PIK3CA c.49C>T ;(p.P17S)

Variant ID: 3-178916662-C-T

NM_006218.2(PIK3CA):c.49C>T;(p.P17S)

This variant was identified in 13 publications

View GRCh38 version.




Publications:


Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine
Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y
Publication Date: 2022-07

Variant appearance in text: PIK3CA: 49C>T; P17S
PubMed Link: 35393784
Variant Present in the following documents:
  • CAM4-11-2767-s001.xlsx, sheet 1
View BVdb publication page



Molecular landscape and efficacy of HER2-targeted therapy in patients with HER2-mutated metastatic breast cancer.

Npj Breast Cancer
Yi, Zongbi Z; Rong, Guohua G; Guan, Yanfang Y; Li, Jin J; Chang, Lianpeng L; Li, Hui H; Liu, Binliang B; Wang, Wenna W; Guan, Xiuwen X; Ouyang, Quchang Q; Li, Lixi L; Zhai, Jingtong J; Li, Chunxiao C; Li, Lifeng L; Xia, Xuefeng X; Yang, Ling L; Qian, Haili H; Yi, Xin X; Xu, Binghe B; Ma, Fei F
Publication Date: 2020

Variant appearance in text: PIK3CA: 49C>T; P17S
PubMed Link: 33145402
Variant Present in the following documents:
  • 41523_2020_201_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation.

Cancer Gene Therapy
Giagulli, Cinzia C; Caccuri, Francesca F; Zorzan, Simone S; Bugatti, Antonella A; Zani, Alberto A; Filippini, Federica F; Manocha, Ekta E; D'Ursi, Pasqualina P; Orro, Alessandro A; Dolcetti, Riccardo R; Caruso, Arnaldo A
Publication Date: 2021-06

Variant appearance in text: PI3K: p17s
PubMed Link: 33093643
Variant Present in the following documents:
  • Main text
  • 41417_2020_Article_246.pdf
View BVdb publication page



B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation.

Cancer Gene Therapy
Giagulli, Cinzia C; Caccuri, Francesca F; Zorzan, Simone S; Bugatti, Antonella A; Zani, Alberto A; Filippini, Federica F; Manocha, Ekta E; D'Ursi, Pasqualina P; Orro, Alessandro A; Dolcetti, Riccardo R; Caruso, Arnaldo A
Publication Date: 2021-06

Variant appearance in text: PI3K: p17s
PubMed Link: 33093643
Variant Present in the following documents:
  • Main text
  • 41417_2020_Article_246.pdf
View BVdb publication page



For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors.

Biomolecules
Buchanan, Christina M CM; Lee, Kate L KL; Shepherd, Peter R PR
Publication Date: 2019-08-22

Variant appearance in text: PI3K: 49C>T
PubMed Link: 31443495
Variant Present in the following documents:
  • Main text
  • biomolecules-09-00402.pdf
View BVdb publication page



Genotype-phenotype correlations in focal malformations of cortical development: a pathway to integrated pathological diagnosis in epilepsy surgery.

Brain Pathology (Zurich, Switzerland)
Benova, Barbora B; Jacques, Thomas S TS
Publication Date: 2019-07

Variant appearance in text: PIK3CA: 49C>T
PubMed Link: 30485578
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prevalence and spectrum of AKT1, PIK3CA, PTEN and TP53 somatic mutations in Chinese breast cancer patients.

Plos One
Li, Guoli G; Guo, Xinwu X; Chen, Ming M; Tang, Lili L; Jiang, Hui H; Day, Julia X JX; Xie, Yueliang Y; Peng, Limin L; Xu, Xunxun X; Li, Jinliang J; Wang, Shouman S; Xiao, Zhi Z; Dai, Lizhong L; Wang, Jun J
Publication Date: 2018

Variant appearance in text: PIK3CA: 49C>T
PubMed Link: 30212483
Variant Present in the following documents:
  • pone.0203495.pdf
View BVdb publication page



The landscape of somatic mutation in sporadic Chinese colorectal cancer.

Oncotarget
Liu, Zhe Z; Yang, Chao C; Li, Xiangchun X; Luo, Wen W; Roy, Bhaskar B; Xiong, Teng T; Zhang, Xiuqing X; Yang, Huanming H; Wang, Jian J; Ye, Zhenhao Z; Chen, Yang Y; Song, Jinghe J; Ma, Shuai S; Zhou, Yong Y; Yang, Min M; Fang, Xiaodong X; Du, Jie J
Publication Date: 2018-06-08

Variant appearance in text: PIK3CA: 49C>T; P17S
PubMed Link: 29937994
Variant Present in the following documents:
  • oncotarget-09-27412-s004.xlsx, sheet 1
View BVdb publication page



A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17.

Scientific Reports
Giagulli, Cinzia C; D'Ursi, Pasqualina P; He, Wangxiao W; Zorzan, Simone S; Caccuri, Francesca F; Varney, Kristen K; Orro, Alessandro A; Marsico, Stefania S; Otjacques, Benoît B; Laudanna, Carlo C; Milanesi, Luciano L; Dolcetti, Riccardo R; Fiorentini, Simona S; Lu, Wuyuan W; Caruso, Arnaldo A
Publication Date: 2017-07-26

Variant appearance in text: PI3K: p17s
PubMed Link: 28747658
Variant Present in the following documents:
  • Main text
  • 41598_2017_Article_6848.pdf
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: PI3K: P17S
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



PIK3CA Mutations Contribute to Acquired Cetuximab Resistance in Patients with Metastatic Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Xu, Jian-Ming JM; Wang, Yan Y; Wang, You-Liang YL; Wang, Yan Y; Liu, Tao T; Ni, Ming M; Li, Man-Sheng MS; Lin, Li L; Ge, Fei-Jiao FJ; Gong, Chun C; Gu, Jun-Yan JY; Jia, Ru R; Wang, He-Fei HF; Chen, Yu-Ling YL; Liu, Rong-Rui RR; Zhao, Chuan-Hua CH; Tan, Zhao-Li ZL; Jin, Yang Y; Zhu, Yun-Ping YP; Ogino, Shuji S; Qian, Zhi-Rong ZR
Publication Date: 2017-08-15

Variant appearance in text: PIK3CA: 49C>T
PubMed Link: 28424201
Variant Present in the following documents:
  • Main text
View BVdb publication page



OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations.

Oncotarget
Riveiro, Maria E ME; Astorgues-Xerri, Lucile L; Vazquez, Ramiro R; Frapolli, Roberta R; Kwee, Ivo I; Rinaldi, Andrea A; Odore, Elodie E; Rezai, Keyvan K; Bekradda, Mohamed M; Inghirami, Giorgio G; D'Incalci, Maurizio M; Noel, Kay K; Cvitkovic, Esteban E; Raymond, Eric E; Bertoni, Francesco F
Publication Date: 2016-12-20

Variant appearance in text: PIK3CA: 49C>T
PubMed Link: 27835869
Variant Present in the following documents:
  • oncotarget-07-84675-s001.pdf
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: PIK3CA: P17S
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells.

Plos One
Giagulli, Cinzia C; Marsico, Stefania S; Magiera, Anna K AK; Bruno, Rosalinda R; Caccuri, Francesca F; Barone, Ines I; Fiorentini, Simona S; Andò, Sebastiano S; Caruso, Arnaldo A
Publication Date: 2011-03-14

Variant appearance in text: PI3K: p17s
PubMed Link: 21423810
Variant Present in the following documents:
  • Main text
  • pone.0017831.pdf
View BVdb publication page