Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
Acta Neuropathologica Communications
Schilling, Sandra S; Pradhan, Ajay A; Heesch, Amelie A; Helbig, Andrea A; Blennow, Kaj K; Koch, Christian C; Bertgen, Lea L; Koo, Edward H EH; Brinkmalm, Gunnar G; Zetterberg, Henrik H; Kins, Stefan S; Eggert, Simone S
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
Life Science Alliance
Stroo, Esther E; Janssen, Leen L; Sin, Olga O; Hogewerf, Wytse W; Koster, Mirjam M; Harkema, Liesbeth L; Youssef, Sameh A SA; Beschorner, Natalie N; Wolters, Anouk Hg AH; Bakker, Bjorn B; Becker, Lore L; Garrett, Lilian L; Marschall, Susan S; Hoelter, Sabine M SM; Wurst, Wolfgang W; Fuchs, Helmut H; Gailus-Durner, Valerie V; Hrabe de Angelis, Martin M; Thathiah, Amantha A; Foijer, Floris F; van de Sluis, Bart B; van Deursen, Jan J; Jucker, Matthias M; de Bruin, Alain A; Nollen, Ellen Aa EA
Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients.
Frontiers In Aging Neuroscience
Daoutsali, Elena E; Pepers, Barry A BA; Stamatakis, Stavros S; van der Graaf, Linda M LM; Terwindt, Gisela M GM; Parfitt, David A DA; Buijsen, Ronald A M RAM; van Roon-Mom, Willeke M C WMC
Human cerebral vascular amyloid contains both antiparallel and parallel in-register Aβ40 fibrils.
The Journal Of Biological Chemistry
Irizarry, Brandon A BA; Davis, Judianne J; Zhu, Xiaoyue X; Boon, Baayla D C BDC; Rozemuller, Annemieke J M AJM; Van Nostrand, William E WE; Smith, Steven O SO
Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila.
Alzheimer'S Research & Therapy
De Mena, Lorena L; Smith, Michael A MA; Martin, Jason J; Dunton, Katie L KL; Ceballos-Diaz, Carolina C; Jansen-West, Karen R KR; Cruz, Pedro E PE; Dillon, Kristy D KD; Rincon-Limas, Diego E DE; Golde, Todd E TE; Moore, Brenda D BD; Levites, Yona Y
Impact of Mutations on the Conformational Transition from α-Helix to β-Sheet Structures in Arctic-Type Aβ40: Insights from Molecular Dynamics Simulations.
An automated clinical mass spectrometric method for identification and quantification of variant and wild-type amyloid-β 1-40 and 1-42 peptides in CSF.
Alzheimer'S & Dementia (Amsterdam, Netherlands)
DeMarco, Mari L ML; Nguyen, Quyen Q; Fok, Alice A; Hsiung, Ging-Yuek Robin GR; van der Gugten, J Grace JG
Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant.
The Journal Of Biological Chemistry
Crooks, Elliot J EJ; Irizarry, Brandon A BA; Ziliox, Martine M; Kawakami, Toru T; Victor, Tiffany T; Xu, Feng F; Hojo, Hironobu H; Chiu, Kelley K; Simmerling, Carlos C; Van Nostrand, William E WE; Smith, Steven O SO; Miller, Lisa M LM
Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue.
Nature Communications
Kollmer, Marius M; Close, William W; Funk, Leonie L; Rasmussen, Jay J; Bsoul, Aref A; Schierhorn, Angelika A; Schmidt, Matthias M; Sigurdson, Christina J CJ; Jucker, Mathias M; Fändrich, Marcus M
Structure-based inhibitors of amyloid beta core suggest a common interface with tau.
Elife
Griner, Sarah L SL; Seidler, Paul P; Bowler, Jeannette J; Murray, Kevin A KA; Yang, Tianxiao Peter TP; Sahay, Shruti S; Sawaya, Michael R MR; Cascio, Duilio D; Rodriguez, Jose A JA; Philipp, Stephan S; Sosna, Justyna J; Glabe, Charles G CG; Gonen, Tamir T; Eisenberg, David S DS
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.
