Publications:

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Indole - a promising pharmacophore in recent antiviral drug discovery.

Rsc Medicinal Chemistry

Dorababu, Atukuri A

Publication Date: 2020-12-17

Variant appearance in text: SI: G140S

PubMed Link: 34095843

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Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors.

Bioorganic & Medicinal Chemistry

Curreli, Francesca F; Ahmed, Shahad S; Benedict Victor, Sofia M SM; Iusupov, Ildar R IR; Spiridonov, Evgeny A EA; Belov, Dmitry S DS; Altieri, Andrea A; Kurkin, Alexander V AV; Debnath, Asim K AK

Publication Date: 2021-02-15

Variant appearance in text: SI: G140S

PubMed Link: 33461144

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The Stereoselective Nitro-Mannich Reaction in the Synthesis of Active Pharmaceutical Ingredients and Other Biologically Active Compounds.

Frontiers In Chemistry

Faisca Phillips, Ana Maria AM; Guedes da Silva, M Fátima C MFC; Pombeiro, Armando J L AJL

Publication Date: 2020

Variant appearance in text: SI: G140S

PubMed Link: 32047742

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• fchem-08-00030.pdf

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Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation.

Journal Of Medicinal Chemistry

Curreli, Francesca F; Ahmed, Shahad S; Benedict Victor, Sofia M SM; Iusupov, Ildar R IR; Belov, Dmitry S DS; Markov, Pavel O PO; Kurkin, Alexander V AV; Altieri, Andrea A; Debnath, Asim K AK

Publication Date: 2020-02-27

Variant appearance in text: SI: G140S

PubMed Link: 32031803

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Discovery of Novel Integrase Inhibitors Acting outside the Active Site Through High-Throughput Screening.

Molecules (Basel, Switzerland)

Aknin, Cindy C; Smith, Elena A EA; Marchand, Christophe C; Andreola, Marie-Line ML; Pommier, Yves Y; Metifiot, Mathieu M

Publication Date: 2019-10-12

Variant appearance in text: SI: G140S

PubMed Link: 31614773

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• molecules-24-03675.pdf

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Epistasis and entrenchment of drug resistance in HIV-1 subtype B.

Elife

Biswas, Avik A; Haldane, Allan A; Arnold, Eddy E; Levy, Ronald M RM

Publication Date: 2019-10-08

Variant appearance in text: SI: G140S

PubMed Link: 31591964

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Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides.

Plos One

Tintori, Cristina C; Iovenitti, Giulia G; Ceresola, Elisa Rita ER; Ferrarese, Roberto R; Zamperini, Claudio C; Brai, Annalaura A; Poli, Giulio G; Dreassi, Elena E; Cagno, Valeria V; Lembo, David D; Canducci, Filippo F; Botta, Maurizio M

Publication Date: 2018

Variant appearance in text: SI: G140S

PubMed Link: 29870553

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Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.

Nucleic Acids Research

Métifiot, Mathieu M; Johnson, Barry C BC; Kiselev, Evgeny E; Marler, Laura L; Zhao, Xue Zhi XZ; Burke, Terrence R TR; Marchand, Christophe C; Hughes, Stephen H SH; Pommier, Yves Y

Publication Date: 2016-08-19

Variant appearance in text: SI: G140S

PubMed Link: 27369381

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• gkw592.pdf

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Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Brai, Annalaura A; Fazi, Roberta R; Tintori, Cristina C; Zamperini, Claudio C; Bugli, Francesca F; Sanguinetti, Maurizio M; Stigliano, Egidio E; Esté, José J; Badia, Roger R; Franco, Sandra S; Martinez, Miguel A MA; Martinez, Javier P JP; Meyerhans, Andreas A; Saladini, Francesco F; Zazzi, Maurizio M; Garbelli, Anna A; Maga, Giovanni G; Botta, Maurizio M

Publication Date: 2016-05-10

Variant appearance in text: SI: G140S

PubMed Link: 27118832

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HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.

Acs Chemical Biology

Zhao, Xue Zhi XZ; Smith, Steven J SJ; Maskell, Daniel P DP; Metifiot, Mathieu M; Pye, Valerie E VE; Fesen, Katherine K; Marchand, Christophe C; Pommier, Yves Y; Cherepanov, Peter P; Hughes, Stephen H SH; Burke, Terrence R TR

Publication Date: 2016-04-15

Variant appearance in text: SI: G140S

PubMed Link: 26808478

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• cb5b00948_si_001.pdf

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4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.

Journal Of Medicinal Chemistry

Zhao, Xue Zhi XZ; Smith, Steven J SJ; Métifiot, Mathieu M; Marchand, Christophe C; Boyer, Paul L PL; Pommier, Yves Y; Hughes, Stephen H SH; Burke, Terrence R TR

Publication Date: 2014-06-26

Variant appearance in text: SI: G140S

PubMed Link: 24901667

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• jm5001908.pdf

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Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.

Journal Of Medicinal Chemistry

Zhao, Xue Zhi XZ; Smith, Steven J SJ; Métifiot, Mathieu M; Johnson, Barry C BC; Marchand, Christophe C; Pommier, Yves Y; Hughes, Stephen H SH; Burke, Terrence R TR

Publication Date: 2014-02-27

Variant appearance in text: SI: G140S

PubMed Link: 24471816

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• jm401902n.pdf

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6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.

Bioorganic & Medicinal Chemistry Letters

Zhao, Xue Zhi XZ; Maddali, Kasthuraiah K; Smith, Steven J SJ; Métifiot, Mathieu M; Johnson, Barry C BC; Marchand, Christophe C; Hughes, Stephen H SH; Pommier, Yves Y; Burke, Terrence R TR

Publication Date: 2012-12-15

Variant appearance in text: SI: G140S

PubMed Link: 23149229

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