APP c.2011A>T ;(p.M671L)

Variant ID: 21-27269938-T-A

NM_000484.3(APP):c.2011A>T;(p.M671L)

This variant was identified in 559 publications

View GRCh38 version.




Publications:


The neuroprotective N-terminal amyloid-β core hexapeptide reverses reactive gliosis and gliotoxicity in Alzheimer's disease pathology models.

Journal Of Neuroinflammation
Lantz, Megan J MJ; Roberts, Alyssa M AM; Delgado, Donovan D DD; Nichols, Robert A RA
Publication Date: 2023-05-27

Variant appearance in text: APP: M671L
PubMed Link: 37245024
Variant Present in the following documents:
  • Main text
  • 12974_2023_Article_2807.pdf
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Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease.

Biorxiv : The Preprint Server For Biology
Chartampila, Elissavet E; Elayouby, Karim S KS; Leary, Paige P; LaFrancois, John J JJ; Alcantara-Gonzalez, David D; Jain, Swati S; Gerencer, Kasey K; Botterill, Justin J JJ; Ginsberg, Stephen D SD; Scharfman, Helen E HE
Publication Date: 2023-05-12

Variant appearance in text: APP: Met671Leu
PubMed Link: 37214805
Variant Present in the following documents:
  • Main text
  • nihpp-2023.05.12.540428v1.pdf
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Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology.

Acta Neuropathologica Communications
Suelves, Nuria N; Saleki, Shirine S; Ibrahim, Tasha T; Palomares, Debora D; Moonen, Sebastiaan S; Koper, Marta J MJ; Vrancx, Céline C; Vadukul, Devkee M DM; Papadopoulos, Nicolas N; Viceconte, Nikenza N; Claude, Eloïse E; Vandenberghe, Rik R; von Arnim, Christine A F CAF; Constantinescu, Stefan N SN; Thal, Dietmar Rudolf DR; Decottignies, Anabelle A; Kienlen-Campard, Pascal P
Publication Date: 2023-05-17

Variant appearance in text: APP: M671L
PubMed Link: 37198698
Variant Present in the following documents:
  • 40478_2023_Article_1578.pdf
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Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis of the Hippocampus from the 5xFAD Alzheimer's Disease Mouse Model.

Cells
Thanou, Evangelia E; Koopmans, Frank F; Pita-Illobre, Débora D; Klaassen, Remco V RV; Özer, Berna B; Charalampopoulos, Ioannis I; Smit, August B AB; Li, Ka Wan KW
Publication Date: 2023-04-25

Variant appearance in text: APP: M671L
PubMed Link: 37174641
Variant Present in the following documents:
  • Main text
  • cells-12-01242.pdf
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Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead.

Frontiers In Integrative Neuroscience
Sahu, Prangya Parimita PP; Tseng, Philip P
Publication Date: 2023

Variant appearance in text: APP: M671L
PubMed Link: 37138796
Variant Present in the following documents:
  • Main text
  • fnint-17-1146687.pdf
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What can traditional Chinese medicine do for adult neurogenesis?

Frontiers In Neuroscience
Shen, Wei W; Jiang, Ning N; Zhou, Wenxia W
Publication Date: 2023

Variant appearance in text: APP: M671L
PubMed Link: 37123359
Variant Present in the following documents:
  • Main text
  • fnins-17-1158228.pdf
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An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease.

Nature Aging
Jiang, Yuanbing Y; Zhou, Xiaopu X; Wong, Hiu Yi HY; Ouyang, Li L; Ip, Fanny C F FCF; Chau, Vicky M N VMN; Lau, Shun-Fat SF; Wu, Wei W; Wong, Daniel Y K DYK; Seo, Heukjin H; Fu, Wing-Yu WY; Lai, Nicole C H NCH; Chen, Yuewen Y; Chen, Yu Y; Tong, Estella P S EPS; , ; Mok, Vincent C T VCT; Kwok, Timothy C Y TCY; Mok, Kin Y KY; Shoai, Maryam M; Lehallier, Benoit B; Losada, Patricia Morán PM; O'Brien, Eleanor E; Porter, Tenielle T; Laws, Simon M SM; Hardy, John J; Wyss-Coray, Tony T; Masters, Colin L CL; Fu, Amy K Y AKY; Ip, Nancy Y NY
Publication Date: 2022-07

Variant appearance in text: APP: Met671Leu
PubMed Link: 37117777
Variant Present in the following documents:
  • Main text
  • 43587_2022_Article_241.pdf
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Alzheimer's disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism.

