Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
Acta Neuropathologica Communications
Schilling, Sandra S; Pradhan, Ajay A; Heesch, Amelie A; Helbig, Andrea A; Blennow, Kaj K; Koch, Christian C; Bertgen, Lea L; Koo, Edward H EH; Brinkmalm, Gunnar G; Zetterberg, Henrik H; Kins, Stefan S; Eggert, Simone S
Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease.
Alzheimer'S Research & Therapy
Gustavsson, Tobias T; Metzendorf, Nicole G NG; Wik, Elin E; Roshanbin, Sahar S; Julku, Ulrika U; Chourlia, Aikaterini A; Nilsson, Per P; Andersson, Ken G KG; Laudon, Hanna H; Hultqvist, Greta G; Syvänen, Stina S; Sehlin, Dag D
Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL-F/NL-F knock-in mouse model of Alzheimer's disease.
Alzheimer'S Research & Therapy
Andersson, Emelie E; Schultz, Nina N; Saito, Takashi T; Saido, Takaomi C TC; Blennow, Kaj K; Gouras, Gunnar K GK; Zetterberg, Henrik H; Hansson, Oskar O
Increase in tau pathology in P290S Mapt knock-in mice crossed with App NL-G-F mice.
Eneuro
Huang, Melissa M; Macdonald, Jennifer J; Lavenir, Isabelle I; Chen, Renren R; Craxton, Molly M; Slavik-Smith, Elizabeth E; Davies, Stephen W SW; Goedert, Michel M
Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer's disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations.
Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.
Acta Neuropathologica Communications
Carpanini, Sarah M SM; Torvell, Megan M; Bevan, Ryan J RJ; Byrne, Robert A J RAJ; Daskoulidou, Nikoleta N; Saito, Takashi T; Saido, Takaomi C TC; Taylor, Philip R PR; Hughes, Timothy R TR; Zelek, Wioleta M WM; Morgan, B Paul BP
Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer's Disease.
Acta Neuropathologica Communications
Tok, S S; Maurin, H H; Delay, C C; Crauwels, D D; Manyakov, N V NV; Van Der Elst, W W; Moechars, D D; Drinkenburg, W H I M WHIM
Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice.
Frontiers In Immunology
Hao, Xiaoxiao X; Li, Zhaofei Z; Li, Wei W; Katz, Jannet J; Michalek, Suzanne M SM; Barnum, Scott R SR; Pozzo-Miller, Lucas L; Saito, Takashi T; Saido, Takaomi C TC; Wang, Qin Q; Roberson, Erik D ED; Zhang, Ping P
Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models.
Genome Medicine
Pauls, Eduardo E; Bayod, Sergi S; Mateo, Lídia L; Alcalde, Víctor V; Juan-Blanco, Teresa T; Sánchez-Soto, Marta M; Saido, Takaomi C TC; Saito, Takashi T; Berrenguer-Llergo, Antoni A; Attolini, Camille Stephan-Otto CS; Gay, Marina M; de Oliveira, Eliandre E; Duran-Frigola, Miquel M; Aloy, Patrick P
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer's disease.
Molecular Psychiatry
Arroyo-García, Luis Enrique LE; Isla, Arturo G AG; Andrade-Talavera, Yuniesky Y; Balleza-Tapia, Hugo H; Loera-Valencia, Raúl R; Alvarez-Jimenez, Laura L; Pizzirusso, Giusy G; Tambaro, Simone S; Nilsson, Per P; Fisahn, André A
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer's disease.
Molecular Psychiatry
Arroyo-García, Luis Enrique LE; Isla, Arturo G AG; Andrade-Talavera, Yuniesky Y; Balleza-Tapia, Hugo H; Loera-Valencia, Raúl R; Alvarez-Jimenez, Laura L; Pizzirusso, Giusy G; Tambaro, Simone S; Nilsson, Per P; Fisahn, André A
Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.
Molecular Neurodegeneration
Benitez, Diana P DP; Jiang, Shenyi S; Wood, Jack J; Wang, Rui R; Hall, Chloe M CM; Peerboom, Carlijn C; Wong, Natalie N; Stringer, Katie M KM; Vitanova, Karina S KS; Smith, Victoria C VC; Joshi, Dhaval D; Saito, Takashi T; Saido, Takaomi C TC; Hardy, John J; Hanrieder, Jörg J; De Strooper, Bart B; Salih, Dervis A DA; Tripathi, Takshashila T; Edwards, Frances A FA; Cummings, Damian M DM
Following spatial Aβ aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics.
Science Advances
Michno, Wojciech W; Stringer, Katie M KM; Enzlein, Thomas T; Passarelli, Melissa K MK; Escrig, Stephane S; Vitanova, Karina K; Wood, Jack J; Blennow, Kaj K; Zetterberg, Henrik H; Meibom, Anders A; Hopf, Carsten C; Edwards, Frances A FA; Hanrieder, Jörg J
11C-PiB and 124I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention.
Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine
Meier, Silvio R SR; Sehlin, Dag D; Roshanbin, Sahar S; Falk, Victoria Lim VL; Saito, Takashi T; Saido, Takaomi C TC; Neumann, Ulf U; Rokka, Johanna J; Eriksson, Jonas J; Syvänen, Stina S
11C-PIB and 124I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention.
Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine
Meier, Silvio R SR; Sehlin, Dag D; Roshanbin, Sahar S; Lim Falk, Victoria V; Saito, Takashi T; Saido, Takaomi C TC; Neumann, Ulf U; Rokka, Johanna J; Eriksson, Jonas J; Syvanen, Stina S