Publications:

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Pharmacological Mechanisms and Clinical Applications of Curcumin: Update.

Aging And Disease

Hao, Min M; Chu, Yue Y; Lei, Jingxuan J; Yao, Zhouhui Z; Wang, Pingping P; Chen, Ziyan Z; Wang, Kuilong K; Sang, Xianan X; Han, Xin X; Wang, Lu L; Cao, Gang G

Publication Date: 2023-06-01

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PubMed Link: 37191432

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Impact of interorganelle coordination between the conventional early secretory pathway and autophagy in cellular homeostasis and stress response.

Frontiers In Cell And Developmental Biology

Tapia, Diego D; Cavieres, Viviana A VA; Burgos, Patricia V PV; Cancino, Jorge J

Publication Date: 2023

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PubMed Link: 37152281

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• fcell-11-1069256.pdf

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In vitro methods in autophagy research: Applications in neurodegenerative diseases and mood disorders.

Frontiers In Molecular Neuroscience

Sánchez-Vidaña, Dalinda Isabel DI; Li, Jingjing J; Abokyi, Samuel S; Chan, Jackie Ngai-Man JN; Ngai, Shirley Pui-Ching SP; Lau, Benson Wui-Man BW

Publication Date: 2023

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PubMed Link: 37122628

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• fnmol-16-1168948.pdf

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α-Synuclein Attenuates Maneb Neurotoxicity through the Modulation of Redox-Sensitive Transcription Factors.

Oxidative Medicine And Cellular Longevity

Conde, M A MA; Alza, N P NP; Funk, M I MI; Maniscalchi, A A; Benzi Juncos, O N ON; Berge, I I; Uranga, R M RM; Salvador, G A GA

Publication Date: 2023

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PubMed Link: 37113744

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• OMCL2023-5803323.pdf

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DJ-1 Deficiency Protects against Sepsis-Induced Myocardial Depression.

Antioxidants (Basel, Switzerland)

Tsoporis, James N JN; Amatullah, Hajera H; Gupta, Sahil S; Izhar, Shehla S; Ektesabi, Amin M AM; Vaswani, Chirag M CM; Desjardins, Jean-Francois JF; Kabir, Golam G; Teixera Monteiro, Ana Paula AP; Varkouhi, Amir K AK; Kavantzas, Nikolaos N; Salpeas, Vasileios V; Rizos, Ioannis I; Marshall, John C JC; Parker, Thomas G TG; Leong-Poi, Howard H; Dos Santos, Claudia C CC

Publication Date: 2023-02-24

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PubMed Link: 36978809

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• antioxidants-12-00561.pdf

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Neuroprotective Effects of Licochalcone D in Oxidative-Stress-Induced Primitive Neural Stem Cells from Parkinson's Disease Patient-Derived iPSCs.

Biomedicines

Oh, Minyoung M; Nam, Juhyeon J; Baek, Areum A; Seo, Ji-Hye JH; Chae, Jung-Il JI; Lee, Seo-Young SY; Chung, Sun-Ku SK; Park, Byoung Chul BC; Park, Sung Goo SG; Kim, Janghwan J; Jeon, Young-Joo YJ

Publication Date: 2023-01-16

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PubMed Link: 36672736

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• biomedicines-11-00228.pdf

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Infections and immunity: associations with obesity and related metabolic disorders.

Journal Of Pathology And Translational Medicine

Ray, Amitabha A; Bonorden, Melissa J L MJL; Pandit, Rajashree R; Nkhata, Katai J KJ; Bishayee, Anupam A

Publication Date: 2023-01

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PubMed Link: 36647284

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• jptm-2022-11-14.pdf

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Neuroprotection and Non-Invasive Brain Stimulation: Facts or Fiction?

