Publications:

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KRAS, NRAS, BRAF, and PIK3CA mutation rates, clinicopathological association, and their prognostic value in Iranian colorectal cancer patients.

Journal Of Clinical Laboratory Analysis

Mirzapoor Abbasabadi, Zohreh Z; Hamedi Asl, Dariush D; Rahmani, Babak B; Shahbadori, Rozhin R; Karami, Sara S; Peymani, Amir A; Taghizadeh, Sara S; Samiee Rad, Fatemeh F

Publication Date: 2023-03-17

Variant appearance in text: PIK3CA: G12R

PubMed Link: 36930789

Variant Present in the following documents:

• Main text
• JCLA-37-e24868.pdf

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Endothelial cell-specific molecule 1 drives cervical cancer progression.

Cell Death & Disease

Lu, Jingjing J; Liu, Qin Q; Zhu, Lixia L; Liu, Yuanyuan Y; Zhu, Xiaoren X; Peng, Shiqing S; Chen, Minbin M; Li, Ping P

Publication Date: 2022-12-15

Variant appearance in text: PI3K: G12R

PubMed Link: 36522312

Variant Present in the following documents:

• 41419_2022_Article_5501.pdf

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The mutational landscape of cancer's vulnerability to ionizing radiation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME

Publication Date: 2022-10-12

Variant appearance in text: PIK3CA: G12R

PubMed Link: 36222846

Variant Present in the following documents:

• 5343.pdf

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Molecular characterization of colorectal cancer related peritoneal metastatic disease.

Nature Communications

Lenos, Kristiaan J KJ; Bach, Sander S; Ferreira Moreno, Leandro L; Ten Hoorn, Sanne S; Sluiter, Nina R NR; Bootsma, Sanne S; Vieira Braga, Felipe A FA; Nijman, Lisanne E LE; van den Bosch, Tom T; Miedema, Daniel M DM; van Dijk, Erik E; Ylstra, Bauke B; Kulicke, Ruth R; Davis, Fred P FP; Stransky, Nicolas N; Smolen, Gromoslaw A GA; Coebergh van den Braak, Robert R J RRJ; IJzermans, Jan N M JNM; Martens, John W M JWM; Hallam, Sally S; Beggs, Andrew D AD; Kops, Geert J P L GJPL; Lansu, Nico N; Bastiaenen, Vivian P VP; Klaver, Charlotte E L CEL; Lecca, Maria C MC; El Makrini, Khalid K; Elbers, Clara C CC; Dings, Mark P G MPG; van Noesel, Carel J M CJM; Kranenburg, Onno O; Medema, Jan Paul JP; Koster, Jan J; Koens, Lianne L; Punt, Cornelis J A CJA; Tanis, Pieter J PJ; de Hingh, Ignace H IH; Bijlsma, Maarten F MF; Tuynman, Jurriaan B JB; Vermeulen, Louis L

Publication Date: 2022-08-04

Variant appearance in text: PIK3CA: G12R

PubMed Link: 35927254

Variant Present in the following documents:

• 41467_2022_32198_MOESM4_ESM.xlsx, sheet 1

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Periplocin Induces Apoptosis of Pancreatic Cancer Cells through Autophagy via the AMPK/mTOR Pathway.

Journal Of Oncology

Zhang, Hewei H; Wang, Yongqiang Y; Zhang, Yan Y; Zheng, Beishi B; Wang, Xiaowu X; Chen, Jiawei J; Chen, Bicheng B; Xie, Gangyin G; Yang, Lihong L

Publication Date: 2022

Variant appearance in text: PI3K: G12R

PubMed Link: 35847371

Variant Present in the following documents:

• JO2022-8055004.pdf

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Characteristics of and Treatment Strategies for Advanced EGFR-Mutant NSCLC With Concomitant BRAF Variations.

