PIK3CA c.328_330del ;(p.E110del)

Variant ID: 3-178916937-TGAA-T

NM_006218.2(PIK3CA):c.328_330del;(p.E110del)

This variant was identified in 94 publications

View GRCh38 version.




Publications:


Phase 1b trial of anti-EGFR antibody JMT101 and Osimertinib in EGFR exon 20 insertion-positive non-small-cell lung cancer.

Nature Communications
Zhao, Shen S; Zhuang, Wu W; Han, Baohui B; Song, Zhengbo Z; Guo, Wei W; Luo, Feng F; Wu, Lin L; Hu, Yi Y; Wang, Huijuan H; Dong, Xiaorong X; Jiang, Da D; Wang, Mingxia M; Miao, Liyun L; Wang, Qian Q; Zhang, Junping J; Fu, Zhenming Z; Huang, Yihua Y; Xu, Chunwei C; Hu, Longyu L; Li, Lei L; Hu, Rong R; Yang, Yang Y; Li, Mengke M; Yang, Xiugao X; Zhang, Li L; Huang, Yan Y; Fang, Wenfeng W
Publication Date: 2023-06-12

Variant appearance in text: PIK3CA: 328_330del; E110del
PubMed Link: 37308490
Variant Present in the following documents:
  • 41467_2023_39139_MOESM4_ESM.xlsx, sheet 7
  • 41467_2023_39139_MOESM4_ESM.xlsx, sheet 3
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: PIK3CA: E110del
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 4
View BVdb publication page



Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer.

Cancer Discovery
Pradat, Yoann Y; Viot, Julien J; Yurchenko, Andrey A AA; Gunbin, Konstantin K; Cerbone, Luigi L; Deloger, Marc M; Grisay, Guillaume G; Verlingue, Loic L; Scott, Veronique V; Padioleau, Ismael I; Panunzi, Leonardo L; Michiels, Stefan S; Hollebecque, Antoine A; Jules-Clement, Gerome G; Mezquita, Laura L; Laine, Antoine A; Loriot, Yohann Y; Besse, Benjamin B; Friboulet, Luc L; Andre, Fabrice F; Cournede, Paul-Henry PH; Gautheret, Daniel D; Nikolaev, Sergey I SI
Publication Date: 2023-03-02

Variant appearance in text: PIK3CA: 328_330del; Glu110del
PubMed Link: 36862804
Variant Present in the following documents:
  • cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 6
View BVdb publication page



A prognostic risk model for glioma patients by systematic evaluation of genomic variations.

Iscience
Zhang, Baifeng B; Wan, Weiqing W; Li, Zibo Z; Gao, Zhixian Z; Ji, Nan N; Xie, Jian J; Wang, Junmei J; Wang, Bin B; Lai-Wan Kwong, Dora D; Guan, Xinyuan X; Gao, Shengjie S; Zhao, Yuanli Y; Lu, Youyong Y; Zhang, Liwei L; Rodland, Karin D KD; Tsang, Shirley X SX
Publication Date: 2022-12-22

Variant appearance in text: PIK3CA: E109del
PubMed Link: 36536675
Variant Present in the following documents:
  • mmc3.xls, sheet 1
View BVdb publication page



Genetic landscape and personalized tracking of tumor mutations in Vietnamese women with breast cancer.

Molecular Oncology
Nguyen Hoang, Van-Anh VA; Nguyen, Sao Trung ST; Nguyen, Trieu Vu TV; Pham, Thanh Huyen TH; Doan, Phuoc Loc PL; Nguyen Thi, Ngoc Thanh NT; Nguyen, Minh Long ML; Dinh, Thi Cuc TC; Pham, Dinh Hoang DH; Nguyen, Ngoc Mai NM; Nguyen, Duy Sinh DS; Nguyen, Du Quyen DQ; Lu, Y-Thanh YT; Do, Thanh Thuy Thi TTT; Truong, Dinh Kiet DK; Phan, Minh-Duy MD; Nguyen, Hoai-Nghia HN; Giang, Hoa H; Tu, Lan N LN
Publication Date: 2022-12-10

Variant appearance in text: PIK3CA: E110del
PubMed Link: 36495126
Variant Present in the following documents:
  • MOL2-17-598-s002.xlsx, sheet 1
View BVdb publication page



Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

Nature Communications
Sivakumar, Smruthy S; Jin, Dexter X DX; Tukachinsky, Hanna H; Murugesan, Karthikeyan K; McGregor, Kimberly K; Danziger, Natalie N; Pavlick, Dean D; Gjoerup, Ole O; Ross, Jeffrey S JS; Harmon, Robert R; Chung, Jon J; Decker, Brennan B; Dennis, Lucas L; Frampton, Garrett M GM; Molinero, Luciana L; Oesterreich, Steffi S; Venstrom, Jeffrey M JM; Oxnard, Geoffrey R GR; Hegde, Priti S PS; Sokol, Ethan S ES
Publication Date: 2022-12-05

Variant appearance in text: PIK3CA: E110del
PubMed Link: 36470901
Variant Present in the following documents:
  • 41467_2022_35245_MOESM4_ESM.xlsx, sheet 12
View BVdb publication page



Comprehensive clinicopathological and genomic profiling of gallbladder cancer reveals actionable targets in half of patients.

Npj Precision Oncology
de Bitter, Tessa J J TJJ; de Reuver, Philip R PR; de Savornin Lohman, Elise A J EAJ; Kroeze, Leonie I LI; Vink-Börger, Marianne E ME; van Vliet, Shannon S; Simmer, Femke F; von Rhein, Daniel D; Jansen, Erik A M EAM; Verheij, Joanne J; van Herpen, Carla M L CML; Nagtegaal, Iris D ID; Ligtenberg, Marjolijn J L MJL; van der Post, Rachel S RS
Publication Date: 2022-11-05

Variant appearance in text: PIK3CA: 328_330del; Glu110del
PubMed Link: 36335173
Variant Present in the following documents:
  • 41698_2022_327_MOESM2_ESM.xlsx, sheet 3
View BVdb publication page



Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics
Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q
Publication Date: 2022-11-04

Variant appearance in text: PIK3CA: 325_327delGAA; E109delE
PubMed Link: 36333792
Variant Present in the following documents:
  • 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



A Case of Sustained Tumor Regression With MP0274, a Novel DARPin Therapeutic Targeting Human Epidermal Growth Factor Receptor 2 Signaling, in Metastatic Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer After Prior Trastuzumab and Pertuzumab.

Jco Precision Oncology
Fischer, Stefanie S; Götze, Thorsten O TO; Omlin, Aurelius A; Baird, Richard D RD; Dawson, Keith M KM; Zitt, Christof C; Arany, Zita Z; Tresch, Gaby G; Fiedler, Ulrike U; Jeger, Simone S; Fung, Samson S; Legenne, Philippe P; Leupin, Nicolas N; Schneeweiss, Andreas A; Fremd, Carlo C
Publication Date: 2022-11

Variant appearance in text: PIK3CA: E110del
PubMed Link: 36331248
Variant Present in the following documents:
  • po-6-e2200006.pdf
View BVdb publication page



Biology and targetability of the extended spectrum of PIK3CA mutations (PIK3CAm) detected in breast carcinoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Rugo, Hope S HS; Raskina, Kira K; Schrock, Alexa B AB; Madison, Russell W RW; Graf, Ryon P RP; Sokol, Ethan S ES; Sivakumar, Smruthy S SS; Lee, Jessica K JK; Fisher, Virginia V; Oxnard, Geoffrey R GR; Tukachinsky, Hanna H
Publication Date: 2022-11-02

Variant appearance in text: PIK3CA: E110del
PubMed Link: 36321996
Variant Present in the following documents:
  • 1056.pdf
View BVdb publication page



Ultrasensitive tumour-agnostic non-invasive detection of colorectal cancer recurrence using ctDNA methylation.

Clinical And Translational Medicine
Xiao, Yu Y; Wang, Xiaodong X; Weng, Hong H; Ding, Zhao Z; Qian, Kaiyu K; Jin, Wan W; Lu, Sen S; Ju, Lingao L; He, Zhiwen Z; Wang, Gang G; Xie, Xiaoyu X; Liu, Dongmei D; Fan, Zhou Z; Wu, Kai K; Li, Sheng S; Guo, Huanhuan H; Qian, Guofeng G; Jiang, Wei W; Leng, Yunji Y; Zhao, Junpeng J; Cao, Xinyue X; Peng, Minsheng M; Jiang, Congqing C; Li, Li L; Zhang, Yi Y; Wang, Xinghuan X
Publication Date: 2022-09

Variant appearance in text: PIK3CA: 325_327del
PubMed Link: 36103400
Variant Present in the following documents:
  • CTM2-12-e1015-s002.xlsx, sheet 1
View BVdb publication page



Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.

