Publications:

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Plasma ctDNA increases tissue NGS-based detection of therapeutically targetable mutations in lung cancers.

Bmc Cancer

Xie, Jianjiang J; Yao, Weishen W; Chen, Lingxiu L; Zhu, Wenjun W; Liu, Qiang Q; Geng, Geng G; Fang, Jing J; Zhao, Yang Y; Xiao, Li L; Huang, Zhenhua Z; Zhao, Jing J

Publication Date: 2023-03-31

Variant appearance in text: PIK3CA: Gly12Ala

PubMed Link: 37004022

Variant Present in the following documents:

• 12885_2023_Article_10674.pdf

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KRAS, NRAS, BRAF, and PIK3CA mutation rates, clinicopathological association, and their prognostic value in Iranian colorectal cancer patients.

Journal Of Clinical Laboratory Analysis

Mirzapoor Abbasabadi, Zohreh Z; Hamedi Asl, Dariush D; Rahmani, Babak B; Shahbadori, Rozhin R; Karami, Sara S; Peymani, Amir A; Taghizadeh, Sara S; Samiee Rad, Fatemeh F

Publication Date: 2023-03-17

Variant appearance in text: PIK3CA: G12A

PubMed Link: 36930789

Variant Present in the following documents:

• Main text
• JCLA-37-e24868.pdf

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Significant response of pulmonary sarcomatoid carcinoma with obstructive atelectasis to treatment with the PD-1 inhibitor camrelizumab combined with transbronchial cryoablation: A case report and literature review.

Frontiers In Oncology

Nian, Jiayun J; Zhu, Yong Y; Fu, Qi Q; Yang, Guowang G; Wang, Xiaomin X

Publication Date: 2022

Variant appearance in text: PIK3CA: G12A

PubMed Link: 36387200

Variant Present in the following documents:

• Main text
• fonc-12-1013047.pdf

View BVdb publication page

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: PIK3CA: 35G>C

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

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Molecular characterization of colorectal cancer related peritoneal metastatic disease.

Nature Communications

Lenos, Kristiaan J KJ; Bach, Sander S; Ferreira Moreno, Leandro L; Ten Hoorn, Sanne S; Sluiter, Nina R NR; Bootsma, Sanne S; Vieira Braga, Felipe A FA; Nijman, Lisanne E LE; van den Bosch, Tom T; Miedema, Daniel M DM; van Dijk, Erik E; Ylstra, Bauke B; Kulicke, Ruth R; Davis, Fred P FP; Stransky, Nicolas N; Smolen, Gromoslaw A GA; Coebergh van den Braak, Robert R J RRJ; IJzermans, Jan N M JNM; Martens, John W M JWM; Hallam, Sally S; Beggs, Andrew D AD; Kops, Geert J P L GJPL; Lansu, Nico N; Bastiaenen, Vivian P VP; Klaver, Charlotte E L CEL; Lecca, Maria C MC; El Makrini, Khalid K; Elbers, Clara C CC; Dings, Mark P G MPG; van Noesel, Carel J M CJM; Kranenburg, Onno O; Medema, Jan Paul JP; Koster, Jan J; Koens, Lianne L; Punt, Cornelis J A CJA; Tanis, Pieter J PJ; de Hingh, Ignace H IH; Bijlsma, Maarten F MF; Tuynman, Jurriaan B JB; Vermeulen, Louis L

Publication Date: 2022-08-04

Variant appearance in text: PIK3CA: G12A

PubMed Link: 35927254

Variant Present in the following documents:

• 41467_2022_32198_MOESM4_ESM.xlsx, sheet 1

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Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Durinikova, Erika E; Reilly, Nicole M NM; Buzo, Kristi K; Mariella, Elisa E; Chilà, Rosaria R; Lorenzato, Annalisa A; Dias, João M L JML; Grasso, Gaia G; Pisati, Federica F; Lamba, Simona S; Corti, Giorgio G; Degasperi, Andrea A; Cancelliere, Carlotta C; Mauri, Gianluca G; Andrei, Pietro P; Linnebacher, Michael M; Marsoni, Silvia S; Siena, Salvatore S; Sartore-Bianchi, Andrea A; Nik-Zainal, Serena S; Di Nicolantonio, Federica F; Bardelli, Alberto A; Arena, Sabrina S

Publication Date: 2022-09-01

Variant appearance in text: PIK3CA: G12A

PubMed Link: 35881546

Variant Present in the following documents:

• EMS151756-supplement-Table_S1.xlsx, sheet 1

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Mesonephric-Like Adenocarcinoma of Uterine Corpus: A Clinicopathological and Targeted Genomic Profiling Study in a Single Institution.

Frontiers In Oncology

Ma, Tianshi T; Chai, Mengyu M; Shou, Huafeng H; Ru, Guoqing G; Zhao, Ming M

Publication Date: 2022

Variant appearance in text: PIK3CA: 35G>C; G12A

PubMed Link: 35865471

Variant Present in the following documents:

• fonc-12-911695.pdf

View BVdb publication page

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Emerging strategies to overcome resistance to third-generation EGFR inhibitors.

