Publications:

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Clinical utility of liquid biopsy and integrative genomic profiling in early-stage and oligometastatic cancer patients treated with radiotherapy.

British Journal Of Cancer

Cifuentes, Guadalupe A GA; Santiago, Adrián A; Méndez Blanco, Lucía L; Fueyo, María M; López Martínez, Esther E; Soria, Raquel R; Martín López, Irene I; Cucarella Beltrán, Pepa P; Pardo-Coto, Pablo P; Rodriguez-Rubi, David D; Urquilla, Karla K; Durán, Noelia S NS; Álvarez, Rebeca R; Lago, Claudia G CG; Otero, Andrea A; Diñeiro, Marta M; Capín, Raquel R; Cadiñanos, Juan J; Cabanillas, Rubén R

Publication Date: 2022-12-22

Variant appearance in text: PIK3CA: 328G>A; Glu110Lys

PubMed Link: 36550207

Variant Present in the following documents:

• Main text
• 41416_2022_Article_2102.pdf
• 41416_2022_2102_MOESM6_ESM.xlsx, sheet 1

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: PIK3CA: 328G>A; E110K

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

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A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research

Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H

Publication Date: 2022-01

Variant appearance in text: PIK3CA: E110K

PubMed Link: 34963661

Variant Present in the following documents:

• supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: PIK3CA: E110K

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Next generation sequencing of glioblastoma circulating tumor cells: non-invasive solution for disease monitoring.

American Journal Of Translational Research

Kolostova, Katarina K; Pospisilova, Eliska E; Pavlickova, Vladimira V; Bartos, Robert R; Sames, Martin M; Pawlak, Ireneusz I; Bobek, Vladimir V

Publication Date: 2021

Variant appearance in text: PIK3CA: 328G>A; E110K

PubMed Link: 34150029

Variant Present in the following documents:

• Main text

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Improved Treatment Outcomes by Using Patient Specific Drug Combinations in Mammalian Target of Rapamycin Activated Advanced Metastatic Cancers.

Frontiers In Pharmacology

Crook, Timothy T; Patil, Darshana D; Gaya, Andrew A; Plowman, Nicholas N; Limaye, Sewanti S; Ranade, Anantbhushan A; Bhatt, Amit A; Page, Raymond R; Akolkar, Dadasaheb D

Publication Date: 2021

Variant appearance in text: PIK3CA: E110K

PubMed Link: 33935721

Variant Present in the following documents:

• Main text

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: PIK3CA: 328G>A; E110K

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

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Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine

Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS

Publication Date: 2021-01

Variant appearance in text: PIK3CA: E110K

PubMed Link: 33314633

Variant Present in the following documents:

• CAM4-10-53-s003.xlsx, sheet 1

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Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.

Cancers

Hamid, Abdulaziz B AB; Petreaca, Ruben C RC

Publication Date: 2020-04-09

Variant appearance in text: PIK3CA: E110K

PubMed Link: 32283832

Variant Present in the following documents:

• cancers-12-00927-s001.pdf

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: PIK3CA: E110K

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer.

Cancer Research And Treatment

Choi, Jung Yoon JY; Choi, Sunho S; Lee, Minhyeok M; Park, Young Soo YS; Sung, Jae Sook JS; Chang, Won Jin WJ; Kim, Ju Won JW; Choi, Yoon Ji YJ; Kim, Jin J; Kim, Dong-Sik DS; Lee, Sung-Ho SH; Seok, Junhee J; Park, Kyong Hwa KH; Kim, Seon Hahn SH; Kim, Yeul Hong YH

Publication Date: 2020-07

Variant appearance in text: PIK3CA: E110K

PubMed Link: 32065847

Variant Present in the following documents:

• crt-2020-044.pdf

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Phase II, 2-stage, 2-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer.