Nature Communications
Coy, Shannon S; Wang, Shu S; Stopka, Sylwia A SA; Lin, Jia-Ren JR; Yapp, Clarence C; Ritch, Cecily C CC; Salhi, Lisa L; Baker, Gregory J GJ; Rashid, Rumana R; Baquer, Gerard G; Regan, Michael M; Khadka, Prasidda P; Cole, Kristina A KA; Hwang, Jaeho J; Wen, Patrick Y PY; Bandopadhayay, Pratiti P; Santi, Mariarita M; De Raedt, Thomas T; Ligon, Keith L KL; Agar, Nathalie Y R NYR; Sorger, Peter K PK; Touat, Mehdi M; Santagata, Sandro S
Publication Date: 2022-08-16

Variant appearance in text: PIK3CA: E110del
PubMed Link: 35973991
Variant Present in the following documents:
  • 41467_2022_32430_MOESM17_ESM.xlsx, sheet 31
View BVdb publication page



Clinical Outcomes of Patients with Recurrent Microsatellite-Stable Endometrial Cancer in Early-Phase Immunotherapy Clinical Trials.

Cancers
How, Jeffrey A JA; Jazaeri, Amir A AA; Fu, Siqing S; Rodon Ahnert, Jordi J; Gong, Jing J; Stephen, Bettzy B; Ferreira Dalla Pria, Hanna H; Bhosale, Priya P; Johnson, Amber A; Yuan, Ying Y; Meric-Bernstam, Funda F; Naing, Aung A
Publication Date: 2022-07-29

Variant appearance in text: PIK3CA: 328_330del
PubMed Link: 35954359
Variant Present in the following documents:
  • Main text
  • cancers-14-03695.pdf
View BVdb publication page



Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer.

International Journal Of Oncology
Nian, Rui R; Jiang, Huihui H; Zhao, Jiangman J; Hou, Wanle W; Zhang, Hua H; Ma, Jiangtao J; Lv, Pengbiao P; Jiang, Lisha L; Wang, Yongpan Y; Xu, Yue Y; Wu, Shouxin S; Lou, Jingwei J; Li, Wanjun W
Publication Date: 2022-09

Variant appearance in text: PIK3CA: 325_327del
PubMed Link: 35796015
Variant Present in the following documents:
  • Supplementary_Data6.xlsx, sheet 1
View BVdb publication page



Clinical and Molecular Spectrum of Sporadic Vascular Malformations: A Single-Center Study.

Biomedicines
Diociaiuti, Andrea A; Rotunno, Roberta R; Pisaneschi, Elisa E; Cesario, Claudia C; Carnevale, Claudia C; Condorelli, Angelo Giuseppe AG; Rollo, Massimo M; Di Cecca, Stefano S; Quintarelli, Concetta C; Novelli, Antonio A; Zambruno, Giovanna G; El Hachem, May M
Publication Date: 2022-06-20

Variant appearance in text: PIK3CA: 325_327delGAA; Glu109del
PubMed Link: 35740480
Variant Present in the following documents:
  • biomedicines-10-01460.pdf
View BVdb publication page



Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Publication Date: 2022-06-15

Variant appearance in text: PIK3CA: E110del
PubMed Link: 35705558
Variant Present in the following documents:
  • 41467_2022_30496_MOESM2_ESM.xls, sheet 1
View BVdb publication page



Molecular landscape and therapeutic alterations in Asian soft-tissue sarcoma patients.

Cancer Medicine
Gan, Meifu M; Zhang, Chen C; Qiu, Liqing L; Wang, Yue Y; Bao, Hua H; Yu, Ruoying R; Liu, Rui R; Wu, Xue X; Shao, Yang Y; Hou, Peifeng P; Fei, Zhenglei Z
Publication Date: 2022-11

Variant appearance in text: PIK3CA: 328_330delGAA; E110del
PubMed Link: 35586877
Variant Present in the following documents:
  • CAM4-11-4070-s004.xlsx, sheet 1
View BVdb publication page



Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma.

Acta Neuropathologica Communications
Wong, Derek D; Lee, Tae Hoon TH; Lum, Amy A; Tao, Valerie Lan VL; Yip, Stephen S
Publication Date: 2022-05-07

Variant appearance in text: PIK3CA: Glu110del
PubMed Link: 35526077
Variant Present in the following documents:
  • 40478_2022_1372_MOESM18_ESM.xlsx, sheet 1
View BVdb publication page



A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.