Journal Of Hematology & Oncology

Shi, Kunyu K; Wang, Guan G; Pei, Junping J; Zhang, Jifa J; Wang, Jiaxing J; Ouyang, Liang L; Wang, Yuxi Y; Li, Weimin W

Publication Date: 2022-07-15

Variant appearance in text: PI3K: G12A

PubMed Link: 35840984

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1311.pdf

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A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma.

International Journal Of Cancer

Jo, Jung Hyun JH; Jung, Dawoon E DE; Lee, Hee Seung HS; Park, Soo Been SB; Chung, Moon Jae MJ; Park, Jeong Youp JY; Bang, Seungmin S; Park, Seung Woo SW; Cho, Sangsook S; Song, Si Young SY

Publication Date: 2022-11-01

Variant appearance in text: PIK3CA: G12A

PubMed Link: 35657348

Variant Present in the following documents:

• IJC-151-1565-s001.pdf

View BVdb publication page

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Cytokines in the Pathogenesis of Large Granular Lymphocytic Leukemia.

Frontiers In Oncology

Isabelle, Colleen C; Boles, Amy A; Chakravarti, Nitin N; Porcu, Pierluigi P; Brammer, Jonathan J; Mishra, Anjali A

Publication Date: 2022

Variant appearance in text: PI3K: G12A

PubMed Link: 35359386

Variant Present in the following documents:

• Main text

View BVdb publication page

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Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium.

Nature Communications

Yamaguchi, Manako M; Nakaoka, Hirofumi H; Suda, Kazuaki K; Yoshihara, Kosuke K; Ishiguro, Tatsuya T; Yachida, Nozomi N; Saito, Kyota K; Ueda, Haruka H; Sugino, Kentaro K; Mori, Yutaro Y; Yamawaki, Kaoru K; Tamura, Ryo R; Revathidevi, Sundaramoorthy S; Motoyama, Teiichi T; Tainaka, Kazuki K; Verhaak, Roel G W RGW; Inoue, Ituro I; Enomoto, Takayuki T

Publication Date: 2022-02-17

Variant appearance in text: PIK3CA: G12A

PubMed Link: 35177608

Variant Present in the following documents:

• 41467_2022_Article_28568.pdf

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KRAS Mutations in Squamous Cell Carcinomas of the Lung.

Frontiers In Oncology

Acker, Fabian F; Stratmann, Jan J; Aspacher, Lukas L; Nguyen, Ngoc Thien Thu NTT; Wagner, Sebastian S; Serve, Hubert H; Wild, Peter J PJ; Sebastian, Martin M

Publication Date: 2021

Variant appearance in text: PIK3CA: G12A

PubMed Link: 34976827

Variant Present in the following documents:

• fonc-11-788084.pdf

View BVdb publication page

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Real-World Approach for Molecular Analysis of Acquired EGFR Tyrosine Kinase Inhibitor Resistance Mechanisms in NSCLC.

Jto Clinical And Research Reports

Hondelink, Liesbeth M LM; Jebbink, Merel M; von der Thüsen, Jan H JH; Cohen, Danielle D; Dubbink, Hendrikus J HJ; Paats, Marthe S MS; Dingemans, Anne-Marie C AC; de Langen, Adrianus J AJ; Boelens, Mirjam C MC; Smit, Egbert F EF; Postmus, Pieter E PE; van Wezel, Tom T; Monkhorst, Kim K

Publication Date: 2021-12

Variant appearance in text: PIK3CA: G12A

PubMed Link: 34849493

Variant Present in the following documents:

• main.pdf

View BVdb publication page

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Emerging strategies to target RAS signaling in human cancer therapy.

Journal Of Hematology & Oncology

Chen, Kun K; Zhang, Yalei Y; Qian, Ling L; Wang, Peng P

Publication Date: 2021-07-23

Variant appearance in text: PI3K: G12A

PubMed Link: 34301278

Variant Present in the following documents:

• 13045_2021_Article_1127.pdf

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Ras Isoforms from Lab Benches to Lives-What Are We Missing and How Far Are We?

International Journal Of Molecular Sciences

Nair, Arathi A; Kubatzky, Katharina F KF; Saha, Bhaskar B

Publication Date: 2021-06-17

Variant appearance in text: PI3K: G12A

PubMed Link: 34204435

Variant Present in the following documents:

• Main text
• ijms-22-06508.pdf

View BVdb publication page

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Establishment and characterization of a new human colon cancer cell line, PUMC-CRC1.

Scientific Reports

Bian, Xiaocui X; Cao, Fang F; Wang, Xiaowan X; Hou, Yuhong Y; Zhao, Haitao H; Liu, Yuqin Y

Publication Date: 2021-06-23

Variant appearance in text: PIK3CA: G12A

PubMed Link: 34162944

Variant Present in the following documents:

• Main text
• 41598_2021_Article_92491.pdf

View BVdb publication page

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Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo.

Scientific Reports

Sakamoto, Kotaro K; Masutani, Teruaki T; Hirokawa, Takatsugu T

Publication Date: 2020-12-10

Variant appearance in text: PI3K: G12A

PubMed Link: 33303890

Variant Present in the following documents:

• Main text
• 41598_2020_Article_78712.pdf

View BVdb publication page

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Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.