Jto Clinical And Research Reports

Wei, Xue-Wu XW; Deng, Jia-Yi JY; Xu, Chong-Rui CR; Chen, Zhi-Hong ZH; Zhu, Dong-Qin DQ; Wu, Qian Q; Zhang, Xu-Chao XC; Wu, Yi-Long YL; Zhou, Qing Q

Publication Date: 2022-07

Variant appearance in text: PIK3CA: G12R

PubMed Link: 35789792

Variant Present in the following documents:

• main.pdf

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A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma.

International Journal Of Cancer

Jo, Jung Hyun JH; Jung, Dawoon E DE; Lee, Hee Seung HS; Park, Soo Been SB; Chung, Moon Jae MJ; Park, Jeong Youp JY; Bang, Seungmin S; Park, Seung Woo SW; Cho, Sangsook S; Song, Si Young SY

Publication Date: 2022-11-01

Variant appearance in text: PIK3CA: G12R

PubMed Link: 35657348

Variant Present in the following documents:

• IJC-151-1565-s001.pdf

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Neoantigen: A Promising Target for the Immunotherapy of Colorectal Cancer.

Disease Markers

Zheng, Yue Y; Fu, Yang Y; Wang, Pei-Pei PP; Ding, Zhen-Yu ZY

Publication Date: 2022

Variant appearance in text: PIK3CA: G12R

PubMed Link: 35211210

Variant Present in the following documents:

• DM2022-8270305.pdf

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The Advance and Correlation of KRAS Mutation With the Fertility-Preservation Treatment of Endometrial Cancer in the Background of Molecular Classification Application.

Pathology Oncology Research : Por

Yu, KeXuan K; Wang, Yiqin Y

Publication Date: 2021

Variant appearance in text: PI3K: G12R

PubMed Link: 34975345

Variant Present in the following documents:

• pore-27-1609906.pdf

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Utility of plasma cell-free DNA for de novo detection and quantification of clonal hematopoiesis.

Haematologica

Gutierrez-Rodrigues, Fernanda F; Beerman, Isabel I; Groarke, Emma M EM; Patel, Bhavisha A BA; Spitofsky, Nina N; Dillon, Laura W LW; Raffo, Diego Quinones DQ; Hourigan, Christopher S CS; Kajigaya, Sachiko S; Ferrucci, Luigi L; Young, Neal S NS

Publication Date: 2022-08-01

Variant appearance in text: PIK3CA: 34G>C; Gly12Arg

PubMed Link: 34587721

Variant Present in the following documents:

• 2021_279230_GUTIERREZ-RODRIGUES_SUPPL.pdf

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PRR11 unveiled as a top candidate biomarker within the RBM3-regulated transcriptome in pancreatic cancer.

The Journal Of Pathology. Clinical Research

Olsson Hau, Sofie S; Wahlin, Sara S; Cervin, Sophie S; Falk, Vilgot V; Nodin, Björn B; Elebro, Jacob J; Eberhard, Jakob J; Moran, Bruce B; Gallagher, William M WM; Karnevi, Emelie E; Jirström, Karin K

Publication Date: 2022-01

Variant appearance in text: PI3K: G12R

PubMed Link: 34379360

Variant Present in the following documents:

• CJP2-8-65.pdf

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Ras Isoforms from Lab Benches to Lives-What Are We Missing and How Far Are We?

International Journal Of Molecular Sciences

Nair, Arathi A; Kubatzky, Katharina F KF; Saha, Bhaskar B

Publication Date: 2021-06-17

Variant appearance in text: PI3K: G12R

PubMed Link: 34204435

Variant Present in the following documents:

• Main text

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Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology.

Cells

László, Loretta L; Kurilla, Anita A; Takács, Tamás T; Kudlik, Gyöngyi G; Koprivanacz, Kitti K; Buday, László L; Vas, Virag V

Publication Date: 2021-03-17

Variant appearance in text: PI3K: G12R

PubMed Link: 33802849

Variant Present in the following documents:

• Main text

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Managing Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors Through Co-Targeting MEK/ERK Signaling.

Lung Cancer (Auckland, N.Z.)

