Variant ID: 21-27269939-C-G

NM_000484.3(APP):c.2010G>C;(p.K670N)

This variant was identified in 1188 publications

View GRCh38 version.




Publications:


Impact of IL-21-associated peripheral and brain crosstalk on the Alzheimer's disease neuropathology.

Cellular And Molecular Life Sciences : Cmls
Agrawal, Sudhanshu S; Baulch, Janet E JE; Madan, Shreya S; Salah, Seher S; Cheeks, Samantha N SN; Krattli, Robert P RP; Subramanian, Veedamali S VS; Acharya, Munjal M MM; Agrawal, Anshu A
Publication Date: 2022-06-01

Variant appearance in text: APP: K670N
PubMed Link: 35648273
Variant Present in the following documents:
  • Main text
  • 18_2022_Article_4347.pdf
View BVdb publication page



Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis.

International Journal Of Molecular Sciences
Sanchez-Varo, Raquel R; Mejias-Ortega, Marina M; Fernandez-Valenzuela, Juan Jose JJ; Nuñez-Diaz, Cristina C; Caceres-Palomo, Laura L; Vegas-Gomez, Laura L; Sanchez-Mejias, Elisabeth E; Trujillo-Estrada, Laura L; Garcia-Leon, Juan Antonio JA; Moreno-Gonzalez, Ines I; Vizuete, Marisa M; Vitorica, Javier J; Baglietto-Vargas, David D; Gutierrez, Antonia A
Publication Date: 2022-05-12

Variant appearance in text: APP: K670N
PubMed Link: 35628216
Variant Present in the following documents:
  • Main text
  • ijms-23-05404.pdf
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Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation.

International Journal Of Molecular Sciences
Yang, Shaobin S; Du, Yaqin Y; Zhao, Xiaoqian X; Tang, Qi Q; Su, Wei W; Hu, Yuemeng Y; Yu, Peng P
Publication Date: 2022-05-11

Variant appearance in text: APP: K670N
PubMed Link: 35628181
Variant Present in the following documents:
  • Main text
  • ijms-23-05367.pdf
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Olfactory Evaluation in Alzheimer's Disease Model Mice.

Brain Sciences
Zhang, Jingjing J; Zhao, Zixuan Z; Sun, Siqi S; Li, Jing J; Wang, Yu Y; Dong, Jingyin J; Yang, Su S; Lou, Yiyi Y; Yang, Jing J; Li, Weiyun W; Li, Shanshan S
Publication Date: 2022-05-06

Variant appearance in text: APP: K670N
PubMed Link: 35624994
Variant Present in the following documents:
  • Main text
  • brainsci-12-00607.pdf
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Advances in Recapitulating Alzheimer's Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models.

Brain Sciences
Hasan, Md Fayad MF; Trushina, Eugenia E
Publication Date: 2022-04-26

Variant appearance in text: APP: K670N
PubMed Link: 35624938
Variant Present in the following documents:
  • Main text
  • brainsci-12-00552.pdf
View BVdb publication page



Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer's Disease.

Antioxidants (Basel, Switzerland)
Zussy, Charleine C; John, Rijo R; Urgin, Théo T; Otaegui, Léa L; Vigor, Claire C; Acar, Niyazi N; Canet, Geoffrey G; Vitalis, Mathieu M; Morin, Françoise F; Planel, Emmanuel E; Oger, Camille C; Durand, Thierry T; Rajshree, Shinde L SL; Givalois, Laurent L; Devarajan, Padma V PV; Desrumaux, Catherine C
Publication Date: 2022-04-25

Variant appearance in text: APP: K670N
PubMed Link: 35624701
Variant Present in the following documents:
  • Main text
  • antioxidants-11-00838.pdf
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Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo.

Cell Reports. Medicine
Kass, Bettina B; Schemmert, Sarah S; Zafiu, Christian C; Pils, Marlene M; Bannach, Oliver O; Kutzsche, Janine J; Bujnicki, Tuyen T; Willbold, Dieter D
Publication Date: 2022-05-17

Variant appearance in text: APP: K670N
PubMed Link: 35584626
Variant Present in the following documents:
  • Main text
  • mmc2.pdf
  • main.pdf
View BVdb publication page



Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation.

Cells
Kasindi, Arielle A; Fuchs, Dieu-Trang DT; Koronyo, Yosef Y; Rentsendorj, Altan A; Black, Keith L KL; Koronyo-Hamaoui, Maya M
Publication Date: 2022-05-07

Variant appearance in text: APP: K670N
PubMed Link: 35563884
Variant Present in the following documents:
  • cells-11-01578.pdf
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Impact of Cerebral Amyloid Angiopathy in Two Transgenic Mouse Models of Cerebral β-Amyloidosis: A Neuropathological Study.

