Downregulation of SMIM3 inhibits growth of leukemia via PI3K-AKT signaling pathway and correlates with prognosis of adult acute myeloid leukemia with normal karyotype.
Journal Of Translational Medicine
Liu, Yu Y; Chen, Yufei Y; Liu, Yajun Y; Li, Mengya M; Zhang, Yu Y; Shi, Luyao L; Yang, Lu L; Li, Tao T; Li, Yafei Y; Jiang, Zhongxing Z; Liu, Yanfang Y; Wang, Chong C; Wang, Shujuan S
Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers.
Nature Communications
Shah, Jennifer B JB; Pueschl, Dana D; Wubbenhorst, Bradley B; Fan, Mengyao M; Pluta, John J; D'Andrea, Kurt K; Hubert, Anna P AP; Shilan, Jake S JS; Zhou, Wenting W; Kraya, Adam A AA; Llop Guevara, Alba A; Ruan, Catherine C; Serra, Violeta V; Balmaña, Judith J; Feldman, Michael M; Morin, Pat J PJ; Nayak, Anupma A; Maxwell, Kara N KN; Domchek, Susan M SM; Nathanson, Katherine L KL
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors.
Scientific Reports
Thulin, Anna A; Andersson, Carola C; Werner Rönnerman, Elisabeth E; De Lara, Shahin S; Chamalidou, Chaido C; Schoenfeld, Arnd A; Kovács, Anikó A; Fagman, Henrik H; Enlund, Fredrik F; Linderholm, Barbro K BK
Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors.
Scientific Reports
Thulin, Anna A; Andersson, Carola C; Werner Rönnerman, Elisabeth E; De Lara, Shahin S; Chamalidou, Chaido C; Schoenfeld, Arnd A; Kovács, Anikó A; Fagman, Henrik H; Enlund, Fredrik F; Linderholm, Barbro K BK
FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia.
Translational Oncology
Fang, Douglas D DD; Zhu, Hengrui H; Tang, Qiuqiong Q; Wang, Guangfeng G; Min, Ping P; Wang, Qixin Q; Li, Na N; Yang, Dajun D; Zhai, Yifan Y
FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia.
Translational Oncology
Fang, Douglas D DD; Zhu, Hengrui H; Tang, Qiuqiong Q; Wang, Guangfeng G; Min, Ping P; Wang, Qixin Q; Li, Na N; Yang, Dajun D; Zhai, Yifan Y
Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy.
Redox Biology
Liu, Chaoyang C; Han, Yuehu Y; Gu, Xiaoming X; Li, Man M; Du, Yanyan Y; Feng, Na N; Li, Juan J; Zhang, Shumiao S; Maslov, Leonid N LN; Wang, Guoen G; Pei, Jianming J; Fu, Feng F; Ding, Mingge M
High-throughput compound screening identifies navitoclax combined with irradiation as a candidate therapy for HPV-negative head and neck squamous cell carcinoma.
Scientific Reports
Tuomainen, Katja K; Hyytiäinen, Aini A; Al-Samadi, Ahmed A; Ianevski, Philipp P; Ianevski, Aleksandr A; Potdar, Swapnil S; Turunen, Laura L; Saarela, Jani J; Kuznetsov, Sergey S; Wahbi, Wafa W; Risteli, Maija M; Mäkitie, Antti A; Monni, Outi O; Salo, Tuula T
Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment.
Clinical And Translational Medicine
Skaga, Erlend E; Kulesskiy, Evgeny E; Brynjulvsen, Marit M; Sandberg, Cecilie J CJ; Potdar, Swapnil S; Langmoen, Iver A IA; Laakso, Aki A; Gaál-Paavola, Emília E; Perola, Markus M; Wennerberg, Krister K; Vik-Mo, Einar O EO
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
The Journal Of Pathology
Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I
Genomic markers of ovarian adenocarcinoma and its relevancy to the effectiveness of chemotherapy.
Oncology Letters
Englert-Golon, Monika M; Burchardt, Bartosz B; Budny, Bartlomiej B; Dębicki, Szymon S; Majchrzycka, Blanka B; Wrotkowska, Elzbieta E; Jasiński, Piotr P; Ziemnicka, Katarzyna K; Słopień, Radosław R; Ruchała, Marek M; Sajdak, Stefan S
The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy.
Oncotarget
Ahn, Sung-Min SM; Ansari, Adnan Ahmad AA; Kim, Jihun J; Kim, Deokhoon D; Chun, Sung-Min SM; Kim, Jiyun J; Kim, Tae Won TW; Park, Inja I; Yu, Chang-Sik CS; Jang, Se Jin SJ
Analysis of tumor template from multiple compartments in a blood sample provides complementary access to peripheral tumor biomarkers.
Oncotarget
Strauss, William M WM; Carter, Chris C; Simmons, Jill J; Klem, Erich E; Goodman, Nathan N; Vahidi, Behrad B; Romero, Juan J; Masterman-Smith, Michael M; O'Regan, Ruth R; Gogineni, Keerthi K; Schwartzberg, Lee L; Austin, Laura K LK; Dempsey, Paul W PW; Cristofanilli, Massimo M