Publications:

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Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial.

Nature Medicine

Cascone, Tina T; Leung, Cheuk H CH; Weissferdt, Annikka A; Pataer, Apar A; Carter, Brett W BW; Godoy, Myrna C B MCB; Feldman, Hope H; William, William N WN; Xi, Yuanxin Y; Basu, Sreyashi S; Sun, Jing Jing JJ; Yadav, Shalini S SS; Rojas Alvarez, Frank R FR; Lee, Younghee Y; Mishra, Aditya K AK; Chen, Lili L; Pradhan, Monika M; Guo, Haiping H; Sinjab, Ansam A; Zhou, Nicolas N; Negrao, Marcelo V MV; Le, Xiuning X; Gay, Carl M CM; Tsao, Anne S AS; Byers, Lauren Averett LA; Altan, Mehmet M; Glisson, Bonnie S BS; Fossella, Frank V FV; Elamin, Yasir Y YY; Blumenschein, George G; Zhang, Jianjun J; Skoulidis, Ferdinandos F; Wu, Jia J; Mehran, Reza J RJ; Rice, David C DC; Walsh, Garrett L GL; Hofstetter, Wayne L WL; Rajaram, Ravi R; Antonoff, Mara B MB; Fujimoto, Junya J; Solis, Luisa M LM; Parra, Edwin R ER; Haymaker, Cara C; Wistuba, Ignacio I II; Swisher, Stephen G SG; Vaporciyan, Ara A AA; Lin, Heather Y HY; Wang, Jing J; Gibbons, Don L DL; Jack Lee, J J; Ajami, Nadim J NJ; Wargo, Jennifer A JA; Allison, James P JP; Sharma, Padmanee P; Kadara, Humam H; Heymach, John V JV; Sepesi, Boris B

Publication Date: 2023-03-16

Variant appearance in text: PIK3CA: G12C

PubMed Link: 36928818

Variant Present in the following documents:

• 41591_2022_2189_MOESM10_ESM.xlsx, sheet 1

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Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.

Nature Communications

Chmielecki, Juliann J; Gray, Jhanelle E JE; Cheng, Ying Y; Ohe, Yuichiro Y; Imamura, Fumio F; Cho, Byoung Chul BC; Lin, Meng-Chih MC; Majem, Margarita M; Shah, Riyaz R; Rukazenkov, Yuri Y; Todd, Alexander A; Markovets, Aleksandra A; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Ramalingam, Suresh S SS

Publication Date: 2023-02-27

Variant appearance in text: PIK3CA: G12C

PubMed Link: 36849494

Variant Present in the following documents:

• 41467_2023_Article_35961.pdf

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Novel Insights into the Role of Kras in Myeloid Differentiation: Engaging with Wnt/β-Catenin Signaling.

Cells

Yokoyama, Noriko N; Nakayama, Hitoshi H; Iwabuchi, Kazuhisa K

Publication Date: 2023-01-14

Variant appearance in text: PI3K: G12C

PubMed Link: 36672256

Variant Present in the following documents:

• Main text
• cells-12-00322.pdf

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CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity.

Scientific Reports

Do, Manh-Hung MH; Thanh, Hien Duong HD; To, Phuong Kim PK; Kim, Min Soo MS; Moon, Changjong C; Jung, Chaeyong C

Publication Date: 2022-12-27

Variant appearance in text: PIK3CA: G12C

PubMed Link: 36575233

Variant Present in the following documents:

• Main text
• 41598_2022_Article_27107.pdf

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2-Deoxyglucose, an Inhibitor of Glycolysis, Enhances the Oncolytic Effect of Coxsackievirus.

Cancers

Vorobyev, Pavel O PO; Kochetkov, Dmitry V DV; Chumakov, Peter M PM; Zakirova, Natalia F NF; Zotova-Nefedorova, Sofia I SI; Vasilenko, Konstantin V KV; Alekseeva, Olga N ON; Kochetkov, Sergey N SN; Bartosch, Birke B; Lipatova, Anastasiya V AV; Ivanov, Alexander V AV

Publication Date: 2022-11-15

Variant appearance in text: PI3K: G12C

PubMed Link: 36428704

Variant Present in the following documents:

• Main text
• cancers-14-05611.pdf

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Proposal of a novel pipeline involving precise bronchoscopy of distal peripheral pulmonary lesions for genetic testing.

