Publications:

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EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity.

Molecular Cancer Research : Mcr

Lucken, Kellie K; O'Regan, Laura L; Choi, Jene J; Sampson, Josephina J; Pashley, Sarah L SL; Bayliss, Richard R; Khan, Sam S; Fry, Andrew M AM

Publication Date: 2022-06-03

Variant appearance in text: ALK: D1270N

PubMed Link: 35656694

Variant Present in the following documents:

• Main text
• 854.pdf

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Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation.

Embo Reports

Sampson, Josephina J; Richards, Mark W MW; Choi, Jene J; Fry, Andrew M AM; Bayliss, Richard R

Publication Date: 2021-12-06

Variant appearance in text: ALK: D1270N

PubMed Link: 34661367

Variant Present in the following documents:

• Main text
• EMBR-22-e53693.pdf

View BVdb publication page

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Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation.

Embo Reports

Sampson, Josephina J; Richards, Mark W MW; Choi, Jene J; Fry, Andrew M AM; Bayliss, Richard R

Publication Date: 2021-12-06

Variant appearance in text: ALK: D1270N

PubMed Link: 34661367

Variant Present in the following documents:

• Main text
• EMBR-22-e53693.pdf

View BVdb publication page

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EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.

Journal Of Cell Science

O'Regan, Laura L; Barone, Giancarlo G; Adib, Rozita R; Woo, Chang Gok CG; Jeong, Hui Jeong HJ; Richardson, Emily L EL; Richards, Mark W MW; Muller, Patricia A J PAJ; Collis, Spencer J SJ; Fennell, Dean A DA; Choi, Jene J; Bayliss, Richard R; Fry, Andrew M AM

Publication Date: 2020-05-11

Variant appearance in text: ALK: D1270N

PubMed Link: 32184261

Variant Present in the following documents:

• Main text

View BVdb publication page

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Early Colorectal Cancers Provide New Evidence for a Lynch Syndrome-to-CMMRD Phenotypic Continuum.

Cancers

Fernandez-Rozadilla, Ceres C; Alvarez-Barona, Miriam M; Schamschula, Esther E; Bodo, Sahra S; Lopez-Novo, Anael A; Dacal, Andres A; Calviño-Costas, Consuelo C; Lancho, Angel A; Amigo, Jorge J; Bello, Xabier X; Cameselle-Teijeiro, Jose Manuel JM; Carracedo, Angel A; Colas, Chrystelle C; Muleris, Martine M; Wimmer, Katharina K; Ruiz-Ponte, Clara C

Publication Date: 2019-07-30

Variant appearance in text: ALK: D1270N

PubMed Link: 31366136

Variant Present in the following documents:

• cancers-11-01081-s001.pdf

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: ALK: D1270N

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 3
• pone.0196434.s001.xlsx, sheet 2
• pone.0196434.s001.xlsx, sheet 1

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Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.

Bmc Cancer

Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Kim, Arum A; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS

Publication Date: 2016-01-18

Variant appearance in text: ALK: 3808G>A; Asp1270Asn

PubMed Link: 26782967

Variant Present in the following documents:

• 12885_2016_2049_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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