APP c.2146A>T ;(p.I716F)

Variant ID: 21-27264099-T-A

NM_000484.3(APP):c.2146A>T;(p.I716F)

This variant was identified in 100 publications

View GRCh38 version.




Publications:


Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.

Acta Neuropathologica Communications
Schilling, Sandra S; Pradhan, Ajay A; Heesch, Amelie A; Helbig, Andrea A; Blennow, Kaj K; Koch, Christian C; Bertgen, Lea L; Koo, Edward H EH; Brinkmalm, Gunnar G; Zetterberg, Henrik H; Kins, Stefan S; Eggert, Simone S
Publication Date: 2023-06-01

Variant appearance in text: APP: I716F
PubMed Link: 37259128
Variant Present in the following documents:
  • Main text
  • 40478_2023_Article_1577.pdf
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Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.

Nature Neuroscience
Calafate, Sara S; Özturan, Gökhan G; Thrupp, Nicola N; Vanderlinden, Jeroen J; Santa-Marinha, Luísa L; Morais-Ribeiro, Rafaela R; Ruggiero, Antonella A; Bozic, Ivan I; Rusterholz, Thomas T; Lorente-Echeverría, Blanca B; Dias, Marcelo M; Chen, Wei-Ting WT; Fiers, Mark M; Lu, Ashley A; Vlaeminck, Ine I; Creemers, Eline E; Craessaerts, Katleen K; Vandenbempt, Joris J; van Boekholdt, Luuk L; Poovathingal, Suresh S; Davie, Kristofer K; Thal, Dietmar Rudolf DR; Wierda, Keimpe K; Oliveira, Tiago Gil TG; Slutsky, Inna I; Adamantidis, Antoine A; De Strooper, Bart B; de Wit, Joris J
Publication Date: 2023-05-15

Variant appearance in text: APP: Ile716Phe
PubMed Link: 37188873
Variant Present in the following documents:
  • 41593_2023_Article_1325.pdf
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease.

Alzheimer'S Research & Therapy
Gustavsson, Tobias T; Metzendorf, Nicole G NG; Wik, Elin E; Roshanbin, Sahar S; Julku, Ulrika U; Chourlia, Aikaterini A; Nilsson, Per P; Andersson, Ken G KG; Laudon, Hanna H; Hultqvist, Greta G; Syvänen, Stina S; Sehlin, Dag D
Publication Date: 2023-05-02

Variant appearance in text: APP: I716F
PubMed Link: 37131196
Variant Present in the following documents:
  • Main text
  • 13195_2023_Article_1236.pdf
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Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL-F/NL-F knock-in mouse model of Alzheimer's disease.

Alzheimer'S Research & Therapy
Andersson, Emelie E; Schultz, Nina N; Saito, Takashi T; Saido, Takaomi C TC; Blennow, Kaj K; Gouras, Gunnar K GK; Zetterberg, Henrik H; Hansson, Oskar O
Publication Date: 2023-03-25

Variant appearance in text: APP: I716F
PubMed Link: 36964585
Variant Present in the following documents:
  • Main text
  • 13195_2023_Article_1196.pdf
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Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.

Scientific Reports
Hashimoto, Shoko S; Matsuba, Yukio Y; Takahashi, Mika M; Kamano, Naoko N; Watamura, Naoto N; Sasaguri, Hiroki H; Takado, Yuhei Y; Yoshihara, Yoshihiro Y; Saito, Takashi T; Saido, Takaomi C TC
Publication Date: 2023-01-20

Variant appearance in text: APP: I716F
PubMed Link: 36670138
Variant Present in the following documents:
  • Main text
  • 41598_2023_Article_27653.pdf
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Increase in tau pathology in P290S Mapt knock-in mice crossed with App NL-G-F mice.

Eneuro
Huang, Melissa M; Macdonald, Jennifer J; Lavenir, Isabelle I; Chen, Renren R; Craxton, Molly M; Slavik-Smith, Elizabeth E; Davies, Stephen W SW; Goedert, Michel M
Publication Date: 2022-12-05

Variant appearance in text: APP: I716F
PubMed Link: 36635241
Variant Present in the following documents:
  • Main text
  • ENEURO.0247-22.2022.pdf
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Chaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection.