Biorxiv : The Preprint Server For Biology
Kuhn, Madison K MK; Fleeman, Rebecca M RM; Beidler, Lynne M LM; Snyder, Amanda M AM; Chan, Dennis C DC; Proctor, Elizabeth A EA
Publication Date: 2023-04-07

Variant appearance in text: APP: M671L
PubMed Link: 37066287
Variant Present in the following documents:
  • Main text
  • nihpp-2023.04.07.536014v1.pdf
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Neurodegenerative Changes in the Brains of the 5xFAD Alzheimer's Disease Model Mice Investigated by High-Field and High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance Spectroscopy.

International Journal Of Molecular Sciences
Yoo, Chi-Hyeon CH; Kim, Jinho J; Baek, Hyeon-Man HM; Chang, Keun-A KA; Choe, Bo-Young BY
Publication Date: 2023-03-07

Variant appearance in text: APP: M671L
PubMed Link: 36982146
Variant Present in the following documents:
  • Main text
  • ijms-24-05073.pdf
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Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer's disease.

Ibro Neuroscience Reports
Chernyuk, D D; Callens, M M; Polozova, M M; Gordeev, A A; Chigriai, M M; Rakovskaya, A A; Ilina, A A; Pchitskaya, E E; Van den Haute, C C; Vervliet, T T; Bultynck, G G; Bezprozvanny, I I
Publication Date: 2023-06

Variant appearance in text: APP: M671L
PubMed Link: 36926591
Variant Present in the following documents:
  • main.pdf
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Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer's Disease.

Cells
Poon, Chi Him CH; Wong, San Tung Nicholas STN; Roy, Jaydeep J; Wang, Yingyi Y; Chan, Hui Wang Hujo HWH; Steinbusch, Harry H; Blokland, Arjan A; Temel, Yasin Y; Aquili, Luca L; Lim, Lee Wei LW
Publication Date: 2023-03-01

Variant appearance in text: APP: M671L
PubMed Link: 36899916
Variant Present in the following documents:
  • Main text
  • cells-12-00780.pdf
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Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets.

Scientific Reports
Kodam, Pradeep P; Sai Swaroop, R R; Pradhan, Sai Sanwid SS; Sivaramakrishnan, Venketesh V; Vadrevu, Ramakrishna R
Publication Date: 2023-03-06

Variant appearance in text: APP: M671L
PubMed Link: 36879094
Variant Present in the following documents:
  • Main text
  • 41598_2023_Article_30892.pdf
  • 41598_2023_30892_MOESM12_ESM.pdf
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CREB3L2-ATF4 heterodimerization defines a transcriptional hub of Alzheimer's disease gene expression linked to neuropathology.

Science Advances
Gouveia Roque, Cláudio C; Chung, Kyung Min KM; McCurdy, Ethan P EP; Jagannathan, Radhika R; Randolph, Lisa K LK; Herline-Killian, Krystal K; Baleriola, Jimena J; Hengst, Ulrich U
Publication Date: 2023-03-03

Variant appearance in text: APP: M671L
PubMed Link: 36867706
Variant Present in the following documents:
  • Main text
  • sciadv.add2671.pdf
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Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice.

Frontiers In Immunology
Daini, Eleonora E; Vandini, Eleonora E; Bodria, Martina M; Liao, Wenjie W; Baraldi, Carlo C; Secco, Valentina V; Ottani, Alessandra A; Zoli, Michele M; Giuliani, Daniela D; Vilella, Antonietta A
Publication Date: 2022

Variant appearance in text: APP: M671L
PubMed Link: 36703981
Variant Present in the following documents:
  • Main text
  • fimmu-13-1082036.pdf
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Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease.