International Journal Of Molecular Sciences

Bovio, Federica F; Epistolio, Samantha S; Mozzi, Alessandra A; Monti, Eugenio E; Fusi, Paola P; Forcella, Matilde M; Frattini, Milo M

Publication Date: 2020-11-20

Variant appearance in text: PIK3CA: G12A

PubMed Link: 33233823

Variant Present in the following documents:

• Main text

View BVdb publication page

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KRAS and PIK3CA bi-mutations predict a poor prognosis in colorectal cancer patients: A single-site report.

Translational Oncology

Luo, Qianxin Q; Chen, Dianke D; Fan, Xinjuan X; Fu, Xinhui X; Ma, Tenghui T; Chen, Daici D

Publication Date: 2020-12

Variant appearance in text: PIK3CA: G12A

PubMed Link: 32947236

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery.

Cancer Metastasis Reviews

Pálfy, Gyula G; Menyhárd, Dóra K DK; Perczel, András A

Publication Date: 2020-12

Variant appearance in text: PI3K: Gly12Ala

PubMed Link: 32815102

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinical impact of a cancer genomic profiling test using an in-house comprehensive targeted sequencing system.

Cancer Science

Hayashi, Hideyuki H; Tanishima, Shigeki S; Fujii, Kyoko K; Mori, Ryo R; Okada, Chihiro C; Yanagita, Emmy E; Shibata, Yuka Y; Matsuoka, Ryosuke R; Amano, Toraji T; Yamada, Takahiro T; Yabe, Ichiro I; Kinoshita, Ichiro I; Komatsu, Yoshito Y; Dosaka-Akita, Hirotoshi H; Nishihara, Hiroshi H

Publication Date: 2020-10

Variant appearance in text: PIK3CA: G12A

PubMed Link: 32772458

Variant Present in the following documents:

• CAS-111-3926-s001.xlsx, sheet 4

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A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.

Cell Research

Qian, Junbin J; Olbrecht, Siel S; Boeckx, Bram B; Vos, Hanne H; Laoui, Damya D; Etlioglu, Emre E; Wauters, Els E; Pomella, Valentina V; Verbandt, Sara S; Busschaert, Pieter P; Bassez, Ayse A; Franken, Amelie A; Bempt, Marlies Vanden MV; Xiong, Jieyi J; Weynand, Birgit B; van Herck, Yannick Y; Antoranz, Asier A; Bosisio, Francesca Maria FM; Thienpont, Bernard B; Floris, Giuseppe G; Vergote, Ignace I; Smeets, Ann A; Tejpar, Sabine S; Lambrechts, Diether D

Publication Date: 2020-09

Variant appearance in text: PIK3CA: G12A

PubMed Link: 32561858

Variant Present in the following documents:

• 41422_2020_355_MOESM15_ESM.xlsx, sheet 1

View BVdb publication page

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Genetic alteration of colorectal adenoma-carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis.

Molecular Genetics & Genomic Medicine

Tanabe, Hiroki H; Moriichi, Kentaro K; Takahashi, Keitaro K; Ono, Yusuke Y; Kobayashi, Yu Y; Murakami, Yuki Y; Iwama, Takuya T; Kunogi, Takehito T; Sasaki, Takahiro T; Ando, Katsuyoshi K; Ueno, Nobuhiro N; Kashima, Shin S; Takei, Hidehiro H; Mizukami, Yusuke Y; Fujiya, Mikihiro M; Okumura, Toshikatsu T

Publication Date: 2020-09

Variant appearance in text: PIK3CA: G12A

PubMed Link: 32543103

Variant Present in the following documents:

• Main text

View BVdb publication page

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TRF2 and VEGF-A: an unknown relationship with prognostic impact on survival of colorectal cancer patients.

Journal Of Experimental & Clinical Cancer Research : Cr

Dinami, Roberto R; Porru, Manuela M; Amoreo, Carla Azzurra CA; Sperduti, Isabella I; Mottolese, Marcella M; Buglioni, Simonetta S; Marinelli, Daniele D; Maugeri-Saccà, Marcello M; Sacconi, Andrea A; Blandino, Giovanni G; Leonetti, Carlo C; Di Rocco, Giuliana G; Verdina, Alessandra A; Spinella, Francesca F; Fiorentino, Francesco F; Ciliberto, Gennaro G; Biroccio, Annamaria A; Zizza, Pasquale P

Publication Date: 2020-06-15

Variant appearance in text: PIK3CA: G12A

PubMed Link: 32539869

Variant Present in the following documents:

• 13046_2020_1612_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation.

Nature Communications

Hamarsheh, Shaima'a S; Osswald, Lena L; Saller, Benedikt S BS; Unger, Susanne S; De Feo, Donatella D; Vinnakota, Janaki Manoja JM; Konantz, Martina M; Uhl, Franziska M FM; Becker, Heiko H; Lübbert, Michael M; Shoumariyeh, Khalid K; Schürch, Christoph C; Andrieux, Geoffroy G; Venhoff, Nils N; Schmitt-Graeff, Annette A; Duquesne, Sandra S; Pfeifer, Dietmar D; Cooper, Matthew A MA; Lengerke, Claudia C; Boerries, Melanie M; Duyster, Justus J; Niemeyer, Charlotte M CM; Erlacher, Miriam M; Blazar, Bruce R BR; Becher, Burkard B; Groß, Olaf O; Brummer, Tilman T; Zeiser, Robert R

