Publications:

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EML4-ALK biology and drug resistance in Non-Small Cell Lung Cancer: a new phase of discoveries.

Molecular Oncology

Elshatlawy, Mariam M; Sampson, Josephina J; Clarke, Katy K; Bayliss, Richard R

Publication Date: 2023-05-07

Variant appearance in text: ALK: F1245C

PubMed Link: 37149843

Variant Present in the following documents:

• Main text
• MOL2-17-950.pdf

View BVdb publication page

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Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results.

Nature Medicine

Goldsmith, Kelly C KC; Park, Julie R JR; Kayser, Kimberly K; Malvar, Jemily J; Chi, Yueh-Yun YY; Groshen, Susan G SG; Villablanca, Judith G JG; Krytska, Kateryna K; Lai, Lillian M LM; Acharya, Patricia T PT; Goodarzian, Fariba F; Pawel, Bruce B; Shimada, Hiroyuki H; Ghazarian, Susan S; States, Lisa L; Marshall, Lynley L; Chesler, Louis L; Granger, Meaghan M; Desai, Ami V AV; Mody, Rajen R; Morgenstern, Daniel A DA; Shusterman, Suzanne S; Macy, Margaret E ME; Pinto, Navin N; Schleiermacher, Gudrun G; Vo, Kieuhoa K; Thurm, Holger C HC; Chen, Joseph J; Liyanage, Marlon M; Peltz, Gerson G; Matthay, Katherine K KK; Berko, Esther R ER; Maris, John M JM; Marachelian, Araz A; Mossé, Yael P YP

Publication Date: 2023-04-03

Variant appearance in text: ALK: F1245C

PubMed Link: 37012551

Variant Present in the following documents:

• Main text
• 41591_2023_Article_2297.pdf

View BVdb publication page

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Genomic ALK alterations in primary and relapsed neuroblastoma.

British Journal Of Cancer

Rosswog, Carolina C; Fassunke, Jana J; Ernst, Angela A; Schömig-Markiefka, Birgid B; Merkelbach-Bruse, Sabine S; Bartenhagen, Christoph C; Cartolano, Maria M; Ackermann, Sandra S; Theissen, Jessica J; Blattner-Johnson, Mirjam M; Jones, Barbara B; Schramm, Kathrin K; Altmüller, Janine J; Nürnberg, Peter P; Ortmann, Monika M; Berthold, Frank F; Peifer, Martin M; Büttner, Reinhard R; Westermann, Frank F; Schulte, Johannes H JH; Simon, Thorsten T; Hero, Barbara B; Fischer, Matthias M

Publication Date: 2023-02-17

Variant appearance in text: ALK: F1245C

PubMed Link: 36807339

Variant Present in the following documents:

• Main text
• 41416_2023_Article_2208.pdf
• 41416_2023_2208_MOESM1_ESM.pdf

View BVdb publication page

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Applications and prospects of targeted therapy for neuroblastoma.

World Journal Of Pediatric Surgery

Wang, Jing J; Yao, Wei W; Li, Kai K

Publication Date: 2020

Variant appearance in text: ALK: F1245C

PubMed Link: 36474924

Variant Present in the following documents:

• Main text
• wjps-2020-000164.pdf

View BVdb publication page

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Integrated analysis of the clinical consequence and associated gene expression of ALK in ALK-positive human cancers.

Heliyon

Saifullah, ; Tsukahara, Toshifumi T

Publication Date: 2022-07

Variant appearance in text: ALK: F1245C

PubMed Link: 35865984

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers.

Nature Communications

Shukla, N N; Levine, M F MF; Gundem, G G; Domenico, D D; Spitzer, B B; Bouvier, N N; Arango-Ossa, J E JE; Glodzik, D D; Medina-Martínez, J S JS; Bhanot, U U; Gutiérrez-Abril, J J; Zhou, Y Y; Fiala, E E; Stockfisch, E E; Li, S S; Rodriguez-Sanchez, M I MI; O'Donohue, T T; Cobbs, C C; Roehrl, M H A MHA; Benhamida, J J; Iglesias Cardenas, F F; Ortiz, M M; Kinnaman, M M; Roberts, S S; Ladanyi, M M; Modak, S S; Farouk-Sait, S S; Slotkin, E E; Karajannis, M A MA; Dela Cruz, F F; Glade Bender, J J; Zehir, A A; Viale, A A; Walsh, M F MF; Kung, A L AL; Papaemmanuil, E E

Publication Date: 2022-05-18

Variant appearance in text: ALK: 3734T>G; F1245C

PubMed Link: 35585047

Variant Present in the following documents:

• 41467_2022_30233_MOESM7_ESM.xlsx, sheet 1

View BVdb publication page

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Molecular Markers of Pediatric Solid Tumors-Diagnosis, Optimizing Treatments, and Determining Susceptibility: Current State and Future Directions.

