Publications:

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Sustained Improvement in the Management of Patients with Non-Small-Cell Lung Cancer (NSCLC) Harboring ALK Translocation: Where Are We Running?

Current Oncology (Toronto, Ont.)

Spitaleri, Gianluca G; Trillo Aliaga, Pamela P; Attili, Ilaria I; Del Signore, Ester E; Corvaja, Carla C; Corti, Chiara C; Crimini, Edoardo E; Passaro, Antonio A; de Marinis, Filippo F

Publication Date: 2023-05-16

Variant appearance in text: ALK: E1210K

PubMed Link: 37232842

Variant Present in the following documents:

• Main text
• curroncol-30-00384.pdf

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EML4-ALK biology and drug resistance in Non-Small Cell Lung Cancer: a new phase of discoveries.

Molecular Oncology

Elshatlawy, Mariam M; Sampson, Josephina J; Clarke, Katy K; Bayliss, Richard R

Publication Date: 2023-05-07

Variant appearance in text: ALK: E1210K

PubMed Link: 37149843

Variant Present in the following documents:

• Main text
• MOL2-17-950.pdf

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Industry involvement in evidence production for genomic medicine: A bibliometric and funding analysis of decision impact studies.

Plos One

Parker, Gillian G; Hunter, Sarah S; Hogarth, Stuart S; Miller, Fiona A FA

Publication Date: 2023

Variant appearance in text: ALK: E1210K

PubMed Link: 37104298

Variant Present in the following documents:

• pone.0285122.s002.xlsx, sheet 1

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Molecular Anatomy of the EML4-ALK Fusion Protein for the Development of Novel Anticancer Drugs.

International Journal Of Molecular Sciences

Cheon, So Yeong SY; Kwon, Sunghark S

Publication Date: 2023-03-18

Variant appearance in text: ALK: E1210K

PubMed Link: 36982897

Variant Present in the following documents:

• Main text
• ijms-24-05821.pdf

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Recent progress in targeted therapy for non-small cell lung cancer.

Frontiers In Pharmacology

Xiao, Yanxia Y; Liu, Pu P; Wei, Jie J; Zhang, Xin X; Guo, Jun J; Lin, Yajun Y

Publication Date: 2023

Variant appearance in text: ALK: E1210K

PubMed Link: 36909198

Variant Present in the following documents:

• Main text
• fphar-14-1125547.pdf

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Non-Small Cell Lung Cancer Targeted Therapy: Drugs and Mechanisms of Drug Resistance.

International Journal Of Molecular Sciences

Wu, Jiajia J; Lin, Zhenghong Z

Publication Date: 2022-12-01

Variant appearance in text: ALK: E1210K

PubMed Link: 36499382

Variant Present in the following documents:

• Main text
• ijms-23-15056.pdf

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Case report: BRAF A598-T599insV mutation as a potential resistance mechanism to alectinib in ALK-rearranged lung adenocarcinoma.

Frontiers In Oncology

Pasau, Thomas T; Wauters, Els E; Wauters, Isabelle I; Duplaquet, Fabrice F; Pirard, Lionel L; Pop-Stanciu, Claudia C; D'Haene, Nicky N; Dupont, Michael M; Vander Borght, Thierry T; Rondelet, Benoît B; Ocak, Sebahat S

Publication Date: 2022

Variant appearance in text: ALK: E1210K

PubMed Link: 36419902

Variant Present in the following documents:

• Main text
• fonc-12-985446.pdf

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The Landscape of ALK-Rearranged Non-Small Cell Lung Cancer: A Comprehensive Review of Clinicopathologic, Genomic Characteristics, and Therapeutic Perspectives.

Cancers

Cognigni, Valeria V; Pecci, Federica F; Lupi, Alessio A; Pinterpe, Giada G; De Filippis, Chiara C; Felicetti, Cristiano C; Cantini, Luca L; Berardi, Rossana R

Publication Date: 2022-09-29

Variant appearance in text: ALK: E1210K

PubMed Link: 36230686

Variant Present in the following documents:

• Main text
• cancers-14-04765.pdf

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Molecular targeted therapy for anticancer treatment.