Publication Date: 2020-04-03

Variant appearance in text: PI3K: G12A

PubMed Link: 32246016

Variant Present in the following documents:

• 41467_2020_15497_MOESM1_ESM.pdf

View BVdb publication page

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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

Nature

Han, Kyuho K; Pierce, Sarah E SE; Li, Amy A; Spees, Kaitlyn K; Anderson, Grace R GR; Seoane, Jose A JA; Lo, Yuan-Hung YH; Dubreuil, Michael M; Olivas, Micah M; Kamber, Roarke A RA; Wainberg, Michael M; Kostyrko, Kaja K; Kelly, Marcus R MR; Yousefi, Maryam M; Simpkins, Scott W SW; Yao, David D; Lee, Keonil K; Kuo, Calvin J CJ; Jackson, Peter K PK; Sweet-Cordero, Alejandro A; Kundaje, Anshul A; Gentles, Andrew J AJ; Curtis, Christina C; Winslow, Monte M MM; Bassik, Michael C MC

Publication Date: 2020-04

Variant appearance in text: PIK3CA: G12A

PubMed Link: 32238925

Variant Present in the following documents:

• NIHMS1549225-supplement-Sup_Tab5.xlsx, sheet 1

View BVdb publication page

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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

Nature

Han, Kyuho K; Pierce, Sarah E SE; Li, Amy A; Spees, Kaitlyn K; Anderson, Gray R GR; Seoane, Jose A JA; Lo, Yuan-Hung YH; Dubreuil, Michael M; Olivas, Micah M; Kamber, Roarke A RA; Wainberg, Michael M; Kostyrko, Kaja K; Kelly, Marcus R MR; Yousefi, Maryam M; Simpkins, Scott W SW; Yao, David D; Lee, Keonil K; Kuo, Calvin J CJ; Jackson, Peter K PK; Sweet-Cordero, Alejandro A; Kundaje, Anshul A; Gentles, Andrew J AJ; Curtis, Christina C; Winslow, Monte M MM; Bassik, Michael C MC

Publication Date: 2020-04

Variant appearance in text: PIK3CA: G12A

PubMed Link: 32238925

Variant Present in the following documents:

• NIHMS1549225-supplement-Sup_Tab5.xlsx, sheet 1

View BVdb publication page

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Overall survival in patients with lung adenocarcinoma harboring "niche" mutations: an observational study.

Oncotarget

Aramini, Beatrice B; Banchelli, Federico F; Bettelli, Stefania S; Manfredini, Samantha S; D'Amico, Roberto R; Masciale, Valentina V; Pinelli, Massimo M; Moretti, Margherita M; Stefani, Alessandro A; Bertolini, Federica F; Dominici, Massimo M; Morandi, Uliano U; Maiorana, Antonino A

Publication Date: 2020-02-04

Variant appearance in text: PIK3CA: G12A

PubMed Link: 32082488

Variant Present in the following documents:

• Main text

View BVdb publication page

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Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth.

Science Advances

Shin, Seung-Min SM; Kim, Ji-Sun JS; Park, Seong-Wook SW; Jun, Sei-Yong SY; Kweon, Hye-Jin HJ; Choi, Dong-Ki DK; Lee, Dakeun D; Cho, Yong Beom YB; Kim, Yong-Sung YS

Publication Date: 2020-01

Variant appearance in text: PIK3CA: G12A

PubMed Link: 31998840

Variant Present in the following documents:

• aay2174_SM.pdf

View BVdb publication page

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Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients.

Plos One

Papadopoulou, Eirini E; Tsoulos, Nikolaos N; Tsantikidi, Katerina K; Metaxa-Mariatou, Vasiliki V; Stamou, Pinelopi Eleftheria PE; Kladi-Skandali, Athina A; Kapeni, Evgenia E; Tsaousis, Georgios G; Pentheroudakis, George G; Petrakis, Dimitrios D; Lampropoulou, Dimitra Ioanna DI; Aravantinos, Gerasimos G; Varthalitis, Ioannis I; Kesisis, George G; Boukovinas, Ioannis I; Papakotoulas, Pavlos P; Katirtzoglou, Nikolaos N; Athanasiadis, Elias E; Stavridi, Flora F; Christodoulou, Christos C; Koumarianou, Anna A; Eralp, Yeşim Y; Nasioulas, George G

Publication Date: 2019

Variant appearance in text: PIK3CA: 35G>C; G12A

PubMed Link: 31860648

Variant Present in the following documents:

• pone.0226853.s001.xlsx, sheet 1

View BVdb publication page

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Development, Implementation and Assessment of Molecular Diagnostics by Next Generation Sequencing in Personalized Treatment of Cancer: Experience of a Public Reference Healthcare Hospital.

Cancers

Simarro, Javier J; Murria, Rosa R; Pérez-Simó, Gema G; Llop, Marta M; Mancheño, Nuria N; Ramos, David D; Juan, Inmaculada de I; Barragán, Eva E; Laiz, Begoña B; Cases, Enrique E; Ansótegui, Emilio E; Gómez-Codina, José J; Aparicio, Jorge J; Salvador, Carmen C; Juan, Óscar Ó; Palanca, Sarai S

Publication Date: 2019-08-16

Variant appearance in text: PIK3CA: 35G>C; Gly12Ala

PubMed Link: 31426418

Variant Present in the following documents:

• cancers-11-01196-s001.pdf

View BVdb publication page

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Systematic analysis of the intersection of disease mutations with protein modifications.

