ALK c.3805G>A ;(p.G1269R)

Variant ID: 2-29432683-C-T

NM_004304.4(ALK):c.3805G>A;(p.G1269R)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


Longitudinal monitoring by next-generation sequencing of plasma cell-free DNA in ALK rearranged NSCLC patients treated with ALK tyrosine kinase inhibitors.

Cancer Medicine
Kwon, Minsuk M; Ku, Bo Mi BM; Olsen, Steve S; Park, Sehhoon S; Lefterova, Martina M; Odegaard, Justin J; Jung, Hyun-Ae HA; Sun, Jong-Mu JM; Lee, Se-Hoon SH; Ahn, Jin Seok JS; Park, Keunchil K; Ahn, Myung-Ju MJ
Publication Date: 2022-08

Variant appearance in text: ALK: G1269R
PubMed Link: 35437925
Variant Present in the following documents:
  • Main text
  • CAM4-11-2944.pdf
View BVdb publication page



Acquired ALK Resistance Mutations Identified from Liquid Biopsy in an ALK-Rearranged Squamous Cell Lung Cancer Patient Treated with Sequential ALK TKI Therapy: A Case Report.

Oncotargets And Therapy
Yao, Bin B; Han, Xue X; Pang, Linrong L; Xu, Caihong C; Liu, Sisi S; Cheng, Xiaochun X; Chen, Jun J
Publication Date: 2021

Variant appearance in text: ALK: G1269R
PubMed Link: 34376997
Variant Present in the following documents:
  • Main text
  • ott-14-4329.pdf
View BVdb publication page



Molecular Modeling of ALK L1198F and/or G1202R Mutations to Determine Differential Crizotinib Sensitivity.

Scientific Reports
Chuang, Yu-Chung YC; Huang, Bo-Yen BY; Chang, Hsin-Wen HW; Yang, Chia-Ning CN
Publication Date: 2019-08-06

Variant appearance in text: ALK: G1269R
PubMed Link: 31388026
Variant Present in the following documents:
  • Main text
  • 41598_2019_Article_46825.pdf
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: ALK: G1269R
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 2
  • pone.0196434.s001.xlsx, sheet 3
View BVdb publication page



Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Publication Date: 2015

Variant appearance in text: ALK: G1269R
PubMed Link: 26010451
Variant Present in the following documents:
  • pone.0127146.s014.xlsx, sheet 3
View BVdb publication page