Frontiers In Oncology
Zhou, Si S; Liu, Songming S; Zhao, Lijian L; Sun, Hai-Xi HX
Publication Date: 2022

Variant appearance in text: PIK3CA: E110del
PubMed Link: 35387130
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
View BVdb publication page



PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology
Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E
Publication Date: 2022-03

Variant appearance in text: PIK3CA: 328_330del
PubMed Link: 35357905
Variant Present in the following documents:
  • po-6-e2100370.pdf
View BVdb publication page



Dynamic changes in gene alterations during chemotherapy in metastatic castrate resistant prostate cancer.

Scientific Reports
Tan, Winston W; Zheng, Tiantian T; Wang, Amy A; Roacho, Joanna J; Thao, Seng S; Du, Pan P; Jia, Shidong S; Yu, Jianjun J; King, Bonnie L BL; Kohli, Manish M
Publication Date: 2022-03-18

Variant appearance in text: PIK3CA: 325_327del; Glu110del
PubMed Link: 35304525
Variant Present in the following documents:
  • 41598_2022_8520_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



ISSVA Classification of Vascular Anomalies and Molecular Biology.

International Journal Of Molecular Sciences
Kunimoto, Kayo K; Yamamoto, Yuki Y; Jinnin, Masatoshi M
Publication Date: 2022-02-21

Variant appearance in text: PIK3CA: E109del
PubMed Link: 35216474
Variant Present in the following documents:
  • Main text
  • ijms-23-02358.pdf
View BVdb publication page



Association between TP53 mutation and high 21-gene recurrence score in estrogen receptor-positive/HER2-negative breast cancer.

Npj Breast Cancer
Ji, Jung Hwan JH; Bae, Soong June SJ; Kim, Kyungsoo K; Chu, Chihhao C; Lee, Kyung-A KA; Kim, Yoonjung Y; Kim, Jee Hung JH; Jeong, Joon J; Ahn, Sung Gwe SG
Publication Date: 2022-02-16

Variant appearance in text: PIK3CA: 328_330delGAA; Glu110del
PubMed Link: 35173185
Variant Present in the following documents:
  • 41523_2022_384_MOESM1_ESM.pdf
View BVdb publication page



Orofacial overgrowth with peripheral nerve enlargement and perineuriomatous pseudo-onion bulb proliferations is part of the PIK3CA-related overgrowth spectrum.

Hgg Advances
Koutlas, Ioannis G IG; Anbinder, Ana-Lia AL; Alshagroud, Rana R; Rodrigues Cavalcante, Ana Sueli AS; Al Kindi, Mohammed M; Crenshaw, Molly M MM; Sapp, Julie C JC; Kondolf, Hannah H; Lindhurst, Marjorie J MJ; Dudley, Jeffrey N JN; Johnston, Jennifer J JJ; Ryan, Elyse E; Rafferty, Keith K; Ganguly, Arupa A; Biesecker, Leslie G LG
Publication Date: 2020-10-22

Variant appearance in text: PIK3CA: 328_330delGAA
PubMed Link: 35047831
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Case Report: Significant Efficacy of Pyrotinib in the Treatment of Extensive Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Cutaneous Metastases: A Report of Five Cases.

Frontiers In Oncology
Wang, Nan N; Li, Lin L; Xiong, Youyi Y; Chi, Jiangrui J; Liu, Xinwei X; Zhong, Chaochao C; Wang, Fang F; Gu, Yuanting Y
Publication Date: 2021

Variant appearance in text: PIK3CA: E110del
PubMed Link: 34976791
Variant Present in the following documents:
  • Main text
  • fonc-11-729212.pdf
View BVdb publication page



Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.

Frontiers In Immunology
Li, Na N; Wang, Jiahong J; Zhan, Xianquan X
Publication Date: 2021

Variant appearance in text: PIK3CA: 328_330delGAA; Glu110del
PubMed Link: 34887858
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
View BVdb publication page



Pan-cancer landscape of CD274 (PD-L1) rearrangements in 283,050 patient samples, its correlation with PD-L1 protein expression, and immunotherapy response.

Journal For Immunotherapy Of Cancer
Kelly, Andrew D AD; Murugesan, Karthikeyan K; Kuang, Zheng Z; Montesion, Meagan M; Ross, Jeffrey S JS; Albacker, Lee A LA; Huang, Richard S P RSP; Lin, Douglas I DI; Demirci, Umut U; Creeden, James J
Publication Date: 2021-11

Variant appearance in text: PIK3CA: E110del
PubMed Link: 34815356
Variant Present in the following documents:
  • jitc-2021-003550supp001.pdf
View BVdb publication page



Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.