International Journal Of Molecular Sciences

Guidetti, Matteo M; Bertini, Alessandro A; Pirone, Francesco F; Sala, Gessica G; Signorelli, Paola P; Ferrarese, Carlo C; Priori, Alberto A; Bocci, Tommaso T

Publication Date: 2022-11-09

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PubMed Link: 36430251

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• ijms-23-13775.pdf

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

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PubMed Link: 36333792

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• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

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Terpenoid natural products exert neuroprotection via the PI3K/Akt pathway.

Frontiers In Pharmacology

Xu, Bingyao B; Bai, Lan L; Chen, Lu L; Tong, Rongsheng R; Feng, Yibin Y; Shi, Jianyou J

Publication Date: 2022

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PubMed Link: 36313360

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• fphar-13-1036506.pdf

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Next-generation whole exome sequencing to delineate the genetic basis of primary congenital glaucoma.

Scientific Reports

Rauf, Bushra B; Khan, Shahid Y SY; Jiao, Xiaodong X; Irum, Bushra B; Ashfaq, Ramla R; Zehra, Mubashra M; Khan, Asma A AA; Naeem, Muhammad Asif MA; Shahzad, Mohsin M; Riazuddin, Sheikh S; Hejtmancik, J Fielding JF; Riazuddin, S Amer SA

Publication Date: 2022-10-14

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PubMed Link: 36241656

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• 41598_2022_20939_MOESM6_ESM.xlsx, sheet 2
• 41598_2022_20939_MOESM5_ESM.xlsx, sheet 2

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A genomic deletion encompassing CRYBB2-CRYBB2P1 is responsible for autosomal recessive congenital cataracts.

Human Genome Variation

Irum, Bushra B; Kabir, Firoz F; Shoshany, Nadav N; Khan, Shahid Y SY; Rauf, Bushra B; Naeem, Muhammad Asif MA; Qaiser, Tanveer A TA; Riazuddin, Sheikh S; Hejtmancik, J Fielding JF; Riazuddin, S Amer SA

Publication Date: 2022-09-08

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PubMed Link: 36075891

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• 41439_2022_208_MOESM5_ESM.xlsx, sheet 2
• 41439_2022_208_MOESM3_ESM.xlsx, sheet 2

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Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.

Nature Communications

Wrobel, Lidia L; Hill, Sandra M SM; Djajadikerta, Alvin A; Fernandez-Estevez, Marian M; Karabiyik, Cansu C; Ashkenazi, Avraham A; Barratt, Victoria J VJ; Stamatakou, Eleanna E; Gunnarsson, Anders A; Rasmusson, Timothy T; Miele, Eric W EW; Beaton, Nigel N; Bruderer, Roland R; Feng, Yuehan Y; Reiter, Lukas L; Castaldi, M Paola MP; Jarvis, Rebecca R; Tan, Keith K; Bürli, Roland W RW; Rubinsztein, David C DC

Publication Date: 2022-07-16

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PubMed Link: 35842429

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• 41467_2022_Article_31905.pdf

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Group I mGluRs in Therapy and Diagnosis of Parkinson's Disease: Focus on mGluR5 Subtype.

Biomedicines

Azam, Shofiul S; Jakaria, Md M; Kim, JoonSoo J; Ahn, Jaeyong J; Kim, In-Su IS; Choi, Dong-Kug DK

Publication Date: 2022-04-07

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PubMed Link: 35453614

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• biomedicines-10-00864.pdf

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Nutraceuticals as Modulators of Autophagy: Relevance in Parkinson's Disease.

International Journal Of Molecular Sciences

Rakowski, Michał M; Porębski, Szymon S; Grzelak, Agnieszka A

Publication Date: 2022-03-26

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PubMed Link: 35408992

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Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases.

Frontiers In Physiology

Wang, Sijian S; Wang, Biyao B; Shang, Dehao D; Zhang, Kaige K; Yan, Xu X; Zhang, Xinwen X

Publication Date: 2022

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PubMed Link: 35222082

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• fphys-13-814285.pdf

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High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson's disease.

