Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
Acta Neuropathologica Communications
Schilling, Sandra S; Pradhan, Ajay A; Heesch, Amelie A; Helbig, Andrea A; Blennow, Kaj K; Koch, Christian C; Bertgen, Lea L; Koo, Edward H EH; Brinkmalm, Gunnar G; Zetterberg, Henrik H; Kins, Stefan S; Eggert, Simone S
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23
Variant appearance in text: APP: 2080G>A; Asp694Asn
Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer's disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations.
MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Kim, Jinhu J; Kim, Seungjoon S; Kim, Hyeonho H; Hwang, In-Wook IW; Bae, Sungwon S; Karki, Sudeep S; Kim, Dongwook D; Ogelman, Roberto R; Bang, Geul G; Kim, Jin Young JY; Kajander, Tommi T; Um, Ji Won JW; Oh, Won Chan WC; Ko, Jaewon J
MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Kim, Jinhu J; Kim, Seungjoon S; Kim, Hyeonho H; Hwang, In-Wook IW; Bae, Sungwon S; Karki, Sudeep S; Kim, Dongwook D; Ogelman, Roberto R; Bang, Geul G; Kim, Jin Young JY; Kajander, Tommi T; Um, Ji Won JW; Oh, Won Chan WC; Ko, Jaewon J
Sex differences in a murine model of Cerebral Amyloid Angiopathy.
Brain, Behavior, & Immunity - Health
Maniskas, Michael E ME; Mack, Alexis F AF; Morales-Scheihing, Diego D; Finger, Carson C; Zhu, Liang L; Paulter, Robia R; Urayama, Akihiko A; McCullough, Louise D LD; Manwani, Bharti B
Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice.
Neurobiology Of Disease
Fusilier, Allison R AR; Davis, Jennifer A JA; Paul, Jodi R JR; Yates, Stefani D SD; McMeekin, Laura J LJ; Goode, Lacy K LK; Mokashi, Mugdha V MV; Remiszewski, Natalie N; van Groen, Thomas T; Cowell, Rita M RM; McMahon, Lori L LL; Roberson, Erik D ED; Gamble, Karen L KL
In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer's Disease.
International Journal Of Molecular Sciences
Schemmert, Sarah S; Camargo, Luana Cristina LC; Honold, Dominik D; Gering, Ian I; Kutzsche, Janine J; Willuweit, Antje A; Willbold, Dieter D
The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer's Disease in SH-SY5Y cells.
Plos One
Guyon, Antoine A; Rousseau, Joël J; Lamothe, Gabriel G; Tremblay, Jacques P JP
Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.
Journal Of Neuroinflammation
Honarpisheh, Pedram P; Lee, Juneyoung J; Banerjee, Anik A; Blasco-Conesa, Maria P MP; Honarpisheh, Parisa P; d'Aigle, John J; Mamun, Abdullah A AA; Ritzel, Rodney M RM; Chauhan, Anjali A; Ganesh, Bhanu P BP; McCullough, Louise D LD
Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau.
Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology
Rayaprolu, Sruti S; Higginbotham, Lenora L; Bagchi, Pritha P; Watson, Caroline M CM; Zhang, Tian T; Levey, Allan I AI; Rangaraju, Srikant S; Seyfried, Nicholas T NT
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.
Human Molecular Genetics
Fowler, Alan J AJ; Hebron, Michaeline M; Balaraman, Kaluvu K; Shi, Wangke W; Missner, Alexander A AA; Greenzaid, Jonathan D JD; Chiu, Timothy L TL; Ullman, Clementina C; Weatherdon, Ethan E; Duka, Val V; Torres-Yaghi, Yasar Y; Pagan, Fernando L FL; Liu, Xiaoguang X; Ressom, Habtom H; Ahn, Jaeil J; Wolf, Christian C; Moussa, Charbel C
Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.
International Journal Of Molecular Sciences
Gatti, Laura L; Tinelli, Francesca F; Scelzo, Emma E; Arioli, Francesco F; Di Fede, Giuseppe G; Obici, Laura L; Pantoni, Leonardo L; Giaccone, Giorgio G; Caroppo, Paola P; Parati, Eugenio Agostino EA; Bersano, Anna A
Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant.
The Journal Of Biological Chemistry
Crooks, Elliot J EJ; Irizarry, Brandon A BA; Ziliox, Martine M; Kawakami, Toru T; Victor, Tiffany T; Xu, Feng F; Hojo, Hironobu H; Chiu, Kelley K; Simmerling, Carlos C; Van Nostrand, William E WE; Smith, Steven O SO; Miller, Lisa M LM
Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model.
International Journal Of Molecular Sciences
Robison, Lisa S LS; Francis, Nikita N; Popescu, Dominique L DL; Anderson, Maria E ME; Hatfield, Joshua J; Xu, Feng F; Anderson, Brenda J BJ; Van Nostrand, William E WE; Robinson, John K JK
Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation.
Nature Communications
Park, Jun Sung JS; Lee, Junehawk J; Jung, Eun Sun ES; Kim, Myeong-Heui MH; Kim, Il Bin IB; Son, Hyeonju H; Kim, Sangwoo S; Kim, Sanghyeon S; Park, Young Mok YM; Mook-Jung, Inhee I; Yu, Seok Jong SJ; Lee, Jeong Ho JH
Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy.
Journal Of Neuroinflammation
Robison, Lisa S LS; Popescu, Dominique L DL; Anderson, Maria E ME; Francis, Nikita N; Hatfield, Joshua J; Sullivan, Joseph K JK; Beigelman, Steven I SI; Xu, Feng F; Anderson, Brenda J BJ; Van Nostrand, William E WE; Robinson, John K JK
A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.
The American Journal Of Pathology
Davis, Judianne J; Xu, Feng F; Hatfield, Joshua J; Lee, Hedok H; Hoos, Michael D MD; Popescu, Dominique D; Crooks, Elliot E; Kim, Regina R; Smith, Steven O SO; Robinson, John K JK; Benveniste, Helene H; Van Nostrand, William E WE
Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid.