PNPLA3 c.444C>G ;(p.I148M)

Variant ID: 22-44324727-C-G

NM_025225.2(PNPLA3):c.444C>G;(p.I148M)

This variant was identified in 1210 publications

View GRCh38 version.




Publications:


The bidirectional impacts of alcohol consumption and MAFLD for progressive fatty liver disease.

Therapeutic Advances In Endocrinology And Metabolism
Kulkarni, Anand V AV; Sarin, Shiv Kumar SK
Publication Date: 2023

Variant appearance in text: rs738409
PubMed Link: 37323163
Variant Present in the following documents:
  • Main text
  • 10.1177_20420188231178370.pdf
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Precision Medicine in Fatty Liver Disease/Non-Alcoholic Fatty Liver Disease.

Journal Of Personalized Medicine
Valenzuela-Vallejo, Laura L; Sanoudou, Despina D; Mantzoros, Christos S CS
Publication Date: 2023-05-14

Variant appearance in text: PNPLA3: i148M; rs738409
PubMed Link: 37241000
Variant Present in the following documents:
  • Main text
  • jpm-13-00830.pdf
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Genetic variants in HFE are associated with non-alcoholic fatty liver disease in lean individuals.

Jhep Reports : Innovation In Hepatology
Sun, Zewen Z; Pan, Xingchen X; Tian, Aowen A; Surakka, Ida I; Wang, Tao T; Jiao, Xu X; He, Shanshan S; Song, Jinfang J; Tian, Xin X; Tong, Dan D; Wen, Jianping J; Zhang, Yonggang Y; Liu, Wanqing W; Chen, Peng P
Publication Date: 2023-07

Variant appearance in text: rs738409
PubMed Link: 37235137
Variant Present in the following documents:
  • Main text
  • mmc4.pdf
  • mmc1.pdf
  • main.pdf
View BVdb publication page



Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease.

Excli Journal
Aasadollahei, Negar N; Rezaei, Niloufar N; Golroo, Reihaneh R; Agarwal, Tarun T; Vosough, Massoud M; Piryaei, Abbas A
Publication Date: 2023

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37223084
Variant Present in the following documents:
  • Main text
  • EXCLI-22-367.pdf
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Lipid droplet biogenesis and functions in health and disease.

Nature Reviews. Endocrinology
Zadoorian, Armella A; Du, Ximing X; Yang, Hongyuan H
Publication Date: 2023-05-23

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 37221402
Variant Present in the following documents:
  • Main text
  • 41574_2023_Article_845.pdf
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Comparison between metabolic-associated fatty liver disease and nonalcoholic fatty liver disease: From nomenclature to clinical outcomes.

World Journal Of Hepatology
Alomari, Mohammad M; Rashid, Mamoon Ur MU; Chadalavada, Pravallika P; Ragheb, Jonathan J; Zafar, Hammad H; Suarez, Zoilo Karim ZK; Khazaaleh, Shrouq S; Gonzalez, Adalberto Jose AJ; Castro, Fernando J FJ
Publication Date: 2023-04-27

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37206648
Variant Present in the following documents:
  • WJH-15-477.pdf
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Hepatic Steatosis in Infancy: The Beginning of Pediatric Nonalcoholic Fatty Liver Disease?

Jpgn Reports
McNelis, Kera K; Yodoshi, Toshifumi T; Divanovic, Senad S; Gandhi, Chandrashekhar C; Kim, Jae H JH; Anton, Christopher G CG; Trout, Andrew T AT; Mouzaki, Marialena M
Publication Date: 2021-08

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37205943
Variant Present in the following documents:
  • pg9-2-e113.pdf
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An international multidisciplinary consensus statement on MAFLD and the risk of CVD.

Hepatology International
Zhou, Xiao-Dong XD; Targher, Giovanni G; Byrne, Christopher D CD; Somers, Virend V; Kim, Seung Up SU; Chahal, C Anwar A CAA; Wong, Vincent Wai-Sun VW; Cai, Jingjing J; Shapiro, Michael D MD; Eslam, Mohammed M; Steg, Philippe Gabriel PG; Sung, Ki-Chul KC; Misra, Anoop A; Li, Jian-Jun JJ; Brotons, Carlos C; Huang, Yuli Y; Papatheodoridis, George V GV; Sun, Aijun A; Yilmaz, Yusuf Y; Chan, Wah Kheong WK; Huang, Hui H; Méndez-Sánchez, Nahum N; Alqahtani, Saleh A SA; Cortez-Pinto, Helena H; Lip, Gregory Y H GYH; de Knegt, Robert J RJ; Ocama, Ponsiano P; Romero-Gomez, Manuel M; Fudim, Marat M; Sebastiani, Giada G; Son, Jang Won JW; Ryan, John D JD; Ikonomidis, Ignatios I; Treeprasertsuk, Sombat S; Pastori, Daniele D; Lupsor-Platon, Monica M; Tilg, Herbert H; Ghazinyan, Hasmik H; Boursier, Jerome J; Hamaguchi, Masahide M; Nguyen, Mindie H MH; Fan, Jian-Gao JG; Goh, George Boon-Bee GB; Al Mahtab, Mamun M; Hamid, Saeed S; Perera, Nilanka N; George, Jacob J; Zheng, Ming-Hua MH
Publication Date: 2023-05-19