Scientific Reports

Takata, So S; Miyake, Kotaro K; Maeda, Daichi D; Hatake, Kazue K; Nagatomo, Izumi I; Shiroyama, Takayuki T; Masuhiro, Kentaro K; Yaga, Moto M; Shirai, Yuya Y; Mitsui, Yuichi Y; Yachida, Shinichi S; Kumanogoh, Atsushi A

Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: G12C

PubMed Link: 36396864

Variant Present in the following documents:

• Main text

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Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway.

Frontiers In Pharmacology

Qi, Yan Y; Zou, Hong H; Zhao, XiaoHui X; Kapeleris, Joanna J; Monteiro, Michael M; Li, Feng F; Xu, Zhi Ping ZP; Deng, Yizhen Y; Wu, Yanheng Y; Tang, Ying Y; Gu, Wenyi W

Publication Date: 2022

Variant appearance in text: PI3K: G12C

PubMed Link: 36386200

Variant Present in the following documents:

• Main text

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Antipsychotic Drug Fluphenazine against Human Cancer Cells.

Biomolecules

Duarte, Diana D; Vale, Nuno N

Publication Date: 2022-09-23

Variant appearance in text: PI3K: G12C

PubMed Link: 36291568

Variant Present in the following documents:

• Main text
• biomolecules-12-01360.pdf

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Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies.

Npj Precision Oncology

Lidsky, Michael E ME; Wang, Zechen Z; Lu, Min M; Liu, Annie A; Hsu, S David SD; McCall, Shannon J SJ; Sheng, Zhecheng Z; Granek, Joshua A JA; Owzar, Kouros K; Anderson, Karen S KS; Wood, Kris C KC

Publication Date: 2022-10-23

Variant appearance in text: PI3K: G12C

PubMed Link: 36274097

Variant Present in the following documents:

• 41698_2022_320_MOESM1_ESM.pdf

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Molecular characterization of colorectal cancer related peritoneal metastatic disease.

Nature Communications

Lenos, Kristiaan J KJ; Bach, Sander S; Ferreira Moreno, Leandro L; Ten Hoorn, Sanne S; Sluiter, Nina R NR; Bootsma, Sanne S; Vieira Braga, Felipe A FA; Nijman, Lisanne E LE; van den Bosch, Tom T; Miedema, Daniel M DM; van Dijk, Erik E; Ylstra, Bauke B; Kulicke, Ruth R; Davis, Fred P FP; Stransky, Nicolas N; Smolen, Gromoslaw A GA; Coebergh van den Braak, Robert R J RRJ; IJzermans, Jan N M JNM; Martens, John W M JWM; Hallam, Sally S; Beggs, Andrew D AD; Kops, Geert J P L GJPL; Lansu, Nico N; Bastiaenen, Vivian P VP; Klaver, Charlotte E L CEL; Lecca, Maria C MC; El Makrini, Khalid K; Elbers, Clara C CC; Dings, Mark P G MPG; van Noesel, Carel J M CJM; Kranenburg, Onno O; Medema, Jan Paul JP; Koster, Jan J; Koens, Lianne L; Punt, Cornelis J A CJA; Tanis, Pieter J PJ; de Hingh, Ignace H IH; Bijlsma, Maarten F MF; Tuynman, Jurriaan B JB; Vermeulen, Louis L

Publication Date: 2022-08-04

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35927254

Variant Present in the following documents:

• 41467_2022_32198_MOESM4_ESM.xlsx, sheet 1

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Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Durinikova, Erika E; Reilly, Nicole M NM; Buzo, Kristi K; Mariella, Elisa E; Chilà, Rosaria R; Lorenzato, Annalisa A; Dias, João M L JML; Grasso, Gaia G; Pisati, Federica F; Lamba, Simona S; Corti, Giorgio G; Degasperi, Andrea A; Cancelliere, Carlotta C; Mauri, Gianluca G; Andrei, Pietro P; Linnebacher, Michael M; Marsoni, Silvia S; Siena, Salvatore S; Sartore-Bianchi, Andrea A; Nik-Zainal, Serena S; Di Nicolantonio, Federica F; Bardelli, Alberto A; Arena, Sabrina S

Publication Date: 2022-09-01

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35881546

Variant Present in the following documents:

• EMS151756-supplement-Table_S1.xlsx, sheet 1

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Multifocal organoids reveal clonal associations between synchronous intestinal tumors with pervasive heterogeneous drug responses.

Npj Genomic Medicine

Jeong, Nahyun N; Kim, Soon-Chan SC; Park, Ji Won JW; Park, Seul Gi SG; Nam, Ki-Hoan KH; Lee, Ja Oh JO; Shin, Young-Kyoung YK; Bae, Jeong Mo JM; Jeong, Seung-Yong SY; Kim, Min Jung MJ; Ku, Ja-Lok JL

Publication Date: 2022-07-19

Variant appearance in text: PIK3CA: 34G>T; Gly12Cys

PubMed Link: 35853873

Variant Present in the following documents:

• 41525_2022_Article_313.pdf

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Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways.

