Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors.
Bioorganic & Medicinal Chemistry
Curreli, Francesca F; Ahmed, Shahad S; Benedict Victor, Sofia M SM; Iusupov, Ildar R IR; Spiridonov, Evgeny A EA; Belov, Dmitry S DS; Altieri, Andrea A; Kurkin, Alexander V AV; Debnath, Asim K AK
Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation.
Journal Of Medicinal Chemistry
Curreli, Francesca F; Ahmed, Shahad S; Benedict Victor, Sofia M SM; Iusupov, Ildar R IR; Belov, Dmitry S DS; Markov, Pavel O PO; Kurkin, Alexander V AV; Altieri, Andrea A; Debnath, Asim K AK
Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Bird, Gregory H GH; Madani, Navid N; Perry, Alisa F AF; Princiotto, Amy M AM; Supko, Jeffrey G JG; He, Xiaoying X; Gavathiotis, Evripidis E; Sodroski, Joseph G JG; Walensky, Loren D LD