Cells

Trubicka, Joanna J; Grajkowska, Wiesława W; Dembowska-Bagińska, Bożenna B

Publication Date: 2022-04-06

Variant appearance in text: ALK: F1245C

PubMed Link: 35406801

Variant Present in the following documents:

• cells-11-01238.pdf

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: ALK: Phe1245Cys

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Holistic View of ALK TKI Resistance in ALK-Positive Anaplastic Large Cell Lymphoma.

Frontiers In Oncology

Wang, Yuan Y; He, Jing J; Xu, Manyu M; Xue, Qingfeng Q; Zhu, Cindy C; Liu, Juan J; Zhang, Yaping Y; Shi, Wenyu W

Publication Date: 2022

Variant appearance in text: ALK: F1245C

PubMed Link: 35211406

Variant Present in the following documents:

• Main text
• fonc-12-815654.pdf

View BVdb publication page

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Deep analysis of neuroblastoma core regulatory circuitries using online databases and integrated bioinformatics shows their pan-cancer roles as prognostic predictors.

Discover. Oncology

Jahangiri, Leila L; Pucci, Perla P; Ishola, Tala T; Pereira, Joao J; Cavanagh, Megan L ML; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: F1245C

PubMed Link: 35201514

Variant Present in the following documents:

• 12672_2021_452_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma.

Journal Of Personalized Medicine

Decaesteker, Bieke B; Durinck, Kaat K; Van Roy, Nadine N; De Wilde, Bram B; Van Neste, Christophe C; Van Haver, Stéphane S; Roberts, Stephen S; De Preter, Katleen K; Vermeirssen, Vanessa V; Speleman, Frank F

Publication Date: 2021-12-03

Variant appearance in text: ALK: F1245C

PubMed Link: 34945759

Variant Present in the following documents:

• Main text
• jpm-11-01286.pdf

View BVdb publication page

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Synthetic Heterocyclic Derivatives as Kinase Inhibitors Tested for the Treatment of Neuroblastoma.

Molecules (Basel, Switzerland)

Musumeci, Francesca F; Cianciusi, Annarita A; D'Agostino, Ilaria I; Grossi, Giancarlo G; Carbone, Anna A; Schenone, Silvia S

Publication Date: 2021-11-23

Variant appearance in text: ALK: F1245C

PubMed Link: 34885651

Variant Present in the following documents:

• Main text

View BVdb publication page

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Synthetic Heterocyclic Derivatives as Kinase Inhibitors Tested for the Treatment of Neuroblastoma.

Molecules (Basel, Switzerland)

Musumeci, Francesca F; Cianciusi, Annarita A; D'Agostino, Ilaria I; Grossi, Giancarlo G; Carbone, Anna A; Schenone, Silvia S

Publication Date: 2021-11-23

Variant appearance in text: ALK: F1245C

PubMed Link: 34885651

Variant Present in the following documents:

• Main text

View BVdb publication page

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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers

Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: F1245C

PubMed Link: 34885113

Variant Present in the following documents:

• Main text

View BVdb publication page

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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers

Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: F1245C

PubMed Link: 34885113

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs.

International Journal Of Molecular Sciences

Ciaccio, Roberto R; De Rosa, Piergiuseppe P; Aloisi, Sara S; Viggiano, Marta M; Cimadom, Leonardo L; Zadran, Suleman Khan SK; Perini, Giovanni G; Milazzo, Giorgio G

Publication Date: 2021-11-28

Variant appearance in text: ALK: Phe1245Cys

PubMed Link: 34884690

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeting Oncogenic Transcriptional Networks in Neuroblastoma: From N-Myc to Epigenetic Drugs.

International Journal Of Molecular Sciences

Ciaccio, Roberto R; De Rosa, Piergiuseppe P; Aloisi, Sara S; Viggiano, Marta M; Cimadom, Leonardo L; Zadran, Suleman Khan SK; Perini, Giovanni G; Milazzo, Giorgio G

Publication Date: 2021-11-28

Variant appearance in text: ALK: Phe1245Cys

PubMed Link: 34884690

Variant Present in the following documents:

• Main text

View BVdb publication page

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BX-795 inhibits neuroblastoma growth and enhances sensitivity towards chemotherapy.

