O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern.
Acs Central Science
Gonzalez-Rodriguez, Edgar E; Zol-Hanlon, Mia M; Bineva-Todd, Ganka G; Marchesi, Andrea A; Skehel, Mark M; Mahoney, Keira E KE; Roustan, Chloë C; Borg, Annabel A; Di Vagno, Lucia L; Kjær, Svend S; Wrobel, Antoni G AG; Benton, Donald J DJ; Nawrath, Philipp P; Flitsch, Sabine L SL; Joshi, Dhira D; González-Ramírez, Andrés Manuel AM; Wilkinson, Katalin A KA; Wilkinson, Robert J RJ; Wall, Emma C EC; Hurtado-Guerrero, Ramón R; Malaker, Stacy A SA; Schumann, Benjamin B
"Is Omicron mild"? Testing this narrative with the mutational landscape of its three lineages and response to existing vaccines and therapeutic antibodies.