The Journal Of Clinical Investigation
Jin, Nan N; Keam, Bhumsuk B; Cho, Janice J; Lee, Michelle J MJ; Kim, Hye Ryun HR; Torosyan, Hayarpi H; Jura, Natalia N; Ng, Patrick Ks PK; Mills, Gordon B GB; Li, Hua H; Zeng, Yan Y; Barbash, Zohar Z; Tarcic, Gabi G; Kang, Hyunseok H; Bauman, Julie E JE; Kim, Mi-Ok MO; VanLandingham, Nathan K NK; Swaney, Danielle L DL; Krogan, Nevan J NJ; Johnson, Daniel E DE; Grandis, Jennifer R JR
Publication Date: 2021-11-15

Variant appearance in text: PIK3CA: E110del
PubMed Link: 34779417
Variant Present in the following documents:
  • Main text
View BVdb publication page



Correlation of PIK3CA mutation with programmed death ligand-1 (PD-L1) expression and their clinicopathological significance in colorectal cancer.

Annals Of Translational Medicine
Ahn, Ae Ri AR; Kim, Kyoung Min KM; Jang, Kyu Yun KY; Moon, Woo Sung WS; Ha, Gi Won GW; Lee, Min Ro MR; Chung, Myoung Ja MJ
Publication Date: 2021-09

Variant appearance in text: PIK3CA: 328_330delGAA; E109del
PubMed Link: 34733958
Variant Present in the following documents:
  • atm-09-18-1406-supplementary.pdf
View BVdb publication page



Case report: identification of ERC1-RET fusion in a patient with pancreatic ductal adenocarcinoma.

Gland Surgery
Ma, Jia J; Wang, Baosheng B; Meng, Erhong E; Meng, Xiangpeng X
Publication Date: 2021-09

Variant appearance in text: PIK3CA: 328_330del; E110del
PubMed Link: 34733735
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification and clinical significance of somatic oncogenic mutations in epithelial ovarian cancer.

Journal Of Ovarian Research
Watanabe, Takafumi T; Nanamiya, Hideaki H; Endo, Yuta Y; Kojima, Manabu M; Nomura, Shinji S; Furukawa, Shigenori S; Soeda, Shu S; Tamura, Hirosumi H; Ryufuku, Masae M; Tanaka, Daisuke D; Isogai, Takao T; Imai, Jun-Ichi JI; Watanabe, Shinya S; Fujimori, Keiya K
Publication Date: 2021-10-06

Variant appearance in text: PIK3CA: 325_327delGAA; Glu109del
PubMed Link: 34615547
Variant Present in the following documents:
  • 13048_2021_876_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Nivolumab in combination with cabozantinib for metastatic triple-negative breast cancer: a phase II and biomarker study.

Npj Breast Cancer
Barroso-Sousa, Romualdo R; Keenan, Tanya E TE; Li, Tianyu T; Tayob, Nabihah N; Trippa, Lorenzo L; Pastorello, Ricardo G RG; Richardson Iii, Edward T ET; Dillon, Deborah D; Amoozgar, Zohreh Z; Overmoyer, Beth B; Schnitt, Stuart J SJ; Winer, Eric P EP; Mittendorf, Elizabeth A EA; Van Allen, Eliezer E; Duda, Dan G DG; Tolaney, Sara M SM
Publication Date: 2021-08-25

Variant appearance in text: PIK3CA: E109del
PubMed Link: 34433812
Variant Present in the following documents:
  • Main text
View BVdb publication page



Safety and efficacy of low-dose PI3K inhibitor taselisib in adult patients with CLOVES and Klippel-Trenaunay syndrome (KTS): the TOTEM trial, a phase 1/2 multicenter, open-label, single-arm study.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Luu, M M; Vabres, P P; Devilliers, H H; Loffroy, R R; Phan, A A; Martin, L L; Morice-Picard, F F; Petit, F F; Willems, M M; Bessis, D D; Jacquemont, M L ML; Maruani, A A; Chiaverini, C C; Mirault, T T; Clayton-Smith, J J; Carpentier, M M; Fleck, C C; Maurer, A A; Yousfi, M M; Parker, V E R VER; Semple, R K RK; Bardou, M M; Faivre, L L
Publication Date: 2021-12