International Journal Of Molecular Sciences
Voronin, Mikhail V MV; Abramova, Elena V EV; Verbovaya, Ekaterina R ER; Vakhitova, Yulia V YV; Seredenin, Sergei B SB
Publication Date: 2023-01-03

Variant appearance in text: APP: Ile716Phe; rs63750399
PubMed Link: 36614266
Variant Present in the following documents:
  • Main text
  • ijms-24-00823.pdf
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Functions and dysfunctions of oligodendrocytes in neurodegenerative diseases.

Frontiers In Cellular Neuroscience
Han, Seungwan S; Gim, Yunho Y; Jang, Eun-Hae EH; Hur, Eun-Mi EM
Publication Date: 2022

Variant appearance in text: APP: I716F
PubMed Link: 36605616
Variant Present in the following documents:
  • Main text
  • fncel-16-1083159.pdf
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Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis.

Fluids And Barriers Of The Cns
Julku, Ulrika U; Xiong, Mengfei M; Wik, Elin E; Roshanbin, Sahar S; Sehlin, Dag D; Syvänen, Stina S
Publication Date: 2022-12-12

Variant appearance in text: APP: I716F
PubMed Link: 36510227
Variant Present in the following documents:
  • Main text
  • 12987_2022_Article_398.pdf
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Fats, Friends or Foes: Investigating the Role of Short- and Medium-Chain Fatty Acids in Alzheimer's Disease.

Biomedicines
Ameen, Aishat O AO; Freude, Kristine K; Aldana, Blanca I BI
Publication Date: 2022-11-01

Variant appearance in text: APP: I716F
PubMed Link: 36359298
Variant Present in the following documents:
  • Main text
  • biomedicines-10-02778.pdf
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Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer's disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations.

Frontiers In Aging Neuroscience
Liu, Yingzi Y; Xiao, Xuewen X; Liu, Hui H; Liao, Xinxin X; Zhou, Yafang Y; Weng, Ling L; Zhou, Lu L; Liu, Xixi X; Bi, Xiang-Yun XY; Xu, Tianyan T; Zhu, Yuan Y; Yang, Qijie Q; Zhang, Sizhe S; Hao, Xiaoli X; Zhang, Weiwei W; Wang, Junling J; Jiao, Bin B; Shen, Lu L
Publication Date: 2022

Variant appearance in text: APP: I716F
PubMed Link: 36313020
Variant Present in the following documents:
  • Main text
  • fnagi-14-1013295.pdf
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Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.

Cell Reports
Shah, Disha D; Gsell, Willy W; Wahis, Jérôme J; Luckett, Emma S ES; Jamoulle, Tarik T; Vermaercke, Ben B; Preman, Pranav P; Moechars, Daan D; Hendrickx, Véronique V; Jaspers, Tom T; Craessaerts, Katleen K; Horré, Katrien K; Wolfs, Leen L; Fiers, Mark M; Holt, Matthew M; Thal, Dietmar Rudolf DR; Callaerts-Vegh, Zsuzsanna Z; D'Hooge, Rudi R; Vandenberghe, Rik R; Himmelreich, Uwe U; Bonin, Vincent V; De Strooper, Bart B
Publication Date: 2022-08-23

Variant appearance in text: APP: I716F
PubMed Link: 36001964
Variant Present in the following documents:
  • Main text
View BVdb publication page



Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.

Acta Neuropathologica Communications
Carpanini, Sarah M SM; Torvell, Megan M; Bevan, Ryan J RJ; Byrne, Robert A J RAJ; Daskoulidou, Nikoleta N; Saito, Takashi T; Saido, Takaomi C TC; Taylor, Philip R PR; Hughes, Timothy R TR; Zelek, Wioleta M WM; Morgan, B Paul BP
Publication Date: 2022-07-06

Variant appearance in text: APP: I716F
PubMed Link: 35794654
Variant Present in the following documents:
  • Main text
  • 40478_2022_Article_1404.pdf
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Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer's Disease.

Acta Neuropathologica Communications
Tok, S S; Maurin, H H; Delay, C C; Crauwels, D D; Manyakov, N V NV; Van Der Elst, W W; Moechars, D D; Drinkenburg, W H I M WHIM
Publication Date: 2022-06-23

Variant appearance in text: APP: I716F
PubMed Link: 35739575
Variant Present in the following documents:
  • 40478_2022_Article_1393.pdf
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An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.