Bmc Medical Genomics

Simpson, Claire M CM; Zhang, Bin B; Hornbeck, Peter V PV; Gnad, Florian F

Publication Date: 2019-07-25

Variant appearance in text: PIK3CA: G12A

PubMed Link: 31345222

Variant Present in the following documents:

• 12920_2019_543_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins.

Acta Pharmaceutica Sinica. B

Zhang, Yuan Y; Wang, Zhihua Z; Ma, Xiaoyao X; Yang, Shengnan S; Hu, Xueyan X; Tao, Jin J; Hou, Yuanyuan Y; Bai, Gang G

Publication Date: 2019-03

Variant appearance in text: PI3K: G12A

PubMed Link: 30976491

Variant Present in the following documents:

• Main text

View BVdb publication page

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A Simple and Highly Specific MassARRAY-Based Stool DNA Assay to Prioritize Follow-up Decisions in Fecal Immunochemical Test-Positive Individuals.

Cancers

Chang, Pi-Yueh PY; Chen, Chia-Chun CC; Chiang, Jy-Ming JM; Chang, Shih-Cheng SC; Wang, Mei-Chia MC; Chen, Jinn-Shiun JS; Tsai, Wen-Sy WS; You, Jeng Fu JF; Lu, Jang-Jih JJ

Publication Date: 2019-03-25

Variant appearance in text: PIK3CA: G12A

PubMed Link: 30934598

Variant Present in the following documents:

• cancers-11-00423-s001.pdf

View BVdb publication page

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Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence.

Scientific Reports

Pasternack, Helen H; Fassunke, Jana J; Plum, Patrick Sven PS; Chon, Seung-Hun SH; Hescheler, Daniel Alexander DA; Gassa, Asmae A; Merkelbach-Bruse, Sabine S; Bruns, Christiane Josephine CJ; Perner, Sven S; Hallek, Michael M; Büttner, Reinhard R; Bollschweiler, Elfriede E; Hölscher, Arnulf Heinrich AH; Quaas, Alexander A; Zander, Thomas T; Weiss, Jonathan J; Alakus, Hakan H

Publication Date: 2018-10-08

Variant appearance in text: PIK3CA: 35G>C; G12A

PubMed Link: 30297788

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

The Lancet. Gastroenterology & Hepatology

Domingo, Enric E; Camps, Carme C; Kaisaki, Pamela J PJ; Parsons, Marie J MJ; Mouradov, Dmitri D; Pentony, Melissa M MM; Makino, Seiko S; Palmieri, Michelle M; Ward, Robyn L RL; Hawkins, Nicholas J NJ; Gibbs, Peter P; Askautrud, Hanne H; Oukrif, Dahmane D; Wang, Haitao H; Wood, Joe J; Tomlinson, Evie E; Bark, Yasmine Y; Kaur, Kulvinder K; Johnstone, Elaine C EC; Palles, Claire C; Church, David N DN; Novelli, Marco M; Danielsen, Havard E HE; Sherlock, Jon J; Kerr, David D; Kerr, Rachel R; Sieber, Oliver O; Taylor, Jenny C JC; Tomlinson, Ian I

Publication Date: 2018-09

Variant appearance in text: PIK3CA: G12A

PubMed Link: 30042065

Variant Present in the following documents:

• mmc1.pdf

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Next‑generation sequencing‑based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, Her‑2 and TP53 mutations in patients with non‑small cell lung cancer.

Molecular Medicine Reports

Jing, Changwen C; Mao, Xuhua X; Wang, Zhuo Z; Sun, Kejing K; Ma, Rong R; Wu, Jianzhong J; Cao, Haixia H

Publication Date: 2018-08

Variant appearance in text: PIK3CA: 35G>C

PubMed Link: 29956783

Variant Present in the following documents:

• mmr-18-02-2191.pdf

View BVdb publication page

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Integrated Molecular Characterization of Testicular Germ Cell Tumors.

Cell Reports

Shen, Hui H; Shih, Juliann J; Hollern, Daniel P DP; Wang, Linghua L; Bowlby, Reanne R; Tickoo, Satish K SK; Thorsson, Vésteinn V; Mungall, Andrew J AJ; Newton, Yulia Y; Hegde, Apurva M AM; Armenia, Joshua J; Sánchez-Vega, Francisco F; Pluta, John J; Pyle, Louise C LC; Mehra, Rohit R; Reuter, Victor E VE; Godoy, Guilherme G; Jones, Jeffrey J; Shelley, Carl S CS; Feldman, Darren R DR; Vidal, Daniel O DO; Lessel, Davor D; Kulis, Tomislav T; Cárcano, Flavio M FM; Leraas, Kristen M KM; Lichtenberg, Tara M TM; Brooks, Denise D; Cherniack, Andrew D AD; Cho, Juok J; Heiman, David I DI; Kasaian, Katayoon K; Liu, Minwei M; Noble, Michael S MS; Xi, Liu L; Zhang, Hailei H; Zhou, Wanding W; ZenKlusen, Jean C JC; Hutter, Carolyn M CM; Felau, Ina I; Zhang, Jiashan J; Schultz, Nikolaus N; Getz, Gad G; Meyerson, Matthew M; Stuart, Joshua M JM; , ; Akbani, Rehan R; Wheeler, David A DA; Laird, Peter W PW; Nathanson, Katherine L KL; Cortessis, Victoria K VK; Hoadley, Katherine A KA

Publication Date: 2018-06-12

Variant appearance in text: PIK3CA: G12A

PubMed Link: 29898407

Variant Present in the following documents:

• NIHMS977848-supplement-2.xlsx, sheet 1

View BVdb publication page

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Dynamic changes of circulating tumour DNA in surgical lung cancer patients: protocol for a prospective observational study.