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37204656
Variant Present in the following documents:
  • Main text
  • 12072_2023_Article_10543.pdf
View BVdb publication page



Comparison of Machine Learning Models and the Fatty Liver Index in Predicting Lean Fatty Liver.

Diagnostics (Basel, Switzerland)
Su, Pei-Yuan PY; Chen, Yang-Yuan YY; Lin, Chun-Yu CY; Su, Wei-Wen WW; Huang, Siou-Ping SP; Yen, Hsu-Heng HH
Publication Date: 2023-04-13

Variant appearance in text: rs738409
PubMed Link: 37189508
Variant Present in the following documents:
  • Main text
  • diagnostics-13-01407.pdf
View BVdb publication page



The Values and Perspectives of Organoids in the Field of Metabolic Syndrome.

International Journal Of Molecular Sciences
Tan, Chen C; Ding, Min M; Zheng, Yun-Wen YW
Publication Date: 2023-05-01

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 37175830
Variant Present in the following documents:
  • Main text
  • ijms-24-08125.pdf
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One Carbon Metabolism and S-Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes.

Livers
Fernández-Ramos, David D; Lopitz-Otsoa, Fernando F; Millet, Oscar O; Alonso, Cristina C; Lu, Shelly C SC; Mato, José M JM
Publication Date: 2022-12

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37123053
Variant Present in the following documents:
  • Main text
  • nihms-1886670.pdf
View BVdb publication page



Prevalence of alcohol-associated liver disease: a systematic review and meta-analysis.

Hepatology Communications
Amonker, Sachin S; Houshmand, Aryo A; Hinkson, Alexander A; Rowe, Ian I; Parker, Richard R
Publication Date: 2023-05-01

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 37102767
Variant Present in the following documents:
  • hc9-7-e0133.pdf
View BVdb publication page



The rationale and study design of two phase II trials examining the effects of BI 685,509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis.

Trials
Reiberger, Thomas T; Berzigotti, Annalisa A; Trebicka, Jonel J; Ertle, Judith J; Gashaw, Isabella I; Swallow, Ros R; Tomisser, Andrea A
Publication Date: 2023-04-24

Variant appearance in text: rs738409
PubMed Link: 37095557
Variant Present in the following documents:
  • Main text
  • 13063_2023_Article_7291.pdf
View BVdb publication page



Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH.

Cell Reports. Medicine
Conway, Jake J; Pouryahya, Maryam M; Gindin, Yevgeniy Y; Pan, David Z DZ; Carrasco-Zevallos, Oscar M OM; Mountain, Victoria V; Subramanian, G Mani GM; Montalto, Michael C MC; Resnick, Murray M; Beck, Andrew H AH; Huss, Ryan S RS; Myers, Robert P RP; Taylor-Weiner, Amaro A; Wapinski, Ilan I; Chung, Chuhan C
Publication Date: 2023-04-18

Variant appearance in text: rs738409
PubMed Link: 37075704
Variant Present in the following documents:
  • Main text
  • mmc2.pdf
  • main.pdf
View BVdb publication page



Low vitamin A levels are associated with liver-related mortality: a nationally representative cohort study.

Hepatology Communications
Song, Jiunn J; Jiang, Z Gordon ZG
Publication Date: 2023-05-01

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37058112
Variant Present in the following documents:
  • Main text
  • hc9-7-e0124.pdf
View BVdb publication page



Wilson's Disease-Genetic Puzzles with Diagnostic Implications.

Diagnostics (Basel, Switzerland)
Gromadzka, Grażyna G; Bendykowska, Maria M; Przybyłkowski, Adam A
Publication Date: 2023-03-29

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 37046505
Variant Present in the following documents:
  • Main text
  • diagnostics-13-01287.pdf
View BVdb publication page



Glutathione: Pharmacological aspects and implications for clinical use in non-alcoholic fatty liver disease.

Frontiers In Medicine
Santacroce, Giovanni G; Gentile, Antonella A; Soriano, Simone S; Novelli, Andrea A; Lenti, Marco Vincenzo MV; Di Sabatino, Antonio A
Publication Date: 2023

Variant appearance in text: rs738409
PubMed Link: 37035339
Variant Present in the following documents:
  • Main text
  • fmed-10-1124275.pdf
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
View BVdb publication page



Human liver organoid: modeling liver steatosis and beyond.