Yu, Danlei D; Zhao, Wen W; Vallega, Karin A KA; Sun, Shi-Yong SY

Publication Date: 2021

Variant appearance in text: PI3K: G12R

PubMed Link: 33574724

Variant Present in the following documents:

• lctt-12-1.pdf

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Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Cancer Research And Treatment

Lee, Youngwoo Y; Lee, Soohyeon S; Sung, Jae Sook JS; Chung, Hee-Joon HJ; Lim, Ah-Reum AR; Kim, Ju Won JW; Choi, Yoon Ji YJ; Park, Kyong Hwa KH; Kim, Yeul Hong YH

Publication Date: 2021-01

Variant appearance in text: PIK3CA: G12R

PubMed Link: 32810930

Variant Present in the following documents:

• crt-2020-559-suppl3.pdf

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Integrated genetic and epigenetic analysis of cancer-related genes in non-ampullary duodenal adenomas and intramucosal adenocarcinomas.

The Journal Of Pathology

Ota, Ryosuke R; Sawada, Takeshi T; Tsuyama, Sho S; Sasaki, Yasushi Y; Suzuki, Hiromu H; Kaizaki, Yasuharu Y; Hasatani, Kenkei K; Yamamoto, Eiichiro E; Nakanishi, Hiroyoshi H; Inagaki, Satoko S; Tsuji, Shigetsugu S; Yoshida, Naohiro N; Doyama, Hisashi H; Minato, Hiroshi H; Nakamura, Keishi K; Kasashima, Satomi S; Kubota, Eiji E; Kataoka, Hiromi H; Tokino, Takashi T; Yao, Takashi T; Minamoto, Toshinari T

Publication Date: 2020-11

Variant appearance in text: PIK3CA: Gly12Arg

PubMed Link: 32770675

Variant Present in the following documents:

• PATH-252-330-s002.xlsx, sheet 8

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Genetic alteration of colorectal adenoma-carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis.

Molecular Genetics & Genomic Medicine

Tanabe, Hiroki H; Moriichi, Kentaro K; Takahashi, Keitaro K; Ono, Yusuke Y; Kobayashi, Yu Y; Murakami, Yuki Y; Iwama, Takuya T; Kunogi, Takehito T; Sasaki, Takahiro T; Ando, Katsuyoshi K; Ueno, Nobuhiro N; Kashima, Shin S; Takei, Hidehiro H; Mizukami, Yusuke Y; Fujiya, Mikihiro M; Okumura, Toshikatsu T

Publication Date: 2020-09

Variant appearance in text: PIK3CA: G12R

PubMed Link: 32543103

Variant Present in the following documents:

• Main text

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TRF2 and VEGF-A: an unknown relationship with prognostic impact on survival of colorectal cancer patients.

Journal Of Experimental & Clinical Cancer Research : Cr

Dinami, Roberto R; Porru, Manuela M; Amoreo, Carla Azzurra CA; Sperduti, Isabella I; Mottolese, Marcella M; Buglioni, Simonetta S; Marinelli, Daniele D; Maugeri-Saccà, Marcello M; Sacconi, Andrea A; Blandino, Giovanni G; Leonetti, Carlo C; Di Rocco, Giuliana G; Verdina, Alessandra A; Spinella, Francesca F; Fiorentino, Francesco F; Ciliberto, Gennaro G; Biroccio, Annamaria A; Zizza, Pasquale P

Publication Date: 2020-06-15

Variant appearance in text: PIK3CA: G12R

PubMed Link: 32539869

Variant Present in the following documents:

• 13046_2020_1612_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Pharmacogenomic Testing to Guide Personalized Cancer Medicine Decisions in Private Oncology Practice: A Case Study.

Frontiers In Oncology

Astras, George G; Papagiannopoulos, Christos I CI; Kyritsis, Konstantinos A KA; Markitani, Constantina C; Vizirianakis, Ioannis S IS

Publication Date: 2020

Variant appearance in text: PIK3CA: 34G>C

PubMed Link: 32411592

Variant Present in the following documents:

• fonc-10-00521.pdf

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Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma.

