PIK3CA c.419G>A ;(p.R140Q)

Variant ID: 3-178917544-G-A

NM_006218.2(PIK3CA):c.419G>A;(p.R140Q)

This variant was identified in 28 publications

View GRCh38 version.




Publications:


DeteX: A highly accurate software for detecting SNV and InDel in single and paired NGS data in cancer research.

Frontiers In Genetics
Cui, Yunlong Y; Li, Hongfeng H; Liu, Pengfei P; Wang, Hailong H; Zhang, Zhenzhen Z; Qu, Hongzhu H; Tian, Caijuan C; Fang, Xiangdong X
Publication Date: 2022

Variant appearance in text: PIK3CA: 419G>A; Arg140Gln
PubMed Link: 36685970
Variant Present in the following documents:
  • Table5.xlsx, sheet 1
View BVdb publication page



Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: PIK3CA: R140Q
PubMed Link: 36561320
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
  • Table2.xlsx, sheet 5
View BVdb publication page



Downregulation of SMIM3 inhibits growth of leukemia via PI3K-AKT signaling pathway and correlates with prognosis of adult acute myeloid leukemia with normal karyotype.

Journal Of Translational Medicine
Liu, Yu Y; Chen, Yufei Y; Liu, Yajun Y; Li, Mengya M; Zhang, Yu Y; Shi, Luyao L; Yang, Lu L; Li, Tao T; Li, Yafei Y; Jiang, Zhongxing Z; Liu, Yanfang Y; Wang, Chong C; Wang, Shujuan S
Publication Date: 2022-12-22

Variant appearance in text: PI3K: R140Q
PubMed Link: 36550462
Variant Present in the following documents:
  • 12967_2022_Article_3831.pdf
View BVdb publication page



Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers.

Nature Communications
Shah, Jennifer B JB; Pueschl, Dana D; Wubbenhorst, Bradley B; Fan, Mengyao M; Pluta, John J; D'Andrea, Kurt K; Hubert, Anna P AP; Shilan, Jake S JS; Zhou, Wenting W; Kraya, Adam A AA; Llop Guevara, Alba A; Ruan, Catherine C; Serra, Violeta V; Balmaña, Judith J; Feldman, Michael M; Morin, Pat J PJ; Nayak, Anupma A; Maxwell, Kara N KN; Domchek, Susan M SM; Nathanson, Katherine L KL
Publication Date: 2022-11-07

Variant appearance in text: PIK3CA: R140Q
PubMed Link: 36344544
Variant Present in the following documents:
  • 41467_2022_34523_MOESM4_ESM.xlsx, sheet 2
View BVdb publication page



Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Publication Date: 2022-07-13

Variant appearance in text: PIK3CA: 419G>A; R140H
PubMed Link: 35831314
Variant Present in the following documents:
  • 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3
View BVdb publication page



Characterization of the Estrogen Response Helps to Predict Prognosis and Identify Potential Therapeutic Targets in Cholangiocarcinoma.

Frontiers In Oncology
Lu, Chenglin C; Miao, Ji J; Li, Minhuan M; Zheng, Qisi Q; Xu, Feng F; Pan, Yiming Y; Wang, Yizhou Y; Yang, Zhi Z; Xia, Xuefeng X; Zhu, Hao H; Chen, Jie J; Bao, Shanhua S
Publication Date: 2022

Variant appearance in text: PI3K: R140Q
PubMed Link: 35664769
Variant Present in the following documents:
  • DataSheet_1.pdf
View BVdb publication page



Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors.

Scientific Reports
Thulin, Anna A; Andersson, Carola C; Werner Rönnerman, Elisabeth E; De Lara, Shahin S; Chamalidou, Chaido C; Schoenfeld, Arnd A; Kovács, Anikó A; Fagman, Henrik H; Enlund, Fredrik F; Linderholm, Barbro K BK
Publication Date: 2021-12-07

Variant appearance in text: PIK3CA: R140Q
PubMed Link: 34876602
Variant Present in the following documents:
  • 41598_2021_2903_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors.

Scientific Reports
Thulin, Anna A; Andersson, Carola C; Werner Rönnerman, Elisabeth E; De Lara, Shahin S; Chamalidou, Chaido C; Schoenfeld, Arnd A; Kovács, Anikó A; Fagman, Henrik H; Enlund, Fredrik F; Linderholm, Barbro K BK
Publication Date: 2021-12-07

Variant appearance in text: PIK3CA: R140Q
PubMed Link: 34876602
Variant Present in the following documents:
  • 41598_2021_2903_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia.

