PIK3CA c.-76-18864C>A

Variant ID: 3-178897674-C-A

NM_006218.2(PIK3CA):c.-76-18864C>A

This variant was identified in 18 publications

View GRCh38 version.




Publications:


Thrombospondin-2 and LDH Are Putative Predictive Biomarkers for Treatment with Everolimus in Second-Line Metastatic Clear Cell Renal Cell Carcinoma (MARC-2 Study).

Cancers
Zeuschner, Philip P; Hölters, Sebastian S; Stöckle, Michael M; Seliger, Barbara B; Mueller, Anja A; Bachmann, Hagen S HS; Grünwald, Viktor V; Christoph, Daniel C DC; Stenzl, Arnulf A; Grimm, Marc-Oliver MO; Brüning, Fabian F; Goebell, Peter J PJ; Augustin, Marinela M; Roos, Frederik F; Harde, Johanna J; Benz-Rüd, Iris I; Staehler, Michael M; Junker, Kerstin K
Publication Date: 2021-05-25

Variant appearance in text: rs6443624
PubMed Link: 34070677
Variant Present in the following documents:
  • Main text
  • cancers-13-02594.pdf
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Genetic and molecular biology of bladder cancer among Iranian patients.

Molecular Genetics & Genomic Medicine
Mojarrad, Majid M; Moghbeli, Meysam M
Publication Date: 2020-06

Variant appearance in text: rs6443624
PubMed Link: 32253828
Variant Present in the following documents:
  • Main text
  • MGG3-8-e1233.pdf
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Association of FGFR2 and PI3KCA genetic variants with the risk of breast cancer in a Chinese population.

Cancer Management And Research
Wang, Yang Y; Zhang, Haiyu H; Lin, Mingzhen M; Wang, Yongsheng Y
Publication Date: 2018

Variant appearance in text: rs6443624
PubMed Link: 29872343
Variant Present in the following documents:
  • Main text
  • cmar-10-1305.pdf
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Genetic variations in the PI3K/PTEN/AKT/mTOR pathway predict tumor response and disease-free survival in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy and radical surgery.

Journal Of Cancer
Peng, Jianhong J; Ma, Wenjuan W; Zhou, Zhongguo Z; Gu, Yangkui Y; Lu, Zhenhai Z; Zhang, Rongxin R; Pan, Zhizhong Z
Publication Date: 2018

Variant appearance in text: rs6443624
PubMed Link: 29581786
Variant Present in the following documents:
  • Main text
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Association between single nucleotide polymorphisms in the PI3K/AKT/mTOR pathway and bladder cancer risk in a sample of Iranian population.

Excli Journal
Bizhani, Fatemeh F; Hashemi, Mohammad M; Danesh, Hiva H; Nouralizadeh, Akbar A; Narouie, Behzad B; Bahari, Gholamreza G; Ghavami, Saeid S
Publication Date: 2018

Variant appearance in text: rs6443624
PubMed Link: 29383014
Variant Present in the following documents:
  • Main text
  • EXCLI-17-3.pdf
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Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib.

Scientific Reports
Cebrián, Arancha A; Gómez Del Pulgar, Teresa T; Méndez-Vidal, María José MJ; Gonzálvez, María Luisa ML; Lainez, Nuria N; Castellano, Daniel D; García-Carbonero, Iciar I; Esteban, Emilio E; Sáez, Maria Isabel MI; Villatoro, Rosa R; Suárez, Cristina C; Carrato, Alfredo A; Munárriz-Ferrándiz, Javier J; Basterrechea, Laura L; García-Alonso, Mirta M; González-Larriba, José Luis JL; Perez-Valderrama, Begoña B; Cruz-Jurado, Josefina J; González Del Alba, Aránzazu A; Moreno, Fernando F; Reynés, Gaspar G; Rodríguez-Remírez, María M; Boni, Valentina V; Mahillo-Fernández, Ignacio I; Martin, Yolanda Y; Viqueira, Andrea A; García-Foncillas, Jesús J
Publication Date: 2017-01-24

Variant appearance in text: rs6443624
PubMed Link: 28117391
Variant Present in the following documents:
  • Main text
  • srep41371.pdf
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Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects.

International Journal Of Molecular Sciences
Granata, Simona S; Dalla Gassa, Alessandra A; Carraro, Amedeo A; Brunelli, Matteo M; Stallone, Giovanni G; Lupo, Antonio A; Zaza, Gianluigi G
Publication Date: 2016-05-14

Variant appearance in text: rs6443624
PubMed Link: 27187382
Variant Present in the following documents:
  • Main text
  • ijms-17-00735.pdf
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Genetic association between PIK3CA gene and oral squamous cell carcinoma: a case control study conducted in Chongqing, China.

International Journal Of Clinical And Experimental Pathology
Wan, Xiaoxiao X; Li, Xian X; Yang, Junyan J; Lv, Wei W; Wang, Qiming Q; Chen, Ying Y; Li, Yong Y
Publication Date: 2015

Variant appearance in text: rs6443624
PubMed Link: 26722541
Variant Present in the following documents:
  • Main text
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Germline determinants of clinical outcome of cutaneous melanoma.

Pigment Cell & Melanoma Research
Vogelsang, Matjaz M; Wilson, Melissa M; Kirchhoff, Tomas T
Publication Date: 2016-01

Variant appearance in text: rs6443624
PubMed Link: 26342156
Variant Present in the following documents:
  • Main text
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Genetic variants of EGF and VEGF predict prognosis of patients with advanced esophageal squamous cell carcinoma.