Journal Of Translational Medicine

Wang, Fei F; Yuan, Chong C; Liu, Bo B; Yang, Yan-Fang YF; Wu, He-Zhen HZ

Publication Date: 2022-07-06

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35794555

Variant Present in the following documents:

• Main text
• 12967_2022_Article_3504.pdf

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Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis.

Bmc Cancer

Hao, Xuewei X; Zhang, Jun J; Chen, Guoyou G; Cao, Weiwei W; Chen, Hongyang H; Chen, Shuo S

Publication Date: 2022-06-21

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35729618

Variant Present in the following documents:

• 12885_2022_9711_MOESM3_ESM.xlsx, sheet 1

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A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma.

International Journal Of Cancer

Jo, Jung Hyun JH; Jung, Dawoon E DE; Lee, Hee Seung HS; Park, Soo Been SB; Chung, Moon Jae MJ; Park, Jeong Youp JY; Bang, Seungmin S; Park, Seung Woo SW; Cho, Sangsook S; Song, Si Young SY

Publication Date: 2022-11-01

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35657348

Variant Present in the following documents:

• IJC-151-1565-s001.pdf

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Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway.

International Journal Of Biological Sciences

Liu, Nannan N; Jiang, Xinxiu X; Guo, Leiming L; Zhang, Chuchu C; Jiang, Meimei M; Sun, Zhuoran Z; Zhang, Yizheng Y; Mi, Wunan W; Li, Jiehan J; Fu, Yang Y; Wang, Feng F; Zhang, Lingling L; Zhang, Yingjie Y

Publication Date: 2022

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35414774

Variant Present in the following documents:

• ijbsv18p2419.pdf

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Altered Signaling Pathways Revealed by Comprehensive Genomic Profiling in Patients With Unknown Primary Tumors.

Frontiers In Oncology

Yang, Zhen Z; Cui, Wei W; Yu, Ruoying R; Dong, Xinhua X; Zhao, Jian J; Dai, Lu L; Ou, Qiuxiang Q; Bao, Hua H; Wu, Xue X; Wu, Chuanxin C; Lai, Jinhuo J

Publication Date: 2022

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35402276

Variant Present in the following documents:

• fonc-12-753311.pdf

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Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.

Journal Of The American Chemical Society

Borsari, Chiara C; Keles, Erhan E; McPhail, Jacob A JA; Schaefer, Alexander A; Sriramaratnam, Rohitha R; Goch, Wojciech W; Schaefer, Thorsten T; De Pascale, Martina M; Bal, Wojciech W; Gstaiger, Matthias M; Burke, John E JE; Wymann, Matthias P MP

Publication Date: 2022-04-13

Variant appearance in text: PI3K: G12C

PubMed Link: 35353516

Variant Present in the following documents:

• ja1c13568.pdf
• ja1c13568_si_001.pdf

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Establishment of a 7-microRNA prognostic signature and identification of hub target genes in colorectal carcinoma.

Translational Cancer Research

Jiang, Shengying S; Xie, Xiaoli X; Jiang, Huiqing H

Publication Date: 2022-02

Variant appearance in text: PI3K: G12C

PubMed Link: 35281422

Variant Present in the following documents:

• tcr-11-02-367.pdf

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Outcomes in Patients With Lung Adenocarcinoma With Transformation to Small Cell Lung Cancer After EGFR Tyrosine Kinase Inhibitors Resistance: A Systematic Review and Pooled Analysis.

Frontiers In Oncology

Xu, Jinhe J; Xu, Lihuan L; Wang, Baoshan B; Kong, Wencui W; Chen, Ying Y; Yu, Zongyang Z

Publication Date: 2021

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35223450

Variant Present in the following documents:

• Table_1.xlsx, sheet 1

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Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium.

Nature Communications

Yamaguchi, Manako M; Nakaoka, Hirofumi H; Suda, Kazuaki K; Yoshihara, Kosuke K; Ishiguro, Tatsuya T; Yachida, Nozomi N; Saito, Kyota K; Ueda, Haruka H; Sugino, Kentaro K; Mori, Yutaro Y; Yamawaki, Kaoru K; Tamura, Ryo R; Revathidevi, Sundaramoorthy S; Motoyama, Teiichi T; Tainaka, Kazuki K; Verhaak, Roel G W RGW; Inoue, Ituro I; Enomoto, Takayuki T

Publication Date: 2022-02-17

Variant appearance in text: PIK3CA: G12C

PubMed Link: 35177608

Variant Present in the following documents:

• 41467_2022_Article_28568.pdf

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Characterization With KRAS Mutant Is a Critical Determinant in Immunotherapy and Other Multiple Therapies for Non-Small Cell Lung Cancer.