Translational Oncology
Fang, Douglas D DD; Zhu, Hengrui H; Tang, Qiuqiong Q; Wang, Guangfeng G; Min, Ping P; Wang, Qixin Q; Li, Na N; Yang, Dajun D; Zhai, Yifan Y
Publication Date: 2021-10-25

Variant appearance in text: PI3K: R140Q
PubMed Link: 34710737
Variant Present in the following documents:
  • Main text
View BVdb publication page



FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia.

Translational Oncology
Fang, Douglas D DD; Zhu, Hengrui H; Tang, Qiuqiong Q; Wang, Guangfeng G; Min, Ping P; Wang, Qixin Q; Li, Na N; Yang, Dajun D; Zhai, Yifan Y
Publication Date: 2022-01

Variant appearance in text: PI3K: R140Q
PubMed Link: 34710737
Variant Present in the following documents:
  • Main text
View BVdb publication page



Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy.

Redox Biology
Liu, Chaoyang C; Han, Yuehu Y; Gu, Xiaoming X; Li, Man M; Du, Yanyan Y; Feng, Na N; Li, Juan J; Zhang, Shumiao S; Maslov, Leonid N LN; Wang, Guoen G; Pei, Jianming J; Fu, Feng F; Ding, Mingge M
Publication Date: 2021-10

Variant appearance in text: PI3K: R140Q
PubMed Link: 34418601
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



High-throughput compound screening identifies navitoclax combined with irradiation as a candidate therapy for HPV-negative head and neck squamous cell carcinoma.

Scientific Reports
Tuomainen, Katja K; Hyytiäinen, Aini A; Al-Samadi, Ahmed A; Ianevski, Philipp P; Ianevski, Aleksandr A; Potdar, Swapnil S; Turunen, Laura L; Saarela, Jani J; Kuznetsov, Sergey S; Wahbi, Wafa W; Risteli, Maija M; Mäkitie, Antti A; Monni, Outi O; Salo, Tuula T
Publication Date: 2021-07-20

Variant appearance in text: PI3K: R140Q
PubMed Link: 34285300
Variant Present in the following documents:
  • 41598_2021_94259_MOESM1_ESM.pdf
  • 41598_2021_94259_MOESM3_ESM.pdf
View BVdb publication page



NGS-based liquid biopsy profiling identifies mechanisms of resistance to ALK inhibitors: a step toward personalized NSCLC treatment.

Molecular Oncology
Sánchez-Herrero, Estela E; Serna-Blasco, Roberto R; Ivanchuk, Vadym V; García-Campelo, Rosario R; Dómine Gómez, Manuel M; Sánchez, José M JM; Massutí, Bartomeu B; Reguart, Noemi N; Camps, Carlos C; Sanz-Moreno, Sandra S; Calabuig-Fariñas, Silvia S; Jantus-Lewintre, Eloísa E; Arnal, Magdalena M; Fernández-Orth, Dietmar D; Calvo, Virginia V; González-Rumayor, Víctor V; Provencio, Mariano M; Romero, Atocha A
Publication Date: 2021-09

Variant appearance in text: PIK3CA: 419G>A
PubMed Link: 34058070
Variant Present in the following documents:
  • MOL2-15-2363.pdf
View BVdb publication page



NGS-based liquid biopsy profiling identifies mechanisms of resistance to ALK inhibitors: a step toward personalized NSCLC treatment.

Molecular Oncology
Sánchez-Herrero, Estela E; Serna-Blasco, Roberto R; Ivanchuk, Vadym V; García-Campelo, Rosario R; Dómine Gómez, Manuel M; Sánchez, José M JM; Massutí, Bartomeu B; Reguart, Noemi N; Camps, Carlos C; Sanz-Moreno, Sandra S; Calabuig-Fariñas, Silvia S; Jantus-Lewintre, Eloísa E; Arnal, Magdalena M; Fernández-Orth, Dietmar D; Calvo, Virginia V; González-Rumayor, Víctor V; Provencio, Mariano M; Romero, Atocha A
Publication Date: 2021-09

Variant appearance in text: PIK3CA: 419G>A
PubMed Link: 34058070
Variant Present in the following documents:
  • MOL2-15-2363.pdf
View BVdb publication page



Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.

Nature Communications
Desbois, Mélanie M; Udyavar, Akshata R AR; Ryner, Lisa L; Kozlowski, Cleopatra C; Guan, Yinghui Y; Dürrbaum, Milena M; Lu, Shan S; Fortin, Jean-Philippe JP; Koeppen, Hartmut H; Ziai, James J; Chang, Ching-Wei CW; Keerthivasan, Shilpa S; Plante, Marie M; Bourgon, Richard R; Bais, Carlos C; Hegde, Priti P; Daemen, Anneleen A; Turley, Shannon S; Wang, Yulei Y
Publication Date: 2020-11-04

Variant appearance in text: PIK3CA: Arg140Gln
PubMed Link: 33149148
Variant Present in the following documents:
  • 41467_2020_19408_MOESM8_ESM.xlsx, sheet 10
View BVdb publication page



Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types.

