Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma.
Nature Communications
Berko, Esther R ER; Witek, Gabriela M GM; Matkar, Smita S; Petrova, Zaritza O ZO; Wu, Megan A MA; Smith, Courtney M CM; Daniels, Alex A; Kalna, Joshua J; Kennedy, Annie A; Gostuski, Ivan I; Casey, Colleen C; Krytska, Kateryna K; Gerelus, Mark M; Pavlick, Dean D; Ghazarian, Susan S; Park, Julie R JR; Marachelian, Araz A; Maris, John M JM; Goldsmith, Kelly C KC; Radhakrishnan, Ravi R; Lemmon, Mark A MA; Mossé, Yaël P YP
Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results.
Nature Medicine
Goldsmith, Kelly C KC; Park, Julie R JR; Kayser, Kimberly K; Malvar, Jemily J; Chi, Yueh-Yun YY; Groshen, Susan G SG; Villablanca, Judith G JG; Krytska, Kateryna K; Lai, Lillian M LM; Acharya, Patricia T PT; Goodarzian, Fariba F; Pawel, Bruce B; Shimada, Hiroyuki H; Ghazarian, Susan S; States, Lisa L; Marshall, Lynley L; Chesler, Louis L; Granger, Meaghan M; Desai, Ami V AV; Mody, Rajen R; Morgenstern, Daniel A DA; Shusterman, Suzanne S; Macy, Margaret E ME; Pinto, Navin N; Schleiermacher, Gudrun G; Vo, Kieuhoa K; Thurm, Holger C HC; Chen, Joseph J; Liyanage, Marlon M; Peltz, Gerson G; Matthay, Katherine K KK; Berko, Esther R ER; Maris, John M JM; Marachelian, Araz A; Mossé, Yael P YP
Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome.
Nature Genetics
Körber, Verena V; Stainczyk, Sabine A SA; Kurilov, Roma R; Henrich, Kai-Oliver KO; Hero, Barbara B; Brors, Benedikt B; Westermann, Frank F; Höfer, Thomas T
Publication Date: 2023-03-27
Variant appearance in text: ALK: R1275Q; rs113994087
Segmental chromosomal aberrations as the poor prognostic factor in children over 18 months with stage 3 neuroblastoma without MYCN amplification.
Frontiers In Oncology
Wieczorek, Aleksandra A; Szewczyk, Katarzyna K; Klekawka, Tomasz T; Stefanowicz, Joanna J; Ussowicz, Marek M; Drabik, Grazyna G; Pawinska-Wasikowska, Katarzyna K; Balwierz, Walentyna W
Genomic ALK alterations in primary and relapsed neuroblastoma.
British Journal Of Cancer
Rosswog, Carolina C; Fassunke, Jana J; Ernst, Angela A; Schömig-Markiefka, Birgid B; Merkelbach-Bruse, Sabine S; Bartenhagen, Christoph C; Cartolano, Maria M; Ackermann, Sandra S; Theissen, Jessica J; Blattner-Johnson, Mirjam M; Jones, Barbara B; Schramm, Kathrin K; Altmüller, Janine J; Nürnberg, Peter P; Ortmann, Monika M; Berthold, Frank F; Peifer, Martin M; Büttner, Reinhard R; Westermann, Frank F; Schulte, Johannes H JH; Simon, Thorsten T; Hero, Barbara B; Fischer, Matthias M
Germline pathogenic variants in 786 neuroblastoma patients.
Medrxiv : The Preprint Server For Health Sciences
Kim, Jung J; Vaksman, Zalman Z; Egolf, Laura E LE; Kaufman, Rebecca R; Evans, J Perry JP; Conkrite, Karina L KL; Danesh, Arnavaz A; Lopez, Gonzalo G; Randall, Michael P MP; Dent, Maiah H MH; Farra, Lance M LM; Menghani, Neil N; Dymek, Malwina M; Desai, Heena H; Hausler, Ryan R; , ; , ; , ; Auvil, Jaime Guidry JG; Gerhard, Daniela S DS; Hakonarson, Hakon H; Maxwell, Kara N KN; Cole, Kristina A KA; Pugh, Trevor J TJ; Bosse, Kristopher R KR; Khan, Javed J; Wei, Jun S JS; Maris, John M JM; Stewart, Douglas R DR; Diskin, Sharon J SJ
Publication Date: 2023-01-25
Variant appearance in text: ALK: 3824G>A; R1275Q; rs113994087
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations.
