Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Cancer Discovery
Huang, Yung-Hsin YH; Chen, Chun-Wei CW; Sundaramurthy, Venkatasubramaniam V; Słabicki, Mikołaj M; Hao, Dapeng D; Watson, Caroline J CJ; Tovy, Ayala A; Reyes, Jaime M JM; Dakhova, Olga O; Crovetti, Brielle R BR; Galonska, Christina C; Lee, Minjung M; Brunetti, Lorenzo L; Zhou, Yubin Y; Tatton-Brown, Katrina K; Huang, Yun Y; Cheng, Xiaodong X; Meissner, Alexander A; Valk, Peter J M PJM; Van Maldergem, Lionel L; Sanders, Mathijs A MA; Blundell, Jamie R JR; Li, Wei W; Ebert, Benjamin L BL; Goodell, Margaret A MA
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.
Nature Communications
Williamson, Chris T CT; Miller, Rowan R; Pemberton, Helen N HN; Jones, Samuel E SE; Campbell, James J; Konde, Asha A; Badham, Nicholas N; Rafiq, Rumana R; Brough, Rachel R; Gulati, Aditi A; Ryan, Colm J CJ; Francis, Jeff J; Vermulen, Peter B PB; Reynolds, Andrew R AR; Reaper, Philip M PM; Pollard, John R JR; Ashworth, Alan A; Lord, Christopher J CJ