Automated optimisation of solubility and conformational stability of antibodies and proteins.
Nature Communications
Rosace, Angelo A; Bennett, Anja A; Oeller, Marc M; Mortensen, Mie M MM; Sakhnini, Laila L; Lorenzen, Nikolai N; Poulsen, Christian C; Sormanni, Pietro P
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Journal Of Hepatology
Sumazin, Pavel P; Peters, Tricia L TL; Sarabia, Stephen F SF; Kim, Hyunjae R HR; Urbicain, Martin M; Hollingsworth, Emporia Faith EF; Alvarez, Karla R KR; Perez, Cintia R CR; Pozza, Alice A; Najaf Panah, Mohammad Javad MJ; Epps, Jessica L JL; Scorsone, Kathy K; Zorman, Barry B; Katzenstein, Howard H; O'Neill, Allison F AF; Meyers, Rebecka R; Tiao, Greg G; Geller, Jim J; Ranganathan, Sarangarajan S; Rangaswami, Arun A AA; Woodfield, Sarah E SE; Goss, John A JA; Vasudevan, Sanjeev A SA; Heczey, Andras A; Roy, Angshumoy A; Fisher, Kevin E KE; Alaggio, Rita R; Patel, Kalyani R KR; Finegold, Milton J MJ; López-Terrada, Dolores H DH
Spatially interacting phosphorylation sites and mutations in cancer.
Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.
The Journal Of Biological Chemistry
Guo, Xiao X; Ramirez, Ivan I; Garcia, Yenni A YA; Velasquez, Erick F EF; Gholkar, Ankur A AA; Cohn, Whitaker W; Whitelegge, Julian P JP; Tofig, Bobby B; Damoiseaux, Robert R; Torres, Jorge Z JZ
Identification of relevant genetic alterations in cancer using topological data analysis.
Nature Communications
Rabadán, Raúl R; Mohamedi, Yamina Y; Rubin, Udi U; Chu, Tim T; Alghalith, Adam N AN; Elliott, Oliver O; Arnés, Luis L; Cal, Santiago S; Obaya, Álvaro J ÁJ; Levine, Arnold J AJ; Cámara, Pablo G PG
Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder within the RASopathy Clinical Spectrum.
American Journal Of Human Genetics
Motta, Marialetizia M; Pannone, Luca L; Pantaleoni, Francesca F; Bocchinfuso, Gianfranco G; Radio, Francesca Clementina FC; Cecchetti, Serena S; Ciolfi, Andrea A; Di Rocco, Martina M; Elting, Mariet W MW; Brilstra, Eva H EH; Boni, Stefania S; Mazzanti, Laura L; Tamburrino, Federica F; Walsh, Larry L; Payne, Katelyn K; Fernández-Jaén, Alberto A; Ganapathi, Mythily M; Chung, Wendy K WK; Grange, Dorothy K DK; Dave-Wala, Ashita A; Reshmi, Shalini C SC; Bartholomew, Dennis W DW; Mouhlas, Danielle D; Carpentieri, Giovanna G; Bruselles, Alessandro A; Pizzi, Simone S; Bellacchio, Emanuele E; Piceci-Sparascio, Francesca F; Lißewski, Christina C; Brinkmann, Julia J; Waclaw, Ronald R RR; Waisfisz, Quinten Q; van Gassen, Koen K; Wentzensen, Ingrid M IM; Morrow, Michelle M MM; Álvarez, Sara S; Martínez-García, Mónica M; De Luca, Alessandro A; Memo, Luigi L; Zampino, Giuseppe G; Rossi, Cesare C; Seri, Marco M; Gelb, Bruce D BD; Zenker, Martin M; Dallapiccola, Bruno B; Stella, Lorenzo L; Prada, Carlos E CE; Martinelli, Simone S; Flex, Elisabetta E; Tartaglia, Marco M
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Taylor, Clinton A CA; Cormier, Kevin W KW; Keenan, Shannon E SE; Earnest, Svetlana S; Stippec, Steve S; Wichaidit, Chonlarat C; Juang, Yu-Chi YC; Wang, Junmei J; Shvartsman, Stanislav Y SY; Goldsmith, Elizabeth J EJ; Cobb, Melanie H MH
Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma.
Oncotarget
Chakraborty, Rikhia R; Hampton, Oliver A OA; Abhyankar, Harshal H; Zinn, Daniel J DJ; Grimes, Amanda A; Skull, Brooks B; Eckstein, Olive O; Mahmood, Nadia N; Wheeler, David A DA; Lopez-Terrada, Dolores D; Peters, Tricia L TL; Hicks, John M JM; Elghetany, Tarek T; Krance, Robert R; Poulikakos, Poulikos I PI; Merad, Miriam M; McClain, Kenneth L KL; Allen, Carl E CE; Parsons, Donald W DW
Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.
Cell Reports
Brenan, Lisa L; Andreev, Aleksandr A; Cohen, Ofir O; Pantel, Sasha S; Kamburov, Atanas A; Cacchiarelli, Davide D; Persky, Nicole S NS; Zhu, Cong C; Bagul, Mukta M; Goetz, Eva M EM; Burgin, Alex B AB; Garraway, Levi A LA; Getz, Gad G; Mikkelsen, Tarjei S TS; Piccioni, Federica F; Root, David E DE; Johannessen, Cory M CM
PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.
Plos Computational Biology
Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J
Recurrent inactivating RASA2 mutations in melanoma.
Nature Genetics
Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Nature Genetics
Krauthammer, Michael M; Kong, Yong Y; Bacchiocchi, Antonella A; Evans, Perry P; Pornputtapong, Natapol N; Wu, Cen C; McCusker, James P JP; Ma, Shuangge S; Cheng, Elaine E; Straub, Robert R; Serin, Merdan M; Bosenberg, Marcus M; Ariyan, Stephan S; Narayan, Deepak D; Sznol, Mario M; Kluger, Harriet M HM; Mane, Shrikant S; Schlessinger, Joseph J; Lifton, Richard P RP; Halaban, Ruth R
A highly recurrent RPS27 5'UTR mutation in melanoma.
Oncotarget
Dutton-Regester, Ken K; Gartner, Jared J JJ; Emmanuel, Rafi R; Qutob, Nouar N; Davies, Michael A MA; Gershenwald, Jeffrey E JE; Robinson, William W; Robinson, Steven S; Rosenberg, Steven A SA; Scolyer, Richard A RA; Mann, Graham J GJ; Thompson, John F JF; Hayward, Nicholas K NK; Samuels, Yardena Y
Copper is required for oncogenic BRAF signalling and tumorigenesis.
Nature
Brady, Donita C DC; Crowe, Matthew S MS; Turski, Michelle L ML; Hobbs, G Aaron GA; Yao, Xiaojie X; Chaikuad, Apirat A; Knapp, Stefan S; Xiao, Kunhong K; Campbell, Sharon L SL; Thiele, Dennis J DJ; Counter, Christopher M CM