Bmj Open

Chen, Kezhong K; Zhao, Heng H; Yang, Fan F; Hui, Bengang B; Wang, Tianyang T; Wang, Lieu Tu LT; Shi, Yanbin Y; Wang, Jun J

Publication Date: 2018-02-06

Variant appearance in text: PIK3CA: G12A

PubMed Link: 29437753

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• Main text
• bmjopen-2017-019012.pdf

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Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Nature Communications

Baker, Ann-Marie AM; Huang, Weini W; Wang, Xiao-Ming Mindy XM; Jansen, Marnix M; Ma, Xiao-Jun XJ; Kim, Jeffrey J; Anderson, Courtney M CM; Wu, Xingyong X; Pan, Liuliu L; Su, Nan N; Luo, Yuling Y; Domingo, Enric E; Heide, Timon T; Sottoriva, Andrea A; Lewis, Annabelle A; Beggs, Andrew D AD; Wright, Nicholas A NA; Rodriguez-Justo, Manuel M; Park, Emily E; Tomlinson, Ian I; Graham, Trevor A TA

Publication Date: 2017-12-08

Variant appearance in text: PIK3CA: 35G>C

PubMed Link: 29222441

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• 41467_2017_2295_MOESM1_ESM.pdf

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Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer.

Oncotarget

Shimada, Yoshifumi Y; Kameyama, Hitoshi H; Nagahashi, Masayuki M; Ichikawa, Hiroshi H; Muneoka, Yusuke Y; Yagi, Ryoma R; Tajima, Yosuke Y; Okamura, Takuma T; Nakano, Masato M; Sakata, Jun J; Kobayashi, Takashi T; Nogami, Hitoshi H; Maruyama, Satoshi S; Takii, Yasumasa Y; Hayashida, Tetsu T; Takaishi, Hiromasa H; Kitagawa, Yuko Y; Oki, Eiji E; Konishi, Tsuyoshi T; Ishida, Fumio F; Kudo, Shin-Ei SE; Ring, Jennifer E JE; Protopopov, Alexei A; Lyle, Stephen S; Ling, Yiwei Y; Okuda, Shujiro S; Ishikawa, Takashi T; Akazawa, Kohei K; Takabe, Kazuaki K; Wakai, Toshifumi T

Publication Date: 2017-11-07

Variant appearance in text: PIK3CA: G12A

PubMed Link: 29212173

Variant Present in the following documents:

• oncotarget-08-93567-s003.xlsx, sheet 1

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Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment.

International Journal Of Molecular Sciences

Bignucolo, Alessia A; De Mattia, Elena E; Cecchin, Erika E; Roncato, Rossana R; Toffoli, Giuseppe G

Publication Date: 2017-07-14

Variant appearance in text: PIK3CA: 35G>C

PubMed Link: 28708103

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• Main text
• ijms-18-01522.pdf

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Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.

Molecular Cancer

Berg, Kaja C G KCG; Eide, Peter W PW; Eilertsen, Ina A IA; Johannessen, Bjarne B; Bruun, Jarle J; Danielsen, Stine A SA; Bjørnslett, Merete M; Meza-Zepeda, Leonardo A LA; Eknæs, Mette M; Lind, Guro E GE; Myklebost, Ola O; Skotheim, Rolf I RI; Sveen, Anita A; Lothe, Ragnhild A RA

Publication Date: 2017-07-06

Variant appearance in text: PIK3CA: G12A

PubMed Link: 28683746

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In vivo and ex vivo cetuximab sensitivity assay using three-dimensional primary culture system to stratify KRAS mutant colorectal cancer.

Plos One

Tashiro, Takahiro T; Okuyama, Hiroaki H; Endo, Hiroko H; Kawada, Kenji K; Ashida, Yasuko Y; Ohue, Masayuki M; Sakai, Yoshiharu Y; Inoue, Masahiro M

Publication Date: 2017

Variant appearance in text: PIK3CA: G12A

PubMed Link: 28301591

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• Main text
• pone.0174151.pdf

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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Nature Communications