Variant appearance in text: PIK3CA: 328_330delGAA
PubMed Link: 34385668
Variant Present in the following documents:
  • Main text
  • 41436_2021_Article_1290.pdf
View BVdb publication page



Safety and efficacy of low-dose PI3K inhibitor taselisib in adult patients with CLOVES and Klippel-Trenaunay syndrome (KTS): the TOTEM trial, a phase 1/2 multicenter, open-label, single-arm study.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Luu, M M; Vabres, P P; Devilliers, H H; Loffroy, R R; Phan, A A; Martin, L L; Morice-Picard, F F; Petit, F F; Willems, M M; Bessis, D D; Jacquemont, M L ML; Maruani, A A; Chiaverini, C C; Mirault, T T; Clayton-Smith, J J; Carpentier, M M; Fleck, C C; Maurer, A A; Yousfi, M M; Parker, V E R VER; Semple, R K RK; Bardou, M M; Faivre, L L
Publication Date: 2021-12

Variant appearance in text: PIK3CA: 328_330delGAA
PubMed Link: 34385668
Variant Present in the following documents:
  • Main text
  • 41436_2021_Article_1290.pdf
View BVdb publication page



Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations.

Orphanet Journal Of Rare Diseases
Brouillard, Pascal P; Schlögel, Matthieu J MJ; Homayun Sepehr, Nassim N; Helaers, Raphaël R; Queisser, Angela A; Fastré, Elodie E; Boutry, Simon S; Schmitz, Sandra S; Clapuyt, Philippe P; Hammer, Frank F; Dompmartin, Anne A; Weitz-Tuoretmaa, Annamaria A; Laranne, Jussi J; Pasquesoone, Louise L; Vilain, Catheline C; Boon, Laurence M LM; Vikkula, Miikka M
Publication Date: 2021-06-10

Variant appearance in text: PIK3CA: E110del
PubMed Link: 34112235
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutational Landscape of PI3K-AKT-mTOR Pathway in Breast Cancer: Implications for Targeted Therapeutics.

Journal Of Cancer
Xiao, Weikai W; Zhang, Guochun G; Chen, Bo B; Chen, Xiaoqing X; Wen, Lingzhu L; Lai, Jianguo J; Li, Xuerui X; Li, Min M; Liu, Hao H; Liu, Jing J; Han-Zhang, Han H; Lizaso, Analyn A; Liao, Ning N
Publication Date: 2021

Variant appearance in text: PIK3CA: E110del
PubMed Link: 34093841
Variant Present in the following documents:
  • Main text
  • jcav12p4408.pdf
View BVdb publication page



Detection of PIK3CA Gene Mutation in Head and Neck Squamous Cell Carcinoma Using Droplet Digital PCR and RT-qPCR.

Biomolecules
Borkowska, Edyta M EM; Barańska, Magda M; Kowalczyk, Magdalena M; Pietruszewska, Wioletta W
Publication Date: 2021-05-31

Variant appearance in text: PIK3CA: E109del
PubMed Link: 34072735
Variant Present in the following documents:
  • Main text
  • biomolecules-11-00818.pdf
View BVdb publication page



Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer.

Journal Of Hematology & Oncology
Chen, Gong G; Peng, Junjie J; Xiao, Qian Q; Wu, Hao-Xiang HX; Wu, Xiaojun X; Wang, Fulong F; Li, Liren L; Ding, Peirong P; Zhao, Qi Q; Li, Yaqi Y; Wang, Da D; Shao, Yang Y; Bao, Hua H; Pan, Zhizhong Z; Ding, Ke-Feng KF; Cai, Sanjun S; Wang, Feng F; Xu, Rui-Hua RH
Publication Date: 2021-05-17

Variant appearance in text: PIK3CA: E110del
PubMed Link: 34001194
Variant Present in the following documents:
  • 13045_2021_1089_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Nature Communications
Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A
Publication Date: 2021-04-14

Variant appearance in text: PIK3CA: E110del
PubMed Link: 33854067
Variant Present in the following documents:
  • 41467_2021_22478_MOESM8_ESM.xlsx, sheet 9
View BVdb publication page



A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer.