Scientific Reports
Sanagavarapu, Kalyani K; Nüske, Elisabeth E; Nasir, Irem I; Meisl, Georg G; Immink, Jasper N JN; Sormanni, Pietro P; Vendruscolo, Michele M; Knowles, Tuomas P J TPJ; Malmendal, Anders A; Cabaleiro-Lago, Celia C; Linse, Sara S
Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.
The Journal Of Biological Chemistry
Tang, Tzu-Chun TC; Kienlen-Campard, Pascal P; Hu, Yi Y; Perrin, Florian F; Opsomer, Rémi R; Octave, Jean-Noël JN; Constantinescu, Stefan N SN; Smith, Steven O SO
A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.
The American Journal Of Pathology
Davis, Judianne J; Xu, Feng F; Hatfield, Joshua J; Lee, Hedok H; Hoos, Michael D MD; Popescu, Dominique D; Crooks, Elliot E; Kim, Regina R; Smith, Steven O SO; Robinson, John K JK; Benveniste, Helene H; Van Nostrand, William E WE
Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins.
The Journal Of Biological Chemistry
Hur, Woosuk S WS; Mazinani, Nima N; Lu, X J David XJD; Yefet, Leeor S LS; Byrnes, James R JR; Ho, Laura L; Yeon, Ju Hun JH; Filipenko, Sam S; Wolberg, Alisa S AS; Jefferies, Wilfred A WA; Kastrup, Christian J CJ
Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.
β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.
Scientific Reports
Hu, Yi Y; Kienlen-Campard, Pascal P; Tang, Tzu-Chun TC; Perrin, Florian F; Opsomer, Rémi R; Decock, Marie M; Pan, Xiaoshu X; Octave, Jean-Noel JN; Constantinescu, Stefan N SN; Smith, Steven O SO
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.
The World Journal Of Biological Psychiatry : The Official Journal Of The World Federation Of Societies Of Biological Psychiatry
Lewczuk, Piotr P; Riederer, Peter P; O'Bryant, Sid E SE; Verbeek, Marcel M MM; Dubois, Bruno B; Visser, Pieter Jelle PJ; Jellinger, Kurt A KA; Engelborghs, Sebastiaan S; Ramirez, Alfredo A; Parnetti, Lucilla L; Jack, Clifford R CR; Teunissen, Charlotte E CE; Hampel, Harald H; Lleó, Alberto A; Jessen, Frank F; Glodzik, Lidia L; de Leon, Mony J MJ; Fagan, Anne M AM; Molinuevo, José Luis JL; Jansen, Willemijn J WJ; Winblad, Bengt B; Shaw, Leslie M LM; Andreasson, Ulf U; Otto, Markus M; Mollenhauer, Brit B; Wiltfang, Jens J; Turner, Martin R MR; Zerr, Inga I; Handels, Ron R; Thompson, Alexander G AG; Johansson, Gunilla G; Ermann, Natalia N; Trojanowski, John Q JQ; Karaca, Ilker I; Wagner, Holger H; Oeckl, Patrick P; van Waalwijk van Doorn, Linda L; Bjerke, Maria M; Kapogiannis, Dimitrios D; Kuiperij, H Bea HB; Farotti, Lucia L; Li, Yi Y; Gordon, Brian A BA; Epelbaum, Stéphane S; Vos, Stephanie J B SJB; Klijn, Catharina J M CJM; Van Nostrand, William E WE; Minguillon, Carolina C; Schmitz, Matthias M; Gallo, Carla C; Lopez Mato, Andrea A; Thibaut, Florence F; Lista, Simone S; Alcolea, Daniel D; Zetterberg, Henrik H; Blennow, Kaj K; Kornhuber, Johannes J; ,
The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.
Journal Of Neurology, Neurosurgery, And Psychiatry
Banerjee, Gargi G; Carare, Roxana R; Cordonnier, Charlotte C; Greenberg, Steven M SM; Schneider, Julie A JA; Smith, Eric E EE; Buchem, Mark van MV; Grond, Jeroen van der JV; Verbeek, Marcel M MM; Werring, David J DJ