Schütte, Moritz M; Risch, Thomas T; Abdavi-Azar, Nilofar N; Boehnke, Karsten K; Schumacher, Dirk D; Keil, Marlen M; Yildiriman, Reha R; Jandrasits, Christine C; Borodina, Tatiana T; Amstislavskiy, Vyacheslav V; Worth, Catherine L CL; Schweiger, Caroline C; Liebs, Sandra S; Lange, Martin M; Warnatz, Hans-Jörg HJ; Butcher, Lee M LM; Barrett, James E JE; Sultan, Marc M; Wierling, Christoph C; Golob-Schwarzl, Nicole N; Lax, Sigurd S; Uranitsch, Stefan S; Becker, Michael M; Welte, Yvonne Y; Regan, Joseph Lewis JL; Silvestrov, Maxine M; Kehler, Inge I; Fusi, Alberto A; Kessler, Thomas T; Herwig, Ralf R; Landegren, Ulf U; Wienke, Dirk D; Nilsson, Mats M; Velasco, Juan A JA; Garin-Chesa, Pilar P; Reinhard, Christoph C; Beck, Stephan S; Schäfer, Reinhold R; Regenbrecht, Christian R A CR; Henderson, David D; Lange, Bodo B; Haybaeck, Johannes J; Keilholz, Ulrich U; Hoffmann, Jens J; Lehrach, Hans H; Yaspo, Marie-Laure ML

Publication Date: 2017-02-10

Variant appearance in text: PIK3CA: G12A

PubMed Link: 28186126

Variant Present in the following documents:

• ncomms14262-s16.xlsx, sheet 8

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Evaluation of Novel Targeted Therapies in Aggressive Biology Sarcoma Patients after progression from US FDA approved Therapies.

Scientific Reports

Subbiah, Vivek V; Hess, Kenneth R KR; Khawaja, Muhammad Rizwan MR; Wagner, Michael J MJ; Tang, Chad C; Naing, Aung A; Fu, Siqing S; Janku, Filip F; Piha-Paul, Sarina S; Tsimberidou, Apostolia M AM; Herzog, Cynthia E CE; Ludwig, Joseph A JA; Patel, Shreyaskumar S; Ravi, Vinod V; Benjamin, Robert S RS; Meric-Bernstam, Funda F; Hong, David S DS

Publication Date: 2016-10-17

Variant appearance in text: PIK3CA: G12A

PubMed Link: 27748430

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• Main text
• srep35448.pdf

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In-depth molecular profiling of the biphasic components of uterine carcinosarcomas.

The Journal Of Pathology. Clinical Research

McConechy, Melissa K MK; Hoang, Lien N LN; Chui, Michael Herman MH; Senz, Janine J; Yang, Winnie W; Rozenberg, Nirit N; Mackenzie, Robertson R; McAlpine, Jessica N JN; Huntsman, David G DG; Clarke, Blaise A BA; Gilks, Cyril Blake CB; Lee, Cheng-Han CH

Publication Date: 2015-07

Variant appearance in text: PIK3CA: G12A

PubMed Link: 27499902

Variant Present in the following documents:

• CJP2-1-173-s002.xlsx, sheet 1

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Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models.

Oncotarget

Lee, Michael S MS; Helms, Timothy L TL; Feng, Ningping N; Gay, Jason J; Chang, Qing Edward QE; Tian, Feng F; Wu, Ji Y JY; Toniatti, Carlo C; Heffernan, Timothy P TP; Powis, Garth G; Kwong, Lawrence N LN; Kopetz, Scott S

Publication Date: 2016-06-28

Variant appearance in text: PIK3CA: G12A

PubMed Link: 27167191

Variant Present in the following documents:

• oncotarget-07-39595-s001.pdf

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VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.

Nucleic Acids Research

Lai, Zhongwu Z; Markovets, Aleksandra A; Ahdesmaki, Miika M; Chapman, Brad B; Hofmann, Oliver O; McEwen, Robert R; Johnson, Justin J; Dougherty, Brian B; Barrett, J Carl JC; Dry, Jonathan R JR

Publication Date: 2016-06-20

Variant appearance in text: PIK3CA: 35G>C; G12A

PubMed Link: 27060149

Variant Present in the following documents:

• supp_gkw227_nar-03544-met-k-2015-File003.xls, sheet 2

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Mutations of KRAS/NRAS/BRAF predict cetuximab resistance in metastatic colorectal cancer patients.

Oncotarget

Hsu, Hung-Chih HC; Thiam, Tan Kien TK; Lu, Yen-Jung YJ; Yeh, Chien Yuh CY; Tsai, Wen-Sy WS; You, Jeng Fu JF; Hung, Hsin Yuan HY; Tsai, Chi-Neu CN; Hsu, An A; Chen, Hua-Chien HC; Chen, Shu-Jen SJ; Yang, Tsai-Sheng TS

Publication Date: 2016-04-19

Variant appearance in text: PIK3CA: 35G>C; G12A

PubMed Link: 26989027

Variant Present in the following documents:

• oncotarget-07-22257-s001.pdf

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Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.

Oncotarget

Lieu, Christopher H CH; Klauck, Peter J PJ; Henthorn, Patrick K PK; Tentler, John J JJ; Tan, Aik-Choon AC; Spreafico, Anna A; Selby, Heather M HM; Britt, Blair C BC; Bagby, Stacey M SM; Arcaroli, John J JJ; Messersmith, Wells A WA; Pitts, Todd M TM; Eckhardt, S Gail SG

Publication Date: 2015-10-27

Variant appearance in text: PIK3CA: G12A

PubMed Link: 26439693

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• Main text

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Safety and efficacy of the addition of simvastatin to cetuximab in previously treated KRAS mutant metastatic colorectal cancer patients.