Npj Parkinson'S Disease

Antoniou, Nasia N; Prodromidou, Kanella K; Kouroupi, Georgia G; Boumpoureka, Ioanna I; Samiotaki, Martina M; Panayotou, George G; Xilouri, Maria M; Kloukina, Ismini I; Stefanis, Leonidas L; Grailhe, Regis R; Taoufik, Era E; Matsas, Rebecca R

Publication Date: 2022-02-11

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PubMed Link: 35149677

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• 41531_2022_278_MOESM1_ESM.pdf

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A Review of Pharmacology, Toxicity and Pharmacokinetics of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside.

Frontiers In Pharmacology

Wang, Cheng C; Dai, Shu S; Gong, Lihong L; Fu, Ke K; Ma, Cheng C; Liu, Yanfang Y; Zhou, Honglin H; Li, Yunxia Y

Publication Date: 2021

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PubMed Link: 35069206

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Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson's Disease.

Cells

Bonam, Srinivasa Reddy SR; Tranchant, Christine C; Muller, Sylviane S

Publication Date: 2021-12-15

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PubMed Link: 34944054

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Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson's Disease.

Cells

Bonam, Srinivasa Reddy SR; Tranchant, Christine C; Muller, Sylviane S

Publication Date: 2021-12-15

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PubMed Link: 34944054

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Targeting Mitochondria by Plant Secondary Metabolites: A Promising Strategy in Combating Parkinson's Disease.

International Journal Of Molecular Sciences

Fakhri, Sajad S; Abdian, Sadaf S; Zarneshan, Seyede Nazanin SN; Akkol, Esra Küpeli EK; Farzaei, Mohammad Hosein MH; Sobarzo-Sánchez, Eduardo E

Publication Date: 2021-11-22

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PubMed Link: 34830453

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• Main text
• ijms-22-12570.pdf

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Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions.

Biomedicines

Magalhães, João Duarte JD; Fão, Lígia L; Vilaça, Rita R; Cardoso, Sandra Morais SM; Rego, Ana Cristina AC

Publication Date: 2021-11-05

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PubMed Link: 34829854

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Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson's Disease.

International Journal Of Molecular Sciences

Martínez-Menárguez, José Ángel JÁ; Martínez-Alonso, Emma E; Cara-Esteban, Mireia M; Tomás, Mónica M

Publication Date: 2021-11-08

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PubMed Link: 34769517

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• ijms-22-12087.pdf

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Plant Polyphenols for Aging Health: Implication from Their Autophagy Modulating Properties in Age-Associated Diseases.

Pharmaceuticals (Basel, Switzerland)

Brimson, James Michael JM; Prasanth, Mani Iyer MI; Malar, Dicson Sheeja DS; Thitilertdecha, Premrutai P; Kabra, Atul A; Tencomnao, Tewin T; Prasansuklab, Anchalee A

Publication Date: 2021-09-27

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PubMed Link: 34681206

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• pharmaceuticals-14-00982.pdf

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Natural Products in Therapeutic Management of Multineurodegenerative Disorders by Targeting Autophagy.

Oxidative Medicine And Cellular Longevity

Shaikh, Sibhghatulla S; Ahmad, Khurshid K; Ahmad, Syed Sayeed SS; Lee, Eun Ju EJ; Lim, Jeong Ho JH; Beg, Mirza Masroor Ali MMA; Verma, Amit K AK; Choi, Inho I

Publication Date: 2021

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PubMed Link: 34557265

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• Main text
• OMCL2021-6347792.pdf

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Orexinergic System in Neurodegenerative Diseases.

Frontiers In Aging Neuroscience

Wang, Qinqin Q; Cao, Fei F; Wu, Yili Y

Publication Date: 2021

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PubMed Link: 34483883

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• fnagi-13-713201.pdf

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Natural compounds modulate the autophagy with potential implication of stroke.

