IDH1 c.395G>A ;(p.R132H)

Variant ID: 2-209113112-C-T

NM_005896.2(IDH1):c.395G>A;(p.R132H)

This variant was identified in 2523 publications

View GRCh38 version.




Publications:


RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.

The Journal Of Clinical Investigation
Ren, Jian-Gang JG; Xing, Bowen B; Lv, Kaosheng K; O'Keefe, Rachel A RA; Wu, Mengfang M; Wang, Ruoxing R; Bauer, Kaylyn M KM; Ghazaryan, Arevik A; Burslem, George M GM; Zhang, Jing J; O'Connell, Ryan M RM; Pillai, Vinodh V; Hexner, Elizabeth O EO; Philips, Mark R MR; Tong, Wei W
Publication Date: 2023-06-15

Variant appearance in text: IDH1: R132H
PubMed Link: 37317963
Variant Present in the following documents:
  • jci-133-165510-s058.xlsx, sheet 1
View BVdb publication page



Introducing HDAC-Targeting Radiopharmaceuticals for Glioblastoma Imaging and Therapy.

Pharmaceuticals (Basel, Switzerland)
Everix, Liesbeth L; Seane, Elsie Neo EN; Ebenhan, Thomas T; Goethals, Ingeborg I; Bolcaen, Julie J
Publication Date: 2023-02-01

Variant appearance in text: IDH1: R132H
PubMed Link: 37259375
Variant Present in the following documents:
  • pharmaceuticals-16-00227.pdf
View BVdb publication page



From Theory to Practice: Implementing the WHO 2021 Classification of Adult Diffuse Gliomas in Neuropathology Diagnosis.

Brain Sciences
Martin, Karina Chornenka KC; Ma, Crystal C; Yip, Stephen S
Publication Date: 2023-05-18

Variant appearance in text: IDH1: R132H
PubMed Link: 37239289
Variant Present in the following documents:
  • Main text
  • brainsci-13-00817.pdf
View BVdb publication page



The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis.

Rna Biology
Shen, Tao T; Wang, Haiyang H; Tang, Bin B; Zhu, Guoping G; Wang, Xiangting X
Publication Date: 2023-01

Variant appearance in text: IDH1: R132H
PubMed Link: 37221841
Variant Present in the following documents:
  • Main text
  • KRNB_20_2216562.pdf
View BVdb publication page



Mutant Isocitrate Dehydrogenase 1 Expression Enhances Response of Gliomas to the Histone Deacetylase Inhibitor Belinostat.

Tomography (Ann Arbor, Mich.)
Chang, Chi-Ming CM; Ramesh, Karthik K KK; Huang, Vicki V; Gurbani, Saumya S; Kleinberg, Lawrence R LR; Weinberg, Brent D BD; Shim, Hyunsuk H; Shu, Hui-Kuo G HG
Publication Date: 2023-05-04

Variant appearance in text: IDH1: R132H
PubMed Link: 37218937
Variant Present in the following documents:
  • Main text
  • tomography-09-00077.pdf
View BVdb publication page



The Role of Biomarkers in Guiding Clinical Decision-Making in Oncology.

Journal Of The Advanced Practitioner In Oncology
Moore, Donald C DC; Guinigundo, Andrew S AS
Publication Date: 2023-04

Variant appearance in text: IDH1: R132H
PubMed Link: 37206905
Variant Present in the following documents:
  • Main text
  • jadpro-14-15.pdf
View BVdb publication page



Genetic mutations in HER2-positive breast cancer: possible association with response to trastuzumab therapy.

Human Genomics
Zakaria, Nermine H NH; Hashad, Doaa D; Saied, Marwa H MH; Hegazy, Neamat N; Elkayal, Alyaa A; Tayae, Eman E
Publication Date: 2023-05-18

Variant appearance in text: IDH1: Arg132His
PubMed Link: 37202799
Variant Present in the following documents:
  • Main text
  • 40246_2023_Article_493.pdf
View BVdb publication page



Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis.

Scientific Reports
Lee, Kwanghoon K; Kim, Seong-Ik SI; Kim, Eric Eunshik EE; Shim, Yu-Mi YM; Won, Jae-Kyung JK; Park, Chul-Kee CK; Choi, Seung Hong SH; Yun, Hongseok H; Lee, Hyunju H; Park, Sung-Hye SH
Publication Date: 2023-04-25

Variant appearance in text: IDH1: R132H
PubMed Link: 37185778
Variant Present in the following documents:
  • Main text
  • 41598_2023_Article_32153.pdf
View BVdb publication page



Assessment of Gliomas' Grade of Malignancy and Extent of Resection Using Intraoperative Flow Cytometry.

