Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis.
Frontiers In Cellular And Infection Microbiology
Chengalroyen, Melissa D MD; Jordaan, Audrey A; Seldon, Ronnett R; Ioerger, Thomas T; Franzblau, Scott G SG; Nasr, Mohamed M; Warner, Digby F DF; Mizrahi, Valerie V
Integrated molecular drivers coordinate biological and clinical states in melanoma.
Nature Genetics
Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.
Nature Communications
George, Julie J; Walter, Vonn V; Peifer, Martin M; Alexandrov, Ludmil B LB; Seidel, Danila D; Leenders, Frauke F; Maas, Lukas L; Müller, Christian C; Dahmen, Ilona I; Delhomme, Tiffany M TM; Ardin, Maude M; Leblay, Noemie N; Byrnes, Graham G; Sun, Ruping R; De Reynies, Aurélien A; McLeer-Florin, Anne A; Bosco, Graziella G; Malchers, Florian F; Menon, Roopika R; Altmüller, Janine J; Becker, Christian C; Nürnberg, Peter P; Achter, Viktor V; Lang, Ulrich U; Schneider, Peter M PM; Bogus, Magdalena M; Soloway, Matthew G MG; Wilkerson, Matthew D MD; Cun, Yupeng Y; McKay, James D JD; Moro-Sibilot, Denis D; Brambilla, Christian G CG; Lantuejoul, Sylvie S; Lemaitre, Nicolas N; Soltermann, Alex A; Weder, Walter W; Tischler, Verena V; Brustugun, Odd Terje OT; Lund-Iversen, Marius M; Helland, Åslaug Å; Solberg, Steinar S; Ansén, Sascha S; Wright, Gavin G; Solomon, Benjamin B; Roz, Luca L; Pastorino, Ugo U; Petersen, Iver I; Clement, Joachim H JH; Sänger, Jörg J; Wolf, Jürgen J; Vingron, Martin M; Zander, Thomas T; Perner, Sven S; Travis, William D WD; Haas, Stefan A SA; Olivier, Magali M; Foll, Matthieu M; Büttner, Reinhard R; Hayes, David Neil DN; Brambilla, Elisabeth E; Fernandez-Cuesta, Lynnette L; Thomas, Roman K RK
The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.
Acs Infectious Diseases
Singh, Vinayak V; Donini, Stefano S; Pacitto, Angela A; Sala, Claudia C; Hartkoorn, Ruben C RC; Dhar, Neeraj N; Keri, Gyorgy G; Ascher, David B DB; Mondésert, Guillaume G; Vocat, Anthony A; Lupien, Andréanne A; Sommer, Raphael R; Vermet, Hélène H; Lagrange, Sophie S; Buechler, Joe J; Warner, Digby F DF; McKinney, John D JD; Pato, Janos J; Cole, Stewart T ST; Blundell, Tom L TL; Rizzi, Menico M; Mizrahi, Valerie V
Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Bowers, Peter M PM; Horlick, Robert A RA; Neben, Tamlyn Y TY; Toobian, Rachelle M RM; Tomlinson, Geoffrey L GL; Dalton, Jennifer L JL; Jones, Heather A HA; Chen, Andy A; Altobell, Laurence L; Zhang, Xue X; Macomber, John L JL; Krapf, Irina P IP; Wu, Betty F BF; McConnell, Audrey A; Chau, Betty B; Holland, Trevin T; Berkebile, Ashley D AD; Neben, Steven S SS; Boyle, William J WJ; King, David J DJ