Acta Pharmaceutica Sinica. B

Ahsan, Anil A; Liu, Mengru M; Zheng, Yanrong Y; Yan, Wenping W; Pan, Lin L; Li, Yue Y; Ma, Shijia S; Zhang, Xingxian X; Cao, Ming M; Wu, Zhanxun Z; Hu, Weiwei W; Chen, Zhong Z; Zhang, Xiangnan X

Publication Date: 2021-07

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PubMed Link: 34386317

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Diabetes mellitus and Parkinson's disease: dangerous liaisons between insulin and dopamine.

Neural Regeneration Research

De Iuliis, Angela A; Montinaro, Ennio E; Fatati, Giuseppe G; Plebani, Mario M; Colosimo, Carlo C

Publication Date: 2022-03

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PubMed Link: 34380882

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• NRR-17-523.pdf

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The role of mTOR in age-related diseases.

Journal Of Enzyme Inhibition And Medicinal Chemistry

Chrienova, Zofia Z; Nepovimova, Eugenie E; Kuca, Kamil K

Publication Date: 2021-12

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PubMed Link: 34309456

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• IENZ_36_1955873.pdf

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Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease.

Current Neuropharmacology

Costas, Carmen C; Faro, Lilian R F LRF

Publication Date: 2022

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PubMed Link: 33882808

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• Main text
• CN-20-432.pdf

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Pharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration.

Aging

Zhang, Qitao Q; Presswalla, Feriel F; Ali, Robin R RR; Zacks, David N DN; Thompson, Debra A DA; Miller, Jason M L JML

Publication Date: 2021-04-19

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PubMed Link: 33872219

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• aging-13-202974.pdf

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Alterations of Nigral Dopamine Levels in Parkinson's Disease after Environmental Enrichment and PACAP Treatment in Aging Rats.

Life (Basel, Switzerland)

Jungling, Adel A; Reglodi, Dora D; Maasz, Gabor G; Zrinyi, Zita Z; Schmidt, Janos J; Rivnyak, Adam A; Horvath, Gabor G; Pirger, Zsolt Z; Tamas, Andrea A

Publication Date: 2021-01-08

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PubMed Link: 33429934

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• life-11-00035.pdf

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Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson's Disease: An Insight Into Role of Pharmacological Interventions.

Frontiers In Cell And Developmental Biology

Vaidya, Bhupesh B; Sharma, Shyam Sunder SS

Publication Date: 2020

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PubMed Link: 33330461

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• fcell-08-584513.pdf

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Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention.

Biomedicines

Rahman, Md Ataur MA; Rahman, M D Hasanur MDH; Hossain, Md Shahadat MS; Biswas, Partha P; Islam, Rokibul R; Uddin, Md Jamal MJ; Rahman, Md Habibur MH; Rhim, Hyewhon H

Publication Date: 2020-11-19

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PubMed Link: 33228222

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Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies.

Molecules (Basel, Switzerland)

Korolenko, Tatiana A TA; Johnston, Thomas P TP; Vetvicka, Vaclav V

Publication Date: 2020-10-30

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PubMed Link: 33143272

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Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation.

Antioxidants (Basel, Switzerland)

Limanaqi, Fiona F; Biagioni, Francesca F; Mastroiacovo, Federica F; Polzella, Maico M; Lazzeri, Gloria G; Fornai, Francesco F

Publication Date: 2020-10-20

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PubMed Link: 33092300

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• antioxidants-09-01022.pdf

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Mitochondrial Metabolism, Contact Sites and Cellular Calcium Signaling: Implications for Tumorigenesis.

Cancers

Peruzzo, Roberta R; Costa, Roberto R; Bachmann, Magdalena M; Leanza, Luigi L; Szabò, Ildikò I

Publication Date: 2020-09-10

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PubMed Link: 32927611

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• cancers-12-02574.pdf

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Endosomal-lysosomal dysfunction in metabolic diseases and Alzheimer's disease.