Nature Cancer
Villani, Anita A; Davidson, Scott S; Kanwar, Nisha N; Lo, Winnie W WW; Li, Yisu Y; Cohen-Gogo, Sarah S; Fuligni, Fabio F; Edward, Lisa-Monique LM; Light, Nicholas N; Layeghifard, Mehdi M; Harripaul, Ricardo R; Waldman, Larissa L; Gallinger, Bailey B; Comitani, Federico F; Brunga, Ledia L; Hayes, Reid R; Anderson, Nathaniel D ND; Ramani, Arun K AK; Yuki, Kyoko E KE; Blay, Sasha S; Johnstone, Brittney B; Inglese, Cara C; Hammad, Rawan R; Goudie, Catherine C; Shuen, Andrew A; Wasserman, Jonathan D JD; Venier, Rosemarie E RE; Eliou, Marianne M; Lorenti, Miranda M; Ryan, Carol Ann CA; Braga, Michael M; Gloven-Brown, Meagan M; Han, Jianan J; Montero, Maria M; Spatare, Famida F; Whitlock, James A JA; Scherer, Stephen W SW; Chun, Kathy K; Somerville, Martin J MJ; Hawkins, Cynthia C; Abdelhaleem, Mohamed M; Ramaswamy, Vijay V; Somers, Gino R GR; Kyriakopoulou, Lianna L; Hitzler, Johann J; Shago, Mary M; Morgenstern, Daniel A DA; Tabori, Uri U; Meyn, Stephen S; Irwin, Meredith S MS; Malkin, David D; Shlien, Adam A
Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM.
Npj Precision Oncology
Peterziel, Heike H; Jamaladdin, Nora N; ElHarouni, Dina D; Gerloff, Xenia F XF; Herter, Sonja S; Fiesel, Petra P; Berker, Yannick Y; Blattner-Johnson, Mirjam M; Schramm, Kathrin K; Jones, Barbara C BC; Reuss, David D; Turunen, Laura L; Friedenauer, Aileen A; Holland-Letz, Tim T; Sill, Martin M; Weiser, Lena L; Previti, Christopher C; Balasubramanian, Gnanaprakash G; Gerber, Nicolas U NU; Gojo, Johannes J; Hutter, Caroline C; Øra, Ingrid I; Lohi, Olli O; Kattamis, Antonis A; de Wilde, Bram B; Westermann, Frank F; Tippelt, Stephan S; Graf, Norbert N; Nathrath, Michaela M; Sparber-Sauer, Monika M; Sehested, Astrid A; Kramm, Christof M CM; Dirksen, Uta U; Kallioniemi, Olli O; Pfister, Stefan M SM; van Tilburg, Cornelis M CM; Jones, David T W DTW; Saarela, Jani J; Pietiäinen, Vilja V; Jäger, Natalie N; Schlesner, Matthias M; Kopp-Schneider, Annette A; Oppermann, Sina S; Milde, Till T; Witt, Olaf O; Oehme, Ina I
Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations.
Nature Communications
van Alderwerelt van Rosenburgh, Iris K IK; Lu, David M DM; Grant, Michael J MJ; Stayrook, Steven E SE; Phadke, Manali M; Walther, Zenta Z; Goldberg, Sarah B SB; Politi, Katerina K; Lemmon, Mark A MA; Ashtekar, Kumar D KD; Tsutsui, Yuko Y
Loss of ALK hotspot mutations in relapsed neuroblastoma.
Genes, Chromosomes & Cancer
Allinson, Lisa M LM; Potts, Aaron A; Goodman, Angharad A; Bown, Nick N; Bashton, Matthew M; Thompson, Dean D; Basta, Nermine O NO; Gabriel, Alem S AS; McCorkindale, Michael M; Ng, Antony A; McNally, Richard J Q RJQ; Tweddle, Deborah A DA
Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.
Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.
Acs Infectious Diseases
Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S
Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers.
Nature Communications
Shukla, N N; Levine, M F MF; Gundem, G G; Domenico, D D; Spitzer, B B; Bouvier, N N; Arango-Ossa, J E JE; Glodzik, D D; Medina-Martínez, J S JS; Bhanot, U U; Gutiérrez-Abril, J J; Zhou, Y Y; Fiala, E E; Stockfisch, E E; Li, S S; Rodriguez-Sanchez, M I MI; O'Donohue, T T; Cobbs, C C; Roehrl, M H A MHA; Benhamida, J J; Iglesias Cardenas, F F; Ortiz, M M; Kinnaman, M M; Roberts, S S; Ladanyi, M M; Modak, S S; Farouk-Sait, S S; Slotkin, E E; Karajannis, M A MA; Dela Cruz, F F; Glade Bender, J J; Zehir, A A; Viale, A A; Walsh, M F MF; Kung, A L AL; Papaemmanuil, E E