International Journal Of Molecular Sciences
Marazuela, Paula P; Paez-Montserrat, Berta B; Bonaterra-Pastra, Anna A; Solé, Montse M; Hernández-Guillamon, Mar M
Publication Date: 2022-04-29

Variant appearance in text: APP: K670N
PubMed Link: 35563362
Variant Present in the following documents:
  • ijms-23-04972.pdf
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Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet.

International Journal Of Molecular Sciences
Mietelska-Porowska, Anna A; Domańska, Justyna J; Want, Andrew A; Więckowska-Gacek, Angelika A; Chutorański, Dominik D; Koperski, Maciej M; Wojda, Urszula U
Publication Date: 2022-04-25

Variant appearance in text: APP: K670N
PubMed Link: 35563135
Variant Present in the following documents:
  • ijms-23-04744.pdf
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GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease.

Frontiers In Immunology
Islam, Jahirul J; Cho, Jung-Ah JA; Kim, Ju-Yong JY; Park, Kyung-Sun KS; Koh, Young-Jae YJ; Chung, Chu Young CY; Lee, Eun-Jae EJ; Nam, Soo Jeong SJ; Lee, Kyoungyul K; Kim, Seoung-Heon SH; Park, Sung-Hye SH; Lee, Dong Young DY; Kim, Byeong C BC; Lee, Kyung-Hwa KH; Seong, Seung-Yong SY
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35464490
Variant Present in the following documents:
  • fimmu-13-766919.pdf
View BVdb publication page



Cellular Reprogramming and Its Potential Application in Alzheimer's Disease.

Frontiers In Neuroscience
Zhou, Chao C; Ni, Wanyan W; Zhu, Taiyang T; Dong, Shuyu S; Sun, Ping P; Hua, Fang F
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35464309
Variant Present in the following documents:
  • fnins-16-884667.pdf
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Mucin-Type O-Glycosylation Proximal to β-Secretase Cleavage Site Affects APP Processing and Aggregation Fate.

Frontiers In Chemistry
Singh, YashoNandini Y; Regmi, Deepika D; Ormaza, David D; Ayyalasomayajula, Ramya R; Vela, Nancy N; Mundim, Gustavo G; Du, Deguo D; Minond, Dmitriy D; Cudic, Maré M
Publication Date: 2022

Variant appearance in text: APP: Lys670Asn
PubMed Link: 35464218
Variant Present in the following documents:
  • fchem-10-859822.pdf
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Recent Advances in the Modeling of Alzheimer's Disease.

Frontiers In Neuroscience
Sasaguri, Hiroki H; Hashimoto, Shoko S; Watamura, Naoto N; Sato, Kaori K; Takamura, Risa R; Nagata, Kenichi K; Tsubuki, Satoshi S; Ohshima, Toshio T; Yoshiki, Atsushi A; Sato, Kenya K; Kumita, Wakako W; Sasaki, Erika E; Kitazume, Shinobu S; Nilsson, Per P; Winblad, Bengt B; Saito, Takashi T; Iwata, Nobuhisa N; Saido, Takaomi C TC
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35431779
Variant Present in the following documents:
  • fnins-16-807473.pdf
View BVdb publication page



Microglial Endocannabinoid Signalling in AD.

Cells
Scipioni, Lucia L; Ciaramellano, Francesca F; Carnicelli, Veronica V; Leuti, Alessandro A; Lizzi, Anna Rita AR; De Dominicis, Noemi N; Oddi, Sergio S; Maccarrone, Mauro M
Publication Date: 2022-04-06

Variant appearance in text: APP: K670N
PubMed Link: 35406803
Variant Present in the following documents:
  • cells-11-01237.pdf
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Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease.

Cell Death & Disease
Tong, Xin-Kang XK; Royea, Jessika J; Hamel, Edith E
Publication Date: 2022-04-09

Variant appearance in text: APP: K670N
PubMed Link: 35397630
Variant Present in the following documents:
  • 41419_2022_Article_4784.pdf
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AGE-TXNIP axis drives inflammation in Alzheimer's by targeting Aβ to mitochondria in microglia.