International Journal Of Cancer

Myers, Andrea P AP; Konstantinopoulos, Panagiotis A PA; Barry, William T WT; Luo, Weixiu W; Broaddus, Russell R RR; Makker, Vicky V; Drapkin, Ronny R; Liu, Joyce J; Doyle, Austin A; Horowitz, Neil S NS; Meric-Bernstam, Funda F; Birrer, Michael M; Aghajanian, Carol C; Coleman, Robert L RL; Mills, Gordon B GB; Cantley, Lewis C LC; Matulonis, Ursula A UA; Westin, Shannon N SN

Publication Date: 2020-07-15

Variant appearance in text: PIK3CA: E110K

PubMed Link: 31714586

Variant Present in the following documents:

• Main text

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SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study).

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer

Langer, Corey J CJ; Redman, Mary W MW; Wade, James L JL; Aggarwal, Charu C; Bradley, Jeffrey D JD; Crawford, Jeffrey J; Stella, Philip J PJ; Knapp, Mark H MH; Miao, Jieling J; Minichiello, Katherine K; Herbst, Roy S RS; Kelly, Karen K; Gandara, David R DR; Papadimitrakopoulou, Vassiliki A VA

Publication Date: 2019-10

Variant appearance in text: PI3K: E110K

PubMed Link: 31158500

Variant Present in the following documents:

• Main text

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Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Nature Communications

Chen, Li L; Yang, Liu L; Yao, Ling L; Kuang, Xia-Ying XY; Zuo, Wen-Jia WJ; Li, Shan S; Qiao, Feng F; Liu, Yi-Rong YR; Cao, Zhi-Gang ZG; Zhou, Shu-Ling SL; Zhou, Xiao-Yan XY; Yang, Wen-Tao WT; Shi, Jin-Xiu JX; Huang, Wei W; Hu, Xin X; Shao, Zhi-Ming ZM

Publication Date: 2018-04-10

Variant appearance in text: PIK3CA: E110K

PubMed Link: 29636477

Variant Present in the following documents:

• 41467_2018_3867_MOESM1_ESM.pdf

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Circulating tumour-derived DNA in metastatic soft tissue sarcoma.

Oncotarget

Eastley, Nicholas C NC; Ottolini, Barbara B; Neumann, Rita R; Luo, Jin-Li JL; Hastings, Robert K RK; Khan, Imran I; Moore, David A DA; Esler, Claire P CP; Shaw, Jacqueline A JA; Royle, Nicola J NJ; Ashford, Robert U RU

Publication Date: 2018-02-13

Variant appearance in text: PIK3CA: E110K

PubMed Link: 29535826

Variant Present in the following documents:

• Main text
• oncotarget-09-10549.pdf

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Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications

Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ

Publication Date: 2017-08-04

Variant appearance in text: PIK3CA: 328G>A; E110K

PubMed Link: 28775315

Variant Present in the following documents:

• 41467_2017_289_MOESM7_ESM.xlsx, sheet 1

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: PI3K: 328G>A

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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PIK3CA Mutations Contribute to Acquired Cetuximab Resistance in Patients with Metastatic Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Xu, Jian-Ming JM; Wang, Yan Y; Wang, You-Liang YL; Wang, Yan Y; Liu, Tao T; Ni, Ming M; Li, Man-Sheng MS; Lin, Li L; Ge, Fei-Jiao FJ; Gong, Chun C; Gu, Jun-Yan JY; Jia, Ru R; Wang, He-Fei HF; Chen, Yu-Ling YL; Liu, Rong-Rui RR; Zhao, Chuan-Hua CH; Tan, Zhao-Li ZL; Jin, Yang Y; Zhu, Yun-Ping YP; Ogino, Shuji S; Qian, Zhi-Rong ZR

Publication Date: 2017-08-15

Variant appearance in text: PIK3CA: 328G>A

PubMed Link: 28424201

Variant Present in the following documents:

• Main text

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Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology.

