Alzheimer's Disease: Treatment Strategies and Their Limitations.
International Journal Of Molecular Sciences
Passeri, Elodie E; Elkhoury, Kamil K; Morsink, Margaretha M; Broersen, Kerensa K; Linder, Michel M; Tamayol, Ali A; Malaplate, Catherine C; Yen, Frances T FT; Arab-Tehrany, Elmira E
Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.
Molecular Psychiatry
Jia, Xiaoming X; Goes, Fernando S FS; Locke, Adam E AE; Palmer, Duncan D; Wang, Weiqing W; Cohen-Woods, Sarah S; Genovese, Giulio G; Jackson, Anne U AU; Jiang, Chen C; Kvale, Mark M; Mullins, Niamh N; Nguyen, Hoang H; Pirooznia, Mehdi M; Rivera, Margarita M; Ruderfer, Douglas M DM; Shen, Ling L; Thai, Khanh K; Zawistowski, Matthew M; Zhuang, Yongwen Y; Abecasis, Gonçalo G; Akil, Huda H; Bergen, Sarah S; Burmeister, Margit M; Chapman, Sinéad S; DelaBastide, Melissa M; Juréus, Anders A; Kang, Hyun Min HM; Kwok, Pui-Yan PY; Li, Jun Z JZ; Levy, Shawn E SE; Monson, Eric T ET; Moran, Jennifer J; Sobell, Janet J; Watson, Stanley S; Willour, Virginia V; Zöllner, Sebastian S; Adolfsson, Rolf R; Blackwood, Douglas D; Boehnke, Michael M; Breen, Gerome G; Corvin, Aiden A; Craddock, Nick N; DiFlorio, Arianna A; Hultman, Christina M CM; Landen, Mikael M; Lewis, Cathryn C; McCarroll, Steven A SA; Richard McCombie, W W; McGuffin, Peter P; McIntosh, Andrew A; McQuillin, Andrew A; Morris, Derek D; Myers, Richard M RM; O'Donovan, Michael M; Ophoff, Roel R; Boks, Marco M; Kahn, Rene R; Ouwehand, Willem W; Owen, Michael M; Pato, Carlos C; Pato, Michele M; Posthuma, Danielle D; Potash, James B JB; Reif, Andreas A; Sklar, Pamela P; Smoller, Jordan J; Sullivan, Patrick F PF; Vincent, John J; Walters, James J; Neale, Benjamin B; Purcell, Shaun S; Risch, Neil N; Schaefer, Catherine C; Stahl, Eli A EA; Zandi, Peter P PP; Scott, Laura J LJ
The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer's Disease in SH-SY5Y cells.
Plos One
Guyon, Antoine A; Rousseau, Joël J; Lamothe, Gabriel G; Tremblay, Jacques P JP
Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation.
Nature Communications
Park, Jun Sung JS; Lee, Junehawk J; Jung, Eun Sun ES; Kim, Myeong-Heui MH; Kim, Il Bin IB; Son, Hyeonju H; Kim, Sangwoo S; Kim, Sanghyeon S; Park, Young Mok YM; Mook-Jung, Inhee I; Yu, Seok Jong SJ; Lee, Jeong Ho JH
APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation.
Stem Cell Reports
Mertens, Jerome J; Stüber, Kathrin K; Wunderlich, Patrick P; Ladewig, Julia J; Kesavan, Jaideep C JC; Vandenberghe, Rik R; Vandenbulcke, Mathieu M; van Damme, Philip P; Walter, Jochen J; Brüstle, Oliver O; Koch, Philipp P
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.
Embo Molecular Medicine
Zhou, Lujia L; Brouwers, Nathalie N; Benilova, Iryna I; Vandersteen, Annelies A; Mercken, Marc M; Van Laere, Koen K; Van Damme, Philip P; Demedts, David D; Van Leuven, Fred F; Sleegers, Kristel K; Broersen, Kerensa K; Van Broeckhoven, Christine C; Vandenberghe, Rik R; De Strooper, Bart B
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees.
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Klunk, William E WE; Price, Julie C JC; Mathis, Chester A CA; Tsopelas, Nicholas D ND; Lopresti, Brian J BJ; Ziolko, Scott K SK; Bi, Wenzhu W; Hoge, Jessica A JA; Cohen, Ann D AD; Ikonomovic, Milos D MD; Saxton, Judith A JA; Snitz, Beth E BE; Pollen, Daniel A DA; Moonis, Majaz M; Lippa, Carol F CF; Swearer, Joan M JM; Johnson, Keith A KA; Rentz, Dorene M DM; Fischman, Alan J AJ; Aizenstein, Howard J HJ; DeKosky, Steven T ST