Cell Death & Disease
Sbai, Oualid O; Djelloul, Mehdi M; Auletta, Antonia A; Ieraci, Alessandro A; Vascotto, Carlo C; Perrone, L L
Publication Date: 2022-04-04

Variant appearance in text: APP: K670N
PubMed Link: 35379773
Variant Present in the following documents:
  • 41419_2022_4758_MOESM1_ESM.pdf
View BVdb publication page



KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion.

Ebiomedicine
Han, Xiaolei X; Wang, Chaoqun C; Song, Lin L; Wang, Xiaojie X; Tang, Shi S; Hou, Tingting T; Liu, Cuicui C; Liang, Xiaoyan X; Qiu, Chengxuan C; Wang, Yongxiang Y; Du, Yifeng Y
Publication Date: 2022-03-31

Variant appearance in text: APP: K670N
PubMed Link: 35367771
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease.

International Journal Of Biological Sciences
Park, Hyunjun H; Lee, Yeong-Bae YB; Chang, Keun-A KA
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35342350
Variant Present in the following documents:
  • ijbsv18p2220.pdf
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Effects of subchronic dietary exposure to the engineered nanomaterials SiO2 and CeO2 in C57BL/6J and 5xFAD Alzheimer model mice.

Particle And Fibre Toxicology
Sofranko, Adriana A; Wahle, Tina T; Kolling, Julia J; Heusinkveld, Harm J HJ; Stahlmecke, Burkhard B; Rosenbruch, Martin M; Albrecht, Catrin C; Schins, Roel P F RPF
Publication Date: 2022-03-25

Variant appearance in text: APP: K670N
PubMed Link: 35337343
Variant Present in the following documents:
  • 12989_2022_Article_461.pdf
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Personalized Management and Treatment of Alzheimer's Disease.

Life (Basel, Switzerland)
Cacabelos, Ramón R; Naidoo, Vinogran V; Martínez-Iglesias, Olaia O; Corzo, Lola L; Cacabelos, Natalia N; Pego, Rocío R; Carril, Juan C JC
Publication Date: 2022-03-21

Variant appearance in text: APP: K670N
PubMed Link: 35330211
Variant Present in the following documents:
  • life-12-00460.pdf
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Effects of Deferasirox in Alzheimer's Disease and Tauopathy Animal Models.

Biomolecules
Kwan, Ping P; Ho, Amy A; Baum, Larry L
Publication Date: 2022-02-25

Variant appearance in text: APP: K670N
PubMed Link: 35327557
Variant Present in the following documents:
  • biomolecules-12-00365.pdf
View BVdb publication page



Amelioration of Experimental Autoimmune Encephalomyelitis in Alzheimer's Disease Mouse Models: A Potential Role for Aβ.

Cells
Shi, Changjie C; Cha, Jiaxue J; Gong, Junyuan J; Wang, Shaodeng S; Zeng, Peng P; Lian, Junjiang J; Zhang, Bowen B; Hua, Qiuhong Q; Lv, Jie J; Du, Changsheng C; Xie, Xin X; Zhang, Ru R
Publication Date: 2022-03-16

Variant appearance in text: APP: K670N
PubMed Link: 35326455
Variant Present in the following documents:
  • cells-11-01004.pdf
View BVdb publication page



The Cardiac Dysfunction Caused by Metabolic Alterations in Alzheimer's Disease.

Frontiers In Cardiovascular Medicine
Murphy, Jiayuan J; Le, Tran Ngoc Van TNV; Fedorova, Julia J; Yang, Yi Y; Krause-Hauch, Meredith M; Davitt, Kayla K; Zoungrana, Linda Ines LI; Fatmi, Mohammad Kasim MK; Lesnefsky, Edward J EJ; Li, Ji J; Ren, Di D
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35274014
Variant Present in the following documents:
  • fcvm-09-850538.pdf
View BVdb publication page



Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice.

International Journal Of Molecular Sciences
Wang, Yanhong Y; Hong, Yuzhu Y; Yan, Jiyu J; Brown, Breanna B; Lin, Xiaoyang X; Zhang, Xiaolin X; Shen, Ning N; Li, Minghua M; Cai, Jianfeng J; Gordon, Marcia M; Morgan, David D; Zhou, Qingyu Q; Cao, Chuanhai C
Publication Date: 2022-03-02

Variant appearance in text: APP: K670N
PubMed Link: 35269905
Variant Present in the following documents:
  • ijms-23-02757.pdf
View BVdb publication page



Failure of Alzheimer's Mice Brain Resident Neural Precursor Cells in Supporting Microglia-Mediated Amyloid β Clearance.