International Review Of Neurobiology

Almeida, Michael F MF; Bahr, Ben A BA; Kinsey, Stephen T ST

Publication Date: 2020

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PubMed Link: 32739009

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Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson's disease models through activating the MEF2-PGC1α and BDNF/CREB pathways.

Aging

Chen, Haiyun H; Cao, Jie J; Zha, Ling L; Wang, Peile P; Liu, Zheng Z; Guo, Baojian B; Zhang, Gaoxiao G; Sun, Yewei Y; Zhang, Zaijun Z; Wang, Yuqiang Y

Publication Date: 2020-07-24

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PubMed Link: 32710729

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• Main text
• aging-12-103551.pdf

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The Stemness of Human Ovarian Granulosa Cells and the Role of Resveratrol in the Differentiation of MSCs-A Review Based on Cellular and Molecular Knowledge.

Cells

Jozkowiak, Malgorzata M; Hutchings, Greg G; Jankowski, Maurycy M; Kulcenty, Katarzyna K; Mozdziak, Paul P; Kempisty, Bartosz B; Spaczynski, Robert Z RZ; Piotrowska-Kempisty, Hanna H

Publication Date: 2020-06-07

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PubMed Link: 32517362

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• Main text
• cells-09-01418.pdf

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Mechanism of N-acetylcysteine in alleviating diabetic myocardial ischemia reperfusion injury by regulating PTEN/Akt pathway through promoting DJ-1.

Bioscience Reports

Li, Wenyuan W; Li, Wei W; Leng, Yan Y; Xiong, Yonghong Y; Xue, Rui R; Chen, Rong R; Xia, Zhongyuan Z

Publication Date: 2020-06-26

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PubMed Link: 32347295

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• bsr-40-bsr20192118.pdf

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Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson's Disease.

Journal Of Clinical Medicine

Jin, Wook W

Publication Date: 2020-01-17

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PubMed Link: 31963575

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Unconventional secretion of α-Crystallin B requires the Autophagic pathway and is controlled by phosphorylation of its serine 59 residue.

Scientific Reports

D'Agostino, M M; Scerra, G G; Cannata Serio, M M; Caporaso, M G MG; Bonatti, S S; Renna, M M

Publication Date: 2019-11-15

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PubMed Link: 31729431

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• 41598_2019_53226_MOESM1_ESM.pdf

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The Autophagy Signaling Pathway: A Potential Multifunctional Therapeutic Target of Curcumin in Neurological and Neuromuscular Diseases.

Nutrients

Perrone, Lorena L; Squillaro, Tiziana T; Napolitano, Filomena F; Terracciano, Chiara C; Sampaolo, Simone S; Melone, Mariarosa Anna Beatrice MAB

Publication Date: 2019-08-13

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PubMed Link: 31412596

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• Main text
• nutrients-11-01881.pdf

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A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy.

Cells

Khandia, Rekha R; Dadar, Maryam M; Munjal, Ashok A; Dhama, Kuldeep K; Karthik, Kumaragurubaran K; Tiwari, Ruchi R; Yatoo, Mohd Iqbal MI; Iqbal, Hafiz M N HMN; Singh, Karam Pal KP; Joshi, Sunil K SK; Chaicumpa, Wanpen W

Publication Date: 2019-07-03

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PubMed Link: 31277291

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Recent progress in the role of autophagy in neurological diseases.

Cell Stress

Meng, Tian T; Lin, Shiyin S; Zhuang, Haixia H; Huang, Haofeng H; He, Zhengjie Z; Hu, Yongquan Y; Gong, Qing Q; Feng, Du D

Publication Date: 2019-04-29

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PubMed Link: 31225510

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Salidroside protects SH‑SY5Y from pathogenic α‑synuclein by promoting cell autophagy via mediation of mTOR/p70S6K signaling.