Scientific Reports

Hirotsu, Yosuke Y; Otake, Sotaro S; Ohyama, Hiroshi H; Amemiya, Kenji K; Higuchi, Rumi R; Oyama, Toshio T; Mochizuki, Hitoshi H; Goto, Taichiro T; Omata, Masao M

Publication Date: 2020-02-25

Variant appearance in text: PIK3CA: 34G>C

PubMed Link: 32099048

Variant Present in the following documents:

• 41598_2020_Article_60361.pdf

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Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients.

Plos One

Papadopoulou, Eirini E; Tsoulos, Nikolaos N; Tsantikidi, Katerina K; Metaxa-Mariatou, Vasiliki V; Stamou, Pinelopi Eleftheria PE; Kladi-Skandali, Athina A; Kapeni, Evgenia E; Tsaousis, Georgios G; Pentheroudakis, George G; Petrakis, Dimitrios D; Lampropoulou, Dimitra Ioanna DI; Aravantinos, Gerasimos G; Varthalitis, Ioannis I; Kesisis, George G; Boukovinas, Ioannis I; Papakotoulas, Pavlos P; Katirtzoglou, Nikolaos N; Athanasiadis, Elias E; Stavridi, Flora F; Christodoulou, Christos C; Koumarianou, Anna A; Eralp, Yeşim Y; Nasioulas, George G

Publication Date: 2019

Variant appearance in text: PIK3CA: 34G>C; G12R

PubMed Link: 31860648

Variant Present in the following documents:

• pone.0226853.s001.xlsx, sheet 1

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Using somatic variant richness to mine signals from rare variants in the cancer genome.

Nature Communications

Chakraborty, Saptarshi S; Arora, Arshi A; Begg, Colin B CB; Shen, Ronglai R

Publication Date: 2019-12-03

Variant appearance in text: PIK3CA: G12R

PubMed Link: 31796730

Variant Present in the following documents:

• 41467_2019_Article_13402.pdf

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Update on current pancreatic treatments: from molecular pathways to treatment.

Journal Of Cancer

Sapalidis, Konstantinos K; Kosmidis, Christoforos C; Funtanidou, Varvara V; Katsaounis, Athanasios A; Barmpas, Amastasios A; Koimtzis, Georgios G; Mantalobas, Stylianos S; Alexandrou, Vyron V; Aidoni, Zoi Z; Koulouris, Charilaos C; Pavlidis, Efstathios E; Giannakidis, Dimitrios D; Surlin, Valeriu V; Pantea, Stelian S; Strambu, Victor V; Constantina, Rogoveanu Otilia RO; Amaniti, Aikaterini A; Zarogoulidis, Paul P; Mogoantă, Stelian S; Kesisoglou, Isaak I; Sardeli, Chrysanthi C

Publication Date: 2019

Variant appearance in text: PI3K: G12R

PubMed Link: 31602269

Variant Present in the following documents:

• Main text

View BVdb publication page

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DNA sequencing of cytopathologically inconclusive EUS-FNA from solid pancreatic lesions suspicious for malignancy confirms EUS diagnosis.

Endoscopic Ultrasound

Plougmann, Julie Isabelle JI; Klausen, Pia P; Toxvaerd, Anders A; Abedi, Armita Armina AA; Kovacevic, Bojan B; Karstensen, John Gásdal JG; Poulsen, Tim Svenstrup TS; Kalaitzakis, Evangelos E; Høgdall, Estrid E; Vilmann, Peter P

Publication Date: 2020

Variant appearance in text: PIK3CA: G12R

PubMed Link: 31552911

Variant Present in the following documents:

• EUS-9-37.pdf

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Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness.