Cells
Lachish, Marva M; Fainstein, Nina N; Ganz, Tal T; Sofer, Lihi L; Ben-Hur, Tamir T
Publication Date: 2022-03-03

Variant appearance in text: APP: K670N
PubMed Link: 35269501
Variant Present in the following documents:
  • cells-11-00876.pdf
View BVdb publication page



Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer's Disease.

Frontiers In Aging Neuroscience
Cope, Zackary A ZA; Murai, Takeshi T; Sukoff Rizzo, Stacey J SJ
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35250541
Variant Present in the following documents:
  • fnagi-14-805063.pdf
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A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer's Disease.

Frontiers In Aging Neuroscience
Jayatunga, Dona P W DPW; Hone, Eugene E; Fernando, W M A D Binosha WMADB; Garg, Manohar L ML; Verdile, Giuseppe G; Martins, Ralph N RN
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35250535
Variant Present in the following documents:
  • fnagi-14-780602.pdf
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Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer's mouse model.

Iscience
Rey, Christophe Clément CC; Robert, Vincent V; Bouisset, Guillaume G; Loisy, Maïthé M; Lopez, Sébastien S; Cattaud, Vanessa V; Lejards, Camille C; Piskorowski, Rebecca Ann RA; Rampon, Claire C; Chevaleyre, Vivien V; Verret, Laure L
Publication Date: 2022-03-18

Variant appearance in text: APP: K670N
PubMed Link: 35243253
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease.

Iscience
Kaneshiro, Nanaka N; Komai, Masato M; Imaoka, Ryosuke R; Ikeda, Atsuya A; Kamikubo, Yuji Y; Saito, Takashi T; Saido, Takaomi C TC; Tomita, Taisuke T; Hashimoto, Tadafumi T; Iwatsubo, Takeshi T; Sakurai, Takashi T; Uehara, Takashi T; Takasugi, Nobumasa N
Publication Date: 2022-03-18

Variant appearance in text: APP: K670N
PubMed Link: 35243232
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.

Nature Communications
Zhao, Yuanyuan Y; Hu, Di D; Wang, Rihua R; Sun, Xiaoyan X; Ropelewski, Philip P; Hubler, Zita Z; Lundberg, Kathleen K; Wang, Quanqiu Q; Adams, Drew J DJ; Xu, Rong R; Qi, Xin X
Publication Date: 2022-03-02

Variant appearance in text: APP: K670N
PubMed Link: 35236834
Variant Present in the following documents:
  • 41467_2022_28769_MOESM2_ESM.pdf
  • 41467_2022_Article_28769.pdf
View BVdb publication page



Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology.

Journal Of Neuroinflammation
Ren, Xiao X; Yao, Lingling L; Wang, YongGang Y; Mei, Lin L; Xiong, Wen-Cheng WC
Publication Date: 2022-03-02

Variant appearance in text: APP: K670N
PubMed Link: 35236374
Variant Present in the following documents:
  • 12974_2022_Article_2422.pdf
View BVdb publication page



Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.

Cellular And Molecular Life Sciences : Cmls
Marengo, Liana L; Armbrust, Fred F; Schoenherr, Caroline C; Storck, Steffen E SE; Schmitt, Ulrich U; Zampar, Silvia S; Wirths, Oliver O; Altmeppen, Hermann H; Glatzel, Markus M; Kaether, Christoph C; Weggen, Sascha S; Becker-Pauly, Christoph C; Pietrzik, Claus U CU
Publication Date: 2022-03-02

Variant appearance in text: APP: K670N
PubMed Link: 35235058
Variant Present in the following documents:
  • 18_2022_Article_4205.pdf
View BVdb publication page



Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation.

Frontiers In Immunology
Lee, Hyun-Ju HJ; Park, Jin-Hee JH; Hoe, Hyang-Sook HS
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35222363
Variant Present in the following documents:
  • fimmu-13-749336.pdf
View BVdb publication page



Neuroimaging of Mouse Models of Alzheimer's Disease.

Biomedicines
Jullienne, Amandine A; Trinh, Michelle V MV; Obenaus, Andre A
Publication Date: 2022-01-28

Variant appearance in text: APP: K670N
PubMed Link: 35203515
Variant Present in the following documents:
  • biomedicines-10-00305.pdf
View BVdb publication page



Expression of the Adenosine A2A-A3 Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APPSw,Ind Alzheimer's Disease Model.

Biomedicines
Lillo, Alejandro A; Raïch, Iu I; Lillo, Jaume J; Pérez-Olives, Catalina C; Navarro, Gemma G; Franco, Rafael R
Publication Date: 2022-01-19

Variant appearance in text: APP: K670N
PubMed Link: 35203424
Variant Present in the following documents:
  • biomedicines-10-00214.pdf
View BVdb publication page



Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.