Cancers
Vartholomatos, George G; Markopoulos, Georgios S GS; Vartholomatos, Eyrysthenis E; Goussia, Anna C AC; Dova, Lefkothea L; Dimitriadis, Savvas S; Mantziou, Stefania S; Zoi, Vaso V; Nasios, Anastasios A; Sioka, Chrissa C; Kyritsis, Athanasios P AP; Voulgaris, Spyridon S; Alexiou, George A GA
Publication Date: 2023-04-27

Variant appearance in text: IDH1: 395G>A
PubMed Link: 37173975
Variant Present in the following documents:
  • Main text
  • cancers-15-02509.pdf
View BVdb publication page



Impact of Clonal Architecture on Clinical Course and Prognosis in Patients With Myeloproliferative Neoplasms.

Hemasphere
Luque Paz, Damien D; Bader, Michael S MS; Nienhold, Ronny R; Rai, Shivam S; Almeida Fonseca, Tiago T; Stetka, Jan J; Hao-Shen, Hui H; Mild-Schneider, Gabriele G; Passweg, Jakob R JR; Skoda, Radek C RC
Publication Date: 2023-05

Variant appearance in text: IDH1: R132H
PubMed Link: 37153874
Variant Present in the following documents:
  • hs9-7-e885-s001.xlsx, sheet 2
View BVdb publication page



MRI-based classification of IDH mutation and 1p/19q codeletion status of gliomas using a 2.5D hybrid multi-task convolutional neural network.

Neuro-Oncology Advances
Chakrabarty, Satrajit S; LaMontagne, Pamela P; Shimony, Joshua J; Marcus, Daniel S DS; Sotiras, Aristeidis A
Publication Date: 2023

Variant appearance in text: IDH1: R132H
PubMed Link: 37152810
Variant Present in the following documents:
  • vdad023.pdf
View BVdb publication page



Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3.

Scientific Reports
Park, Sooyong S; Yun, Jiwon J; Choi, Sung Yoon SY; Jeong, Dajeong D; Gu, Ja-Yoon JY; Lee, Jee-Soo JS; Seong, Moon-Woo MW; Chang, Yoon Hwan YH; Yun, Hongseok H; Kim, Hyun Kyung HK
Publication Date: 2023-05-04

Variant appearance in text: IDH1: 395G>A; Arg132His
PubMed Link: 37142644
Variant Present in the following documents:
  • 41598_2023_33928_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer.

Acta Pharmaceutica Sinica. B
Liu, Yang Y; Xu, Wei W; Li, Mingxue M; Yang, Yueying Y; Sun, Dejuan D; Chen, Lidian L; Li, Hua H; Chen, Lixia L
Publication Date: 2023-04

Variant appearance in text: IDH1: R132H
PubMed Link: 37139412
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



P16 immunohistochemistry is a sensitive and specific surrogate marker for CDKN2A homozygous deletion in gliomas.

Acta Neuropathologica Communications
Vij, Meenakshi M; Cho, Benjamin B BB; Yokoda, Raquel T RT; Rashidipour, Omid O; Umphlett, Melissa M; Richardson, Timothy E TE; Tsankova, Nadejda M NM
Publication Date: 2023-05-03

Variant appearance in text: IDH1: 395G>A; R132H
PubMed Link: 37138345
Variant Present in the following documents:
  • 40478_2023_1573_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Discovery and Validation of Novel LonP1 and Proteasome Inhibitor in IDH1-R132H Malignant Astrocytoma Models.

Biorxiv : The Preprint Server For Biology
Douglas, Christopher C; Lomeli, Naomi N; Lepe, Javier J; Di, Kaijun K; Nandwana, Nitesh Kumar NK; Vu, Thao T; Pham, James J; Kenney, Maria Cristina MC; Das, Bhaskar B; Bota, Daniela A DA
Publication Date: 2023-04-17

Variant appearance in text: IDH1: R132H
PubMed Link: 37131786
Variant Present in the following documents:
  • Main text
  • nihpp-2023.04.13.536816v1.pdf
View BVdb publication page



LonP1 Drives Proneural Mesenchymal Transition in IDH1-R132H Diffuse Glioma.