Plos One
Yang, Pei-Wen PW; Hsieh, Min-Shu MS; Huang, Ya-Chuan YC; Hsieh, Ching-Yueh CY; Chiang, Tzu-Hsuan TH; Lee, Jang-Ming JM
Publication Date: 2014

Variant appearance in text: rs6443624
PubMed Link: 24945674
Variant Present in the following documents:
  • Main text
  • pone.0100326.pdf
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Gene variants in angiogenesis and lymphangiogenesis and cutaneous melanoma progression.

Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Park, Jong Y JY; Amankwah, Ernest K EK; Anic, Gabriella M GM; Lin, Hui-Yi HY; Walls, Brooke B; Park, Hyun H; Krebs, Kevin K; Madden, Melissa M; Maddox, Kristen K; Marzban, Suroosh S; Fang, Shenying S; Chen, Wei W; Lee, Jeffrey E JE; Wei, Qingyi Q; Amos, Christopher I CI; Messina, Jane L JL; Sondak, Vernon K VK; Sellers, Thomas A TA; Egan, Kathleen M KM
Publication Date: 2013-05

Variant appearance in text: rs6443624
PubMed Link: 23462921
Variant Present in the following documents:
  • Main text
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Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population.

Carcinogenesis
Slattery, Martha L ML; John, Esther M EM; Torres-Mejia, Gabriela G; Lundgreen, Abbie A; Herrick, Jennifer S JS; Baumgartner, Kathy B KB; Hines, Lisa M LM; Stern, Mariana C MC; Wolff, Roger K RK
Publication Date: 2012-08

Variant appearance in text: rs6443624
PubMed Link: 22562547
Variant Present in the following documents:
  • Main text
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Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.

Journal Of Cancer Research And Clinical Oncology
Wang, Li-E LE; Ma, Hongxia H; Hale, Katherine S KS; Yin, Ming M; Meyer, Larissa A LA; Liu, Hongliang H; Li, Jie J; Lu, Karen H KH; Hennessy, Bryan T BT; Li, Xuesong X; Spitz, Margaret R MR; Wei, Qingyi Q; Mills, Gordon B GB
Publication Date: 2012-03

Variant appearance in text: rs6443624
PubMed Link: 22146979
Variant Present in the following documents:
  • Main text
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Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome.

Fertility And Sterility
Goodarzi, Mark O MO; Louwers, Yvonne V YV; Taylor, Kent D KD; Jones, Michelle R MR; Cui, Jinrui J; Kwon, Soonil S; Chen, Yii-Der I YD; Guo, Xiuqing X; Stolk, Lisette L; Uitterlinden, André G AG; Laven, Joop S E JS; Azziz, Ricardo R
Publication Date: 2011-04

Variant appearance in text: rs6443624
PubMed Link: 21300347
Variant Present in the following documents:
  • Main text
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Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study.

Gynecologic Oncology
Lacey, James V JV; Yang, Hannah H; Gaudet, Mia M MM; Dunning, Alison A; Lissowska, Jolanta J; Sherman, Mark E ME; Peplonska, Beata B; Brinton, Louise A LA; Healey, Catherine S CS; Ahmed, Shahana S; Pharoah, Paul P; Easton, Douglas D; Chanock, Stephen S; Garcia-Closas, Montserrat M
Publication Date: 2011-02

Variant appearance in text: rs6443624
PubMed Link: 21093899
Variant Present in the following documents:
  • Main text
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PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy.

Lung Cancer (Amsterdam, Netherlands)
Pu, Xia X; Hildebrandt, Michelle A T MA; Lu, Charles C; Lin, Jie J; Stewart, David J DJ; Ye, Yuanqing Y; Gu, Jian J; Spitz, Margaret R MR; Wu, Xifeng X
Publication Date: 2011-01

Variant appearance in text: rs6443624
PubMed Link: 20447721
Variant Present in the following documents:
  • Main text
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Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer.

British Journal Of Cancer
Quaye, L L; Song, H H; Ramus, S J SJ; Gentry-Maharaj, A A; Høgdall, E E; DiCioccio, R A RA; McGuire, V V; Wu, A H AH; Van Den Berg, D J DJ; Pike, M C MC; Wozniak, E E; Doherty, J A JA; Rossing, M A MA; Ness, R B RB; Moysich, K B KB; Høgdall, C C; Blaakaer, J J; , ; Easton, D F DF; Ponder, B A J BA; Jacobs, I J IJ; Menon, U U; Whittemore, A S AS; Krüger-Kjaer, S S; Pearce, C L CL; Pharoah, P D P PD; Gayther, S A SA
Publication Date: 2009-03-24

Variant appearance in text: rs6443624
PubMed Link: 19240718
Variant Present in the following documents:
  • Main text
  • 6604947a.pdf
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Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Hildebrandt, Michelle A T MA; Yang, Hushan H; Hung, Mien-Chie MC; Izzo, Julie G JG; Huang, Maosheng M; Lin, Jie J; Ajani, Jaffer A JA; Wu, Xifeng X
Publication Date: 2009-02-20

Variant appearance in text: rs6443624
PubMed Link: 19164214
Variant Present in the following documents:
  • Main text
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