Theranostics
Cai, Cui-Zan CZ; Zhuang, Xu-Xu XX; Zhu, Qi Q; Wu, Ming-Yue MY; Su, Huanxing H; Wang, Xiao-Jin XJ; Iyaswamy, Ashok A; Yue, Zhenyu Z; Wang, Qian Q; Zhang, Bin B; Xue, Yu Y; Tan, Jieqiong J; Li, Min M; He, Huanhuan H; Lu, Jia-Hong JH
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35198070
Variant Present in the following documents:
  • thnov12p1738.pdf
View BVdb publication page



Electro-Acupuncture Improve the Early Pattern Separation in Alzheimer's Disease Mice via Basal Forebrain-Hippocampus Cholinergic Neural Circuit.

Frontiers In Aging Neuroscience
Li, Long L; Li, Jianhong J; Dai, Yaling Y; Yang, Minguang M; Liang, Shengxiang S; Wang, Zhifu Z; Liu, Weilin W; Chen, Lidian L; Tao, Jing J
Publication Date: 2021

Variant appearance in text: APP: K670N
PubMed Link: 35185516
Variant Present in the following documents:
  • fnagi-13-770948.pdf
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PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer's disease.

Genome Medicine
Tsai, Andy P AP; Dong, Chuanpeng C; Lin, Peter Bor-Chian PB; Messenger, Evan J EJ; Casali, Brad T BT; Moutinho, Miguel M; Liu, Yunlong Y; Oblak, Adrian L AL; Lamb, Bruce T BT; Landreth, Gary E GE; Bissel, Stephanie J SJ; Nho, Kwangsik K
Publication Date: 2022-02-18

Variant appearance in text: APP: K670N
PubMed Link: 35180881
Variant Present in the following documents:
  • 13073_2022_Article_1022.pdf
View BVdb publication page



Protective Role of Microglia on Neuronal Survival after Exposure to Amyloid Beta.

Chonnam Medical Journal
Lee, Sunjun S; Choi, Won-Seok WS
Publication Date: 2022-01

Variant appearance in text: APP: K670N
PubMed Link: 35169554
Variant Present in the following documents:
  • Main text
  • cmj-58-13.pdf
View BVdb publication page



New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction.

International Journal Of Molecular Sciences
Tsuneura, Yumi Y; Nakai, Tsuyoshi T; Mizoguchi, Hiroyuki H; Yamada, Kiyofumi K
Publication Date: 2022-02-06

Variant appearance in text: APP: K670N
PubMed Link: 35163751
Variant Present in the following documents:
  • Main text
  • ijms-23-01829.pdf
View BVdb publication page



Aquaporin 4 deficiency eliminates the beneficial effects of voluntary exercise in a mouse model of Alzheimer's disease.

Neural Regeneration Research
Liu, Yun Y; Hu, Pan-Pan PP; Zhai, Shuang S; Feng, Wei-Xi WX; Zhang, Rui R; Li, Qian Q; Marshall, Charles C; Xiao, Ming M; Wu, Ting T
Publication Date: 2022-09

Variant appearance in text: APP: K670N
PubMed Link: 35142700
Variant Present in the following documents:
  • NRR-17-2079.pdf
View BVdb publication page



Editorial: The Molecular Mechanisms of Synaptic Plasticity Impairments in Alzheimer's Disease.

Frontiers In Cell And Developmental Biology
Liu, Gong-Ping GP; Lei, Peng P; Dong, Zhi-Fang ZF; Li, Shu-Peng SP
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 35127687
Variant Present in the following documents:
  • Main text
  • fcell-10-832728.pdf
View BVdb publication page



Sodium-calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer's disease.

Scientific Reports
Afewerky, Henok Kessete HK; Li, Hao H; Zhang, Tongmei T; Li, Xinyan X; Mahaman, Yacoubou Abdoul Razak YAR; Duan, Limin L; Qin, Pengwei P; Zheng, Jiequn J; Pei, Lei L; Lu, Youming Y
Publication Date: 2022-01-27

Variant appearance in text: APP: K670N
PubMed Link: 35087161
Variant Present in the following documents:
  • Main text
View BVdb publication page



Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease.