Cell Regeneration (London, England)
Wei, Jinsong J; Zhang, Wen W; Zhao, Bing B
Publication Date: 2023-04-03

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37009924
Variant Present in the following documents:
  • Main text
  • 13619_2023_Article_161.pdf
View BVdb publication page



Should we undertake surveillance for HCC in patients with MAFLD?

Therapeutic Advances In Endocrinology And Metabolism
Norero, Blanca B; Dufour, Jean-François JF
Publication Date: 2023

Variant appearance in text: PNPLA3: I148M
PubMed Link: 37006779
Variant Present in the following documents:
  • Main text
  • 10.1177_20420188231160389.pdf
View BVdb publication page



Hepatic stellate cell activation markers are regulated by the vagus nerve in systemic inflammation.

Bioelectronic Medicine
Ahmed, Osman O; Caravaca, April S AS; Crespo, Maria M; Dai, Wanmin W; Liu, Ting T; Guo, Qi Q; Leiva, Magdalena M; Sabio, Guadalupe G; Shavva, Vladimir S VS; Malin, Stephen G SG; Olofsson, Peder S PS
Publication Date: 2023-03-31

Variant appearance in text: PNPLA3: I148M
PubMed Link: 36997988
Variant Present in the following documents:
  • 42234_2023_Article_108.pdf
View BVdb publication page



Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes.

Nature Communications
Li, Lingling L; Jiang, Dongxian D; Liu, Hui H; Guo, Chunmei C; Zhao, Rui R; Zhang, Qiao Q; Xu, Chen C; Qin, Zhaoyu Z; Feng, Jinwen J; Liu, Yang Y; Wang, Haixing H; Chen, Weijie W; Zhang, Xue X; Li, Bin B; Bai, Lin L; Tian, Sha S; Tan, Subei S; Yu, Zixiang Z; Chen, Lingli L; Huang, Jie J; Zhao, Jian-Yuan JY; Hou, Yingyong Y; Ding, Chen C
Publication Date: 2023-03-29

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 36991000
Variant Present in the following documents:
  • 41467_2023_37221_MOESM5_ESM.xlsx, sheet 3
View BVdb publication page



Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome.

Medicina (Kaunas, Lithuania)
Abenavoli, Ludovico L; Scarlata, Giuseppe Guido Maria GGM; Scarpellini, Emidio E; Boccuto, Luigi L; Spagnuolo, Rocco R; Tilocca, Bruno B; Roncada, Paola P; Luzza, Francesco F
Publication Date: 2023-03-17

Variant appearance in text: rs738409
PubMed Link: 36984595
Variant Present in the following documents:
  • Main text
  • medicina-59-00594.pdf
View BVdb publication page



Correlation between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction in non-obese adults: a cross-sectional study.

Bmc Gastroenterology
Cong, Fangyuan F; Zhu, Luying L; Deng, Lihua L; Xue, Qian Q; Wang, Jingtong J
Publication Date: 2023-03-27

Variant appearance in text: rs738409
PubMed Link: 36973654
Variant Present in the following documents:
  • Main text
  • 12876_2023_Article_2708.pdf
View BVdb publication page



Fatty liver disease in children (MAFLD/PeFLD Type 2): unique classification considerations and challenges.

Therapeutic Advances In Endocrinology And Metabolism
Hegarty, Robert R; Kyrana, Eirini E; Fitzpatrick, Emer E; Dhawan, Anil A
Publication Date: 2023

Variant appearance in text: rs738409
PubMed Link: 36968656
Variant Present in the following documents:
  • Main text
  • 10.1177_20420188231160388.pdf
View BVdb publication page



The I148M PNPLA3 variant mitigates niacin beneficial effects: How the genetic screening in non-alcoholic fatty liver disease patients gains value.

Frontiers In Nutrition
Paolini, Erika E; Longo, Miriam M; Meroni, Marica M; Tria, Giada G; Cespiati, Annalisa A; Lombardi, Rosa R; Badiali, Sara S; Maggioni, Marco M; Fracanzani, Anna Ludovica AL; Dongiovanni, Paola P
Publication Date: 2023

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 36937355
Variant Present in the following documents:
  • Main text
  • fnut-10-1101341.pdf
  • Data_Sheet_1.pdf
View BVdb publication page



Uncovering the NAFLD burden in people living with HIV from high- and middle-income nations: a meta-analysis with a data gap from Subsaharan Africa.

