APP c.2010G>T ;(p.K670N)

Variant ID: 21-27269939-C-A

NM_000484.3(APP):c.2010G>T;(p.K670N)

This variant was identified in 1197 publications

View GRCh38 version.




Publications:


Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy.

Journal Of Ginseng Research
Wang, Ni N; Yang, Junyan J; Chen, Ruijun R; Liu, Yunyun Y; Liu, Shunjie S; Pan, Yining Y; Lei, Qingfeng Q; Wang, Yuzhou Y; He, Lu L; Song, Youqiang Y; Li, Zhong Z
Publication Date: 2023-05

Variant appearance in text: APP: K670N
PubMed Link: 37252274
Variant Present in the following documents:
  • Main text
  • main.pdf
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Preliminary In Vitro and In Vivo Insights of In Silico Candidate Repurposed Drugs for Alzheimer's Disease.

Life (Basel, Switzerland)
Savva, Kyriaki K; Zachariou, Margarita M; Kynigopoulos, Demos D; Fella, Eleni E; Vitali, Maria-Ioanna MI; Kosofidou, Xeni X; Spyrou, Michail M; Sargiannidou, Irene I; Panayiotou, Elena E; Dietis, Nikolas N; Spyrou, George M GM
Publication Date: 2023-04-27

Variant appearance in text: APP: K670N
PubMed Link: 37240740
Variant Present in the following documents:
  • Main text
  • life-13-01095.pdf
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Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology.

Acta Neuropathologica Communications
Suelves, Nuria N; Saleki, Shirine S; Ibrahim, Tasha T; Palomares, Debora D; Moonen, Sebastiaan S; Koper, Marta J MJ; Vrancx, Céline C; Vadukul, Devkee M DM; Papadopoulos, Nicolas N; Viceconte, Nikenza N; Claude, Eloïse E; Vandenberghe, Rik R; von Arnim, Christine A F CAF; Constantinescu, Stefan N SN; Thal, Dietmar Rudolf DR; Decottignies, Anabelle A; Kienlen-Campard, Pascal P
Publication Date: 2023-05-17

Variant appearance in text: APP: K670N
PubMed Link: 37198698
Variant Present in the following documents:
  • Main text
  • 40478_2023_Article_1578.pdf
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Suspension TRAPping Filter (sTRAP) Sample Preparation for Quantitative Proteomics in the Low µg Input Range Using a Plasmid DNA Micro-Spin Column: Analysis of the Hippocampus from the 5xFAD Alzheimer's Disease Mouse Model.

Cells
Thanou, Evangelia E; Koopmans, Frank F; Pita-Illobre, Débora D; Klaassen, Remco V RV; Özer, Berna B; Charalampopoulos, Ioannis I; Smit, August B AB; Li, Ka Wan KW
Publication Date: 2023-04-25

Variant appearance in text: APP: K670N
PubMed Link: 37174641
Variant Present in the following documents:
  • Main text
  • cells-12-01242.pdf
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Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead.

Frontiers In Integrative Neuroscience
Sahu, Prangya Parimita PP; Tseng, Philip P
Publication Date: 2023

Variant appearance in text: APP: K670N
PubMed Link: 37138796
Variant Present in the following documents:
  • Main text
  • fnint-17-1146687.pdf
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A comparison of machine learning approaches for the quantification of microglial cells in the brain of mice, rats and non-human primates.

Plos One
Anwer, Danish M DM; Gubinelli, Francesco F; Kurt, Yunus A YA; Sarauskyte, Livija L; Jacobs, Febe F; Venuti, Chiara C; Sandoval, Ivette M IM; Yang, Yiyi Y; Stancati, Jennifer J; Mazzocchi, Martina M; Brandi, Edoardo E; O'Keeffe, Gerard G; Steece-Collier, Kathy K; Li, Jia-Yi JY; Deierborg, Tomas T; Manfredsson, Fredric P FP; Davidsson, Marcus M; Heuer, Andreas A
Publication Date: 2023

Variant appearance in text: APP: K670N
PubMed Link: 37126506
Variant Present in the following documents:
  • Main text
  • pone.0284480.pdf
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An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease.