Science Advances
Watamura, Naoto N; Sato, Kaori K; Shiihashi, Gen G; Iwasaki, Ayami A; Kamano, Naoko N; Takahashi, Mika M; Sekiguchi, Misaki M; Mihira, Naomi N; Fujioka, Ryo R; Nagata, Kenichi K; Hashimoto, Shoko S; Saito, Takashi T; Ohshima, Toshio T; Saido, Takaomi C TC; Sasaguri, Hiroki H
Publication Date: 2022-06-10

Variant appearance in text: APP: I716F
PubMed Link: 35675411
Variant Present in the following documents:
  • Main text
  • sciadv.abm6155.pdf
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Recent Advances in the Modeling of Alzheimer's Disease.

Frontiers In Neuroscience
Sasaguri, Hiroki H; Hashimoto, Shoko S; Watamura, Naoto N; Sato, Kaori K; Takamura, Risa R; Nagata, Kenichi K; Tsubuki, Satoshi S; Ohshima, Toshio T; Yoshiki, Atsushi A; Sato, Kenya K; Kumita, Wakako W; Sasaki, Erika E; Kitazume, Shinobu S; Nilsson, Per P; Winblad, Bengt B; Saito, Takashi T; Iwata, Nobuhisa N; Saido, Takaomi C TC
Publication Date: 2022

Variant appearance in text: APP: I716F
PubMed Link: 35431779
Variant Present in the following documents:
  • Main text
  • fnins-16-807473.pdf
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Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer's Disease.

Frontiers In Aging Neuroscience
Cope, Zackary A ZA; Murai, Takeshi T; Sukoff Rizzo, Stacey J SJ
Publication Date: 2022

Variant appearance in text: APP: I716F
PubMed Link: 35250541
Variant Present in the following documents:
  • Main text
  • fnagi-14-805063.pdf
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Alzheimer's Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model.

Frontiers In Pharmacology
Aldabbagh, Yousif Y; Islam, Anam A; Zhang, Weicong W; Whiting, Paul P; Ali, Afia B AB
Publication Date: 2022

Variant appearance in text: APP: I716F
PubMed Link: 35185574
Variant Present in the following documents:
  • Main text
  • fphar-13-822499.pdf
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Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice.

Frontiers In Immunology
Hao, Xiaoxiao X; Li, Zhaofei Z; Li, Wei W; Katz, Jannet J; Michalek, Suzanne M SM; Barnum, Scott R SR; Pozzo-Miller, Lucas L; Saito, Takashi T; Saido, Takaomi C TC; Wang, Qin Q; Roberson, Erik D ED; Zhang, Ping P
Publication Date: 2022

Variant appearance in text: APP: I716F
PubMed Link: 35178049
Variant Present in the following documents:
  • Main text
View BVdb publication page



APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?

Alzheimer'S & Dementia : The Journal Of The Alzheimer'S Association
Jordà-Siquier, Tomàs T; Petrel, Melina M; Kouskoff, Vladimir V; Smailovic, Una U; Cordelières, Fabrice F; Frykman, Susanne S; Müller, Ulrike U; Mulle, Christophe C; Barthet, Gaël G
Publication Date: 2022-11

Variant appearance in text: APP: I716F
PubMed Link: 35076178
Variant Present in the following documents:
  • Main text
  • ALZ-18-2099.pdf
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Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models.

Cell Reports
Zarhin, Daniel D; Atsmon, Refaela R; Ruggiero, Antonella A; Baeloha, Halit H; Shoob, Shiri S; Scharf, Oded O; Heim, Leore R LR; Buchbinder, Nadav N; Shinikamin, Ortal O; Shapira, Ilana I; Styr, Boaz B; Braun, Gabriella G; Harel, Michal M; Sheinin, Anton A; Geva, Nitzan N; Sela, Yaniv Y; Saito, Takashi T; Saido, Takaomi T; Geiger, Tamar T; Nir, Yuval Y; Ziv, Yaniv Y; Slutsky, Inna I
Publication Date: 2022-01-18

Variant appearance in text: APP: I716F
PubMed Link: 35045289
Variant Present in the following documents:
  • Main text
View BVdb publication page



MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease.