Molecular Medicine Reports

Chen, Shasha S; Cai, Feng F; Wang, Jirong J; Yang, Zhouxin Z; Gu, Chi C; Wang, Guofu G; Mao, Genxiang G; Yan, Jing J

Publication Date: 2019-07

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PubMed Link: 31180515

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Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure.

International Journal Of Molecular Sciences

Naoi, Makoto M; Wu, Yuqiu Y; Shamoto-Nagai, Masayo M; Maruyama, Wakako W

Publication Date: 2019-05-17

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PubMed Link: 31108962

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• Main text
• ijms-20-02451.pdf

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Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo.

Cell Stress & Chaperones

Liu, Qiu Q; Jin, Zhiquan Z; Xu, Zhiliang Z; Yang, Hao H; Li, Liang L; Li, Guiping G; Li, Fang F; Gu, Shaoli S; Zong, Shaobo S; Zhou, Jun J; Cao, Liang L; Wang, Zhenzhong Z; Xiao, Wei W

Publication Date: 2019-03

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PubMed Link: 30815818

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Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease.

British Journal Of Pharmacology

Khalifeh, Masoomeh M; Barreto, George E GE; Sahebkar, Amirhossein A

Publication Date: 2019-05

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PubMed Link: 30767205

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Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson's Disease.

Frontiers In Neuroscience

Liu, Mei-Fang MF; Xue, Yan Y; Liu, Cui C; Liu, Yun-Hai YH; Diao, Hui-Ling HL; Wang, Ying Y; Pan, Yi-Peng YP; Chen, Lei L

Publication Date: 2018

Variant appearance in text: PI3K: A53T

PubMed Link: 30524223

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• fnins-12-00835.pdf

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Genistein Ameliorates Scopolamine-Induced Amnesia in Mice Through the Regulation of the Cholinergic Neurotransmission, Antioxidant System and the ERK/CREB/BDNF Signaling.

Frontiers In Pharmacology

Lu, Cong C; Wang, Yan Y; Xu, Teng T; Li, Qi Q; Wang, Donghui D; Zhang, Lijing L; Fan, Bei B; Wang, Fengzhong F; Liu, Xinmin X

Publication Date: 2018

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PubMed Link: 30369882

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• fphar-09-01153.pdf

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Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases.

Metabolic Brain Disease

Pierzynowska, Karolina K; Gaffke, Lidia L; Cyske, Zuzanna Z; Puchalski, Michał M; Rintz, Estera E; Bartkowski, Michał M; Osiadły, Marta M; Pierzynowski, Michał M; Mantej, Jagoda J; Piotrowska, Ewa E; Węgrzyn, Grzegorz G

Publication Date: 2018-08

Variant appearance in text: PI3K: A53T

PubMed Link: 29542037

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• 11011_2018_Article_214.pdf

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NADPH oxidases in Parkinson's disease: a systematic review.

Molecular Neurodegeneration

Belarbi, Karim K; Cuvelier, Elodie E; Destée, Alain A; Gressier, Bernard B; Chartier-Harlin, Marie-Christine MC

Publication Date: 2017-11-13

Variant appearance in text: PI3K: A53T

PubMed Link: 29132391

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• 13024_2017_Article_225.pdf

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The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.

Frontiers In Molecular Neuroscience

Manecka, Destiny-Love DL; Vanderperre, Benoît B; Fon, Edward A EA; Durcan, Thomas M TM

Publication Date: 2017

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PubMed Link: 29021741

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Neuroprotective effect of chondroitin sulfate on SH‑SY5Y cells overexpressing wild‑type or A53T mutant α‑synuclein.

Molecular Medicine Reports

Ju, Chuanxia C; Gao, Jianjun J; Hou, Lin L; Wang, Lei L; Zhang, Fang F; Sun, Fusheng F; Zhang, Tingting T; Xu, Pingping P; Shi, Zhenyan Z; Hu, Fang F; Zhang, Congxiao C

Publication Date: 2017-12

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PubMed Link: 28990084

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• mmr-16-06-8721.pdf

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