DNMT3A c.2311_2312delinsGC ;(p.R771A)

Variant ID: 2-25463181-CG-GC

NM_022552.4(DNMT3A):c.2311_2312delinsGC;(p.R771A)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.

The Journal Of Biological Chemistry
Sandoval, Jonathan E JE; Reich, Norbert O NO
Publication Date: 2019-11-29

Variant appearance in text: DNMT3A: R771A
PubMed Link: 31640986
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation.

The Journal Of Biological Chemistry
Holz-Schietinger, Celeste C; Matje, Doug M DM; Reich, Norbert O NO
Publication Date: 2012-09-07

Variant appearance in text: DNMT3A: R771A
PubMed Link: 22722925
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation.

The Journal Of Biological Chemistry
Holz-Schietinger, Celeste C; Matje, Douglas M DM; Harrison, Madeleine Flexer MF; Reich, Norbert O NO
Publication Date: 2011-12-02

Variant appearance in text: DNMT3A: R771A
PubMed Link: 21979949
Variant Present in the following documents:
  • Main text
View BVdb publication page