Nature Aging
Jiang, Yuanbing Y; Zhou, Xiaopu X; Wong, Hiu Yi HY; Ouyang, Li L; Ip, Fanny C F FCF; Chau, Vicky M N VMN; Lau, Shun-Fat SF; Wu, Wei W; Wong, Daniel Y K DYK; Seo, Heukjin H; Fu, Wing-Yu WY; Lai, Nicole C H NCH; Chen, Yuewen Y; Chen, Yu Y; Tong, Estella P S EPS; , ; Mok, Vincent C T VCT; Kwok, Timothy C Y TCY; Mok, Kin Y KY; Shoai, Maryam M; Lehallier, Benoit B; Losada, Patricia Morán PM; O'Brien, Eleanor E; Porter, Tenielle T; Laws, Simon M SM; Hardy, John J; Wyss-Coray, Tony T; Masters, Colin L CL; Fu, Amy K Y AKY; Ip, Nancy Y NY
Publication Date: 2022-07

Variant appearance in text: APP: Lys670Asn
PubMed Link: 37117777
Variant Present in the following documents:
  • Main text
  • 43587_2022_Article_241.pdf
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Alzheimer's disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism.

Biorxiv : The Preprint Server For Biology
Kuhn, Madison K MK; Fleeman, Rebecca M RM; Beidler, Lynne M LM; Snyder, Amanda M AM; Chan, Dennis C DC; Proctor, Elizabeth A EA
Publication Date: 2023-04-07

Variant appearance in text: APP: K670N
PubMed Link: 37066287
Variant Present in the following documents:
  • Main text
  • nihpp-2023.04.07.536014v1.pdf
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Long-Term Administration of Vespa velutina nigrithorax Venom Ameliorates Alzheimer's Phenotypes in 5xFAD Transgenic Mice.

Toxins
Jeong, Yoon Ah YA; Yun, Hyun Seok HS; Kim, Yoonsu Y; Jang, Chan Ho CH; Lim, Ji Sun JS; Kim, Hyo Jung HJ; Choi, Moon Bo MB; Jung, Jae Woo JW; Oh, Jisun J; Kim, Jong-Sang JS
Publication Date: 2023-03-06

Variant appearance in text: APP: K670N
PubMed Link: 36977094
Variant Present in the following documents:
  • Main text
  • toxins-15-00203.pdf
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Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone.

Alzheimer'S Research & Therapy
Chen, Li L; Xiong, Lei L; Yao, Lingling L; Pan, Jinxiu J; Arzola, Emily E; Zhu, Xiaojuan X; Mei, Lin L; Xiong, Wen-Cheng WC
Publication Date: 2023-03-14

Variant appearance in text: APP: K670N
PubMed Link: 36918976
Variant Present in the following documents:
  • Main text
  • 13195_2023_Article_1202.pdf
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Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer's Disease.

Cells
Poon, Chi Him CH; Wong, San Tung Nicholas STN; Roy, Jaydeep J; Wang, Yingyi Y; Chan, Hui Wang Hujo HWH; Steinbusch, Harry H; Blokland, Arjan A; Temel, Yasin Y; Aquili, Luca L; Lim, Lee Wei LW
Publication Date: 2023-03-01

Variant appearance in text: APP: K670N
PubMed Link: 36899916
Variant Present in the following documents:
  • Main text
  • cells-12-00780.pdf
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Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets.

Scientific Reports
Kodam, Pradeep P; Sai Swaroop, R R; Pradhan, Sai Sanwid SS; Sivaramakrishnan, Venketesh V; Vadrevu, Ramakrishna R
Publication Date: 2023-03-06

Variant appearance in text: APP: K670N
PubMed Link: 36879094
Variant Present in the following documents:
  • Main text
  • 41598_2023_30892_MOESM12_ESM.pdf
  • 41598_2023_Article_30892.pdf
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Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 in Alzheimer's disease.

Scientific Reports
Fertan, Emre E; Gendron, William H WH; Wong, Aimée A AA; Hanson, Gabrielle M GM; Brown, Richard E RE; Weaver, Ian C G ICG
Publication Date: 2023-02-04

Variant appearance in text: APP: K670N
PubMed Link: 36739453
Variant Present in the following documents:
  • Main text
  • 41598_2023_Article_29248.pdf
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Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier.

Molecular Neurodegeneration
Kisler, Kassandra K; Sagare, Abhay P AP; Lazic, Divna D; Bazzi, Sam S; Lawson, Erica E; Hsu, Ching-Ju CJ; Wang, Yaoming Y; Ramanathan, Anita A; Nelson, Amy R AR; Zhao, Zhen Z; Zlokovic, Berislav V BV
Publication Date: 2023-01-27

Variant appearance in text: APP: K670N
PubMed Link: 36707892
Variant Present in the following documents:
  • Main text
  • 13024_2023_Article_597.pdf
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Leveraging genetic diversity in mice to inform individual differences in brain microstructure and memory.

Frontiers In Behavioral Neuroscience
Murdy, Thomas J TJ; Dunn, Amy R AR; Singh, Surjeet S; Telpoukhovskaia, Maria A MA; Zhang, Shanrong S; White, Jacqueline K JK; Kahn, Itamar I; Febo, Marcelo M; Kaczorowski, Catherine C CC
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 36703722
Variant Present in the following documents:
  • Main text
  • fnbeh-16-1033975.pdf
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Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease.