Genome Research
Boot, Arnoud A; Ng, Alvin W T AWT; Chong, Fui Teen FT; Ho, Szu-Chi SC; Yu, Willie W; Tan, Daniel S W DSW; Iyer, N Gopalakrishna NG; Rozen, Steven G SG
Publication Date: 2020-06

Variant appearance in text: PIK3CA: R140Q
PubMed Link: 32661091
Variant Present in the following documents:
  • supp_gr.255620.119_Supplemental_Table_S2.xlsx, sheet 1
View BVdb publication page



Does breast carcinoma belong to the Lynch syndrome tumor spectrum? - Somatic mutational profiles vs. ovarian and colorectal carcinomas.

Oncotarget
Porkka, Noora K NK; Olkinuora, Alisa A; Kuopio, Teijo T; Ahtiainen, Maarit M; Eldfors, Samuli S; Almusa, Henrikki H; Mecklin, Jukka-Pekka JP; Peltomäki, Päivi P
Publication Date: 2020-04-07

Variant appearance in text: PIK3CA: 419G>A
PubMed Link: 32292574
Variant Present in the following documents:
  • oncotarget-11-1244-s005.xlsx, sheet 1
View BVdb publication page



Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment.

Clinical And Translational Medicine
Skaga, Erlend E; Kulesskiy, Evgeny E; Brynjulvsen, Marit M; Sandberg, Cecilie J CJ; Potdar, Swapnil S; Langmoen, Iver A IA; Laakso, Aki A; Gaál-Paavola, Emília E; Perola, Markus M; Wennerberg, Krister K; Vik-Mo, Einar O EO
Publication Date: 2019-12-30

Variant appearance in text: PI3K: R140Q
PubMed Link: 31889236
Variant Present in the following documents:
  • 40169_2019_253_MOESM7_ESM.pdf
  • 40169_2019_253_MOESM6_ESM.pdf
View BVdb publication page



Targeting Metabolic Reprogramming in Acute Myeloid Leukemia.

Cells
Castro, Isabel I; Sampaio-Marques, Belém B; Ludovico, Paula P
Publication Date: 2019-08-24

Variant appearance in text: PI3K: R140Q
PubMed Link: 31450562
Variant Present in the following documents:
  • Main text
View BVdb publication page



A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing.

Genome Medicine
Cao, Ye Y; Tokita, Mari J MJ; Chen, Edward S ES; Ghosh, Rajarshi R; Chen, Tiansheng T; Feng, Yanming Y; Gorman, Elizabeth E; Gibellini, Federica F; Ward, Patricia A PA; Braxton, Alicia A; Wang, Xia X; Meng, Linyan L; Xiao, Rui R; Bi, Weimin W; Xia, Fan F; Eng, Christine M CM; Yang, Yaping Y; Gambin, Tomasz T; Shaw, Chad C; Liu, Pengfei P; Stankiewicz, Pawel P
Publication Date: 2019-07-26

Variant appearance in text: PIK3CA: 419G>A; R140Q
PubMed Link: 31349857
Variant Present in the following documents:
  • Main text
View BVdb publication page



Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma.

Bmc Cancer
Skaga, Erlend E; Kulesskiy, Evgeny E; Fayzullin, Artem A; Sandberg, Cecilie J CJ; Potdar, Swapnil S; Kyttälä, Aija A; Langmoen, Iver A IA; Laakso, Aki A; Gaál-Paavola, Emília E; Perola, Markus M; Wennerberg, Krister K; Vik-Mo, Einar O EO
Publication Date: 2019-06-25

Variant appearance in text: PI3K: R140Q
PubMed Link: 31238897
Variant Present in the following documents:
  • 12885_2019_5861_MOESM9_ESM.pdf
  • 12885_2019_5861_MOESM8_ESM.pdf
View BVdb publication page



Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer.

Genomics & Informatics
Yoon, Kyong-Ah KA; Woo, Sang Myung SM; Kim, Yun-Hee YH; Kong, Sun-Young SY; Han, Sung-Sik SS; Park, Sang-Jae SJ; Lee, Woo Jin WJ
Publication Date: 2018-12

Variant appearance in text: PIK3CA: 419G>A
PubMed Link: 30602096
Variant Present in the following documents:
  • Main text
View BVdb publication page



Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium.