Scientific Reports

Revilla, Giovanna G; Pons, Monica de Pablo MP; Baila-Rueda, Lucía L; García-León, Annabel A; Santos, David D; Cenarro, Ana A; Magalhaes, Marcelo M; Blanco, R M RM; Moral, Antonio A; Ignacio Pérez, José J; Sabé, Gerard G; González, Cintia C; Fuste, Victoria V; Lerma, Enrique E; Faria, Manuel Dos Santos MDS; de Leiva, Alberto A; Corcoy, Rosa R; Carles Escolà-Gil, Joan J; Mato, Eugenia E

Publication Date: 2019-07-16

Variant appearance in text: PI3K: G12R

PubMed Link: 31311983

Variant Present in the following documents:

• Main text
• 41598_2019_Article_46727.pdf

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Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: PI3K: G12R

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_564_MOESM2_ESM.xlsx, sheet 13

View BVdb publication page

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Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

The Lancet. Gastroenterology & Hepatology

Domingo, Enric E; Camps, Carme C; Kaisaki, Pamela J PJ; Parsons, Marie J MJ; Mouradov, Dmitri D; Pentony, Melissa M MM; Makino, Seiko S; Palmieri, Michelle M; Ward, Robyn L RL; Hawkins, Nicholas J NJ; Gibbs, Peter P; Askautrud, Hanne H; Oukrif, Dahmane D; Wang, Haitao H; Wood, Joe J; Tomlinson, Evie E; Bark, Yasmine Y; Kaur, Kulvinder K; Johnstone, Elaine C EC; Palles, Claire C; Church, David N DN; Novelli, Marco M; Danielsen, Havard E HE; Sherlock, Jon J; Kerr, David D; Kerr, Rachel R; Sieber, Oliver O; Taylor, Jenny C JC; Tomlinson, Ian I

Publication Date: 2018-09

Variant appearance in text: PIK3CA: G12R

PubMed Link: 30042065

Variant Present in the following documents:

• mmc1.pdf

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Integrated Molecular Characterization of Testicular Germ Cell Tumors.

Cell Reports

Shen, Hui H; Shih, Juliann J; Hollern, Daniel P DP; Wang, Linghua L; Bowlby, Reanne R; Tickoo, Satish K SK; Thorsson, Vésteinn V; Mungall, Andrew J AJ; Newton, Yulia Y; Hegde, Apurva M AM; Armenia, Joshua J; Sánchez-Vega, Francisco F; Pluta, John J; Pyle, Louise C LC; Mehra, Rohit R; Reuter, Victor E VE; Godoy, Guilherme G; Jones, Jeffrey J; Shelley, Carl S CS; Feldman, Darren R DR; Vidal, Daniel O DO; Lessel, Davor D; Kulis, Tomislav T; Cárcano, Flavio M FM; Leraas, Kristen M KM; Lichtenberg, Tara M TM; Brooks, Denise D; Cherniack, Andrew D AD; Cho, Juok J; Heiman, David I DI; Kasaian, Katayoon K; Liu, Minwei M; Noble, Michael S MS; Xi, Liu L; Zhang, Hailei H; Zhou, Wanding W; ZenKlusen, Jean C JC; Hutter, Carolyn M CM; Felau, Ina I; Zhang, Jiashan J; Schultz, Nikolaus N; Getz, Gad G; Meyerson, Matthew M; Stuart, Joshua M JM; , ; Akbani, Rehan R; Wheeler, David A DA; Laird, Peter W PW; Nathanson, Katherine L KL; Cortessis, Victoria K VK; Hoadley, Katherine A KA

Publication Date: 2018-06-12

Variant appearance in text: PIK3CA: G12R

PubMed Link: 29898407

Variant Present in the following documents:

• NIHMS977848-supplement-2.xlsx, sheet 1

View BVdb publication page

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Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer.

Oncogenesis

Beadnell, Thomas C TC; Nassar, Kelsey W KW; Rose, Madison M MM; Clark, Erin G EG; Danysh, Brian P BP; Hofmann, Marie-Claude MC; Pozdeyev, Nikita N; Schweppe, Rebecca E RE

Publication Date: 2018-02-28

Variant appearance in text: PI3K: G12R

PubMed Link: 29487290

Variant Present in the following documents:

• Main text
• 41389_2017_Article_15.pdf

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Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.

Oncotarget

Osoegawa, Atsushi A; Gills, Joell J JJ; Kawabata, Shigeru S; Dennis, Phillip A PA

Publication Date: 2017-10-20

Variant appearance in text: PI3K: G12R

PubMed Link: 29152062

Variant Present in the following documents:

• Main text
• oncotarget-08-87044.pdf

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Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia.