Translational Oncology

Chilamakuri, Rameswari R; Rouse, Danielle C DC; Yu, Yang Y; Kabir, Abbas S AS; Muth, Aaron A; Yang, Jianhua J; Lipton, Jeffery M JM; Agarwal, Saurabh S

Publication Date: 2022-01

Variant appearance in text: ALK: F1245C

PubMed Link: 34823094

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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BX-795 inhibits neuroblastoma growth and enhances sensitivity towards chemotherapy.

Translational Oncology

Chilamakuri, Rameswari R; Rouse, Danielle C DC; Yu, Yang Y; Kabir, Abbas S AS; Muth, Aaron A; Yang, Jianhua J; Lipton, Jeffery M JM; Agarwal, Saurabh S

Publication Date: 2021-11-22

Variant appearance in text: ALK: F1245C

PubMed Link: 34823094

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer.

International Journal Of Molecular Sciences

Wulf, Anna M AM; Moreno, Marcela M MM; Paka, Chloé C; Rampasekova, Alexandra A; Liu, Karen J KJ

Publication Date: 2021-10-29

Variant appearance in text: ALK: F1245C

PubMed Link: 34769149

Variant Present in the following documents:

• Main text
• ijms-22-11718.pdf

View BVdb publication page

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The Resistance Mechanisms and Treatment Strategies for ALK-Rearranged Non-Small Cell Lung Cancer.

Frontiers In Oncology

Pan, Yue Y; Deng, Chao C; Qiu, Zhenhua Z; Cao, Chenghui C; Wu, Fang F

Publication Date: 2021

Variant appearance in text: ALK: F1245C

PubMed Link: 34660278

Variant Present in the following documents:

• Main text
• fonc-11-713530.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: ALK: F1245C

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Therapeutic Targeting of the Anaplastic Lymphoma Kinase (ALK) in Neuroblastoma-A Comprehensive Update.

Pharmaceutics

Brenner, Annette K AK; Gunnes, Maria W MW

Publication Date: 2021-09-08

Variant appearance in text: ALK: F1245C

PubMed Link: 34575503

Variant Present in the following documents:

• Main text
• pharmaceutics-13-01427.pdf

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Exceptional response to the ALK and ROS1 inhibitor lorlatinib and subsequent mechanism of resistance in relapsed ALK F1174L-mutated neuroblastoma.

Cold Spring Harbor Molecular Case Studies

Liu, Tingting T; Merguerian, Matthew D MD; Rowe, Steven P SP; Pratilas, Christine A CA; Chen, Allen R AR; Ladle, Brian H BH

Publication Date: 2021-08

Variant appearance in text: ALK: F1245C

PubMed Link: 34210658

Variant Present in the following documents:

• Main text
• MCS006064Liu.pdf

View BVdb publication page

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TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations.

Molecular Cancer Therapeutics

Murray, Brion W BW; Zhai, Dayong D; Deng, Wei W; Zhang, Xin X; Ung, Jane J; Nguyen, Vivian V; Zhang, Han H; Barrera, Maria M; Parra, Ana A; Cowell, Jessica J; Lee, Dong J DJ; Aloysius, Herve H; Rogers, Evan E

Publication Date: 2021-09

Variant appearance in text: ALK: F1245C

PubMed Link: 34158340

Variant Present in the following documents:

• Main text
• 1499.pdf

View BVdb publication page

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Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1).

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology

Bellini, Angela A; Pötschger, Ulrike U; Bernard, Virginie V; Lapouble, Eve E; Baulande, Sylvain S; Ambros, Peter F PF; Auger, Nathalie N; Beiske, Klaus K; Bernkopf, Marie M; Betts, David R DR; Bhalshankar, Jaydutt J; Bown, Nick N; de Preter, Katleen K; Clément, Nathalie N; Combaret, Valérie V; Font de Mora, Jaime J; George, Sally L SL; Jiménez, Irene I; Jeison, Marta M; Marques, Barbara B; Martinsson, Tommy T; Mazzocco, Katia K; Morini, Martina M; Mühlethaler-Mottet, Annick A; Noguera, Rosa R; Pierron, Gaelle G; Rossing, Maria M; Taschner-Mandl, Sabine S; Van Roy, Nadine N; Vicha, Ales A; Chesler, Louis L; Balwierz, Walentyna W; Castel, Victoria V; Elliott, Martin M; Kogner, Per P; Laureys, Geneviève G; Luksch, Roberto R; Malis, Josef J; Popovic-Beck, Maja M; Ash, Shifra S; Delattre, Olivier O; Valteau-Couanet, Dominique D; Tweddle, Deborah A DA; Ladenstein, Ruth R; Schleiermacher, Gudrun G

Publication Date: 2021-10-20

Variant appearance in text: ALK: F1245C

PubMed Link: 34115544

Variant Present in the following documents:

• Main text
• jco-39-3377.pdf

View BVdb publication page

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A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma.