Scientific Reports
Popp, Bernt B; Krumbiegel, Mandy M; Grosch, Janina J; Sommer, Annika A; Uebe, Steffen S; Kohl, Zacharias Z; Plötz, Sonja S; Farrell, Michaela M; Trautmann, Udo U; Kraus, Cornelia C; Ekici, Arif B AB; Asadollahi, Reza R; Regensburger, Martin M; Günther, Katharina K; Rauch, Anita A; Edenhofer, Frank F; Winkler, Jürgen J; Winner, Beate B; Reis, André A
Publication Date: 2018-11-21

Variant appearance in text: PIK3CA: 419G>A
PubMed Link: 30464253
Variant Present in the following documents:
  • 41598_2018_35506_MOESM5_ESM.xlsx, sheet 4
View BVdb publication page



Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues.

Oncology Reports
Tamura, Hirosumi H; Higa, Arisa A; Hoshi, Hirotaka H; Hiyama, Gen G; Takahashi, Nobuhiko N; Ryufuku, Masae M; Morisawa, Gaku G; Yanagisawa, Yuka Y; Ito, Emi E; Imai, Jun-Ichi JI; Dobashi, Yuu Y; Katahira, Kiyoaki K; Soeda, Shu S; Watanabe, Takafumi T; Fujimori, Keiya K; Watanabe, Shinya S; Takagi, Motoki M
Publication Date: 2018-08

Variant appearance in text: PI3K: R140Q
PubMed Link: 29917168
Variant Present in the following documents:
  • Main text
View BVdb publication page



Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

The Journal Of Pathology
Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I
Publication Date: 2018-07

Variant appearance in text: PIK3CA: 419G>A; R140Q
PubMed Link: 29604063
Variant Present in the following documents:
  • PATH-245-283-s022.xlsx, sheet 1
View BVdb publication page



Genomic markers of ovarian adenocarcinoma and its relevancy to the effectiveness of chemotherapy.

Oncology Letters
Englert-Golon, Monika M; Burchardt, Bartosz B; Budny, Bartlomiej B; Dębicki, Szymon S; Majchrzycka, Blanka B; Wrotkowska, Elzbieta E; Jasiński, Piotr P; Ziemnicka, Katarzyna K; Słopień, Radosław R; Ruchała, Marek M; Sajdak, Stefan S
Publication Date: 2017-09

Variant appearance in text: PIK3CA: 419G>A; R140Q
PubMed Link: 28927094
Variant Present in the following documents:
  • Main text
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: PI3K: 419G>A
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy.

Oncotarget
Ahn, Sung-Min SM; Ansari, Adnan Ahmad AA; Kim, Jihun J; Kim, Deokhoon D; Chun, Sung-Min SM; Kim, Jiyun J; Kim, Tae Won TW; Park, Inja I; Yu, Chang-Sik CS; Jang, Se Jin SJ
Publication Date: 2016-10-18

Variant appearance in text: PIK3CA: R140Q
PubMed Link: 27612425
Variant Present in the following documents:
  • oncotarget-07-68638-s008.xlsx, sheet 1
View BVdb publication page



Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples.

Journal Of Translational Medicine
Dallol, Ashraf A; Buhmeida, Abdelbaset A; Al-Ahwal, Mahmoud Shaheen MS; Al-Maghrabi, Jaudah J; Bajouh, Osama O; Al-Khayyat, Shadi S; Alam, Rania R; Abusanad, Atlal A; Turki, Rola R; Elaimi, Aisha A; Alhadrami, Hani A HA; Abuzenadah, Mohammed M; Banni, Huda H; Al-Qahtani, Mohammed H MH; Abuzenadah, Adel M AM
Publication Date: 2016-05-04

Variant appearance in text: PIK3CA: Arg140Gln
PubMed Link: 27146902
Variant Present in the following documents:
  • Main text
View BVdb publication page



Analysis of tumor template from multiple compartments in a blood sample provides complementary access to peripheral tumor biomarkers.

Oncotarget
Strauss, William M WM; Carter, Chris C; Simmons, Jill J; Klem, Erich E; Goodman, Nathan N; Vahidi, Behrad B; Romero, Juan J; Masterman-Smith, Michael M; O'Regan, Ruth R; Gogineni, Keerthi K; Schwartzberg, Lee L; Austin, Laura K LK; Dempsey, Paul W PW; Cristofanilli, Massimo M
Publication Date: 2016-05-03

Variant appearance in text: PIK3CA: R140Q
PubMed Link: 27049831
Variant Present in the following documents:
  • Main text
View BVdb publication page



Single-Nucleotide Mutations in FMR1 Reveal Novel Functions and Regulatory Mechanisms of the Fragile X Syndrome Protein FMRP.

Journal Of Experimental Neuroscience
Suhl, Joshua A JA; Warren, Stephen T ST
Publication Date: 2015

Variant appearance in text: PI3K: R140Q
PubMed Link: 26819560
Variant Present in the following documents:
  • Main text
View BVdb publication page