Experimental & Molecular Medicine

Min, Hye-Young HY; Lee, Ho-Young HY

Publication Date: 2022-10

Variant appearance in text: ALK: E1210K

PubMed Link: 36224343

Variant Present in the following documents:

• Main text
• 12276_2022_Article_864.pdf

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Liquid biopsy using ascitic fluid and pleural effusion supernatants for genomic profiling in gastrointestinal and lung cancers.

Bmc Cancer

Wu, Huita H; Ji, Haonan H; Yang, Wenhui W; Zhang, Min M; Guo, Yifang Y; Li, Bangkai B; Wang, Jiayin J; Chen, Rongrong R; Chen, Yuan Y; Wang, Xin X

Publication Date: 2022-09-27

Variant appearance in text: ALK: E1210K

PubMed Link: 36167530

Variant Present in the following documents:

• 12885_2022_9922_MOESM5_ESM.xlsx, sheet 1

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Liquid Biopsy Analysis as a Tool for TKI-Based Treatment in Non-Small Cell Lung Cancer.

Cells

Buszka, Karolina K; Ntzifa, Aliki A; Owecka, Barbara B; Kamińska, Paula P; Kolecka-Bednarczyk, Agata A; Zabel, Maciej M; Nowicki, Michał M; Lianidou, Evi E; Budna-Tukan, Joanna J

Publication Date: 2022-09-14

Variant appearance in text: ALK: E1210K

PubMed Link: 36139444

Variant Present in the following documents:

• Main text
• cells-11-02871.pdf

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Durable clinical response to ALK tyrosine kinase inhibitors in ALK-rearranged non-small cell lung cancer: a case report.

Translational Cancer Research

Hu, Han H; Dai, Hui H; Ding, Liren L

Publication Date: 2022-08

Variant appearance in text: ALK: E1210K

PubMed Link: 36093526

Variant Present in the following documents:

• Main text
• tcr-11-08-2967.pdf

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AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery

Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,

Publication Date: 2022-09-02

Variant appearance in text: ALK: E1210K

PubMed Link: 35819403

Variant Present in the following documents:

• cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1

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Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.

Frontiers In Oncology

Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J

Publication Date: 2022

Variant appearance in text: ALK: 3628G>A; E1210K

PubMed Link: 35814426

Variant Present in the following documents:

• DataSheet_1.xlsx, sheet 2

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The Impact of Comprehensive Genomic Profiling (CGP) on the Decision-Making Process in the Treatment of ALK-Rearranged Advanced Non-Small Cell Lung Cancer (aNSCLC) After Failure of 2nd/3rd-Generation ALK Tyrosine Kinase Inhibitors (TKIs).

Frontiers In Oncology

Raphael, Ari A; Onn, Amir A; Holtzman, Liran L; Dudnik, Julia J; Urban, Damien D; Kian, Waleed W; Cohen, Aharon Y AY; Moskovitz, Mor M; Zer, Alona A; Bar, Jair J; Rabinovich, Natalie Maimon NM; Grynberg, Shirly S; Oedegaard, Cecilie C; Agbarya, Abed A; Peled, Nir N; Shochat, Tzippy T; Dudnik, Elizabeth E

Publication Date: 2022

Variant appearance in text: ALK: E1210K

PubMed Link: 35646707

Variant Present in the following documents:

• Table_2.xlsx, sheet 1

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Targeting ALK Rearrangements in NSCLC: Current State of the Art.