Oxidative Medicine And Cellular Longevity
Mizuno, Yuri Y; Abolhassani, Nona N; Mazzei, Guianfranco G; Sakumi, Kunihiko K; Saito, Takashi T; Saido, Takaomi C TC; Ninomiya, Toshiharu T; Iwaki, Toru T; Yamasaki, Ryo R; Kira, Jun-Ichi JI; Nakabeppu, Yusaku Y
Publication Date: 2021

Variant appearance in text: APP: I716F
PubMed Link: 34970419
Variant Present in the following documents:
  • Main text
View BVdb publication page



Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.

International Journal Of Molecular Sciences
Kim, Meewhi M; Bezprozvanny, Ilya I
Publication Date: 2021-12-18

Variant appearance in text: APP: I716F
PubMed Link: 34948396
Variant Present in the following documents:
  • Main text
  • ijms-22-13600.pdf
View BVdb publication page



Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.

International Journal Of Molecular Sciences
Kim, Meewhi M; Bezprozvanny, Ilya I
Publication Date: 2021-12-18

Variant appearance in text: APP: I716F
PubMed Link: 34948396
Variant Present in the following documents:
  • Main text
  • ijms-22-13600.pdf
View BVdb publication page



Τhe Greek Variant in APP Gene: The Phenotypic Spectrum of APP Mutations.

International Journal Of Molecular Sciences
Kalampokini, Stefania S; Georgouli, Despoina D; Patrikiou, Eleni E; Provatas, Antonios A; Valotassiou, Varvara V; Georgoulias, Panagiotis P; Spanaki, Cleanthe C; Hadjigeorgiou, Georgios M GM; Xiromerisiou, Georgia G
Publication Date: 2021-11-16

Variant appearance in text: APP: I716F
PubMed Link: 34830236
Variant Present in the following documents:
  • Main text
  • ijms-22-12355.pdf
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An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments.

Cell Research
Pang, Keliang K; Jiang, Richeng R; Zhang, Wei W; Yang, Zhengyi Z; Li, Lin-Lin LL; Shimozawa, Makoto M; Tambaro, Simone S; Mayer, Johanna J; Zhang, Baogui B; Li, Man M; Wang, Jiesi J; Liu, Hang H; Yang, Ailing A; Chen, Xi X; Liu, Jiazheng J; Winblad, Bengt B; Han, Hua H; Jiang, Tianzi T; Wang, Weiwen W; Nilsson, Per P; Guo, Wei W; Lu, Bai B
Publication Date: 2022-02

Variant appearance in text: APP: I716F
PubMed Link: 34789895
Variant Present in the following documents:
  • Main text
  • 41422_2021_Article_582.pdf
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Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models.

Genome Medicine
Pauls, Eduardo E; Bayod, Sergi S; Mateo, Lídia L; Alcalde, Víctor V; Juan-Blanco, Teresa T; Sánchez-Soto, Marta M; Saido, Takaomi C TC; Saito, Takashi T; Berrenguer-Llergo, Antoni A; Attolini, Camille Stephan-Otto CS; Gay, Marina M; de Oliveira, Eliandre E; Duran-Frigola, Miquel M; Aloy, Patrick P
Publication Date: 2021-10-26

Variant appearance in text: APP: I716F
PubMed Link: 34702310
Variant Present in the following documents:
  • Main text
  • 13073_2021_Article_983.pdf
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HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.

Communications Biology
Tanaka, Hikari H; Kondo, Kanoh K; Fujita, Kyota K; Homma, Hidenori H; Tagawa, Kazuhiko K; Jin, Xiaocen X; Jin, Meihua M; Yoshioka, Yuki Y; Takayama, Sumire S; Masuda, Hitomi H; Tokuyama, Rie R; Nakazaki, Yukoh Y; Saito, Takashi T; Saido, Takaomi T; Murayama, Shigeo S; Ikura, Teikichi T; Ito, Nobutoshi N; Yamamori, Yu Y; Tomii, Kentaro K; Bianchi, Marco E ME; Okazawa, Hitoshi H
Publication Date: 2021-10-11

Variant appearance in text: APP: I716F
PubMed Link: 34635772
Variant Present in the following documents:
  • Main text
View BVdb publication page



Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease.

