ALK c.3368G>A ;(p.G1123D)

Variant ID: 2-29445465-C-T

NM_004304.4(ALK):c.3368G>A;(p.G1123D)

This variant was identified in 9 publications

View GRCh38 version.




Publications:


The Resistance Mechanisms and Treatment Strategies for ALK-Rearranged Non-Small Cell Lung Cancer.

Frontiers In Oncology
Pan, Yue Y; Deng, Chao C; Qiu, Zhenhua Z; Cao, Chenghui C; Wu, Fang F
Publication Date: 2021

Variant appearance in text: ALK: G1123D
PubMed Link: 34660278
Variant Present in the following documents:
  • Main text
  • fonc-11-713530.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: ALK: G1123D
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



A Novel Sequentially Evolved EML4-ALK Variant 3 G1202R/S1206Y Double Mutation In Cis Confers Resistance to Lorlatinib: A Brief Report and Literature Review.

Jto Clinical And Research Reports
Zhu, Viola W VW; Nagasaka, Misako M; Madison, Russell R; Schrock, Alexa B AB; Cui, Jean J; Ou, Sai-Hong Ignatius SI
Publication Date: 2021-01

Variant appearance in text: ALK: G1123D
PubMed Link: 34589977
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: ALK: G1123D
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Treatment with Next-Generation ALK Inhibitors Fuels Plasma ALK Mutation Diversity.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Dagogo-Jack, Ibiayi I; Rooney, Marguerite M; Lin, Jessica J JJ; Nagy, Rebecca J RJ; Yeap, Beow Y BY; Hubbeling, Harper H; Chin, Emily E; Ackil, Jennifer J; Farago, Anna F AF; Hata, Aaron N AN; Lennerz, Jochen K JK; Gainor, Justin F JF; Lanman, Richard B RB; Shaw, Alice T AT
Publication Date: 2019-11-15

Variant appearance in text: ALK: G1123D
PubMed Link: 31358542
Variant Present in the following documents:
  • Main text
View BVdb publication page



Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer.

Cell Chemical Biology
Kaserer, Teresa T; Blagg, Julian J
Publication Date: 2018-11-15

Variant appearance in text: ALK: G1123D
PubMed Link: 30146241
Variant Present in the following documents:
  • Main text
  • mmc9.pdf
  • main.pdf
View BVdb publication page



Structure and energy based quantitative missense variant effect analysis provides insights into drug resistance mechanisms of anaplastic lymphoma kinase mutations.

Scientific Reports
Li, Jianzong J; Huang, Yue Y; Wu, Miaomiao M; Wu, Chuanfang C; Li, Xin X; Bao, Jinku J
Publication Date: 2018-07-13

Variant appearance in text: ALK: G1123D
PubMed Link: 30006516
Variant Present in the following documents:
  • 41598_2018_28752_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Current Molecular-Targeted Therapies in NSCLC and Their Mechanism of Resistance.

Cancers
Schrank, Zachary Z; Chhabra, Gagan G; Lin, Leo L; Iderzorig, Tsatsral T; Osude, Chike C; Khan, Nabiha N; Kuckovic, Adijan A; Singh, Sanjana S; Miller, Rachel J RJ; Puri, Neelu N
Publication Date: 2018-07-04

Variant appearance in text: ALK: G1123D
PubMed Link: 29973561
Variant Present in the following documents:
  • Main text
  • cancers-10-00224.pdf
View BVdb publication page



ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Heuckmann, Johannes M JM; Hölzel, Michael M; Sos, Martin L ML; Heynck, Stefanie S; Balke-Want, Hyatt H; Koker, Mirjam M; Peifer, Martin M; Weiss, Jonathan J; Lovly, Christine M CM; Grütter, Christian C; Rauh, Daniel D; Pao, William W; Thomas, Roman K RK
Publication Date: 2011-12-01

Variant appearance in text: ALK: G1123D
PubMed Link: 21948233
Variant Present in the following documents:
  • Main text
View BVdb publication page