Frontiers In Oncology

Shen, Mo M; Qi, Rongbin R; Ren, Justin J; Lv, Dongqing D; Yang, Haihua H

Publication Date: 2021

Variant appearance in text: PI3K: G12C

PubMed Link: 35070984

Variant Present in the following documents:

• fonc-11-780655.pdf

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The value of cell-free circulating tumour DNA profiling in advanced non-small cell lung cancer (NSCLC) management.

Cancer Cell International

Fernandes, Maria Gabriela O MGO; Cruz-Martins, Natália N; Machado, José Carlos JC; Costa, José Luís JL; Hespanhol, Venceslau V

Publication Date: 2021-12-16

Variant appearance in text: PIK3CA: Gly12Cys

PubMed Link: 34915883

Variant Present in the following documents:

• Main text
• 12935_2021_Article_2382.pdf

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The value of cell-free circulating tumour DNA profiling in advanced non-small cell lung cancer (NSCLC) management.

Cancer Cell International

Fernandes, Maria Gabriela O MGO; Cruz-Martins, Natália N; Machado, José Carlos JC; Costa, José Luís JL; Hespanhol, Venceslau V

Publication Date: 2021-12-16

Variant appearance in text: PIK3CA: Gly12Cys

PubMed Link: 34915883

Variant Present in the following documents:

• Main text
• 12935_2021_Article_2382.pdf

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Context Matters-Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer.

Frontiers In Cell And Developmental Biology

Sankarasubramanian, Sushmitha S; Pfohl, Ulrike U; Regenbrecht, Christian R A CRA; Reinhard, Christoph C; Wedeken, Lena L

Publication Date: 2021

Variant appearance in text: PI3K: G12C

PubMed Link: 34805167

Variant Present in the following documents:

• fcell-09-760705.pdf

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Pharmacogenomics characterization of the MDM2 inhibitor MI-773 reveals candidate tumours and predictive biomarkers.

Npj Precision Oncology

Vuaroqueaux, Vincent V; Hendriks, Hans R HR; Al-Hasani, Hoor H; Peille, Anne-Lise AL; Das, Samayita S; Fiebig, Heinz-Herbert HH

Publication Date: 2021-10-28

Variant appearance in text: PI3K: G12C

PubMed Link: 34711913

Variant Present in the following documents:

• 41698_2021_235_MOESM1_ESM.pdf

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Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy-A Review of the Literature.

Biomolecules

Schlick, Konstantin K; Kiem, Dominik D; Greil, Richard R

Publication Date: 2021-10-06

Variant appearance in text: PI3K: G12C

PubMed Link: 34680101

Variant Present in the following documents:

• Main text
• biomolecules-11-01469.pdf

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The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms.

Endocrine-Related Cancer

Venizelos, Andreas A; Elvebakken, Hege H; Perren, Aurel A; Nikolaienko, Oleksii O; Deng, Wei W; Lothe, Inger Marie B IMB; Couvelard, Anne A; Hjortland, Geir Olav GO; Sundlöv, Anna A; Svensson, Johanna J; Garresori, Harrish H; Kersten, Christian C; Hofsli, Eva E; Detlefsen, Sönke S; Krogh, Merete M; Sorbye, Halfdan H; Knappskog, Stian S

Publication Date: 2021-11-11

Variant appearance in text: PIK3CA: G12C

PubMed Link: 34647903

Variant Present in the following documents:

• supplementary_table_4.xlsx, sheet 1

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Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells.

Oncotarget

Kaczmarczyk, Jan A JA; Roberts, Rhonda R RR; Luke, Brian T BT; Chan, King C KC; Van Wagoner, Carly M CM; Felder, Robin A RA; Saul, Richard G RG; Simona, Colantonio C; Blonder, Josip J

Publication Date: 2021-09-28

Variant appearance in text: PI3K: G12C

PubMed Link: 34611477

Variant Present in the following documents:

• Main text
• oncotarget-12-2022.pdf

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The Utility of Next-Generation Sequencing in the Treatment Decision-Making for Metastatic Non-Small-Cell Lung Cancer.