Bmc Cancer
Xiao, Jian J; Li, Wenyun W; Huang, Yan Y; Huang, Mengli M; Li, Shanshan S; Zhai, Xiaohui X; Zhao, Jing J; Gao, Chan C; Xie, Wenzhuan W; Qin, Hao H; Cai, Shangli S; Bai, Yuezong Y; Lan, Ping P; Zou, Yifeng Y
Publication Date: 2021-03-16

Variant appearance in text: PIK3CA: 328_330del; E110del
PubMed Link: 33726687
Variant Present in the following documents:
  • 12885_2021_7942_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: PIK3CA: 325_327delGAA; E109del
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement.

Nature Communications
Zhang, Yiqun Y; Chen, Fengju F; Donehower, Lawrence A LA; Scheurer, Michael E ME; Creighton, Chad J CJ
Publication Date: 2021-02-10

Variant appearance in text: PIK3CA: 328_330del; E110del
PubMed Link: 33568653
Variant Present in the following documents:
  • 41467_2021_21081_MOESM8_ESM.xlsx, sheet 3
View BVdb publication page



Targetable alterations in invasive pleomorphic lobular carcinoma of the breast.

Breast Cancer Research : Bcr
Riedlinger, Gregory M GM; Joshi, Sonali S; Hirshfield, Kim M KM; Barnard, Nicola N; Ganesan, Shridar S
Publication Date: 2021-01-13

Variant appearance in text: PIK3CA: E110del
PubMed Link: 33441174
Variant Present in the following documents:
  • Main text
  • 13058_2020_Article_1385.pdf
View BVdb publication page



Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine
Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS
Publication Date: 2021-01

Variant appearance in text: PIK3CA: E109del
PubMed Link: 33314633
Variant Present in the following documents:
  • CAM4-10-53-s004.xlsx, sheet 1
  • CAM4-10-53-s003.xlsx, sheet 1
  • CAM4-10-53-s002.xlsx, sheet 1
View BVdb publication page



Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups.

Bmc Medical Genomics
Miller, Eirwen M EM; Patterson, Nicole E NE; Gressel, Gregory M GM; Karabakhtsian, Rouzan G RG; Bejerano-Sagie, Michal M; Ravi, Nivedita N; Maslov, Alexander A; Quispe-Tintaya, Wilber W; Wang, Tao T; Lin, Juan J; Smith, Harriet O HO; Goldberg, Gary L GL; Kuo, Dennis Y S DYS; Montagna, Cristina C
Publication Date: 2020-11-30

Variant appearance in text: PIK3CA: 325_327delGAA
PubMed Link: 33256706
Variant Present in the following documents:
  • Main text
  • 12920_2020_Article_824.pdf
  • 12920_2020_824_MOESM7_ESM.xlsx, sheet 1
  • 12920_2020_824_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Genetic profiling of somatic alterations by Oncomine Focus Assay in Korean patients with advanced gastric cancer.

Oncology Letters
Park, Joonhong J; Lee, Sang-Il SI; Shin, Soyoung S; Hong, Jang Hee JH; Yoo, Han Mo HM; Kim, Jeong Goo JG
Publication Date: 2020-11

Variant appearance in text: PIK3CA: 328_330delGAA; Glu109del
PubMed Link: 32934698
Variant Present in the following documents:
  • Main text
View BVdb publication page



Use of a Targeted Exome Next-Generation Sequencing Panel Offers Therapeutic Opportunity and Clinical Benefit in a Subset of Patients With Advanced Cancers.

Jco Precision Oncology
Kopetz, Scott S; Mills Shaw, Kenna R KR; Lee, J Jack JJ; Zhang, Jiexin J; Litzenburger, Beate B; Holla, Vijaykumar V; Kinyua, Walter W; Broaddus, Emily E; Daniels, Molly S MS; Meric-Bernstam, Funda F; Broaddus, Russell R RR
Publication Date: 2019

Variant appearance in text: PIK3CA: E110del
PubMed Link: 32914008
Variant Present in the following documents:
  • Main text
  • PO.18.00213.pdf
View BVdb publication page



Identification of relevant genetic alterations in cancer using topological data analysis.

Nature Communications
Rabadán, Raúl R; Mohamedi, Yamina Y; Rubin, Udi U; Chu, Tim T; Alghalith, Adam N AN; Elliott, Oliver O; Arnés, Luis L; Cal, Santiago S; Obaya, Álvaro J ÁJ; Levine, Arnold J AJ; Cámara, Pablo G PG
Publication Date: 2020-07-30

Variant appearance in text: PIK3CA: E110del
PubMed Link: 32732999
Variant Present in the following documents:
  • 41467_2020_17659_MOESM3_ESM.xls, sheet 1
View BVdb publication page



Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Nature Communications
Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U
Publication Date: 2020-07-20

Variant appearance in text: PIK3CA: 325_327del
PubMed Link: 32686686
Variant Present in the following documents:
  • 41467_2020_17386_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Histomolecular characterization of intracranial meningiomas developed in patients exposed to high-dose cyproterone acetate: an antiandrogen treatment.