Alzheimer'S Research & Therapy
Li, Xiao X; Zhang, Deng-Feng DF; Bi, Rui R; Tan, Li-Wen LW; Chen, Xiaogang X; Xu, Min M; Yao, Yong-Gang YG
Publication Date: 2023-01-21

Variant appearance in text: APP: K670N
PubMed Link: 36670424
Variant Present in the following documents:
  • Main text
  • 13195_2022_Article_1159.pdf
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iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes.

International Journal Of Molecular Sciences
Zhou, Xiaojing X; Sheikh, Abdullah Md AM; Matsumoto, Ken-Ichi KI; Mitaki, Shingo S; Shibly, Abu Zaffar AZ; Zhang, Yuchi Y; A, Garu G; Yano, Shozo S; Nagai, Atsushi A
Publication Date: 2022-12-30

Variant appearance in text: APP: K670N
PubMed Link: 36614115
Variant Present in the following documents:
  • Main text
  • ijms-24-00672.pdf
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Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey.

Aging Brain
Chan, Anthony W S AWS; Cho, In Ki IK; Li, Chun-Xia CX; Zhang, Xiaodong X; Patel, Sudeep S; Rusnak, Rebecca R; Raper, Jessica J; Bachevalier, Jocelyne J; Moran, Sean P SP; Chi, Tim T; Cannon, Katherine H KH; Hunter, Carissa E CE; Martin, Ryan C RC; Xiao, Hailian H; Yang, Shang-Hsun SH; Gumber, Sanjeev S; Herndon, James G JG; Rosen, Rebecca F RF; Hu, William T WT; Lah, James J JJ; Levey, Allan I AI; Smith, Yoland Y; Walker, Lary C LC
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 36589695
Variant Present in the following documents:
  • Main text
  • nihms-1859693.pdf
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The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities.

Molecular Neurobiology
Brandimarti, Renato R; Irollo, Elena E; Meucci, Olimpia O
Publication Date: 2022-12-28

Variant appearance in text: APP: K670N
PubMed Link: 36576708
Variant Present in the following documents:
  • Main text
  • 12035_2022_Article_3153.pdf
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Glial Gap Junction Pathology in the Spinal Cord of the 5xFAD Mouse Model of Early-Onset Alzheimer's Disease.

International Journal Of Molecular Sciences
Pechlivanidou, Maria M; Kousiappa, Ioanna I; Angeli, Stella S; Sargiannidou, Irene I; Koupparis, Andreas M AM; Papacostas, Savvas S SS; Kleopa, Kleopas A KA
Publication Date: 2022-12-09

Variant appearance in text: APP: K670N
PubMed Link: 36555237
Variant Present in the following documents:
  • Main text
  • ijms-23-15597.pdf
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No difference in cerebral perfusion between the wild-type and the 5XFAD mouse model of Alzheimer's disease.

Scientific Reports
DeBay, Drew R DR; Phi, Tân-Trào TT; Bowen, Chris V CV; Burrell, Steven C SC; Darvesh, Sultan S
Publication Date: 2022-12-22

Variant appearance in text: APP: K670N
PubMed Link: 36550188
Variant Present in the following documents:
  • Main text
  • 41598_2022_Article_26713.pdf
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Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ42 oligomers by controlling their interactions with cell membranes.

Chemical Science
Yu, Zhengxin Z; Guo, Weijie W; Patel, Shrey S; Cho, Hong-Jun HJ; Sun, Liang L; Mirica, Liviu M LM
Publication Date: 2022-11-09

Variant appearance in text: APP: K670N
PubMed Link: 36519059
Variant Present in the following documents:
  • SC-013-D2SC02654F-s001.pdf
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Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer's disease in a 5 × FAD mouse model.

Frontiers In Aging Neuroscience
Sun, Ting T; Zeng, Li L; Cai, Zhongdi Z; Liu, Qingshan Q; Li, Zhuorong Z; Liu, Rui R
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 36466608
Variant Present in the following documents:
  • Main text
  • fnagi-14-1020699.pdf
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Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models.