Gut

Singhi, Aatur D AD; McGrath, Kevin K; Brand, Randall E RE; Khalid, Asif A; Zeh, Herbert J HJ; Chennat, Jennifer S JS; Fasanella, Kenneth E KE; Papachristou, Georgios I GI; Slivka, Adam A; Bartlett, David L DL; Dasyam, Anil K AK; Hogg, Melissa M; Lee, Kenneth K KK; Marsh, James Wallis JW; Monaco, Sara E SE; Ohori, N Paul NP; Pingpank, James F JF; Tsung, Allan A; Zureikat, Amer H AH; Wald, Abigail I AI; Nikiforova, Marina N MN

Publication Date: 2018-12

Variant appearance in text: PIK3CA: G12R

PubMed Link: 28970292

Variant Present in the following documents:

• Main text
• gutjnl-2016-313586supp003.pdf

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Mutational heterogeneity in non-serous ovarian cancers.

Scientific Reports

Teer, Jamie K JK; Yoder, Sean S; Gjyshi, Anxhela A; Nicosia, Santo V SV; Zhang, Chaomei C; Monteiro, Alvaro N A ANA

Publication Date: 2017-08-29

Variant appearance in text: PIK3CA: G12R

PubMed Link: 28852190

Variant Present in the following documents:

• 41598_2017_10432_MOESM2_ESM.xlsx, sheet 5

View BVdb publication page

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Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment.

International Journal Of Molecular Sciences

Bignucolo, Alessia A; De Mattia, Elena E; Cecchin, Erika E; Roncato, Rossana R; Toffoli, Giuseppe G

Publication Date: 2017-07-14

Variant appearance in text: PIK3CA: 34G>C

PubMed Link: 28708103

Variant Present in the following documents:

• Main text

View BVdb publication page

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Prognostic Impact of miR-224 and RAS Mutations in Medullary Thyroid Carcinoma.

International Journal Of Endocrinology

Cavedon, Elisabetta E; Barollo, Susi S; Bertazza, Loris L; Pennelli, Gianmaria G; Galuppini, Francesca F; Watutantrige-Fernando, Sara S; Censi, Simona S; Iacobone, Maurizio M; Benna, Clara C; Vianello, Federica F; Zovato, Stefania S; Nacamulli, Davide D; Mian, Caterina C

Publication Date: 2017

Variant appearance in text: PI3K: G12R

PubMed Link: 28676824

Variant Present in the following documents:

• IJE2017-4915736.pdf

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2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells.

Plos One

Sun, Linlin L; Liu, Xiuju X; Fu, Haian H; Zhou, Wei W; Zhong, Diansheng D

Publication Date: 2016

Variant appearance in text: PI3K: G12R

PubMed Link: 28033353

Variant Present in the following documents:

• Main text

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Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection.

British Journal Of Cancer

Cacheux, Wulfran W; Rouleau, Etienne E; Briaux, Adrien A; Tsantoulis, Petros P; Mariani, Pascale P; Richard-Molard, Marion M; Buecher, Bruno B; Dangles-Marie, Virginie V; Richon, Sophie S; Lazartigues, Julien J; Jeannot, Emmanuelle E; Farkhondeh, Fereshteh F; Sastre-Garau, Xavier X; de La Rochefordière, Anne A; Labib, Alain A; Falcou, Marie-Christine MC; Stevens, Denise D; Roth, Arnaud A; Roman-Roman, Sergio S; Mitry, Emmanuel E; Bièche, Ivan I; Lièvre, Astrid A

Publication Date: 2016-06-14

Variant appearance in text: PIK3CA: G12R

PubMed Link: 27219019

Variant Present in the following documents:

• Main text

View BVdb publication page

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Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis.