Frontiers In Oncology

Peng, Ling L; Zhu, Liping L; Sun, Yilan Y; Stebbing, Justin J; Selvaggi, Giovanni G; Zhang, Yongchang Y; Yu, Zhentao Z

Publication Date: 2022

Variant appearance in text: ALK: E1210K

PubMed Link: 35463328

Variant Present in the following documents:

• Main text
• fonc-12-863461.pdf

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Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications

Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L

Publication Date: 2022-03-10

Variant appearance in text: ALK: 3628G>A; E1210K

PubMed Link: 35273153

Variant Present in the following documents:

• 41467_2022_28840_MOESM7_ESM.xlsx, sheet 1

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Holistic View of ALK TKI Resistance in ALK-Positive Anaplastic Large Cell Lymphoma.

Frontiers In Oncology

Wang, Yuan Y; He, Jing J; Xu, Manyu M; Xue, Qingfeng Q; Zhu, Cindy C; Liu, Juan J; Zhang, Yaping Y; Shi, Wenyu W

Publication Date: 2022

Variant appearance in text: ALK: E1210K

PubMed Link: 35211406

Variant Present in the following documents:

• Main text
• fonc-12-815654.pdf

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Real-world circulating tumor DNA analysis depicts resistance mechanism and clonal evolution in ALK inhibitor-treated lung adenocarcinoma patients.

Esmo Open

Hua, G G; Zhang, X X; Zhang, M M; Wang, Q Q; Chen, X X; Yu, R R; Bao, H H; Liu, J J; Wu, X X; Shao, Y Y; Liang, B B; Lu, K K

Publication Date: 2022-02-02

Variant appearance in text: ALK: E1210K

PubMed Link: 35123209

Variant Present in the following documents:

• Main text
• main.pdf

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Real-world circulating tumor DNA analysis depicts resistance mechanism and clonal evolution in ALK inhibitor-treated lung adenocarcinoma patients.

Esmo Open

Hua, G G; Zhang, X X; Zhang, M M; Wang, Q Q; Chen, X X; Yu, R R; Bao, H H; Liu, J J; Wu, X X; Shao, Y Y; Liang, B B; Lu, K K

Publication Date: 2022-02

Variant appearance in text: ALK: E1210K

PubMed Link: 35123209

Variant Present in the following documents:

• Main text
• main.pdf

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Utility of the Ba/F3 cell system for exploring on-target mechanisms of resistance to targeted therapies for lung cancer.

Cancer Science

Koga, Takamasa T; Suda, Kenichi K; Mitsudomi, Tetsuya T

Publication Date: 2022-03

Variant appearance in text: ALK: E1210K

PubMed Link: 34997674

Variant Present in the following documents:

• CAS-113-815-s001.pdf

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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers

Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: E1210K

PubMed Link: 34885113

Variant Present in the following documents:

• Main text
• cancers-13-06003.pdf

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Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL.

Cancers

Hare, Lucy L; Burke, G A Amos GAA; Turner, Suzanne D SD

Publication Date: 2021-11-29

Variant appearance in text: ALK: E1210K

PubMed Link: 34885113

Variant Present in the following documents:

• Main text
• cancers-13-06003.pdf

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Two novel strategies to overcome the resistance to ALK tyrosine kinase inhibitor drugs: Macrocyclic inhibitors and proteolysis-targeting chimeras.

Medcomm

Song, Xiaoling X; Zhong, Hui H; Qu, Xiaojuan X; Yang, Linsong L; Jiang, Biao B

Publication Date: 2021-09

Variant appearance in text: ALK: E1210K

PubMed Link: 34766150

Variant Present in the following documents:

• Main text
• MCO2-2-341.pdf

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New Advances in Liquid Biopsy Technologies for Anaplastic Lymphoma Kinase (ALK)-Positive Cancer.

Cancers

Villa, Matteo M; Sharma, Geeta G GG; Manfroni, Chiara C; Cortinovis, Diego D; Mologni, Luca L

Publication Date: 2021-10-14

Variant appearance in text: ALK: E1210K

PubMed Link: 34680298

Variant Present in the following documents:

• Main text

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The Resistance Mechanisms and Treatment Strategies for ALK-Rearranged Non-Small Cell Lung Cancer.