Cureus

Orlov-Slavu, Maria Cristina MC; Popa, Ana Maria AM; Tulin, Adrian A; Pantea Stoian, Anca A; Poiana, Catalina C; Paleru, Cristian C; Calu, Valentin V; Nitipir, Cornelia C

Publication Date: 2021-08

Variant appearance in text: PIK3CA: G12C

PubMed Link: 34513491

Variant Present in the following documents:

• Main text

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Ras isoform-specific expression, chromatin accessibility, and signaling.

Biophysical Reviews

Nussinov, Ruth R; Zhang, Mingzhen M; Maloney, Ryan R; Jang, Hyunbum H

Publication Date: 2021-08

Variant appearance in text: PI3K: G12C

PubMed Link: 34466166

Variant Present in the following documents:

• Main text

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Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.

Nature Communications

Sun, Hua H; Cao, Song S; Mashl, R Jay RJ; Mo, Chia-Kuei CK; Zaccaria, Simone S; Wendl, Michael C MC; Davies, Sherri R SR; Bailey, Matthew H MH; Primeau, Tina M TM; Hoog, Jeremy J; Mudd, Jacqueline L JL; Dean, Dennis A DA; Patidar, Rajesh R; Chen, Li L; Wyczalkowski, Matthew A MA; Jayasinghe, Reyka G RG; Rodrigues, Fernanda Martins FM; Terekhanova, Nadezhda V NV; Li, Yize Y; Lim, Kian-Huat KH; Wang-Gillam, Andrea A; Van Tine, Brian A BA; Ma, Cynthia X CX; Aft, Rebecca R; Fuh, Katherine C KC; Schwarz, Julie K JK; Zevallos, Jose P JP; Puram, Sidharth V SV; Dipersio, John F JF; , ; Davis-Dusenbery, Brandi B; Ellis, Matthew J MJ; Lewis, Michael T MT; Davies, Michael A MA; Herlyn, Meenhard M; Fang, Bingliang B; Roth, Jack A JA; Welm, Alana L AL; Welm, Bryan E BE; Meric-Bernstam, Funda F; Chen, Feng F; Fields, Ryan C RC; Li, Shunqiang S; Govindan, Ramaswamy R; Doroshow, James H JH; Moscow, Jeffrey A JA; Evrard, Yvonne A YA; Chuang, Jeffrey H JH; Raphael, Benjamin J BJ; Ding, Li L

Publication Date: 2021-08-24

Variant appearance in text: PIK3CA: G12C

PubMed Link: 34429404

Variant Present in the following documents:

• 41467_2021_Article_25177.pdf

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The Importance of Being PI3K in the RAS Signaling Network.

Genes

Cuesta, Cristina C; Arévalo-Alameda, Cristina C; Castellano, Esther E

Publication Date: 2021-07-19

Variant appearance in text: PI3K: G12C

PubMed Link: 34356110

Variant Present in the following documents:

• Main text

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Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification.

Frontiers In Molecular Biosciences

Osaka, Natsuki N; Hirota, Yoshihisa Y; Ito, Doshun D; Ikeda, Yoshiki Y; Kamata, Ryo R; Fujii, Yuki Y; Chirasani, Venkat R VR; Campbell, Sharon L SL; Takeuchi, Koh K; Senda, Toshiya T; Sasaki, Atsuo T AT

Publication Date: 2021

Variant appearance in text: PI3K: G12C

PubMed Link: 34307463

Variant Present in the following documents:

• Main text

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Targeting Small GTPases and Their Prenylation in Diabetes Mellitus.

Journal Of Medicinal Chemistry

Gendaszewska-Darmach, Edyta E; Garstka, Malgorzata A MA; Błażewska, Katarzyna M KM

Publication Date: 2021-07-22

Variant appearance in text: PI3K: G12C

PubMed Link: 34236862

Variant Present in the following documents:

• Main text

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The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets.

Cancer Science

Burns, Julie E JE; Hurst, Carolyn D CD; Knowles, Margaret A MA; Phillips, Roger M RM; Allison, Simon J SJ

Publication Date: 2021-09

Variant appearance in text: PIK3CA: G12C

PubMed Link: 34181805

Variant Present in the following documents:

• CAS-112-3822-s004.xlsx, sheet 1

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Naproxen inhibits spontaneous lung adenocarcinoma formation in KrasG12V mice.

Neoplasia (New York, N.Y.)

Kumar, Gaurav G; Madka, Venkateshwar V; Singh, Anil A; Farooqui, Mudassir M; Stratton, Nicole N; Lightfoot, Stanley S; Mohammed, Altaf A; Rao, Chinthalapally V CV

Publication Date: 2021-06

Variant appearance in text: PI3K: G12C

PubMed Link: 34091121

Variant Present in the following documents:

• Main text
• main.pdf

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The Crossroads between RAS and RHO Signaling Pathways in Cellular Transformation, Motility and Contraction.