Elife
Wu, Xiaoting X; Saito, Takashi T; Saido, Takaomi C TC; Barron, Anna M AM; Ruedl, Christiane C
Publication Date: 2021-10-05

Variant appearance in text: APP: I716F
PubMed Link: 34609281
Variant Present in the following documents:
  • Main text
  • elife-71879.pdf
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Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.

The Journal Of Biological Chemistry
Nies, Sarah Helena SH; Takahashi, Hideyuki H; Herber, Charlotte S CS; Huttner, Anita A; Chase, Alison A; Strittmatter, Stephen M SM
Publication Date: 2021-10

Variant appearance in text: APP: I716F
PubMed Link: 34480901
Variant Present in the following documents:
  • Main text
View BVdb publication page



Deconstructing Alzheimer's Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

International Journal Of Molecular Sciences
Vignon, Anaïs A; Salvador-Prince, Lucie L; Lehmann, Sylvain S; Perrier, Véronique V; Torrent, Joan J
Publication Date: 2021-08-16

Variant appearance in text: APP: I716F
PubMed Link: 34445475
Variant Present in the following documents:
  • Main text
View BVdb publication page



Advances in Genetic and Molecular Understanding of Alzheimer's Disease.

Genes
Ibanez, Laura L; Cruchaga, Carlos C; Fernández, Maria Victoria MV
Publication Date: 2021-08-15

Variant appearance in text: APP: I716F
PubMed Link: 34440421
Variant Present in the following documents:
  • Main text
View BVdb publication page



Functional Neurophysiological Biomarkers of Early-Stage Alzheimer's Disease: A Perspective of Network Hyperexcitability in Disease Progression.

Journal Of Alzheimer'S Disease : Jad
Tok, Sean S; Ahnaou, Abdallah A; Drinkenburg, Wilhelmus W
Publication Date: 2022

Variant appearance in text: APP: I716F
PubMed Link: 34420957
Variant Present in the following documents:
  • Main text
  • jad-88-jad210397.pdf
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Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer's disease.

Molecular Psychiatry
Arroyo-García, Luis Enrique LE; Isla, Arturo G AG; Andrade-Talavera, Yuniesky Y; Balleza-Tapia, Hugo H; Loera-Valencia, Raúl R; Alvarez-Jimenez, Laura L; Pizzirusso, Giusy G; Tambaro, Simone S; Nilsson, Per P; Fisahn, André A
Publication Date: 2021-10

Variant appearance in text: APP: I716F
PubMed Link: 34385602
Variant Present in the following documents:
  • Main text
  • 41380_2021_Article_1257.pdf
View BVdb publication page



Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer's disease.

Molecular Psychiatry
Arroyo-García, Luis Enrique LE; Isla, Arturo G AG; Andrade-Talavera, Yuniesky Y; Balleza-Tapia, Hugo H; Loera-Valencia, Raúl R; Alvarez-Jimenez, Laura L; Pizzirusso, Giusy G; Tambaro, Simone S; Nilsson, Per P; Fisahn, André A
Publication Date: 2021-08-12

Variant appearance in text: APP: I716F
PubMed Link: 34385602
Variant Present in the following documents:
  • Main text
  • 41380_2021_Article_1257.pdf
View BVdb publication page



Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis.

Communications Biology
Jin, Meihua M; Jin, Xiaocen X; Homma, Hidenori H; Fujita, Kyota K; Tanaka, Hikari H; Murayama, Shigeo S; Akatsu, Hiroyasu H; Tagawa, Kazuhiko K; Okazawa, Hitoshi H
Publication Date: 2021-08-12

Variant appearance in text: APP: I716F
PubMed Link: 34385591
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease.

The American Journal Of Pathology
Kalaria, Rajesh N RN; Sepulveda-Falla, Diego D
Publication Date: 2021-11

Variant appearance in text: APP: Ile716Phe
PubMed Link: 34331941
Variant Present in the following documents:
  • Main text
  • main.pdf
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A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.