Neuro-Oncology Advances
Portet, Sylvain S; Naoufal, Rania R; Tachon, Gaëlle G; Simonneau, Adrien A; Chalant, Anaïs A; Naar, Amir A; Milin, Serge S; Bataille, Benoit B; Karayan-Tapon, Lucie L
Publication Date: 2019

Variant appearance in text: PIK3CA: E110del
PubMed Link: 32642646
Variant Present in the following documents:
  • Main text
  • vdz003.pdf
View BVdb publication page



Phase and context shape the function of composite oncogenic mutations.

Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Publication Date: 2020-06

Variant appearance in text: PIK3CA: E110del
PubMed Link: 32461694
Variant Present in the following documents:
  • NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2
View BVdb publication page



Frequency and spectrum of PIK3CA somatic mutations in breast cancer.

Breast Cancer Research : Bcr
Martínez-Sáez, Olga O; Chic, Nuria N; Pascual, Tomás T; Adamo, Barbara B; Vidal, Maria M; González-Farré, Blanca B; Sanfeliu, Esther E; Schettini, Francesco F; Conte, Benedetta B; Brasó-Maristany, Fara F; Rodríguez, Adela A; Martínez, Débora D; Galván, Patricia P; Rodríguez, Ana Belén AB; Martinez, Antonio A; Muñoz, Montserrat M; Prat, Aleix A
Publication Date: 2020-05-13

Variant appearance in text: PIK3CA: E110del
PubMed Link: 32404150
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prevalence and characteristics of PIK3CA mutation in mismatch repair-deficient colorectal cancer.

Journal Of Cancer
Li, Weihua W; Qiu, Tian T; Dong, Lin L; Zhang, Fanshuang F; Guo, Lei L; Ying, Jianming J
Publication Date: 2020

Variant appearance in text: PIK3CA: E110del
PubMed Link: 32328187
Variant Present in the following documents:
  • jcav11p3827s1.pdf
View BVdb publication page



Clinical and genomic insights into circulating tumor DNA-based alterations across the spectrum of metastatic hormone-sensitive and castrate-resistant prostate cancer.

Ebiomedicine
Kohli, Manish M; Tan, Winston W; Zheng, Tiantian T; Wang, Amy A; Montesinos, Carlos C; Wong, Calven C; Du, Pan P; Jia, Shidong S; Yadav, Siddhartha S; Horvath, Lisa G LG; Mahon, Kate L KL; Kwan, Edmond M EM; Fettke, Heidi H; Yu, Jianjun J; Azad, Arun A AA
Publication Date: 2020-04

Variant appearance in text: PIK3CA: Glu110del
PubMed Link: 32268276
Variant Present in the following documents:
  • mmc5.xlsx, sheet 2
View BVdb publication page



White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer.

Nature Communications
Leal, Alessandro A; van Grieken, Nicole C T NCT; Palsgrove, Doreen N DN; Phallen, Jillian J; Medina, Jamie E JE; Hruban, Carolyn C; Broeckaert, Mark A M MAM; Anagnostou, Valsamo V; Adleff, Vilmos V; Bruhm, Daniel C DC; Canzoniero, Jenna V JV; Fiksel, Jacob J; Nordsmark, Marianne M; Warmerdam, Fabienne A R M FARM; Verheul, Henk M W HMW; van Spronsen, Dick Johan DJ; Beerepoot, Laurens V LV; Geenen, Maud M MM; Portielje, Johanneke E A JEA; Jansen, Edwin P M EPM; van Sandick, Johanna J; Meershoek-Klein Kranenbarg, Elma E; van Laarhoven, Hanneke W M HWM; van der Peet, Donald L DL; van de Velde, Cornelis J H CJH; Verheij, Marcel M; Fijneman, Remond R; Scharpf, Robert B RB; Meijer, Gerrit A GA; Cats, Annemieke A; Velculescu, Victor E VE
Publication Date: 2020-01-27

Variant appearance in text: PIK3CA: E109del
PubMed Link: 31988276
Variant Present in the following documents:
  • 41467_2020_14310_MOESM1_ESM.pdf
View BVdb publication page