Genes

Soriano, Olga O; Alcón-Pérez, Marta M; Vicente-Manzanares, Miguel M; Castellano, Esther E

Publication Date: 2021-05-27

Variant appearance in text: PI3K: G12C

PubMed Link: 34071831

Variant Present in the following documents:

• Main text

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Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations.

Oncotarget

Joshi, Asim A; Mishra, Rohit R; Desai, Sanket S; Chandrani, Pratik P; Kore, Hitesh H; Sunder, Roma R; Hait, Supriya S; Iyer, Prajish P; Trivedi, Vaishakhi V; Choughule, Anuradha A; Noronha, Vanita V; Joshi, Amit A; Patil, Vijay V; Menon, Nandini N; Kumar, Rajiv R; Prabhash, Kumar K; Dutt, Amit A

Publication Date: 2021-03-16

Variant appearance in text: PIK3CA: G12C

PubMed Link: 33796225

Variant Present in the following documents:

• oncotarget-12-578-s006.xlsx, sheet 1

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Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches.

Frontiers In Cell And Developmental Biology

Alvarado-Ortiz, Eduardo E; de la Cruz-López, Karen Griselda KG; Becerril-Rico, Jared J; Sarabia-Sánchez, Miguel Angel MA; Ortiz-Sánchez, Elizabeth E; García-Carrancá, Alejandro A

Publication Date: 2020

Variant appearance in text: PI3K: G12C

PubMed Link: 33644030

Variant Present in the following documents:

• Main text
• fcell-08-607670.pdf

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Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.

Cancer Research

Singh, Kamini K; Lin, Jianan J; Lecomte, Nicolas N; Mohan, Prathibha P; Gokce, Askan A; Sanghvi, Viraj R VR; Jiang, Man M; Grbovic-Huezo, Olivera O; Burčul, Antonija A; Stark, Stefan G SG; Romesser, Paul B PB; Chang, Qing Q; Melchor, Jerry P JP; Beyer, Rachel K RK; Duggan, Mark M; Fukase, Yoshiyuki Y; Yang, Guangli G; Ouerfelli, Ouathek O; Viale, Agnes A; de Stanchina, Elisa E; Stamford, Andrew W AW; Meinke, Peter T PT; Rätsch, Gunnar G; Leach, Steven D SD; Ouyang, Zhengqing Z; Wendel, Hans-Guido HG

Publication Date: 2021-04-15

Variant appearance in text: PI3K: G12C

PubMed Link: 33632898

Variant Present in the following documents:

• Main text

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Usual-Type Endocervical Adenocarcinoma with a Microcystic, Elongated, and Fragmented Pattern of Stromal Invasion: A Case Report with Emphasis on Ki-67 Immunostaining and Targeted Sequencing Results.

Case Reports In Oncology

Choi, Sangjoon S; Hwang, Soohyun S; Do, Sung-Im SI; Kim, Hyun-Soo HS

Publication Date: 2020

Variant appearance in text: PIK3CA: 34G>T; Gly12Cys

PubMed Link: 33442366

Variant Present in the following documents:

• cro-0013-1421.pdf

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Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo.

Scientific Reports

Sakamoto, Kotaro K; Masutani, Teruaki T; Hirokawa, Takatsugu T

Publication Date: 2020-12-10

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PubMed Link: 33303890

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Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.

International Journal Of Molecular Sciences

Bovio, Federica F; Epistolio, Samantha S; Mozzi, Alessandra A; Monti, Eugenio E; Fusi, Paola P; Forcella, Matilde M; Frattini, Milo M

Publication Date: 2020-11-20

Variant appearance in text: PIK3CA: G12C

PubMed Link: 33233823

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Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.

Molecular Cell

Bieging-Rolett, Kathryn T KT; Kaiser, Alyssa M AM; Morgens, David W DW; Boutelle, Anthony M AM; Seoane, Jose A JA; Van Nostrand, Eric L EL; Zhu, Changyu C; Houlihan, Shauna L SL; Mello, Stephano S SS; Yee, Brian A BA; McClendon, Jacob J; Pierce, Sarah E SE; Winters, Ian P IP; Wang, Mengxiong M; Connolly, Andrew J AJ; Lowe, Scott W SW; Curtis, Christina C; Yeo, Gene W GW; Winslow, Monte M MM; Bassik, Michael C MC; Attardi, Laura D LD

Publication Date: 2020-11-05

Variant appearance in text: PIK3CA: G12C

PubMed Link: 33157015

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Evolution of Mutational Landscape and Tumor Immune-Microenvironment in Liver Oligo-Metastatic Colorectal Cancer.