Oncotarget

Ibarrola-Villava, Maider M; Fleitas, Tania T; Llorca-Cardeñosa, Marta J MJ; Mongort, Cristina C; Alonso, Elisa E; Navarro, Samuel S; Burgues, Octavio O; Vivancos, Ana A; Cejalvo, Juan Miguel JM; Perez-Fidalgo, José Alejandro JA; Roselló, Susana S; Ribas, Gloria G; Cervantes, Andrés A

Publication Date: 2016-04-19

Variant appearance in text: PIK3CA: E110K

PubMed Link: 26968814

Variant Present in the following documents:

• oncotarget-07-22543-s001.pdf

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High-throughput profiling identifies clinically actionable mutations in salivary duct carcinoma.

Journal Of Translational Medicine

Ku, Bo Mi BM; Jung, Hyun Ae HA; Sun, Jong-Mu JM; Ko, Young Hyeh YH; Jeong, Han-Sin HS; Son, Young-Ik YI; Baek, Chung-Hwan CH; Park, Keunchil K; Ahn, Myung-Ju MJ

Publication Date: 2014-10-25

Variant appearance in text: PIK3CA: E110K

PubMed Link: 25343854

Variant Present in the following documents:

• Main text
• 12967_2014_Article_299.pdf

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Triple-negative breast cancer patients treated at MD Anderson Cancer Center in phase I trials: improved outcomes with combination chemotherapy and targeted agents.

Molecular Cancer Therapeutics

Ganesan, Prasanth P; Moulder, Stacy S; Lee, J Jack JJ; Janku, Filip F; Valero, Vicente V; Zinner, Ralph G RG; Naing, Aung A; Fu, Siqing S; Tsimberidou, Apostolia M AM; Hong, David D; Stephen, Bettzy B; Stephens, Philip P; Yelensky, Roman R; Meric-Bernstam, Funda F; Kurzrock, Razelle R; Wheler, Jennifer J JJ

Publication Date: 2014-12

Variant appearance in text: PIK3CA: E110K

PubMed Link: 25253784

Variant Present in the following documents:

• Main text

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A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.

Bmc Cancer

Wiegand, Kimberly C KC; Hennessy, Bryan T BT; Leung, Samuel S; Wang, Yemin Y; Ju, Zhenlin Z; McGahren, Mollianne M; Kalloger, Steve E SE; Finlayson, Sarah S; Stemke-Hale, Katherine K; Lu, Yiling Y; Zhang, Fan F; Anglesio, Michael S MS; Gilks, Blake B; Mills, Gordon B GB; Huntsman, David G DG; Carey, Mark S MS

Publication Date: 2014-02-22

Variant appearance in text: PIK3CA: E110K

PubMed Link: 24559118

Variant Present in the following documents:

• Main text
• 1471-2407-14-120.pdf

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Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors.

Cell Reports

Janku, Filip F; Hong, David S DS; Fu, Siqing S; Piha-Paul, Sarina A SA; Naing, Aung A; Falchook, Gerald S GS; Tsimberidou, Apostolia M AM; Stepanek, Vanda M VM; Moulder, Stacy L SL; Lee, J Jack JJ; Luthra, Rajyalakshmi R; Zinner, Ralph G RG; Broaddus, Russell R RR; Wheler, Jennifer J JJ; Kurzrock, Razelle R

Publication Date: 2014-01-30

Variant appearance in text: PIK3CA: E110K

PubMed Link: 24440717

Variant Present in the following documents:

• Main text

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Target-based therapeutic matching in early-phase clinical trials in patients with advanced colorectal cancer and PIK3CA mutations.