The Journal Of Biological Chemistry
Sato, Kaori K; Watamura, Naoto N; Fujioka, Ryo R; Mihira, Naomi N; Sekiguchi, Misaki M; Nagata, Kenichi K; Ohshima, Toshio T; Saito, Takashi T; Saido, Takaomi C TC; Sasaguri, Hiroki H
Publication Date: 2021-09

Variant appearance in text: APP: I716F
PubMed Link: 34329683
Variant Present in the following documents:
  • Main text
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Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.

Molecular Neurodegeneration
Benitez, Diana P DP; Jiang, Shenyi S; Wood, Jack J; Wang, Rui R; Hall, Chloe M CM; Peerboom, Carlijn C; Wong, Natalie N; Stringer, Katie M KM; Vitanova, Karina S KS; Smith, Victoria C VC; Joshi, Dhaval D; Saito, Takashi T; Saido, Takaomi C TC; Hardy, John J; Hanrieder, Jörg J; De Strooper, Bart B; Salih, Dervis A DA; Tripathi, Takshashila T; Edwards, Frances A FA; Cummings, Damian M DM
Publication Date: 2021-07-15

Variant appearance in text: APP: I716F
PubMed Link: 34266459
Variant Present in the following documents:
  • 13024_2021_Article_457.pdf
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A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the AppNL-F/NL-F knock-in mouse model.

Aging Cell
Mazzei, Guianfranco G; Ikegami, Ryohei R; Abolhassani, Nona N; Haruyama, Naoki N; Sakumi, Kunihiko K; Saito, Takashi T; Saido, Takaomi C TC; Nakabeppu, Yusaku Y
Publication Date: 2021-08

Variant appearance in text: APP: I716F
PubMed Link: 34245097
Variant Present in the following documents:
  • Main text
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Synaptic Plasticity and Oscillations in Alzheimer's Disease: A Complex Picture of a Multifaceted Disease.

Frontiers In Molecular Neuroscience
Andrade-Talavera, Yuniesky Y; Rodríguez-Moreno, Antonio A
Publication Date: 2021

Variant appearance in text: APP: I716F
PubMed Link: 34220451
Variant Present in the following documents:
  • Main text
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Amyloid Beta-Mediated Changes in Synaptic Function and Spine Number of Neocortical Neurons Depend on NMDA Receptors.

International Journal Of Molecular Sciences
Back, Michaela K MK; Ruggieri, Sonia S; Jacobi, Eric E; von Engelhardt, Jakob J
Publication Date: 2021-06-11

Variant appearance in text: APP: I716F
PubMed Link: 34208315
Variant Present in the following documents:
  • Main text
  • ijms-22-06298.pdf
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Following spatial Aβ aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics.

Science Advances
Michno, Wojciech W; Stringer, Katie M KM; Enzlein, Thomas T; Passarelli, Melissa K MK; Escrig, Stephane S; Vitanova, Karina K; Wood, Jack J; Blennow, Kaj K; Zetterberg, Henrik H; Meibom, Anders A; Hopf, Carsten C; Edwards, Frances A FA; Hanrieder, Jörg J
Publication Date: 2021-06

Variant appearance in text: APP: I716F
PubMed Link: 34134980
Variant Present in the following documents:
  • Main text
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11C-PiB and 124I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention.

Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine
Meier, Silvio R SR; Sehlin, Dag D; Roshanbin, Sahar S; Falk, Victoria Lim VL; Saito, Takashi T; Saido, Takaomi C TC; Neumann, Ulf U; Rokka, Johanna J; Eriksson, Jonas J; Syvänen, Stina S
Publication Date: 2022-02

Variant appearance in text: APP: I716F
PubMed Link: 34088777
Variant Present in the following documents:
  • Main text
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11C-PIB and 124I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention.

Journal Of Nuclear Medicine : Official Publication, Society Of Nuclear Medicine
Meier, Silvio R SR; Sehlin, Dag D; Roshanbin, Sahar S; Lim Falk, Victoria V; Saito, Takashi T; Saido, Takaomi C TC; Neumann, Ulf U; Rokka, Johanna J; Eriksson, Jonas J; Syvanen, Stina S
Publication Date: 2021-06-04

Variant appearance in text: APP: I716F
PubMed Link: 34088777
Variant Present in the following documents:
  • Main text
View BVdb publication page