Frontiers In Oncology

Pan, Yue Y; Deng, Chao C; Qiu, Zhenhua Z; Cao, Chenghui C; Wu, Fang F

Publication Date: 2021

Variant appearance in text: ALK: E1210K

PubMed Link: 34660278

Variant Present in the following documents:

• Main text
• fonc-11-713530.pdf

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: ALK: E1210K

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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A Novel Sequentially Evolved EML4-ALK Variant 3 G1202R/S1206Y Double Mutation In Cis Confers Resistance to Lorlatinib: A Brief Report and Literature Review.

Jto Clinical And Research Reports

Zhu, Viola W VW; Nagasaka, Misako M; Madison, Russell R; Schrock, Alexa B AB; Cui, Jean J; Ou, Sai-Hong Ignatius SI

Publication Date: 2021-01

Variant appearance in text: ALK: E1210K

PubMed Link: 34589977

Variant Present in the following documents:

• Main text
• main.pdf

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Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases.

Thoracic Cancer

Mitsumura, Takahiro T; Kumaki, Yuichi Y; Takahashi, Kenta K; Matsudera, Shotaro S; Sakakibara, Rie R; Honda, Takayuki T; Ishizuka, Masahiro M; Iijima, Yuki Y; Shirai, Tsuyoshi T; Okamoto, Tsukasa T; Tateishi, Tomoya T; Sakashita, Hiroyuki H; Miyake, Satoshi S; Ikeda, Sadakatsu S; Miyazaki, Yasunari Y

Publication Date: 2021-09

Variant appearance in text: ALK: E1210K

PubMed Link: 34378333

Variant Present in the following documents:

• Main text

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Treatment of advanced lung cancer based on genomic profiling using liquid biopsy (plasma): A review of three cases.

Thoracic Cancer

Mitsumura, Takahiro T; Kumaki, Yuichi Y; Takahashi, Kenta K; Matsudera, Shotaro S; Sakakibara, Rie R; Honda, Takayuki T; Ishizuka, Masahiro M; Iijima, Yuki Y; Shirai, Tsuyoshi T; Okamoto, Tsukasa T; Tateishi, Tomoya T; Sakashita, Hiroyuki H; Miyake, Satoshi S; Ikeda, Sadakatsu S; Miyazaki, Yasunari Y

Publication Date: 2021-09

Variant appearance in text: ALK: E1210K

PubMed Link: 34378333

Variant Present in the following documents:

• Main text

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Acquired ALK Resistance Mutations Identified from Liquid Biopsy in an ALK-Rearranged Squamous Cell Lung Cancer Patient Treated with Sequential ALK TKI Therapy: A Case Report.

Oncotargets And Therapy

Yao, Bin B; Han, Xue X; Pang, Linrong L; Xu, Caihong C; Liu, Sisi S; Cheng, Xiaochun X; Chen, Jun J

Publication Date: 2021

Variant appearance in text: ALK: E1210K

PubMed Link: 34376997

Variant Present in the following documents:

• Main text
• ott-14-4329.pdf

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Will the clinical development of 4th-generation "double mutant active" ALK TKIs (TPX-0131 and NVL-655) change the future treatment paradigm of ALK+ NSCLC?

Translational Oncology

Ou, Sai-Hong Ignatius SI; Nagasaka, Misako M; Brazel, Danielle D; Hou, Yujie Y; Zhu, Viola W VW

Publication Date: 2021-11

Variant appearance in text: ALK: E1210K

PubMed Link: 34365220

Variant Present in the following documents:

• Main text

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One-Step Polymerase Chain Reaction-Free Nanowire-Based Plasma Cell-Free DNA Assay to Detect EML4-ALK Fusion and to Monitor Resistance in Lung Cancer.