Molecular Cancer Therapeutics

Ganesan, Prasanth P; Janku, Filip F; Naing, Aung A; Hong, David S DS; Tsimberidou, Apostolia M AM; Falchook, Gerald S GS; Wheler, Jennifer J JJ; Piha-Paul, Sarina A SA; Fu, Siqing S; Stepanek, Vanda M VM; Lee, J Jack JJ; Luthra, Rajyalakshmi R; Overman, Michael J MJ; Kopetz, E Scott ES; Wolff, Robert A RA; Kurzrock, Razelle R

Publication Date: 2013-12

Variant appearance in text: PIK3CA: E110K

PubMed Link: 24092809

Variant Present in the following documents:

• Main text

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Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

Cancer Discovery

Lui, Vivian W Y VW; Hedberg, Matthew L ML; Li, Hua H; Vangara, Bhavana S BS; Pendleton, Kelsey K; Zeng, Yan Y; Lu, Yiling Y; Zhang, Qiuhong Q; Du, Yu Y; Gilbert, Breean R BR; Freilino, Maria M; Sauerwein, Sam S; Peyser, Noah D ND; Xiao, Dong D; Diergaarde, Brenda B; Wang, Lin L; Chiosea, Simion S; Seethala, Raja R; Johnson, Jonas T JT; Kim, Seungwon S; Duvvuri, Umamaheswar U; Ferris, Robert L RL; Romkes, Marjorie M; Nukui, Tomoko T; Kwok-Shing Ng, Patrick P; Garraway, Levi A LA; Hammerman, Peter S PS; Mills, Gordon B GB; Grandis, Jennifer R JR

Publication Date: 2013-07

Variant appearance in text: PIK3CA: E110K

PubMed Link: 23619167

Variant Present in the following documents:

• Main text

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PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials.

Cancer Research

Janku, Filip F; Wheler, Jennifer J JJ; Naing, Aung A; Falchook, Gerald S GS; Hong, David S DS; Stepanek, Vanda M VM; Fu, Siqing S; Piha-Paul, Sarina A SA; Lee, J Jack JJ; Luthra, Rajyalakshmi R; Tsimberidou, Apostolia M AM; Kurzrock, Razelle R

Publication Date: 2013-01-01

Variant appearance in text: PIK3CA: E110K

PubMed Link: 23066039

Variant Present in the following documents:

• Main text

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Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells.

Cancer Biology & Therapy

Dickstein, Rian J RJ; Nitti, Giovanni G; Dinney, Colin P CP; Davies, Barry R BR; Kamat, Ashish M AM; McConkey, David J DJ

Publication Date: 2012-11

Variant appearance in text: PIK3CA: E110K

PubMed Link: 22895070

Variant Present in the following documents:

• Main text

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Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers.

Breast Cancer Research And Treatment

Santarpia, Libero L; Qi, Yuan Y; Stemke-Hale, Katherine K; Wang, Bailiang B; Young, Elliana J EJ; Booser, Daniel J DJ; Holmes, Frankie A FA; O'Shaughnessy, Joyce J; Hellerstedt, Beth B; Pippen, John J; Vidaurre, Tatiana T; Gomez, Henry H; Valero, Vicente V; Hortobagyi, Gabriel N GN; Symmans, W Fraser WF; Bottai, Giulia G; Di Leo, Angelo A; Gonzalez-Angulo, Ana M AM; Pusztai, Lajos L

Publication Date: 2012-07

Variant appearance in text: PIK3CA: 328G>A

PubMed Link: 22538770

Variant Present in the following documents:

• Main text

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: PIK3CA: E110K

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.

Cancer Research

Stemke-Hale, Katherine K; Gonzalez-Angulo, Ana Maria AM; Lluch, Ana A; Neve, Richard M RM; Kuo, Wen-Lin WL; Davies, Michael M; Carey, Mark M; Hu, Zhi Z; Guan, Yinghui Y; Sahin, Aysegul A; Symmans, W Fraser WF; Pusztai, Lajos L; Nolden, Laura K LK; Horlings, Hugo H; Berns, Katrien K; Hung, Mien-Chie MC; van de Vijver, Marc J MJ; Valero, Vicente V; Gray, Joe W JW; Bernards, René R; Mills, Gordon B GB; Hennessy, Bryan T BT

Publication Date: 2008-08-01

Variant appearance in text: PIK3CA: E110K

PubMed Link: 18676830

Variant Present in the following documents:

• Main text

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