Cancers

Ottaiano, Alessandro A; Caraglia, Michele M; Di Mauro, Annabella A; Botti, Gerardo G; Lombardi, Angela A; Galon, Jerome J; Luce, Amalia A; D'Amore, Luigi L; Perri, Francesco F; Santorsola, Mariachiara M; Hermitte, Fabienne F; Savarese, Giovanni G; Tatangelo, Fabiana F; Granata, Vincenza V; Izzo, Francesco F; Belli, Andrea A; Scala, Stefania S; Delrio, Paolo P; Circelli, Luisa L; Nasti, Guglielmo G

Publication Date: 2020-10-21

Variant appearance in text: PIK3CA: Gly12Cys

PubMed Link: 33096795

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• cancers-12-03073-s001.pdf

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Ras, PI3K and mTORC2 - three's a crowd?

Journal Of Cell Science

Smith, Stephen F SF; Collins, Shannon E SE; Charest, Pascale G PG

Publication Date: 2020-10-08

Variant appearance in text: PI3K: G12C

PubMed Link: 33033115

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BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer.

Communications Biology

Conciatori, Fabiana F; Bazzichetto, Chiara C; Amoreo, Carla Azzurra CA; Sperduti, Isabella I; Donzelli, Sara S; Diodoro, Maria Grazia MG; Buglioni, Simonetta S; Falcone, Italia I; Shirasawa, Senji S; Blandino, Giovanni G; Ferretti, Gianluigi G; Cognetti, Francesco F; Milella, Michele M; Ciuffreda, Ludovica L

Publication Date: 2020-10-01

Variant appearance in text: PI3K: G12C

PubMed Link: 33004975

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Quinoline-Based Molecules Targeting c-Met, EGF, and VEGF Receptors and the Proteins Involved in Related Carcinogenic Pathways.

Molecules (Basel, Switzerland)

Martorana, Annamaria A; La Monica, Gabriele G; Lauria, Antonino A

Publication Date: 2020-09-18

Variant appearance in text: PI3K: Gly12Cys

PubMed Link: 32961977

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• Main text
• molecules-25-04279.pdf

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PI3K inhibitors: review and new strategies.

Chemical Science

Zhang, Mingzhen M; Jang, Hyunbum H; Nussinov, Ruth R

Publication Date: 2020-06-21

Variant appearance in text: PI3K: G12C

PubMed Link: 32953006

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KRAS and PIK3CA bi-mutations predict a poor prognosis in colorectal cancer patients: A single-site report.

Translational Oncology

Luo, Qianxin Q; Chen, Dianke D; Fan, Xinjuan X; Fu, Xinhui X; Ma, Tenghui T; Chen, Daici D

Publication Date: 2020-12

Variant appearance in text: PIK3CA: G12C

PubMed Link: 32947236

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Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells.

Journal Of The American Chemical Society

Yoo, Daniel Y DY; Barros, Stephanie A SA; Brown, Gordon C GC; Rabot, Christian C; Bar-Sagi, Dafna D; Arora, Paramjit S PS

Publication Date: 2020-08-26

Variant appearance in text: PI3K: G12C

PubMed Link: 32786217

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Mutation analysis and genomic imbalances of cells found in effusion fluids from patients with ovarian cancer.

Oncology Letters

Brunetti, Marta M; Panagopoulos, Ioannis I; Kostolomov, Ilyá I; Davidson, Ben B; Heim, Sverre S; Micci, Francesca F

Publication Date: 2020-09

Variant appearance in text: PIK3CA: 34G>T

PubMed Link: 32782545

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Clinical impact of a cancer genomic profiling test using an in-house comprehensive targeted sequencing system.

Cancer Science

Hayashi, Hideyuki H; Tanishima, Shigeki S; Fujii, Kyoko K; Mori, Ryo R; Okada, Chihiro C; Yanagita, Emmy E; Shibata, Yuka Y; Matsuoka, Ryosuke R; Amano, Toraji T; Yamada, Takahiro T; Yabe, Ichiro I; Kinoshita, Ichiro I; Komatsu, Yoshito Y; Dosaka-Akita, Hirotoshi H; Nishihara, Hiroshi H

Publication Date: 2020-10

Variant appearance in text: PIK3CA: G12C

PubMed Link: 32772458

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• CAS-111-3926-s001.xlsx, sheet 9

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Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo.