Nature Communications
Yang, Yun Y; Tapias, Victor V; Acosta, Diana D; Xu, Hui H; Chen, Huanlian H; Bhawal, Ruchika R; Anderson, Elizabeth T ET; Ivanova, Elena E; Lin, Hening H; Sagdullaev, Botir T BT; Chen, Jianer J; Klein, William L WL; Viola, Kirsten L KL; Gandy, Sam S; Haroutunian, Vahram V; Beal, M Flint MF; Eliezer, David D; Zhang, Sheng S; Gibson, Gary E GE
Publication Date: 2022-01-10

Variant appearance in text: APP: K670N
PubMed Link: 35013160
Variant Present in the following documents:
  • 41467_2021_27572_MOESM2_ESM.pdf
View BVdb publication page



Microbial pathogens induce neurodegeneration in Alzheimer's disease mice: protection by microglial regulation.

Journal Of Neuroinflammation
Ganz, Tal T; Fainstein, Nina N; Elad, Amit A; Lachish, Marva M; Goldfarb, Smadar S; Einstein, Ofira O; Ben-Hur, Tamir T
Publication Date: 2022-01-06

Variant appearance in text: APP: K670N
PubMed Link: 34991645
Variant Present in the following documents:
  • Main text
  • 12974_2021_Article_2369.pdf
View BVdb publication page



Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease.

Molecular Brain
Ohline, Shane M SM; Chan, Connie C; Schoderboeck, Lucia L; Wicky, Hollie E HE; Tate, Warren P WP; Hughes, Stephanie M SM; Abraham, Wickliffe C WC
Publication Date: 2022-01-03

Variant appearance in text: APP: K670N
PubMed Link: 34980189
Variant Present in the following documents:
  • Main text
  • 13041_2021_Article_889.pdf
View BVdb publication page



Identification of Immune Cells and Key Genes associated with Alzheimer's Disease.

International Journal Of Medical Sciences
Liu, Chenming C; Zhang, Xi X; Chai, Huazhen H; Xu, Sutong S; Liu, Qiulu Q; Luo, Yuping Y; Li, Siguang S
Publication Date: 2022

Variant appearance in text: APP: K670N
PubMed Link: 34975305
Variant Present in the following documents:
  • ijmsv19p0112.pdf
View BVdb publication page



Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species.

Frontiers In Molecular Neuroscience
Kaku, Hiroaki H; Ludlow, Alexander V AV; Gutknecht, Michael F MF; Rothstein, Thomas L TL
Publication Date: 2021

Variant appearance in text: APP: K670N
PubMed Link: 34970117
Variant Present in the following documents:
  • Main text
  • fnmol-14-750578.pdf
View BVdb publication page



Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity.

Journal Of Neuroinflammation
Perez-Nievas, Beatriz G BG; Johnson, Louisa L; Beltran-Lobo, Paula P; Hughes, Martina M MM; Gammallieri, Luciana L; Tarsitano, Francesca F; Myszczynska, Monika A MA; Vazquez-Villasenor, Irina I; Jimenez-Sanchez, Maria M; Troakes, Claire C; Wharton, Stephen B SB; Ferraiuolo, Laura L; Noble, Wendy W
Publication Date: 2021-12-28

Variant appearance in text: APP: K670N
PubMed Link: 34963475
Variant Present in the following documents:
  • Main text
  • 12974_2021_Article_2371.pdf
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Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.

Pharmaceuticals (Basel, Switzerland)
Runfola, Massimiliano M; Perni, Michele M; Yang, Xiaoting X; Marchese, Maria M; Bacci, Andrea A; Mero, Serena S; Santorelli, Filippo M FM; Polini, Beatrice B; Chiellini, Grazia G; Giuliani, Daniela D; Vilella, Antonietta A; Bodria, Martina M; Daini, Eleonora E; Vandini, Eleonora E; Rudge, Simon S; Gul, Sheraz S; Wakelam, Michale O J MOJ; Vendruscolo, Michele M; Rapposelli, Simona S
Publication Date: 2021-12-19

Variant appearance in text: APP: K670N
PubMed Link: 34959730
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  • pharmaceuticals-14-01330.pdf
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Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression.

Pharmaceutics
Chen, Xu-Qiao XQ; Barrero, Carlos A CA; Vasquez-Del Carpio, Rodrigo R; Reddy, E Premkumar EP; Fecchio, Chiara C; Merali, Salim S; Deglincerti, Alessia A; Fang, Cheng C; Rogers, Jack J; Maccecchini, Maria L ML
Publication Date: 2021-12-07

Variant appearance in text: APP: K670N
PubMed Link: 34959389
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  • pharmaceutics-13-02109.pdf
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Complement System in Alzheimer's Disease.