Oncotarget

Champa, Devora D; Orlacchio, Arturo A; Patel, Bindi B; Ranieri, Michela M; Shemetov, Anton A AA; Verkhusha, Vladislav V VV; Cuervo, Ana Maria AM; Di Cristofano, Antonio A

Publication Date: 2016-06-07

Variant appearance in text: PIK3CA: G12R

PubMed Link: 27144341

Variant Present in the following documents:

• Main text

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LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer.

Oncotarget

Zhuo, Changhua C; Li, Qingguo Q; Wu, Yuchen Y; Li, Yiwei Y; Nie, Jia J; Li, Dawei D; Peng, Junjie J; Lian, Peng P; Li, Bin B; Cai, Guoxiang G; Li, Xinxiang X; Cai, Sanjun S

Publication Date: 2015-09-15

Variant appearance in text: PIK3CA: 34G>C; Gly12Arg

PubMed Link: 26172297

Variant Present in the following documents:

• oncotarget-06-23820-s001.pdf

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Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab.

Journal Of Translational Medicine

Giampieri, Riccardo R; Mandolesi, Alessandra A; Abouelkhair, Khaled M KM; Loretelli, Cristian C; Del Prete, Michela M; Faloppi, Luca L; Maristella, Bianconi B; Ibrahim, Ezzeldin M EM; Scarpelli, Marina M; Cascinu, Stefano S; Scartozzi, Mario M

Publication Date: 2015-05-07

Variant appearance in text: PIK3CA: G12R

PubMed Link: 25943333

Variant Present in the following documents:

• Main text

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Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinoma.

Journal Of Veterinary Internal Medicine

Campos, M M; Kool, M M J MM; Daminet, S S; Ducatelle, R R; Rutteman, G G; Kooistra, H S HS; Galac, S S; Mol, J A JA

Publication Date: 2014

Variant appearance in text: PIK3CA: G12R

PubMed Link: 25231196

Variant Present in the following documents:

• Main text

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Reporting tumor molecular heterogeneity in histopathological diagnosis.

Plos One

Mafficini, Andrea A; Amato, Eliana E; Fassan, Matteo M; Simbolo, Michele M; Antonello, Davide D; Vicentini, Caterina C; Scardoni, Maria M; Bersani, Samantha S; Gottardi, Marisa M; Rusev, Borislav B; Malpeli, Giorgio G; Corbo, Vincenzo V; Barbi, Stefano S; Sikora, Katarzyna O KO; Lawlor, Rita T RT; Tortora, Giampaolo G; Scarpa, Aldo A

Publication Date: 2014

Variant appearance in text: PIK3CA: G12R

PubMed Link: 25127237

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Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes.

Human Molecular Genetics

Taylor, Claire F CF; Platt, Fiona M FM; Hurst, Carolyn D CD; Thygesen, Helene H HH; Knowles, Margaret A MA

Publication Date: 2014-04-15

Variant appearance in text: PIK3CA: G12R

PubMed Link: 24270882

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• supp_ddt589_ddt589supp_table1.pdf

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A novel fully automated molecular diagnostic system (AMDS) for colorectal cancer mutation detection.

Plos One

Kitano, Shiro S; Myers, Jamie J; Nakamura, Junko J; Yamane, Akio A; Yamashita, Mami M; Nakayama, Masato M; Tsukahara, Yusuke Y; Ushida, Hiroshi H; Liu, Wanqing W; Ratain, Mark J MJ; Amano, Masahiko M

Publication Date: 2013

Variant appearance in text: PI3K: G12R

PubMed Link: 23671647

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Multiple genetic alterations within the PI3K pathway are responsible for AKT activation in patients with ovarian carcinoma.

Plos One

De Marco, Carmela C; Rinaldo, Nicola N; Bruni, Paola P; Malzoni, Carmine C; Zullo, Fulvio F; Fabiani, Fernanda F; Losito, Simona S; Scrima, Marianna M; Marino, Federica Zito FZ; Franco, Renato R; Quintiero, Alfina A; Agosti, Valter V; Viglietto, Giuseppe G

Publication Date: 2013

Variant appearance in text: PIK3CA: G12R

PubMed Link: 23408974

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Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.