Cancer Science

Wang, Xingshun X; Feng, Weimin W; Peng, Cheng C; Chen, Shiyun S; Ji, Hongbin H; Zhong, Hanbing H; Ge, Wei W; Zhang, Yandong Y

Publication Date: 2020-10

Variant appearance in text: PI3K: G12C

PubMed Link: 32767810

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Molecular profiling of non-small cell lung cancer.

Plos One

Forsythe, Marika L ML; Alwithenani, Akram A; Bethune, Drew D; Castonguay, Mathieu M; Drucker, Arik A; Flowerdew, Gordon G; French, Daniel D; Fris, John J; Greer, Wenda W; Henteleff, Harry H; MacNeil, Mary M; Marignani, Paola P; Morzycki, Wojciech W; Plourde, Madelaine M; Snow, Stephanie S; Xu, Zhaolin Z

Publication Date: 2020

Variant appearance in text: PIK3CA: 34G>T; Gly12Cys

PubMed Link: 32756609

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Beyond the Genomic Mutation: Rethinking the Molecular Biomarkers of K-RAS Dependency in Pancreatic Cancers.

International Journal Of Molecular Sciences

Mottini, Carla C; Cardone, Luca L

Publication Date: 2020-07-16

Variant appearance in text: PI3K: G12C

PubMed Link: 32708716

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• ijms-21-05023.pdf

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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Nature Communications

Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U

Publication Date: 2020-07-20

Variant appearance in text: PIK3CA: G12C

PubMed Link: 32686686

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• 41467_2020_17386_MOESM4_ESM.xlsx, sheet 1

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Impact and Diagnostic Gaps of Comprehensive Genomic Profiling in Real-World Clinical Practice.

Cancers

Singh, Aditi P AP; Shum, Elaine E; Rajdev, Lakshmi L; Cheng, Haiying H; Goel, Sanjay S; Perez-Soler, Roman R; Halmos, Balazs B

Publication Date: 2020-05-04

Variant appearance in text: PIK3CA: G12C

PubMed Link: 32375398

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Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma.

Cancer Biology & Medicine

Leblanc, Olivia O; Vacher, Sophie S; Lecerf, Charlotte C; Jeannot, Emmanuelle E; Klijanienko, Jerzy J; Berger, Frédérique F; Hoffmann, Caroline C; Calugaru, Valentin V; Badois, Nathalie N; Chilles, Anne A; Lesnik, Maria M; Krhili, Samar S; Bieche, Ivan I; Le Tourneau, Christophe C; Kamal, Maud M

Publication Date: 2020-02-15

Variant appearance in text: PIK3CA: 34G>T; G12C

PubMed Link: 32296588

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• cbm-17-208-s001.pdf

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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

Nature

Han, Kyuho K; Pierce, Sarah E SE; Li, Amy A; Spees, Kaitlyn K; Anderson, Gray R GR; Seoane, Jose A JA; Lo, Yuan-Hung YH; Dubreuil, Michael M; Olivas, Micah M; Kamber, Roarke A RA; Wainberg, Michael M; Kostyrko, Kaja K; Kelly, Marcus R MR; Yousefi, Maryam M; Simpkins, Scott W SW; Yao, David D; Lee, Keonil K; Kuo, Calvin J CJ; Jackson, Peter K PK; Sweet-Cordero, Alejandro A; Kundaje, Anshul A; Gentles, Andrew J AJ; Curtis, Christina C; Winslow, Monte M MM; Bassik, Michael C MC

Publication Date: 2020-04

Variant appearance in text: PIK3CA: G12C

PubMed Link: 32238925

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• NIHMS1549225-supplement-Sup_Tab5.xlsx, sheet 1

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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

Nature

Han, Kyuho K; Pierce, Sarah E SE; Li, Amy A; Spees, Kaitlyn K; Anderson, Grace R GR; Seoane, Jose A JA; Lo, Yuan-Hung YH; Dubreuil, Michael M; Olivas, Micah M; Kamber, Roarke A RA; Wainberg, Michael M; Kostyrko, Kaja K; Kelly, Marcus R MR; Yousefi, Maryam M; Simpkins, Scott W SW; Yao, David D; Lee, Keonil K; Kuo, Calvin J CJ; Jackson, Peter K PK; Sweet-Cordero, Alejandro A; Kundaje, Anshul A; Gentles, Andrew J AJ; Curtis, Christina C; Winslow, Monte M MM; Bassik, Michael C MC

Publication Date: 2020-04

Variant appearance in text: PIK3CA: G12C

PubMed Link: 32238925

Variant Present in the following documents:

• NIHMS1549225-supplement-Sup_Tab5.xlsx, sheet 1

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