International Journal Of Molecular Sciences
Shah, Akash A; Kishore, Uday U; Shastri, Abhishek A
Publication Date: 2021-12-20

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PubMed Link: 34948444
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Primary Cilia Structure Is Prolonged in Enteric Neurons of 5xFAD Alzheimer's Disease Model Mice.

International Journal Of Molecular Sciences
Nguyen, Vu Thu Thuy VTT; Brücker, Lena L; Volz, Ann-Kathrin AK; Baumgärtner, Julia C JC; Dos Santos Guilherme, Malena M; Valeri, Francesco F; May-Simera, Helen H; Endres, Kristina K
Publication Date: 2021-12-17

Variant appearance in text: APP: K670N
PubMed Link: 34948356
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  • ijms-22-13564.pdf
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Time-Dependent Analysis of Plasmalogens in the Hippocampus of an Alzheimer's Disease Mouse Model: A Role of Ethanolamine Plasmalogen.

Brain Sciences
Azad, Abul Kalam AK; Sheikh, Abdullah Md AM; Haque, Md Ahsanul MA; Osago, Harumi H; Sakai, Hiromichi H; Shibly, Abu Zaffar AZ; Yano, Shozo S; Michikawa, Makoto M; Hossain, Shahdat S; Tabassum, Shatera S; A, Garu G; Zhou, Xiaojing X; Zhang, Yuchi Y; Nagai, Atsushi A
Publication Date: 2021-12-02

Variant appearance in text: APP: K670N
PubMed Link: 34942905
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  • Main text
  • brainsci-11-01603.pdf
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Quantitative Brain Positron Emission Tomography in Female 5XFAD Alzheimer Mice: Pathological Features and Sex-Specific Alterations.

Frontiers In Medicine
Bouter, Caroline C; Irwin, Caroline C; Franke, Timon N TN; Beindorff, Nicola N; Bouter, Yvonne Y
Publication Date: 2021

Variant appearance in text: APP: K670N
PubMed Link: 34901060
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  • fmed-08-745064.pdf
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Anti-Inflammatory Gene Therapy Improves Spatial Memory Performance in a Mouse Model of Alzheimer's Disease.

Journal Of Alzheimer'S Disease : Jad
Yoo, Tai June TJ
Publication Date: 2021-12-09

Variant appearance in text: APP: K670N
PubMed Link: 34897091
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  • jad-85-jad215270.pdf
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Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression.

International Journal Of Molecular Sciences
Koh, Han Seok HS; Lee, SangJoon S; Lee, Hyo Jin HJ; Min, Jae-Woong JW; Iwatsubo, Takeshi T; Teunissen, Charlotte E CE; Cho, Hyun-Jeong HJ; Ryu, Jin-Hyeob JH
Publication Date: 2021-12-04

Variant appearance in text: APP: K670N
PubMed Link: 34884940
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  • ijms-22-13136.pdf
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Basal lamina changes in neurodegenerative disorders.

Molecular Neurodegeneration
Nguyen, Benjamin B; Bix, Gregory G; Yao, Yao Y
Publication Date: 2021-12-07

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PubMed Link: 34876200
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Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer's disease.

Journal Of Neuroinflammation
Rui, Wenjuan W; Xiao, Hong H; Fan, Yi Y; Ma, Zhongxuan Z; Xiao, Ming M; Li, Sheng S; Shi, Jingping J
Publication Date: 2021-12-02

Variant appearance in text: APP: K670N
PubMed Link: 34856990
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  • Main text
  • 12974_2021_Article_2329.pdf
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Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence.

Communications Biology
Pan, Jin-Xiu JX; Sun, Dong D; Lee, Daehoon D; Xiong, Lei L; Ren, Xiao X; Guo, Hao-Han HH; Yao, Ling-Ling LL; Lu, Yuyi Y; Jung, Caroline C; Xiong, Wen-Cheng WC
Publication Date: 2021-11-25

Variant appearance in text: APP: K670N
PubMed Link: 34824365
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  • Main text
  • 42003_2021_Article_2843.pdf
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Microglia contribute to the propagation of Aβ into unaffected brain tissue.