Alzheimer'S Research & Therapy
Li, Xiao X; Zhang, Deng-Feng DF; Bi, Rui R; Tan, Li-Wen LW; Chen, Xiaogang X; Xu, Min M; Yao, Yong-Gang YG
Publication Date: 2023-01-21

Variant appearance in text: APP: M671L
PubMed Link: 36670424
Variant Present in the following documents:
  • 13195_2022_Article_1159.pdf
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Preclinical Models for Alzheimer's Disease: Past, Present, and Future Approaches.

Acs Omega
Akhtar, Ansab A; Gupta, Shraddha M SM; Dwivedi, Shubham S; Kumar, Devendra D; Shaikh, Mohd Farooq MF; Negi, Arvind A
Publication Date: 2022-12-27

Variant appearance in text: APP: M671L
PubMed Link: 36591205
Variant Present in the following documents:
  • Main text
  • ao2c05609.pdf
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No difference in cerebral perfusion between the wild-type and the 5XFAD mouse model of Alzheimer's disease.

Scientific Reports
DeBay, Drew R DR; Phi, Tân-Trào TT; Bowen, Chris V CV; Burrell, Steven C SC; Darvesh, Sultan S
Publication Date: 2022-12-22

Variant appearance in text: APP: M671L
PubMed Link: 36550188
Variant Present in the following documents:
  • Main text
  • 41598_2022_Article_26713.pdf
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Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ42 oligomers by controlling their interactions with cell membranes.

Chemical Science
Yu, Zhengxin Z; Guo, Weijie W; Patel, Shrey S; Cho, Hong-Jun HJ; Sun, Liang L; Mirica, Liviu M LM
Publication Date: 2022-11-09

Variant appearance in text: APP: M671L
PubMed Link: 36519059
Variant Present in the following documents:
  • SC-013-D2SC02654F-s001.pdf
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Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer's disease in a 5 × FAD mouse model.

Frontiers In Aging Neuroscience
Sun, Ting T; Zeng, Li L; Cai, Zhongdi Z; Liu, Qingshan Q; Li, Zhuorong Z; Liu, Rui R
Publication Date: 2022

Variant appearance in text: APP: M671L
PubMed Link: 36466608
Variant Present in the following documents:
  • fnagi-14-1020699.pdf
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Interdisciplinary Approaches to Deal with Alzheimer's Disease-From Bench to Bedside: What Feasible Options Do Already Exist Today?

Biomedicines
Ablinger, Irene I; Dressel, Katharina K; Rott, Thea T; Lauer, Anna Andrea AA; Tiemann, Michael M; Batista, João Pedro JP; Taddey, Tim T; Grimm, Heike Sabine HS; Grimm, Marcus Otto Walter MOW
Publication Date: 2022-11-14

Variant appearance in text: APP: M671L
PubMed Link: 36428494
Variant Present in the following documents:
  • Main text
  • biomedicines-10-02922.pdf
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Branched-Chain Amino Acids Are Linked with Alzheimer's Disease-Related Pathology and Cognitive Deficits.

Cells
Siddik, Md Abu Bakkar MAB; Mullins, Caitlyn A CA; Kramer, Alyssa A; Shah, Harsh H; Gannaban, Ritchel B RB; Zabet-Moghaddam, Masoud M; Huebinger, Ryan M RM; Hegde, Vijay K VK; MohanKumar, Sheba M J SMJ; MohanKumar, Puliyur S PS; Shin, Andrew C AC
Publication Date: 2022-11-07

Variant appearance in text: APP: M671L
PubMed Link: 36359919
Variant Present in the following documents:
  • Main text
  • cells-11-03523.pdf
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rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy Type-2.

Cerebral Circulation - Cognition And Behavior
Davis, Judianne J; Xu, Feng F; Zhu, Xiaoyue X; Van Nostrand, William E WE
Publication Date: 2022

Variant appearance in text: APP: M671L
PubMed Link: 36324401
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.