Biorxiv : The Preprint Server For Biology
Douglas, Christopher C; Lomeli, Naomi N; Vu, Thao T; Pham, James J; Bota, Daniela A DA
Publication Date: 2023-04-17

Variant appearance in text: IDH1: R132H
PubMed Link: 37131765
Variant Present in the following documents:
  • Main text
  • nihpp-2023.04.13.536817v1.pdf
View BVdb publication page



Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas.

Epigenetics & Chromatin
Wang, Xinyu X; Dai, Lijun L; Liu, Yang Y; Li, Chenghao C; Fan, Dandan D; Zhou, Yue Y; Li, Pengcheng P; Kong, Qingran Q; Su, Jianzhong J
Publication Date: 2023-04-28

Variant appearance in text: IDH1: R132H
PubMed Link: 37118755
Variant Present in the following documents:
  • 13072_2023_Article_490.pdf
View BVdb publication page



Metabolic Rewiring in Adult-Type Diffuse Gliomas.

International Journal Of Molecular Sciences
Park, Jong-Whi JW
Publication Date: 2023-04-16

Variant appearance in text: IDH1: R132H
PubMed Link: 37108511
Variant Present in the following documents:
  • ijms-24-07348.pdf
View BVdb publication page



Postoperative risk of IDH mutant glioma-associated seizures and their potential management with IDH mutant inhibitors.

The Journal Of Clinical Investigation
Drumm, Michael M; Wang, Wenxia W; Sears, Thomas K TK; Bell-Burdett, Kirsten K; Javier, Rodrigo R; Cotton, Kristen Y KY; Webb, Brynna T BT; Byrne, Kayla T KT; Unruh, Dusten D; Thirunavu, Vineeth V; Walshon, Jordain J; Steffens, Alicia A; McCortney, Kathleen K; Lukas, Rimas V RV; Phillips, Joanna J JJ; Mohamed, Esraa E; Finan, John D JD; Santana-Santos, Lucas L; Heimberger, Amy B AB; Franz, Colin K CK; Kurz, Jonathan E JE; Templer, Jessica W JW; Swanson, Geoffrey T GT; Horbinski, Craig C
Publication Date: 2023-04-27

Variant appearance in text: IDH1: R132H
PubMed Link: 37104042
Variant Present in the following documents:
  • jci-133-168035.pdf
View BVdb publication page



Concurrent IDH1 and IDH2 mutations in glioblastoma: A case report.

Frontiers In Oncology
Haider, Ali S AS; Ene, Chibawanye I CI; Palmisciano, Paolo P; Haider, Maryam M; Rao, Ganesh G; Ballester, Leomar Y LY; Fuller, Gregory N GN
Publication Date: 2023

Variant appearance in text: IDH1: 395G>A; R132H
PubMed Link: 37077830
Variant Present in the following documents:
  • Main text
  • fonc-13-1071792.pdf
View BVdb publication page



Mismatch Repair Deficient Glioma with Spatially Distinct IDH-mutant and IDH-Wildtype Components Arising in the Setting of Lynch Syndrome.

Cold Spring Harbor Molecular Case Studies
Tan, Hao H; Nerison, Caleb C; Stateler, Cooper C; Bowden, Stephen G SG; Raslan, Ahmed M AM; Ambady, Prakash P; Barajas, Ramon F RF; Wood, Matthew D MD
Publication Date: 2023-04-19

Variant appearance in text: IDH1: R132H
PubMed Link: 37076313
Variant Present in the following documents:
  • Main text
  • supp_mcs.a006280_Supplemental_Table_1.xlsx, sheet 1
  • MCS006280Tan.pdf
View BVdb publication page



Therapies for IDH-Mutant Gliomas.

Current Neurology And Neuroscience Reports
Alshiekh Nasany, Ruham R; de la Fuente, Macarena Ines MI
Publication Date: 2023-04-15

Variant appearance in text: IDH1: R132H
PubMed Link: 37060388
Variant Present in the following documents:
  • Main text
  • 11910_2023_Article_1265.pdf
View BVdb publication page



Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide.

International Journal Of Molecular Sciences
Brawanski, Konstantin R KR; Sprung, Susanne S; Freyschlag, Christian F CF; Hoeftberger, Romana R; Ströbel, Thomas T; Haybaeck, Johannes J; Thomé, Claudius C; Manzl, Claudia C; Birkl-Toeglhofer, Anna M AM
Publication Date: 2023-03-24

Variant appearance in text: IDH1: R132H
PubMed Link: 37047153
Variant Present in the following documents:
  • Main text
  • ijms-24-06184.pdf
View BVdb publication page



Same but different. Incidental and symptomatic lower grade gliomas show differences in molecular features and survival.