Journal Of Experimental & Clinical Cancer Research : Cr

Mlakar, Vid V; Morel, Edouard E; Mlakar, Simona Jurkovic SJ; Ansari, Marc M; Gumy-Pause, Fabienne F

Publication Date: 2021-06-08

Variant appearance in text: ALK: F1245C

PubMed Link: 34103089

Variant Present in the following documents:

• Main text
• 13046_2021_Article_1967.pdf

View BVdb publication page

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Intratumoral Cellular Heterogeneity: Implications for Drug Resistance in Patients with Non-Small Cell Lung Cancer.

Cancers

Gregorc, Vanesa V; Lazzari, Chiara C; Mandalá, Mario M; Ippati, Stefania S; Bulotta, Alessandra A; Cangi, Maria Giulia MG; Khater, Abdelrahman A; Viganò, Maria Grazia MG; Mirabile, Aurora A; Pecciarini, Lorenza L; Ogliari, Francesca Rita FR; Arrigoni, Gianluigi G; Grassini, Greta G; Veronesi, Giulia G; Doglioni, Claudio C

Publication Date: 2021-04-22

Variant appearance in text: ALK: F1245C

PubMed Link: 33922215

Variant Present in the following documents:

• Main text

View BVdb publication page

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Downregulation of PDGFRß Signaling Overcomes Crizotinib Resistance in a TYRO3 and ALK Mutated Neuroendocrine-Like Tumor.

Translational Oncology

Quinn, Colin H CH; Beierle, Andee M AM; Williams, Adele P AP; Marayati, Raoud R; Bownes, Laura V LV; Markert, Hooper R HR; Aye, Jamie M JM; Stewart, Jerry E JE; Mroczek-Musulman, Elizabeth E; Crossman, David K DK; Yoon, Karina J KJ; Beierle, Elizabeth A EA

Publication Date: 2021-07

Variant appearance in text: ALK: F1245C

PubMed Link: 33887553

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma.

Journal Of Personalized Medicine

Tucker, Elizabeth R ER; George, Sally S; Angelini, Paola P; Bruna, Alejandra A; Chesler, Louis L

Publication Date: 2021-03-30

Variant appearance in text: ALK: F1245C

PubMed Link: 33808071

Variant Present in the following documents:

• Main text

View BVdb publication page

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Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Patil, Keshav K; Jordan, Earl Joseph EJ; Park, Jin H JH; Suresh, Krishna K; Smith, Courtney M CM; Lemmon, Abigail A AA; Mossé, Yaël P YP; Lemmon, Mark A MA; Radhakrishnan, Ravi R

Publication Date: 2021-03-09

Variant appearance in text: ALK: F1245C

PubMed Link: 33674381

Variant Present in the following documents:

• Main text

View BVdb publication page

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Neuroblastoma Invasion Strategies Are Regulated by the Extracellular Matrix.

Cancers

Gavin, Cian C; Geerts, Nele N; Cavanagh, Brenton B; Haynes, Meagan M; Reynolds, C Patrick CP; Loessner, Daniela D; Ewald, Andrew J AJ; Piskareva, Olga O

Publication Date: 2021-02-10

Variant appearance in text: ALK: F1245C

PubMed Link: 33578855

Variant Present in the following documents:

• Main text
• cancers-13-00736.pdf

View BVdb publication page

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Tyrosine Kinase Receptors in Oncology.

International Journal Of Molecular Sciences

Esteban-Villarrubia, Jorge J; Soto-Castillo, Juan José JJ; Pozas, Javier J; San Román-Gil, María M; Orejana-Martín, Inmaculada I; Torres-Jiménez, Javier J; Carrato, Alfredo A; Alonso-Gordoa, Teresa T; Molina-Cerrillo, Javier J

Publication Date: 2020-11-12

Variant appearance in text: ALK: F1245C

PubMed Link: 33198314

Variant Present in the following documents:

• Main text

View BVdb publication page

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Molecular targeting therapies for neuroblastoma: Progress and challenges.

