Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Nacev, Benjamin A BA; Jones, Kevin B KB; Intlekofer, Andrew M AM; Yu, Jamie S E JSE; Allis, C David CD; Tap, William D WD; Ladanyi, Marc M; Nielsen, Torsten O TO
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.
Biochemistry
Chambers, Jennifer M JM; Miller, Wade W; Quichocho, Giovanni G; Upadhye, Viraj V; Matteo, Diego Avellaneda DA; Bobkov, Andrey A AA; Sohl, Christal D CD; Schiffer, Jamie M JM
Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Fei, Dennis Liang DL; Zhen, Tao T; Durham, Benjamin B; Ferrarone, John J; Zhang, Tuo T; Garrett, Lisa L; Yoshimi, Akihide A; Abdel-Wahab, Omar O; Bradley, Robert K RK; Liu, Paul P; Varmus, Harold H
Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.
The Biochemical Journal
Avellaneda Matteo, Diego D; Wells, Grace A GA; Luna, Lucas A LA; Grunseth, Adam J AJ; Zagnitko, Olga O; Scott, David A DA; Hoang, An A; Luthra, Amit A; Swairjo, Manal A MA; Schiffer, Jamie M JM; Sohl, Christal D CD
Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.
Blood
Dovey, Oliver M OM; Cooper, Jonathan L JL; Mupo, Annalisa A; Grove, Carolyn S CS; Lynn, Claire C; Conte, Nathalie N; Andrews, Robert M RM; Pacharne, Suruchi S; Tzelepis, Konstantinos K; Vijayabaskar, M S MS; Green, Paul P; Rad, Roland R; Arends, Mark M; Wright, Penny P; Yusa, Kosuke K; Bradley, Allan A; Varela, Ignacio I; Vassiliou, George S GS
Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.
The Journal Of Biological Chemistry
Avellaneda Matteo, Diego D; Grunseth, Adam J AJ; Gonzalez, Eric R ER; Anselmo, Stacy L SL; Kennedy, Madison A MA; Moman, Precious P; Scott, David A DA; Hoang, An A; Sohl, Christal D CD
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Cancer Cell
Inoue, Satoshi S; Li, Wanda Y WY; Tseng, Alan A; Beerman, Isabel I; Elia, Andrew J AJ; Bendall, Sean C SC; Lemonnier, François F; Kron, Ken J KJ; Cescon, David W DW; Hao, Zhenyue Z; Lind, Evan F EF; Takayama, Naoya N; Planello, Aline C AC; Shen, Shu Yi SY; Shih, Alan H AH; Larsen, Dana M DM; Li, Qinxi Q; Snow, Bryan E BE; Wakeham, Andrew A; Haight, Jillian J; Gorrini, Chiara C; Bassi, Christian C; Thu, Kelsie L KL; Murakami, Kiichi K; Elford, Alisha R AR; Ueda, Takeshi T; Straley, Kimberly K; Yen, Katharine E KE; Melino, Gerry G; Cimmino, Luisa L; Aifantis, Iannis I; Levine, Ross L RL; De Carvalho, Daniel D DD; Lupien, Mathieu M; Rossi, Derrick J DJ; Nolan, Garry P GP; Cairns, Rob A RA; Mak, Tak W TW
Mutant IDH is sufficient to initiate enchondromatosis in mice.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Hirata, Makoto M; Sasaki, Masato M; Cairns, Rob A RA; Inoue, Satoshi S; Puviindran, Vijitha V; Li, Wanda Y WY; Snow, Bryan E BE; Jones, Lisa D LD; Wei, Qingxia Q; Sato, Shingo S; Tang, Yuning J YJ; Nadesan, Puviindran P; Rockel, Jason J; Whetstone, Heather H; Poon, Raymond R; Weng, Angela A; Gross, Stefan S; Straley, Kimberly K; Gliser, Camelia C; Xu, Yingxia Y; Wunder, Jay J; Mak, Tak W TW; Alman, Benjamin A BA