Alzheimer'S Research & Therapy
Lee, Hee Yang HY; Yoon, Soljee S; Lee, Jeong Hwa JH; Park, Keunwan K; Jung, Youngeun Y; Cho, Illhwan I; Lee, Donghee D; Shin, Jisu J; Kim, Kyeonghwan K; Kim, Sunmi S; Kim, Jimin J; Kim, Koeun K; Han, Seung Hoon SH; Kim, Seong Muk SM; Kim, Hye Ju HJ; Kim, Hye Yun HY; Kim, Ikyon I; Kim, Young Soo YS
Publication Date: 2022-11-29

Variant appearance in text: APP: K670N
PubMed Link: 36443837
Variant Present in the following documents:
  • Main text
  • 13195_2022_Article_1112.pdf
View BVdb publication page



Late-long-term potentiation magnitude, but not Aβ levels and amyloid pathology, is associated with behavioral performance in a rat knock-in model of Alzheimer disease.

Frontiers In Aging Neuroscience
Yesiltepe, Metin M; Yin, Tao T; Tambini, Marc D MD; Breuillaud, Lionel L; Zehntner, Simone P SP; D'Adamio, Luciano L
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 36438008
Variant Present in the following documents:
  • Main text
  • fnagi-14-1040576.pdf
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Interdisciplinary Approaches to Deal with Alzheimer's Disease-From Bench to Bedside: What Feasible Options Do Already Exist Today?

Biomedicines
Ablinger, Irene I; Dressel, Katharina K; Rott, Thea T; Lauer, Anna Andrea AA; Tiemann, Michael M; Batista, João Pedro JP; Taddey, Tim T; Grimm, Heike Sabine HS; Grimm, Marcus Otto Walter MOW
Publication Date: 2022-11-14

Variant appearance in text: APP: K670N
PubMed Link: 36428494
Variant Present in the following documents:
  • Main text
  • biomedicines-10-02922.pdf
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Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease.

Metallomics : Integrated Biometal Science
Mahan, Brandon B; Tacail, Theo T; Lewis, Jamie J; Elliott, Tim T; Habekost, Mette M; Turner, Simon S; Chung, Roger R; Moynier, Frédéric F
Publication Date: 2022-11-23

Variant appearance in text: APP: K670N
PubMed Link: 36416864
Variant Present in the following documents:
  • Main text
  • mfac090.pdf
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MicroRNA super-resolution imaging in blood for Alzheimer's disease.

Bmb Reports
Lee, Mirae M; Woo, Jiwon J; Kim, Sang Tae ST; Moon, Minho M; Kim, Sang Yun SY; Cho, Hanna H; Kim, Sujin S; Kim, Han-Kyeol HK; Park, Jeong-Yoon JY
Publication Date: 2022-11-21

Variant appearance in text: APP: K670N
PubMed Link: 36404596
Variant Present in the following documents:
  • bmb-56-3-190-supple.pdf
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Medin co-aggregates with vascular amyloid-β in Alzheimer's disease.

Nature
Wagner, Jessica J; Degenhardt, Karoline K; Veit, Marleen M; Louros, Nikolaos N; Konstantoulea, Katerina K; Skodras, Angelos A; Wild, Katleen K; Liu, Ping P; Obermüller, Ulrike U; Bansal, Vikas V; Dalmia, Anupriya A; Häsler, Lisa M LM; Lambert, Marius M; De Vleeschouwer, Matthias M; Davies, Hannah A HA; Madine, Jillian J; Kronenberg-Versteeg, Deborah D; Feederle, Regina R; Del Turco, Domenico D; Nilsson, K Peter R KPR; Lashley, Tammaryn T; Deller, Thomas T; Gearing, Marla M; Walker, Lary C LC; Heutink, Peter P; Rousseau, Frederic F; Schymkowitz, Joost J; Jucker, Mathias M; Neher, Jonas J JJ
Publication Date: 2022-12

Variant appearance in text: APP: K670N
PubMed Link: 36385530
Variant Present in the following documents:
  • Main text
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Branched-Chain Amino Acids Are Linked with Alzheimer's Disease-Related Pathology and Cognitive Deficits.

Cells
Siddik, Md Abu Bakkar MAB; Mullins, Caitlyn A CA; Kramer, Alyssa A; Shah, Harsh H; Gannaban, Ritchel B RB; Zabet-Moghaddam, Masoud M; Huebinger, Ryan M RM; Hegde, Vijay K VK; MohanKumar, Sheba M J SMJ; MohanKumar, Puliyur S PS; Shin, Andrew C AC
Publication Date: 2022-11-07

Variant appearance in text: APP: K670N
PubMed Link: 36359919
Variant Present in the following documents:
  • Main text
  • cells-11-03523.pdf
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The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer's Disease.

Cells
Busch, Lukas L; Eggert, Simone S; Endres, Kristina K; Bufe, Bernd B
Publication Date: 2022-10-29

Variant appearance in text: APP: K670N
PubMed Link: 36359817
Variant Present in the following documents:
  • Main text
  • cells-11-03421.pdf
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