Publications:

Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity.

Protein & Cell

Liu, Pengda P; Guo, Jianping J; Gan, Wenjian W; Wei, Wenyi W

Publication Date: 2014-03

Variant appearance in text: PI3K: T86E

PubMed Link: 24481632

Variant Present in the following documents:

• Main text

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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Nature Cell Biology

Liu, Pengda P; Gan, Wenjian W; Inuzuka, Hiroyuki H; Lazorchak, Adam S AS; Gao, Daming D; Arojo, Omotooke O; Liu, Dou D; Wan, Lixin L; Zhai, Bo B; Yu, Yonghao Y; Yuan, Min M; Kim, Byeong Mo BM; Shaik, Shavali S; Menon, Suchithra S; Gygi, Steven P SP; Lee, Tae Ho TH; Asara, John M JM; Manning, Brendan D BD; Blenis, John J; Su, Bing B; Wei, Wenyi W

Publication Date: 2013-11

Variant appearance in text: PI3K: T86E

PubMed Link: 24161930

Variant Present in the following documents:

• Main text
• nihms525963.pdf

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