Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease.
Biorxiv : The Preprint Server For Biology
Chartampila, Elissavet E; Elayouby, Karim S KS; Leary, Paige P; LaFrancois, John J JJ; Alcantara-Gonzalez, David D; Jain, Swati S; Gerencer, Kasey K; Botterill, Justin J JJ; Ginsberg, Stephen D SD; Scharfman, Helen E HE
Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis of the Hippocampus from the 5xFAD Alzheimer's Disease Mouse Model.
Cells
Thanou, Evangelia E; Koopmans, Frank F; Pita-Illobre, Débora D; Klaassen, Remco V RV; Özer, Berna B; Charalampopoulos, Ioannis I; Smit, August B AB; Li, Ka Wan KW
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease.
Nature Aging
Jiang, Yuanbing Y; Zhou, Xiaopu X; Wong, Hiu Yi HY; Ouyang, Li L; Ip, Fanny C F FCF; Chau, Vicky M N VMN; Lau, Shun-Fat SF; Wu, Wei W; Wong, Daniel Y K DYK; Seo, Heukjin H; Fu, Wing-Yu WY; Lai, Nicole C H NCH; Chen, Yuewen Y; Chen, Yu Y; Tong, Estella P S EPS; , ; Mok, Vincent C T VCT; Kwok, Timothy C Y TCY; Mok, Kin Y KY; Shoai, Maryam M; Lehallier, Benoit B; Losada, Patricia Morán PM; O'Brien, Eleanor E; Porter, Tenielle T; Laws, Simon M SM; Hardy, John J; Wyss-Coray, Tony T; Masters, Colin L CL; Fu, Amy K Y AKY; Ip, Nancy Y NY
Neurodegenerative Changes in the Brains of the 5xFAD Alzheimer's Disease Model Mice Investigated by High-Field and High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance Spectroscopy.
International Journal Of Molecular Sciences
Yoo, Chi-Hyeon CH; Kim, Jinho J; Baek, Hyeon-Man HM; Chang, Keun-A KA; Choe, Bo-Young BY
Neuroprotective properties of anti-apoptotic BCL-2 proteins in 5xFAD mouse model of Alzheimer's disease.
Ibro Neuroscience Reports
Chernyuk, D D; Callens, M M; Polozova, M M; Gordeev, A A; Chigriai, M M; Rakovskaya, A A; Ilina, A A; Pchitskaya, E E; Van den Haute, C C; Vervliet, T T; Bultynck, G G; Bezprozvanny, I I
Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer's Disease.
Cells
Poon, Chi Him CH; Wong, San Tung Nicholas STN; Roy, Jaydeep J; Wang, Yingyi Y; Chan, Hui Wang Hujo HWH; Steinbusch, Harry H; Blokland, Arjan A; Temel, Yasin Y; Aquili, Luca L; Lim, Lee Wei LW
Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice.
Frontiers In Immunology
Daini, Eleonora E; Vandini, Eleonora E; Bodria, Martina M; Liao, Wenjie W; Baraldi, Carlo C; Secco, Valentina V; Ottani, Alessandra A; Zoli, Michele M; Giuliani, Daniela D; Vilella, Antonietta A
Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer's disease in a 5 × FAD mouse model.
Frontiers In Aging Neuroscience
Sun, Ting T; Zeng, Li L; Cai, Zhongdi Z; Liu, Qingshan Q; Li, Zhuorong Z; Liu, Rui R
Interdisciplinary Approaches to Deal with Alzheimer's Disease-From Bench to Bedside: What Feasible Options Do Already Exist Today?
Biomedicines
Ablinger, Irene I; Dressel, Katharina K; Rott, Thea T; Lauer, Anna Andrea AA; Tiemann, Michael M; Batista, João Pedro JP; Taddey, Tim T; Grimm, Heike Sabine HS; Grimm, Marcus Otto Walter MOW
Branched-Chain Amino Acids Are Linked with Alzheimer's Disease-Related Pathology and Cognitive Deficits.
Cells
Siddik, Md Abu Bakkar MAB; Mullins, Caitlyn A CA; Kramer, Alyssa A; Shah, Harsh H; Gannaban, Ritchel B RB; Zabet-Moghaddam, Masoud M; Huebinger, Ryan M RM; Hegde, Vijay K VK; MohanKumar, Sheba M J SMJ; MohanKumar, Puliyur S PS; Shin, Andrew C AC
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.
Alzheimer'S & Dementia : The Journal Of The Alzheimer'S Association
Novotny, Brenna C BC; Fernandez, Maria Victoria MV; Wang, Ciyang C; Budde, John P JP; Bergmann, Kristy K; Eteleeb, Abdallah M AM; Bradley, Joseph J; Webster, Carol C; Ebl, Curtis C; Norton, Joanne J; Gentsch, Jen J; Dube, Umber U; Wang, Fengxian F; Morris, John C JC; Bateman, Randall J RJ; Perrin, Richard J RJ; McDade, Eric E; Xiong, Chengjie C; Chhatwal, Jasmeer J; , ; , ; , ; Goate, Alison A; Farlow, Martin M; Schofield, Peter P; Chui, Helena H; Karch, Celeste M CM; Cruchaga, Carlos C; Benitez, Bruno A BA; Harari, Oscar O
Seed-induced Aβ deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer's disease.
Molecular Psychiatry
Ziegler-Waldkirch, Stephanie S; Friesen, Marina M; Loreth, Desirée D; Sauer, Jonas-Frederic JF; Kemna, Solveig S; Hilse, Alexandra A; Erny, Daniel D; Helm, Christina C; D Errico, Paolo P; Prinz, Marco M; Bartos, Marlene M; Meyer-Luehmann, Melanie M
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
Cellular And Molecular Life Sciences : Cmls
Marengo, Liana L; Armbrust, Fred F; Schoenherr, Caroline C; Storck, Steffen E SE; Schmitt, Ulrich U; Zampar, Silvia S; Wirths, Oliver O; Altmeppen, Hermann H; Glatzel, Markus M; Kaether, Christoph C; Weggen, Sascha S; Becker-Pauly, Christoph C; Pietrzik, Claus U CU