The Journal Of Biological Chemistry

Vartanian, Steffan S; Bentley, Carolyn C; Brauer, Matthew J MJ; Li, Li L; Shirasawa, Senji S; Sasazuki, Takehiko T; Kim, Jung-Sik JS; Haverty, Pete P; Stawiski, Eric E; Modrusan, Zora Z; Waldman, Todd T; Stokoe, David D

Publication Date: 2013-01-25

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PubMed Link: 23188824

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Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy.

Translational Oncogenomics

Sun, Daochun D; Tainsky, Michael A MA; Haddad, Ramsi R

Publication Date: 2012

Variant appearance in text: PIK3CA: G12R

PubMed Link: 22346343

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Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors.

Oncotarget

Antico Arciuch, Valeria G VG; Russo, Marika A MA; Dima, Mariavittoria M; Kang, Kristy S KS; Dasrath, Florence F; Liao, Xiao-Hui XH; Refetoff, Samuel S; Montagna, Cristina C; Di Cristofano, Antonio A

Publication Date: 2011-12

Variant appearance in text: PI3K: G12R

PubMed Link: 22190384

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Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours.

British Journal Of Cancer

Weidlich, S S; Walsh, K K; Crowther, D D; Burczynski, M E ME; Feuerstein, G G; Carey, F A FA; Steele, R J C RJ; Wolf, C R CR; Miele, G G; Smith, G G

Publication Date: 2011-07-12

Variant appearance in text: PIK3CA: Gly12Arg

PubMed Link: 21712828

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• bjc2011197a.pdf

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Somatic mutations of PPP2R1A in ovarian and uterine carcinomas.

The American Journal Of Pathology

Shih, Ie-Ming IeM; Panuganti, Pradeep K PK; Kuo, Kuan-Tin KT; Mao, Tsui-Lien TL; Kuhn, Elisabetta E; Jones, Sian S; Velculescu, Victor E VE; Kurman, Robert J RJ; Wang, Tian-Li TL

Publication Date: 2011-04

Variant appearance in text: PIK3CA: G12R

PubMed Link: 21435433

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Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.

Plos One

van Eijk, Ronald R; Licht, Jappe J; Schrumpf, Melanie M; Talebian Yazdi, Mehrdad M; Ruano, Dina D; Forte, Giusi I GI; Nederlof, Petra M PM; Veselic, Maud M; Rabe, Klaus F KF; Annema, Jouke T JT; Smit, Vincent V; Morreau, Hans H; van Wezel, Tom T

Publication Date: 2011-03-08

Variant appearance in text: PIK3CA: 34G>C; G12R

PubMed Link: 21408138

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Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.

Embo Molecular Medicine

Dias-Santagata, Dora D; Akhavanfard, Sara S; David, Serena S SS; Vernovsky, Kathy K; Kuhlmann, Georgiana G; Boisvert, Susan L SL; Stubbs, Hannah H; McDermott, Ultan U; Settleman, Jeffrey J; Kwak, Eunice L EL; Clark, Jeffrey W JW; Isakoff, Steven J SJ; Sequist, Lecia V LV; Engelman, Jeffrey A JA; Lynch, Thomas J TJ; Haber, Daniel A DA; Louis, David N DN; Ellisen, Leif W LW; Borger, Darrell R DR; Iafrate, A John AJ

Publication Date: 2010-05

Variant appearance in text: PIK3CA: G12R

PubMed Link: 20432502

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• emmm0002-0146-SD2.xls, sheet 1

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Mutation detection by real-time PCR: a simple, robust and highly selective method.

Plos One

Morlan, John J; Baker, Joffre J; Sinicropi, Dominick D

Publication Date: 2009

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PubMed Link: 19240792

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• pone.0004584.pdf

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Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts.

The Journal Of Physiology

Pedersen, Stine F SF; Beisner, Kristine H KH; Hougaard, Charlotte C; Willumsen, Berthe M BM; Lambert, Ian H IH; Hoffmann, Else K EK

Publication Date: 2002-06-15

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PubMed Link: 12068040

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