Journal Of Neuro-Oncology
Demetz, Matthias M; Krigers, Aleksandrs A; Moser, Patrizia P; Kerschbaumer, Johannes J; Thomé, Claudius C; Freyschlag, Christian F CF
Publication Date: 2023-04-12

Variant appearance in text: IDH1: R132H
PubMed Link: 37043120
Variant Present in the following documents:
  • Main text
  • 11060_2023_Article_4301.pdf
View BVdb publication page



A Rare Case Report of Intraventricular Anaplastic Pleomorphic Xanthoastrocytoma.

Cureus
Bettencourt, Sofia S; Almeida, Gonçalo G; Maia, Tiago T
Publication Date: 2023-03

Variant appearance in text: IDH1: R132H
PubMed Link: 37041907
Variant Present in the following documents:
  • Main text
  • cureus-0015-00000035975.pdf
View BVdb publication page



Imaging 2-hydroxyglutarate and other brain oncometabolites pertinent to critical genomic alterations in brain tumors.

Bjr Open
Thomas, Teena T; Thakur, Sunitha S; Young, Robert R
Publication Date: 2023

Variant appearance in text: IDH1: R132H
PubMed Link: 37035765
Variant Present in the following documents:
  • Main text
  • bjro.20210070.pdf
View BVdb publication page



Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning.

Nature Communications
de Jong, Anouk C AC; Danyi, Alexandra A; van Riet, Job J; de Wit, Ronald R; Sjöström, Martin M; Feng, Felix F; de Ridder, Jeroen J; Lolkema, Martijn P MP
Publication Date: 2023-04-08

Variant appearance in text: IDH1: R132H; rs121913500
PubMed Link: 37031196
Variant Present in the following documents:
  • 41467_2023_37647_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Rapid detection of isocitrate dehydrogenase 1 mutation status in glioma based on Crispr-Cas12a.

Scientific Reports
Feng, Zhebin Z; Kong, Dongsheng D; Jin, Wei W; He, Kunyu K; Zhao, Junyan J; Liu, Bin B; Xu, Hanyun H; Yu, Xin'guang X; Feng, Shiyu S
Publication Date: 2023-04-07

Variant appearance in text: IDH1: 395G>A; R132H
PubMed Link: 37029174
Variant Present in the following documents:
  • Main text
  • 41598_2023_Article_32957.pdf
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: IDH1: R132H
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 4
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 5
View BVdb publication page



Report of multiple high-grade gliomas in two patients with shared retained ATRX, wild-type IDH, losses of CDKN2A genes and alterations in the PTEN-PI3K axis.

Journal Of Surgical Case Reports
Khatchadourian, Christopher C; Guo, Jin J; Prasad, Chaya J CJ; Orlando, Robert A RA; Parsa, Cyrus C
Publication Date: 2023-03

Variant appearance in text: IDH1: R132H
PubMed Link: 37008737
Variant Present in the following documents:
  • Main text
  • rjad139.pdf
View BVdb publication page



Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia.

Communications Biology
Cheng, Chi-Keung CK; Yung, Yuk-Lin YL; Chan, Hoi-Yun HY; Leung, Kam-Tong KT; Chan, Kathy Y Y KYY; Leung, Alex W K AWK; Cheng, Frankie W T FWT; Li, Chi-Kong CK; Wan, Thomas S K TSK; Luo, Xi X; Pitts, Herbert-Augustus HA; Cheung, Joyce S JS; Chan, Natalie P H NPH; Ng, Margaret H L MHL
Publication Date: 2023-03-31

Variant appearance in text: IDH1: 395G>A; R132H; rs121913500
PubMed Link: 37002311
Variant Present in the following documents:
  • 42003_2023_4732_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrent IDH1- and IDH2-mutant Glioma.

Cancer Research Communications
Fanucci, Kristina K; Pilat, Mary Jo MJ; Shyr, Derek D; Shyr, Yu Y; Boerner, Scott S; Li, Jing J; Durecki, Diane D; Drappatz, Jan J; Puduvalli, Vinay V; Lieberman, Frank Scott FS; Gonzalez, Javier J; Giglio, Pierre P; Ivy, S Percy SP; Bindra, Ranjit S RS; Omuro, Antonio A; LoRusso, Patricia P
Publication Date: 2023-02

Variant appearance in text: IDH1: R132H
PubMed Link: 36968138
Variant Present in the following documents:
  • Main text
  • crc-22-0436.pdf
View BVdb publication page



Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer.