The Oncologist

Lee, Youngjoo Y; Cho, Youngnam Y; Park, Eun Young EY; Park, Seong-Yun SY; Hwang, Kum Hui KH; Han, Ji-Youn JY

Publication Date: 2021-10

Variant appearance in text: ALK: E1210K

PubMed Link: 34272914

Variant Present in the following documents:

• ONCO-26-e1683-s002.pdf

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TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations.

Molecular Cancer Therapeutics

Murray, Brion W BW; Zhai, Dayong D; Deng, Wei W; Zhang, Xin X; Ung, Jane J; Nguyen, Vivian V; Zhang, Han H; Barrera, Maria M; Parra, Ana A; Cowell, Jessica J; Lee, Dong J DJ; Aloysius, Herve H; Rogers, Evan E

Publication Date: 2021-09

Variant appearance in text: ALK: E1210K

PubMed Link: 34158340

Variant Present in the following documents:

• Main text
• 1499.pdf

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An insight into lung cancer: a comprehensive review exploring ALK TKI and mechanisms of resistance.

Bosnian Journal Of Basic Medical Sciences

Patcas, Adela A; Chis, Ana Florica AF; Militaru, Claudia Florentina CF; Bordea, Ioana Roxana IR; Rajnoveanu, Ruxandra R; Coza, Ovidiu Florin OF; Hanna, Reem R; Tiberiu, Tamas T; Todea, Doina Adina DA

Publication Date: 2022-02-01

Variant appearance in text: ALK: E1210K

PubMed Link: 34082691

Variant Present in the following documents:

• Main text
• BJBMS-22-1.pdf

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Current Knowledge about Mechanisms of Drug Resistance against ALK Inhibitors in Non-Small Cell Lung Cancer.

Cancers

Smolle, Elisabeth E; Taucher, Valentin V; Lindenmann, Joerg J; Jost, Philipp J PJ; Pichler, Martin M

Publication Date: 2021-02-09

Variant appearance in text: ALK: E1210K

PubMed Link: 33572278

Variant Present in the following documents:

• Main text
• cancers-13-00699.pdf

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Overcoming TKI resistance in fusion-driven NSCLC: new generation inhibitors and rationale for combination strategies.

Translational Lung Cancer Research

Russo, Alessandro A; Cardona, Andrés F AF; Caglevic, Christian C; Manca, Paolo P; Ruiz-Patiño, Alejandro A; Arrieta, Oscar O; Rolfo, Christian C

Publication Date: 2020-12

Variant appearance in text: ALK: E1210K

PubMed Link: 33489820

Variant Present in the following documents:

• Main text

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Resistance to anaplastic lymphoma kinase inhibitors: knowing the enemy is half the battle won.

Translational Lung Cancer Research

Tabbò, Fabrizio F; Reale, Maria Lucia ML; Bironzo, Paolo P; Scagliotti, Giorgio V GV

Publication Date: 2020-12

Variant appearance in text: ALK: E1210K

PubMed Link: 33489817

Variant Present in the following documents:

• Main text
• tlcr-09-06-2545.pdf

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Detecting Resistance to Therapeutic ALK Inhibitors in Tumor Tissue and Liquid Biopsy Markers: An Update to a Clinical Routine Practice.

Cells

Hofman, Paul P

Publication Date: 2021-01-15

Variant appearance in text: ALK: E1210K

PubMed Link: 33467720

Variant Present in the following documents:

• Main text
• cells-10-00168.pdf

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: ALK: 3628G>A; E1210K

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM9_ESM.xlsx, sheet 1
• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
• 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1

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The Emerging Therapeutic Landscape of ALK Inhibitors in Non-Small Cell Lung Cancer.

Pharmaceuticals (Basel, Switzerland)

Gristina, Valerio V; La Mantia, Maria M; Iacono, Federica F; Galvano, Antonio A; Russo, Antonio A; Bazan, Viviana V

Publication Date: 2020-12-18

Variant appearance in text: ALK: E1210K

PubMed Link: 33352844

Variant Present in the following documents:

• pharmaceuticals-13-00474.pdf

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