Alzheimer'S & Dementia : The Journal Of The Alzheimer'S Association
Novotny, Brenna C BC; Fernandez, Maria Victoria MV; Wang, Ciyang C; Budde, John P JP; Bergmann, Kristy K; Eteleeb, Abdallah M AM; Bradley, Joseph J; Webster, Carol C; Ebl, Curtis C; Norton, Joanne J; Gentsch, Jen J; Dube, Umber U; Wang, Fengxian F; Morris, John C JC; Bateman, Randall J RJ; Perrin, Richard J RJ; McDade, Eric E; Xiong, Chengjie C; Chhatwal, Jasmeer J; , ; , ; , ; Goate, Alison A; Farlow, Martin M; Schofield, Peter P; Chui, Helena H; Karch, Celeste M CM; Cruchaga, Carlos C; Benitez, Bruno A BA; Harari, Oscar O
Publication Date: 2022-10-17

Variant appearance in text: APP: Met671Leu
PubMed Link: 36251323
Variant Present in the following documents:
  • NIHMS1865189-supplement-SUPPORTING_INFORMATION_3.xlsx, sheet 1
View BVdb publication page



Hypothesis review: Alzheimer's overture guidelines.

Brain Pathology (Zurich, Switzerland)
Ferrer, Isidro I
Publication Date: 2022-10-12

Variant appearance in text: APP: M671L
PubMed Link: 36223647
Variant Present in the following documents:
  • Main text
  • BPA-33-e13122.pdf
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Early impairment of cortical circuit plasticity and connectivity in the 5XFAD Alzheimer's disease mouse model.

Translational Psychiatry
Chen, Chang C; Ma, Xiaokuang X; Wei, Jing J; Shakir, Neha N; Zhang, Jessica K JK; Zhang, Le L; Nehme, Antoine A; Cui, Yuehua Y; Ferguson, Deveroux D; Bai, Feng F; Qiu, Shenfeng S
Publication Date: 2022-09-08

Variant appearance in text: APP: M671L
PubMed Link: 36075886
Variant Present in the following documents:
  • Main text
  • 41398_2022_Article_2132.pdf
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Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation.

Experimental & Molecular Medicine
Kim, Dong Kyu DK; Jeong, Hyobin H; Bae, Jingi J; Cha, Moon-Yong MY; Kang, Moonkyung M; Shin, Dongjin D; Ha, Shinwon S; Hyeon, Seung Jae SJ; Kim, Hokeun H; Suh, Kyujin K; Choi, Mi-Sun MS; Ryu, Hoon H; Yu, Seong-Woon SW; Kim, Jong-Il JI; Kim, Yeon-Soo YS; Lee, Sang-Won SW; Hwang, Daehee D; Mook-Jung, Inhee I
Publication Date: 2022-09

Variant appearance in text: APP: M671L
PubMed Link: 36056186
Variant Present in the following documents:
  • Main text
  • 12276_2022_Article_841.pdf
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Seed-induced Aβ deposits in the corpus callosum disrupt white matter integrity in a mouse model of Alzheimer's disease.

Frontiers In Cellular Neuroscience
Aires, Vanessa V; Ziegler-Waldkirch, Stephanie S; Friesen, Marina M; Reichardt, Wilfried W; Erny, Daniel D; Loreth, Desiree D; Harborne, Andrew A; Kretz, Oliver O; von Elverfeldt, Dominik D; Meyer-Luehmann, Melanie M
Publication Date: 2022

Variant appearance in text: APP: M671L
PubMed Link: 36003141
Variant Present in the following documents:
  • fncel-16-862918.pdf
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Seed-induced Aβ deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer's disease.

Molecular Psychiatry
Ziegler-Waldkirch, Stephanie S; Friesen, Marina M; Loreth, Desirée D; Sauer, Jonas-Frederic JF; Kemna, Solveig S; Hilse, Alexandra A; Erny, Daniel D; Helm, Christina C; D Errico, Paolo P; Prinz, Marco M; Bartos, Marlene M; Meyer-Luehmann, Melanie M
Publication Date: 2022-10

Variant appearance in text: APP: M671L
PubMed Link: 35869271
Variant Present in the following documents:
  • 41380_2022_Article_1686.pdf
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Inbred Mice Again at Stake: How the Cognitive Profile of the Wild-Type Mouse Background Discloses Pathogenic Effects of APP Mutations.

Frontiers In Behavioral Neuroscience
Ammassari-Teule, Martine M
Publication Date: 2022

Variant appearance in text: APP: M671L
PubMed Link: 35813596
Variant Present in the following documents:
  • Main text
  • fnbeh-16-868473.pdf
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Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?