Medicinal Research Reviews

Zafar, Atif A; Wang, Wei W; Liu, Gang G; Wang, Xinjie X; Xian, Wa W; McKeon, Frank F; Foster, Jennifer J; Zhou, Jia J; Zhang, Ruiwen R

Publication Date: 2021-03

Variant appearance in text: ALK: F1245C

PubMed Link: 33155698

Variant Present in the following documents:

• Main text
• MED-41-961.pdf

View BVdb publication page

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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs863225283

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: ALK: F1245C

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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[Pharmacology and Clinical Evaluation of Ensartinib Hydrochloride Capsule].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Wang, Yang Y; Yuan, Xiaobin X; Xiong, Jiayan J; Hao, Zhidong Z; Peng, Xingzhe X; Chen, Wanlin W; Cui, Lingling L; Li, Hua H; Wang, Xiulan X; He, Xiangbo X; Yang, Min M; Liang, Congxin C; Ma, Yongbin Y; Ding, Lieming L; Mao, Li L

Publication Date: 2020-08-20

Variant appearance in text: ALK: F1245C

PubMed Link: 32838492

Variant Present in the following documents:

• Main text

View BVdb publication page

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: ALK: F1245C

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: ALK: F1245C

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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Emerging Roles of ALK in Immunity and Insights for Immunotherapy.

Cancers

Wang, Lan L; Lui, Vivian Wai Yan VWY

Publication Date: 2020-02-12

Variant appearance in text: ALK: F1245C

PubMed Link: 32059449

Variant Present in the following documents:

• Main text
• cancers-12-00426.pdf

View BVdb publication page

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Repotrectinib (TPX-0005), effectively reduces growth of ALK driven neuroblastoma cells.

Scientific Reports

Cervantes-Madrid, Diana D; Szydzik, Joanna J; Lind, Dan Emil DE; Borenäs, Marcus M; Bemark, Mats M; Cui, Jean J; Palmer, Ruth Helen RH; Hallberg, Bengt B

Publication Date: 2019-12-18

Variant appearance in text: ALK: F1245C

PubMed Link: 31852910

Variant Present in the following documents:

• Main text

View BVdb publication page

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The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status.

Nature Communications

Trigg, Ricky M RM; Lee, Liam C LC; Prokoph, Nina N; Jahangiri, Leila L; Reynolds, C Patrick CP; Amos Burke, G A GA; Probst, Nicola A NA; Han, Miaojun M; Matthews, Jamie D JD; Lim, Hong Kai HK; Manners, Eleanor E; Martinez, Sonia S; Pastor, Joaquin J; Blanco-Aparicio, Carmen C; Merkel, Olaf O; de Los Fayos Alonso, Ines Garces IG; Kodajova, Petra P; Tangermann, Simone S; Högler, Sandra S; Luo, Ji J; Kenner, Lukas L; Turner, Suzanne D SD

Publication Date: 2019-11-28

Variant appearance in text: ALK: F1245C

PubMed Link: 31780656

Variant Present in the following documents:

• Main text

View BVdb publication page

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Standard operating procedure for curation and clinical interpretation of variants in cancer.

Genome Medicine

Danos, Arpad M AM; Krysiak, Kilannin K; Barnell, Erica K EK; Coffman, Adam C AC; McMichael, Joshua F JF; Kiwala, Susanna S; Spies, Nicholas C NC; Sheta, Lana M LM; Pema, Shahil P SP; Kujan, Lynzey L; Clark, Kaitlin A KA; Wollam, Amber Z AZ; Rao, Shruti S; Ritter, Deborah I DI; Sonkin, Dmitriy D; Raca, Gordana G; Lin, Wan-Hsin WH; Grisdale, Cameron J CJ; Kim, Raymond H RH; Wagner, Alex H AH; Madhavan, Subha S; Griffith, Malachi M; Griffith, Obi L OL

Publication Date: 2019-11-29

Variant appearance in text: ALK: F1245C

PubMed Link: 31779674

Variant Present in the following documents:

• 13073_2019_687_MOESM1_ESM.pdf

View BVdb publication page

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Alectinib, an Anaplastic Lymphoma Kinase Inhibitor, Abolishes ALK Activity and Growth in ALK-Positive Neuroblastoma Cells.

Frontiers In Oncology

Alam, Muhammad Wasi MW; Borenäs, Marcus M; Lind, Dan E DE; Cervantes-Madrid, Diana D; Umapathy, Ganesh G; Palmer, Ruth H RH; Hallberg, Bengt B

Publication Date: 2019

Variant appearance in text: ALK: F1245C

PubMed Link: 31334113

Variant Present in the following documents:

• Main text

View BVdb publication page

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Anaplastic Lymphoma Kinase Confers Resistance to BRAF Kinase Inhibitors in Melanoma.

Iscience

Janostiak, Radoslav R; Malvi, Parmanand P; Wajapeyee, Narendra N

Publication Date: 2019-06-28

Variant appearance in text: ALK: F1245C

PubMed Link: 31229894

Variant Present in the following documents:

• Main text
• main.pdf

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