Nature Neuroscience
d'Errico, Paolo P; Ziegler-Waldkirch, Stephanie S; Aires, Vanessa V; Hoffmann, Philippe P; Mezö, Charlotte C; Erny, Daniel D; Monasor, Laura Sebastian LS; Liebscher, Sabine S; Ravi, Vidhya M VM; Joseph, Kevin K; Schnell, Oliver O; Kierdorf, Katrin K; Staszewski, Ori O; Tahirovic, Sabina S; Prinz, Marco M; Meyer-Luehmann, Melanie M
Publication Date: 2021-11-22

Variant appearance in text: APP: K670N
PubMed Link: 34811521
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  • 41593_2021_951_MOESM2_ESM.pdf
  • 41593_2021_Article_951.pdf
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Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease.

Iscience
Zhang, Jie J; Gao, Feng F; Ma, Yuqian Y; Xue, Tian T; Shen, Yong Y
Publication Date: 2021-11-19

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PubMed Link: 34805789
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Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog.

Frontiers In Veterinary Science
Chandrasekaran, Abinaya A; Thomsen, Barbara Blicher BB; Agerholm, Jørgen Steen JS; Pessôa, Laís Vicari de Figueiredo LVF; Godoy Pieri, Naira Caroline NC; Sabaghidarmiyan, Vahideh V; Langley, Katarina K; Kolko, Miriam M; de Andrade, André Furugen Cesar AFC; Bressan, Fabiana Fernandes FF; Hyttel, Poul P; Berendt, Mette M; Freude, Kristine K
Publication Date: 2021

Variant appearance in text: APP: K670N
PubMed Link: 34805331
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  • fvets-08-725386.pdf
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Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer's disease.

Journal Of Neuroinflammation
Banik, Avijit A; Amaradhi, Radhika R; Lee, Daniel D; Sau, Michael M; Wang, Wenyi W; Dingledine, Raymond R; Ganesh, Thota T
Publication Date: 2021-11-20

Variant appearance in text: APP: K670N
PubMed Link: 34801055
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  • 12974_2021_Article_2297.pdf
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Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer's Disease and Control Mice.

Frontiers In Aging Neuroscience
den Hoedt, Sandra S; Crivelli, Simone M SM; Leijten, Frank P J FPJ; Losen, Mario M; Stevens, Jo A A JAA; Mané-Damas, Marina M; de Vries, Helga E HE; Walter, Jochen J; Mirzaian, Mina M; Sijbrands, Eric J G EJG; Aerts, Johannes M F G JMFG; Verhoeven, Adrie J M AJM; Martinez-Martinez, Pilar P; Mulder, Monique T MT
Publication Date: 2021

Variant appearance in text: APP: K670N
PubMed Link: 34776936
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  • fnagi-13-765252.pdf
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A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets.

Science Advances
Roberts, Jackson A JA; Varma, Vijay R VR; An, Yang Y; Varma, Sudhir S; Candia, Julián J; Fantoni, Giovanna G; Tiwari, Vinod V; Anerillas, Carlos C; Williamson, Andrew A; Saito, Atsushi A; Loeffler, Tina T; Schilcher, Irene I; Moaddel, Ruin R; Khadeer, Mohammed M; Lovett, Jacqueline J; Tanaka, Toshiko T; Pletnikova, Olga O; Troncoso, Juan C JC; Bennett, David A DA; Albert, Marilyn S MS; Yu, Kaiwen K; Niu, Mingming M; Haroutunian, Vahram V; Zhang, Bin B; Peng, Junmin J; Croteau, Deborah L DL; Resnick, Susan M SM; Gorospe, Myriam M; Bohr, Vilhelm A VA; Ferrucci, Luigi L; Thambisetty, Madhav M
Publication Date: 2021-11-12

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PubMed Link: 34757788
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  • sciadv.abi8178.pdf
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N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors.

Alzheimer'S Research & Therapy
Rivas-Santisteban, Rafael R; Lillo, Alejandro A; Lillo, Jaume J; Rebassa, Joan-Biel JB; Contestí, Joan S JS; Saura, Carlos A CA; Franco, Rafael R; Navarro, Gemma G
Publication Date: 2021-11-08

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PubMed Link: 34749800
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  • 13195_2021_Article_920.pdf
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Microglial transcription profiles in mouse and human are driven by APOE4 and sex.

Iscience
Moser, V Alexandra VA; Workman, Michael J MJ; Hurwitz, Samantha J SJ; Lipman, Rachel M RM; Pike, Christian J CJ; Svendsen, Clive N CN
Publication Date: 2021-11-19

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PubMed Link: 34746703
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Protein clearance strategies for disease intervention.

Journal Of Neural Transmission (Vienna, Austria : 1996)
Hommen, Franziska F; Bilican, Saygın S; Vilchez, David D
Publication Date: 2021-10-23

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PubMed Link: 34689261
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