Translational Psychiatry
Targa Dias Anastacio, Helena H; Matosin, Natalie N; Ooi, Lezanne L
Publication Date: 2022-06-22

Variant appearance in text: APP: M671L
PubMed Link: 35732622
Variant Present in the following documents:
  • 41398_2022_Article_2024.pdf
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High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice.

Frontiers In Neuroscience
Yin, Xianzhen X; Zhang, Xiaochuan X; Zhang, Jingjing J; Yang, Weicheng W; Sun, Xian X; Zhang, Haiyan H; Gao, Zhaobing Z; Jiang, Hualiang H
Publication Date: 2022

Variant appearance in text: APP: M671L
PubMed Link: 35516801
Variant Present in the following documents:
  • fnins-16-870520.pdf
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Mucin-Type O-Glycosylation Proximal to β-Secretase Cleavage Site Affects APP Processing and Aggregation Fate.

Frontiers In Chemistry
Singh, YashoNandini Y; Regmi, Deepika D; Ormaza, David D; Ayyalasomayajula, Ramya R; Vela, Nancy N; Mundim, Gustavo G; Du, Deguo D; Minond, Dmitriy D; Cudic, Maré M
Publication Date: 2022

Variant appearance in text: APP: Met671Leu
PubMed Link: 35464218
Variant Present in the following documents:
  • fchem-10-859822.pdf
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Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease.

International Journal Of Molecular Sciences
Ilina, Anastasiia A; Khavinson, Vladimir V; Linkova, Natalia N; Petukhov, Mikhael M
Publication Date: 2022-04-12

Variant appearance in text: APP: M671L
PubMed Link: 35457077
Variant Present in the following documents:
  • Main text
  • ijms-23-04259.pdf
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Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice.

The Journal Of Clinical Investigation
Zou, Hao-Yu HY; Guo, Lin L; Zhang, Bei B; Chen, Si S; Wu, Xin-Rong XR; Liu, Xian-Dong XD; Xu, Xin-Yu XY; Li, Bin-Yin BY; Chen, Shengdi S; Xu, Nan-Jie NJ; Sun, Suya S
Publication Date: 2022-04-15

Variant appearance in text: APP: M671L
PubMed Link: 35426376
Variant Present in the following documents:
  • jci-132-149160.pdf
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miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease.

International Journal Of Biological Sciences
Park, Hyunjun H; Lee, Yeong-Bae YB; Chang, Keun-A KA
Publication Date: 2022

Variant appearance in text: APP: M671L
PubMed Link: 35342350
Variant Present in the following documents:
  • ijbsv18p2220.pdf
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Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.

Cellular And Molecular Life Sciences : Cmls
Marengo, Liana L; Armbrust, Fred F; Schoenherr, Caroline C; Storck, Steffen E SE; Schmitt, Ulrich U; Zampar, Silvia S; Wirths, Oliver O; Altmeppen, Hermann H; Glatzel, Markus M; Kaether, Christoph C; Weggen, Sascha S; Becker-Pauly, Christoph C; Pietrzik, Claus U CU
Publication Date: 2022-03-02

Variant appearance in text: APP: M671L
PubMed Link: 35235058
Variant Present in the following documents:
  • 18_2022_Article_4205.pdf
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Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta.

Chonnam Medical Journal
Lee, Sunjun S; Choi, Won-Seok WS
Publication Date: 2022-01

Variant appearance in text: APP: M671L
PubMed Link: 35169554
Variant Present in the following documents:
  • Main text
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New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction.

International Journal Of Molecular Sciences
Tsuneura, Yumi Y; Nakai, Tsuyoshi T; Mizoguchi, Hiroyuki H; Yamada, Kiyofumi K
Publication Date: 2022-02-06

Variant appearance in text: APP: M671L
PubMed Link: 35163751
Variant Present in the following documents:
  • Main text
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New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction.

International Journal Of Molecular Sciences
Tsuneura, Yumi Y; Nakai, Tsuyoshi T; Mizoguchi, Hiroyuki H; Yamada, Kiyofumi K
Publication Date: 2022-02-06

Variant appearance in text: APP: M671L
PubMed Link: 35163751
Variant Present in the following documents:
  • Main text
View BVdb publication page