Journal Of The International Aids Society
Manzano-Nunez, Ramiro R; Rivera-Esteban, Jesús J; Navarro, Jordi J; Bañares, Juan J; Sena, Elena E; Schattenberg, Jörn M JM; Lazarus, Jeffrey V JV; Curran, Adria A; Pericàs, Juan M JM
Publication Date: 2023-03

Variant appearance in text: rs738409
PubMed Link: 36924219
Variant Present in the following documents:
  • Main text
  • JIA2-26-e26072.pdf
View BVdb publication page



Serum miR-4488 as a potential biomarker of lean nonalcoholic fatty liver disease.

Annals Of Translational Medicine
Shen, Nan N; Tang, Ling L; Qian, Yufan Y; Pan, Jielu J; Pan, Jiashu J; Miao, Hongyu H; Zhang, Haiyan H; Fang, Hong H; Yu, Xiao X; Xing, Lianjun L
Publication Date: 2023-02-28

Variant appearance in text: PNPLA3: I148M
PubMed Link: 36923095
Variant Present in the following documents:
  • Main text
  • atm-11-04-173.pdf
View BVdb publication page



Non-alcoholic fatty liver disease as an emerging risk factor and potential intervention target for atherosclerotic cardiovascular diseases.

Journal Of Cardiovascular Pharmacology
Zhang, Daqing D; Mi, Zhen Z; Peng, Jiya J; Yang, Tiangui T; Han, Yuze Y; Zhai, Yujia Y; Song, Chenliang C; Teng, Xianzhuo X; Sun, Wei W; Guo, Jing J; Bilonda, Kabeya Paulin KP
Publication Date: 2023-03-13

Variant appearance in text: PNPLA3: Ile148Met
PubMed Link: 36917556
Variant Present in the following documents:
  • Main text
  • jcvp-81-327.pdf
View BVdb publication page



TM6SF2-rs58542926 Genetic Variant Modifies the Protective Effect of a "Prudent" Dietary Pattern on Serum Triglyceride Levels.

Nutrients
Kalafati, Ioanna Panagiota IP; Dimitriou, Maria M; Revenas, Konstantinos K; Kokkinos, Alexander A; Deloukas, Panos P; Dedoussis, George V GV
Publication Date: 2023-02-23

Variant appearance in text: PNPLA3: Ile148Met; rs738409
PubMed Link: 36904112
Variant Present in the following documents:
  • Main text
  • nutrients-15-01112.pdf
View BVdb publication page



Patatin-like phospholipase domain-containing 3 gene (PNPLA3) polymorphic (rs738409) single nucleotide polymorphisms and susceptibility to nonalcoholic fatty liver disease: A meta-analysis of twenty studies.

Medicine
Zhao, Yan Y; Zhao, Wenli W; Ma, Jingchao J; Toshiyoshi, Maeda M; Zhao, Ye Y
Publication Date: 2023-03-10

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 36897668
Variant Present in the following documents:
  • Main text
  • medi-102-e33110.pdf
View BVdb publication page



Non-obese or lean nonalcoholic fatty liver disease matters but is it preventable or inevitable in light of its risk factors?

Clinical And Molecular Hepatology
Jang, Heejoon H; Kim, Won W
Publication Date: 2023-03-09

Variant appearance in text: rs738409
PubMed Link: 36891605
Variant Present in the following documents:
  • Main text
  • cmh-2023-0088.pdf
View BVdb publication page



High producer variant of lipoprotein lipase may protect from hepatocellular carcinoma in alcohol-associated cirrhosis.

Jhep Reports : Innovation In Hepatology
Schmalz, Franziska F; Fischer, Janett J; Innes, Hamish H; Buch, Stephan S; Möller, Christine C; Matz-Soja, Madlen M; von Schönfels, Witigo W; Krämer, Benjamin B; Langhans, Bettina B; Klüners, Alexandra A; Soyka, Michael M; Stickel, Felix F; Nattermann, Jacob J; Strassburg, Christian P CP; Berg, Thomas T; Lutz, Philipp P; Nischalke, Hans Dieter HD
Publication Date: 2023-04

Variant appearance in text: PNPLA3: I148M; rs738409
PubMed Link: 36879887
Variant Present in the following documents:
  • Main text
  • mmc4.pdf
  • main.pdf
View BVdb publication page



Epigenetics as a versatile regulator of fibrosis.

Journal Of Translational Medicine
Liu, Yangdan Y; Wen, Dongsheng D; Ho, Chiakang C; Yu, Li L; Zheng, Danning D; O'Reilly, Steven S; Gao, Ya Y; Li, Qingfeng Q; Zhang, Yifan Y
Publication Date: 2023-03-02

Variant appearance in text: PNPLA3: I148M
PubMed Link: 36864460
Variant Present in the following documents:
  • Main text
  • 12967_2023_Article_4018.pdf
View BVdb publication page