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PAK5 c.1717_1718delinsAA ;(p.S573N)
Variant ID: 20-9538280-GA-TT
NM_177990.2(
PAK5
):c.1717_1718delinsAA;(p.S573N)
This variant was identified in 9 publications
View GRCh38 version.
Variant-Specific Resource Links:
gnomAD v2.1.1
Mutalizer Name Checker
Google
UCSC Genome Browser
ClinVar
dbSNP
Publications:
PAK5-stabilized Smuc confers renal cell carcinoma metastasis.
Clinical And Translational Medicine
Huo, Fu-Chun FC; Zhu, Zhi-Man ZM; Du, Qiu-Ying QY; Pei, Dong-Sheng DS
Publication Date: 2021-09
Variant appearance in text: PAK5: S573N
PubMed Link:
34586742
Variant Present in the following documents:
Main text
CTM2-11-e559.pdf
View BVdb publication page
MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway.
Journal Of Biomedical Science
Li, Tong-Tong TT; Mou, Jie J; Pan, Yao-Jie YJ; Huo, Fu-Chun FC; Du, Wen-Qi WQ; Liang, Jia J; Wang, Yang Y; Zhang, Lan-Sheng LS; Pei, Dong-Sheng DS
Publication Date: 2021-08-02
Variant appearance in text: PAK5: S573N
PubMed Link:
34340705
Variant Present in the following documents:
Main text
12929_2021_Article_752.pdf
View BVdb publication page
P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer.
Signal Transduction And Targeted Therapy
Zhang, Ding-Guo DG; Gong, Chan-Chan CC; Wu, Xiao-Jin XJ; Ren, Xin X; Sedaka, Randee S RS; Chen, Wei-Cong WC; Huo, Fu-Chun FC; Chen, Cheng C; Du, Wen-Qi WQ; Pei, Dong-Sheng DS
Publication Date: 2021-02-05
Variant appearance in text: PAK5: S573N
PubMed Link:
33542180
Variant Present in the following documents:
Main text
41392_2020_Article_409.pdf
View BVdb publication page
Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways.
Oncotarget
LaPak, Kyle M KM; Vroom, Dennis C DC; Garg, Ayush A AA; Guan, Xiangnan X; Hays, John L JL; Song, Jonathan W JW; Burd, Christin E CE
Publication Date: 2018-05-22
Variant appearance in text: PAK5: S573N
PubMed Link:
29875996
Variant Present in the following documents:
Main text
oncotarget-09-25386.pdf
View BVdb publication page
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Fawdar, Shameem S; Trotter, Eleanor W EW; Li, Yaoyong Y; Stephenson, Natalie L NL; Hanke, Franziska F; Marusiak, Anna A AA; Edwards, Zoe C ZC; Ientile, Sara S; Waszkowycz, Bohdan B; Miller, Crispin J CJ; Brognard, John J
Publication Date: 2013-07-23
Variant appearance in text: PAK5: S573N
PubMed Link:
23836671
Variant Present in the following documents:
Main text
View BVdb publication page
PAK4-6 in cancer and neuronal development.
Cellular Logistics
Minden, Audrey A
Publication Date: 2012-04-01
Variant appearance in text: PAK5: S573N
PubMed Link:
23125951
Variant Present in the following documents:
Main text
cl-2-95.pdf
View BVdb publication page
Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis.
The Journal Of Cell Biology
Bompard, Guillaume G; Rabeharivelo, Gabriel G; Frank, Marie M; Cau, Julien J; Delsert, Claude C; Morin, Nathalie N
Publication Date: 2010-09-06
Variant appearance in text: PAK5: S573N
PubMed Link:
20805321
Variant Present in the following documents:
Main text
JCB_200912056.pdf
View BVdb publication page
PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.
Molecular Biology Of The Cell
Matenia, Dorthe D; Griesshaber, Bettina B; Li, Xiao-yu XY; Thiessen, Anja A; Johne, Cindy C; Jiao, Jian J; Mandelkow, Eckhard E; Mandelkow, Eva-Maria EM
Publication Date: 2005-09
Variant appearance in text: PAK5: S573N
PubMed Link:
16014608
Variant Present in the following documents:
Main text
View BVdb publication page
PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.
Molecular And Cellular Biology
Dan, Chuntao C; Nath, Niharika N; Liberto, Muriel M; Minden, Audrey A
Publication Date: 2002-01
Variant appearance in text: PAK5: S573N
PubMed Link:
11756552
Variant Present in the following documents:
Main text
View BVdb publication page