Frontiers In Oncology
Ni, Rui R; Li, Ziwei Z; Li, Li L; Peng, Dan D; Ming, Yue Y; Li, Lin L; Liu, Yao Y
Publication Date: 2023

Variant appearance in text: IDH1: R132H
PubMed Link: 36959802
Variant Present in the following documents:
  • Main text
  • fonc-13-1143798.pdf
View BVdb publication page



Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors.

Journal Of Medicinal Chemistry
Liu, Shuang S; Abboud, Martine M; Mikhailov, Victor V; Liu, Xiao X; Reinbold, Raphael R; Schofield, Christopher J CJ
Publication Date: 2023-03-23

Variant appearance in text: IDH1: R132H
PubMed Link: 36952395
Variant Present in the following documents:
  • Main text
  • jm3c00203_si_001.pdf
  • jm3c00203.pdf
View BVdb publication page



Update for astrocytomas: medical and surgical management considerations.

Exploration Of Neuroscience
Willman, Matthew M; Willman, Jonathan J; Figg, John J; Dioso, Emma E; Sriram, Sai S; Olowofela, Bankole B; Chacko, Kevin K; Hernandez, Jairo J; Lucke-Wold, Brandon B
Publication Date: 2023

Variant appearance in text: IDH1: R132H
PubMed Link: 36935776
Variant Present in the following documents:
  • Main text
  • nihms-1879854.pdf
View BVdb publication page



Preclinical development and evaluation of nanobody-based CD70-specific CAR T cells for the treatment of acute myeloid leukemia.

Cancer Immunology, Immunotherapy : Cii
Cheng, Jiali J; Ge, Tong T; Zhu, Xiaojian X; Wang, Jue J; Zeng, Yuhao Y; Mu, Wei W; Cai, Haodong H; Dai, Zhenyu Z; Jin, Jin J; Yang, Yongkun Y; Hu, Guang G; Mao, Xia X; Zhou, Jianfeng J; Zhu, Li L; Huang, Liang L
Publication Date: 2023-03-17

Variant appearance in text: IDH1: R132H
PubMed Link: 36932256
Variant Present in the following documents:
  • 262_2023_3422_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology.

Nature Medicine
Sturm, Dominik D; Capper, David D; Andreiuolo, Felipe F; Gessi, Marco M; Kölsche, Christian C; Reinhardt, Annekathrin A; Sievers, Philipp P; Wefers, Annika K AK; Ebrahimi, Azadeh A; Suwala, Abigail K AK; Gielen, Gerrit H GH; Sill, Martin M; Schrimpf, Daniel D; Stichel, Damian D; Hovestadt, Volker V; Daenekas, Bjarne B; Rode, Agata A; Hamelmann, Stefan S; Previti, Christopher C; Jäger, Natalie N; Buchhalter, Ivo I; Blattner-Johnson, Mirjam M; Jones, Barbara C BC; Warmuth-Metz, Monika M; Bison, Brigitte B; Grund, Kerstin K; Sutter, Christian C; Hirsch, Steffen S; Dikow, Nicola N; Hasselblatt, Martin M; Schüller, Ulrich U; Gerber, Nicolas U NU; White, Christine L CL; Buntine, Molly K MK; Kinross, Kathryn K; Algar, Elizabeth M EM; Hansford, Jordan R JR; Gottardo, Nicholas G NG; Hernáiz Driever, Pablo P; Gnekow, Astrid A; Witt, Olaf O; Müller, Hermann L HL; Calaminus, Gabriele G; Fleischhack, Gudrun G; Kordes, Uwe U; Mynarek, Martin M; Rutkowski, Stefan S; Frühwald, Michael C MC; Kramm, Christof M CM; von Deimling, Andreas A; Pietsch, Torsten T; Sahm, Felix F; Pfister, Stefan M SM; Jones, David T W DTW
Publication Date: 2023-03-16

Variant appearance in text: IDH1: R132H
PubMed Link: 36928815
Variant Present in the following documents:
  • Main text
  • 41591_2023_2255_MOESM3_ESM.xlsx, sheet 5
  • 41591_2023_Article_2255.pdf
View BVdb publication page