; Hebrant, Aline A; Van Valckenborgh, Els E; De Keersmaecker, Sigrid C J SCJ; Roosens, Nancy H NH; Van De Walle, Philippe P; Van Den Bulcke, Marc M; Antoniou, Aline A
Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS.
Metabolites
Sun, Xueni X; Berger, Raffaela S RS; Heinrich, Paul P; Marchiq, Ibtissam I; Pouyssegur, Jacques J; Renner, Kathrin K; Oefner, Peter J PJ; Dettmer, Katja K
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
[The aberrant epigenetic regulation and epigenomic landscape alteration in human acute myelogenous leukemia and the emerged agents that target epigenetic regulators].
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
Integrative omics analyses broaden treatment targets in human cancer.
Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia.
Oncotarget
Singh, Abhishek A AA; Petraglia, Francesca F; Nebbioso, Angela A; Yi, Guoqiang G; Conte, Mariarosaria M; Valente, Sergio S; Mandoli, Amit A; Scisciola, Lucia L; Lindeboom, Rik R; Kerstens, Hinri H; Janssen-Megens, Eva M EM; Pourfarzad, Farzin F; Habibi, Ehsan E; Berentsen, Kim K; Kim, Bowon B; Logie, Colin C; Heath, Simon S; Wierenga, Albertus T J ATJ; Clarke, Laura L; Flicek, Paul P; Jansen, Joop H JH; Kuijpers, Taco T; Yaspo, Marie Laure ML; Valle, Veronique Della VD; Bernard, Olivier O; Gut, Ivo I; Vellenga, Edo E; Stunnenberg, Hendrik G HG; Mai, Antonello A; Altucci, Lucia L; Martens, Joost H A JHA
A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome.
Leukemia
Kelly, A D AD; Kroeger, H H; Yamazaki, J J; Taby, R R; Neumann, F F; Yu, S S; Lee, J T JT; Patel, B B; Li, Y Y; He, R R; Liang, S S; Lu, Y Y; Cesaroni, M M; Pierce, S A SA; Kornblau, S M SM; Bueso-Ramos, C E CE; Ravandi, F F; Kantarjian, H M HM; Jelinek, J J; Issa, J-Pj JP
Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.
Cancer Cell
Bardella, Chiara C; Al-Dalahmah, Osama O; Krell, Daniel D; Brazauskas, Pijus P; Al-Qahtani, Khalid K; Tomkova, Marketa M; Adam, Julie J; Serres, Sébastien S; Lockstone, Helen H; Freeman-Mills, Luke L; Pfeffer, Inga I; Sibson, Nicola N; Goldin, Robert R; Schuster-Böeckler, Benjamin B; Pollard, Patrick J PJ; Soga, Tomoyoshi T; McCullagh, James S JS; Schofield, Christopher J CJ; Mulholland, Paul P; Ansorge, Olaf O; Kriaucionis, Skirmantas S; Ratcliffe, Peter J PJ; Szele, Francis G FG; Tomlinson, Ian I
Minimally-Myelosuppressive Asparaginase-Containing Induction Regimen for Treatment of a Jehovah's Witness with mutant IDH1/NPM1/NRAS Acute Myeloid Leukemia.
Pharmaceuticals (Basel, Switzerland)
Emadi, Ashkan A; Bade, Najeebah A NA; Stevenson, Brandi B; Singh, Zeba Z
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
Nature Chemical Biology
Okoye-Okafor, Ujunwa C UC; Bartholdy, Boris B; Cartier, Jessy J; Gao, Enoch N EN; Pietrak, Beth B; Rendina, Alan R AR; Rominger, Cynthia C; Quinn, Chad C; Smallwood, Angela A; Wiggall, Kenneth J KJ; Reif, Alexander J AJ; Schmidt, Stanley J SJ; Qi, Hongwei H; Zhao, Huizhen H; Joberty, Gerard G; Faelth-Savitski, Maria M; Bantscheff, Marcus M; Drewes, Gerard G; Duraiswami, Chaya C; Brady, Pat P; Groy, Arthur A; Narayanagari, Swathi-Rao SR; Antony-Debre, Iléana I; Mitchell, Kelly K; Wang, Heng Rui HR; Kao, Yun-Ruei YR; Christopeit, Maximilian M; Carvajal, Luis L; Barreyro, Laura L; Paietta, Elisabeth E; Makishima, Hideki H; Will, Britta B; Concha, Nestor N; Adams, Nicholas D ND; Schwartz, Benjamin B; McCabe, Michael T MT; Maciejewski, Jaroslav J; Verma, Amit A; Steidl, Ulrich U
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.
Cancer Cell
Klco, Jeffery M JM; Spencer, David H DH; Miller, Christopher A CA; Griffith, Malachi M; Lamprecht, Tamara L TL; O'Laughlin, Michelle M; Fronick, Catrina C; Magrini, Vincent V; Demeter, Ryan T RT; Fulton, Robert S RS; Eades, William C WC; Link, Daniel C DC; Graubert, Timothy A TA; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Wilson, Richard K RK; Ley, Timothy J TJ
Case series of patients with acute myeloid leukemia receiving hypomethylation therapy and retrospectively found to have IDH1 or IDH2 mutations.
Leukemia & Lymphoma
Benton, Christopher B CB; Ravandi, Farhad F; Andreeff, Michael M; Kadia, Tapan T; Ruvolo, Vivian V; Qiu, Peng P; Wheeler, David A DA; Garcia-Manero, Guillermo G; Cortes, Jorge J; Kantarjian, Hagop M HM; Konopleva, Marina M