Investigational New Drugs

Baas, J M JM; Krens, L L LL; ten Tije, A J AJ; Erdkamp, F F; van Wezel, T T; Morreau, H H; Gelderblom, H H; Guchelaar, H J HJ

Publication Date: 2015-12

Variant appearance in text: PIK3CA: G12A

PubMed Link: 26386973

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• Main text

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Mutations in the Kinase Domain of the HER2/ERBB2 Gene Identified in a Wide Variety of Human Cancers.

The Journal Of Molecular Diagnostics : Jmd

Wen, Wenhsiang W; Chen, Wangjuh Sting WS; Xiao, Nick N; Bender, Ryan R; Ghazalpour, Anatole A; Tan, Zheng Z; Swensen, Jeffrey J; Millis, Sherri Z SZ; Basu, Gargi G; Gatalica, Zoran Z; Press, Michael F MF

Publication Date: 2015-09

Variant appearance in text: PIK3CA: G12A

PubMed Link: 26320869

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• Main text

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Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc

Haley, Lisa L; Tseng, Li-Hui LH; Zheng, Gang G; Dudley, Jonathan J; Anderson, Derek A DA; Azad, Nilofer S NS; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT

Publication Date: 2015-10

Variant appearance in text: PIK3CA: G12A

PubMed Link: 26226847

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• Main text

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LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer.

Oncotarget

Zhuo, Changhua C; Li, Qingguo Q; Wu, Yuchen Y; Li, Yiwei Y; Nie, Jia J; Li, Dawei D; Peng, Junjie J; Lian, Peng P; Li, Bin B; Cai, Guoxiang G; Li, Xinxiang X; Cai, Sanjun S

Publication Date: 2015-09-15

Variant appearance in text: PIK3CA: 35G>C; Gly12Ala

PubMed Link: 26172297

Variant Present in the following documents:

• oncotarget-06-23820-s001.pdf

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A network flow-based method to predict anticancer drug sensitivity.

Plos One

Qin, Yufang Y; Chen, Ming M; Wang, Haiyun H; Zheng, Xiaoqi X

Publication Date: 2015

Variant appearance in text: PIK3CA: G12A

PubMed Link: 25992881

Variant Present in the following documents:

• pone.0127380.s002.xlsx, sheet 1

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Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab.

Journal Of Translational Medicine

Giampieri, Riccardo R; Mandolesi, Alessandra A; Abouelkhair, Khaled M KM; Loretelli, Cristian C; Del Prete, Michela M; Faloppi, Luca L; Maristella, Bianconi B; Ibrahim, Ezzeldin M EM; Scarpelli, Marina M; Cascinu, Stefano S; Scartozzi, Mario M

Publication Date: 2015-05-07

Variant appearance in text: PIK3CA: G12A

PubMed Link: 25943333

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• Main text

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Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.

Neoplasia (New York, N.Y.)

Grasso, Silvina S; Tristante, Elena E; Saceda, Miguel M; Carbonell, Pablo P; Mayor-López, Leticia L; Carballo-Santana, Mar M; Carrasco-García, Estefanía E; Rocamora-Reverte, Lourdes L; García-Morales, Pilar P; Carballo, Fernando F; Ferragut, José A JA; Martínez-Lacaci, Isabel I

Publication Date: 2014-10

Variant appearance in text: PIK3CA: G12A

PubMed Link: 25379021

Variant Present in the following documents:

• main.pdf

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The role of kras mutations and MSI status in diagnosis of colorectal cancer.

Gastroenterology And Hepatology From Bed To Bench

Shemirani, Atena Irani AI; Haghighi, Mahdi Montazer MM; Milanizadeh, Saman S; Taleghani, Mohammad Yaghoob MY; Fatemi, Seyed Reza SR; Damavand, Behzad B; Akbari, Zahra Z; Zali, Mohammad Reza MR

Publication Date: 2011

Variant appearance in text: PIK3CA: 35G>C; G12A

PubMed Link: 24834160

Variant Present in the following documents:

• GHFBB-4-070.pdf

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Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer.

Plos One

Burghel, George J GJ; Lin, Wei-Yu WY; Whitehouse, Helen H; Brock, Ian I; Hammond, David D; Bury, Jonathan J; Stephenson, Yvonne Y; George, Rina R; Cox, Angela A

Publication Date: 2013

Variant appearance in text: PIK3CA: 35G>C

PubMed Link: 24367615

Variant Present in the following documents:

• pone.0083859.s005.xls, sheet 1

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Molecular typing of lung adenocarcinoma on cytological samples using a multigene next generation sequencing panel.

Plos One

Scarpa, Aldo A; Sikora, Katarzyna K; Fassan, Matteo M; Rachiglio, Anna Maria AM; Cappellesso, Rocco R; Antonello, Davide D; Amato, Eliana E; Mafficini, Andrea A; Lambiase, Matilde M; Esposito, Claudia C; Bria, Emilio E; Simonato, Francesca F; Scardoni, Maria M; Turri, Giona G; Chilosi, Marco M; Tortora, Giampaolo G; Fassina, Ambrogio A; Normanno, Nicola N

Publication Date: 2013

Variant appearance in text: PIK3CA: G12A

PubMed Link: 24236184

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• Main text

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